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Items: 16


Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction.

Nault R, Doskey CM, Fader KA, Rockwell CE, Zacharewski T.

Mol Pharmacol. 2018 Aug;94(2):876-884. doi: 10.1124/mol.118.112144. Epub 2018 May 11.


2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice.

Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR.

Toxicol Appl Pharmacol. 2018 Jun 1;348:85-98. doi: 10.1016/j.taap.2018.04.013. Epub 2018 Apr 16.


Corrigendum to "Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17].

Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR.

Toxicol Appl Pharmacol. 2018 Apr 1;344:74. doi: 10.1016/j.taap.2018.03.001. Epub 2018 Mar 2. No abstract available.


Beyond the Aryl Hydrocarbon Receptor: Pathway Interactions in the Hepatotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and Related Compounds.

Fader KA, Zacharewski TR.

Curr Opin Toxicol. 2017 Feb;2:36-41. doi: 10.1016/j.cotox.2017.01.010. Epub 2017 Feb 1.


Loss of liver-specific and sexually dimorphic gene expression by aryl hydrocarbon receptor activation in C57BL/6 mice.

Nault R, Fader KA, Harkema JR, Zacharewski T.

PLoS One. 2017 Sep 18;12(9):e0184842. doi: 10.1371/journal.pone.0184842. eCollection 2017.


2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-elicited effects on bile acid homeostasis: Alterations in biosynthesis, enterohepatic circulation, and microbial metabolism.

Fader KA, Nault R, Zhang C, Kumagai K, Harkema JR, Zacharewski TR.

Sci Rep. 2017 Jul 19;7(1):5921. doi: 10.1038/s41598-017-05656-8.


TCDD influences reservoir of antibiotic resistance genes in murine gut microbiome.

Stedtfeld RD, Stedtfeld TM, Fader KA, Williams MR, Bhaduri P, Quensen J, Zacharewski TR, Tiedje JM, Hashsham SA.

FEMS Microbiol Ecol. 2017 May 1;93(5). doi: 10.1093/femsec/fix058.


Lipidomic Evaluation of Aryl Hydrocarbon Receptor-Mediated Hepatic Steatosis in Male and Female Mice Elicited by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.

Nault R, Fader KA, Lydic TA, Zacharewski TR.

Chem Res Toxicol. 2017 Apr 17;30(4):1060-1075. doi: 10.1021/acs.chemrestox.6b00430. Epub 2017 Mar 20.


Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity.

Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR.

Toxicol Appl Pharmacol. 2017 Apr 15;321:1-17. doi: 10.1016/j.taap.2017.02.006. Epub 2017 Feb 16. Erratum in: Toxicol Appl Pharmacol. 2018 Mar 1;:.


From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.

Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk JP.

Toxicol Sci. 2016 Dec;154(2):381-391. Epub 2016 Sep 9.


Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis.

Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski T.

Toxicol Sci. 2016 Dec;154(2):253-266. Epub 2016 Aug 25.


Comparing listeriosis risks in at-risk populations using a user-friendly quantitative microbial risk assessment tool and epidemiological data.

Falk LE, Fader KA, Cui DS, Totton SC, Fazil AM, Lammerding AM, Smith BA.

Epidemiol Infect. 2016 Oct;144(13):2743-58. doi: 10.1017/S0950268816000327. Epub 2016 Mar 28.


Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.

Najt CP, Senthivinayagam S, Aljazi MB, Fader KA, Olenic SD, Brock JR, Lydic TA, Jones AD, Atshaves BP.

Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G726-38. doi: 10.1152/ajpgi.00436.2015. Epub 2016 Mar 11.


Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR.

Toxicol Sci. 2016 Feb;149(2):358-71. doi: 10.1093/toxsci/kfv245. Epub 2015 Nov 17.


2,3,7,8-Tetrachlorodibenzo-p-Dioxin Alters Lipid Metabolism and Depletes Immune Cell Populations in the Jejunum of C57BL/6 Mice.

Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR.

Toxicol Sci. 2015 Dec;148(2):567-80. doi: 10.1093/toxsci/kfv206. Epub 2015 Sep 16.


RNA-Seq versus oligonucleotide array assessment of dose-dependent TCDD-elicited hepatic gene expression in mice.

Nault R, Fader KA, Zacharewski T.

BMC Genomics. 2015 May 10;16:373. doi: 10.1186/s12864-015-1527-z.

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