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Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice.

Bhat S, Henry RJ, Blanchard AC, Stoica BA, Loane DJ, Faden AI.

J Neurochem. 2020 Jan 11:e14954. doi: 10.1111/jnc.14954. [Epub ahead of print]


Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury.

Ritzel RM, Li Y, He J, Khan N, Doran SJ, Faden AI, Wu J.

Neurobiol Dis. 2019 Dec 13;136:104713. doi: 10.1016/j.nbd.2019.104713. [Epub ahead of print]


Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice.

Sabirzhanov B, Matyas J, Coll-Miro M, Yu LL, Faden AI, Stoica BA, Wu J.

Cell Death Dis. 2019 Nov 4;10(11):839. doi: 10.1038/s41419-019-2079-y.


PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.

Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM.

Autophagy. 2019 Jun 25:1-20. doi: 10.1080/15548627.2019.1628538. [Epub ahead of print]


Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes after acute traumatic brain injury in mice.

Ritzel RM, Doran SJ, Glaser EP, Meadows VE, Faden AI, Stoica BA, Loane DJ.

Neurobiol Aging. 2019 May;77:194-206. doi: 10.1016/j.neurobiolaging.2019.02.010. Epub 2019 Feb 20.


Inhibition of NOX2 signaling limits pain-related behavior and improves motor function in male mice after spinal cord injury: Participation of IL-10/miR-155 pathways.

Sabirzhanov B, Li Y, Coll-Miro M, Matyas JJ, He J, Kumar A, Ward N, Yu J, Faden AI, Wu J.

Brain Behav Immun. 2019 Aug;80:73-87. doi: 10.1016/j.bbi.2019.02.024. Epub 2019 Feb 23.


Neutral Sphingomyelinase Inhibition Alleviates LPS-Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury.

Kumar A, Henry RJ, Stoica BA, Loane DJ, Abulwerdi G, Bhat SA, Faden AI.

J Pharmacol Exp Ther. 2019 Mar;368(3):338-352. doi: 10.1124/jpet.118.253955. Epub 2018 Dec 18.


Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury.

Aubrecht TG, Faden AI, Sabirzhanov B, Glaser EP, Roelofs BA, Polster BM, Makarevich O, Stoica BA.

Cell Death Dis. 2018 Nov 6;9(11):1121. doi: 10.1038/s41419-018-1156-y.


Sex Differences in Acute Neuroinflammation after Experimental Traumatic Brain Injury Are Mediated by Infiltrating Myeloid Cells.

Doran SJ, Ritzel RM, Glaser EP, Henry RJ, Faden AI, Loane DJ.

J Neurotrauma. 2019 Apr 1;36(7):1040-1053. doi: 10.1089/neu.2018.6019. Epub 2018 Nov 16.


Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice.

Henry RJ, Doran SJ, Barrett JP, Meadows VE, Sabirzhanov B, Stoica BA, Loane DJ, Faden AI.

Neurotherapeutics. 2019 Jan;16(1):216-230. doi: 10.1007/s13311-018-0665-9.


MicroRNA-711-Induced Downregulation of Angiopoietin-1 Mediates Neuronal Cell Death.

Sabirzhanov B, Faden AI, Aubrecht T, Henry R, Glaser E, Stoica BA.

J Neurotrauma. 2018 Oct 15;35(20):2462-2481. doi: 10.1089/neu.2017.5572. Epub 2018 Jul 10.


Traumatic meningeal injury and repair mechanisms.

Loane DJ, Faden AI.

Nat Immunol. 2018 May;19(5):431-432. doi: 10.1038/s41590-018-0093-3. No abstract available.


Chronic Alterations in Systemic Immune Function after Traumatic Brain Injury.

Ritzel RM, Doran SJ, Barrett JP, Henry RJ, Ma EL, Faden AI, Loane DJ.

J Neurotrauma. 2018 Jul 1;35(13):1419-1436. doi: 10.1089/neu.2017.5399. Epub 2018 May 3.


Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice.

Ma EL, Smith AD, Desai N, Cheung L, Hanscom M, Stoica BA, Loane DJ, Shea-Donohue T, Faden AI.

Brain Behav Immun. 2017 Nov;66:56-69. doi: 10.1016/j.bbi.2017.06.018. Epub 2017 Jul 1.


NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury.

Barrett JP, Henry RJ, Villapol S, Stoica BA, Kumar A, Burns MP, Faden AI, Loane DJ.

J Neuroinflammation. 2017 Mar 24;14(1):65. doi: 10.1186/s12974-017-0843-4.


Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury.

Kumar A, Stoica BA, Loane DJ, Yang M, Abulwerdi G, Khan N, Kumar A, Thom SR, Faden AI.

J Neuroinflammation. 2017 Mar 15;14(1):47. doi: 10.1186/s12974-017-0819-4.


Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury.

Matyas JJ, O'Driscoll CM, Yu L, Coll-Miro M, Daugherty S, Renn CL, Faden AI, Dorsey SG, Wu J.

J Neurosci. 2017 Apr 5;37(14):3956-3971. doi: 10.1523/JNEUROSCI.3353-16.2017. Epub 2017 Mar 7.


Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury.

Skovira JW, Wu J, Matyas JJ, Kumar A, Hanscom M, Kabadi SV, Fang R, Faden AI.

J Neuroinflammation. 2016 Dec 1;13(1):299.


Endoplasmic Reticulum Stress and Disrupted Neurogenesis in the Brain Are Associated with Cognitive Impairment and Depressive-Like Behavior after Spinal Cord Injury.

Wu J, Zhao Z, Kumar A, Lipinski MM, Loane DJ, Stoica BA, Faden AI.

J Neurotrauma. 2016 Nov 1;33(21):1919-1935. Epub 2016 May 16.


NOX2 drives M1-like microglial/macrophage activation and neurodegeneration following experimental traumatic brain injury.

Kumar A, Barrett JP, Alvarez-Croda DM, Stoica BA, Faden AI, Loane DJ.

Brain Behav Immun. 2016 Nov;58:291-309. doi: 10.1016/j.bbi.2016.07.158. Epub 2016 Jul 28.


Cell cycle inhibition limits development and maintenance of neuropathic pain following spinal cord injury.

Wu J, Zhao Z, Zhu X, Renn CL, Dorsey SG, Faden AI.

Pain. 2016 Feb;157(2):488-503. doi: 10.1097/j.pain.0000000000000393.


Simulated Aeromedical Evacuation Exacerbates Experimental Brain Injury.

Skovira JW, Kabadi SV, Wu J, Zhao Z, DuBose J, Rosenthal R, Fiskum G, Faden AI.

J Neurotrauma. 2016 Jul 15;33(14):1292-302. doi: 10.1089/neu.2015.4189. Epub 2016 Jan 7.


Ablation of the transcription factors E2F1-2 limits neuroinflammation and associated neurological deficits after contusive spinal cord injury.

Wu J, Sabirzhanov B, Stoica BA, Lipinski MM, Zhao Z, Zhao S, Ward N, Yang D, Faden AI.

Cell Cycle. 2015;14(23):3698-712. doi: 10.1080/15384101.2015.1104436.


Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury.

Kumar A, Alvarez-Croda DM, Stoica BA, Faden AI, Loane DJ.

J Neurotrauma. 2016 Oct 1;33(19):1732-1750. Epub 2015 Dec 29.


miR-711 upregulation induces neuronal cell death after traumatic brain injury.

Sabirzhanov B, Stoica BA, Zhao Z, Loane DJ, Wu J, Dorsey SG, Faden AI.

Cell Death Differ. 2016 Apr;23(4):654-68. doi: 10.1038/cdd.2015.132. Epub 2015 Oct 16.


S100B inhibition reduces behavioral and pathologic changes in experimental traumatic brain injury.

Kabadi SV, Stoica BA, Zimmer DB, Afanador L, Duffy KB, Loane DJ, Faden AI.

J Cereb Blood Flow Metab. 2015 Dec;35(12):2010-20. doi: 10.1038/jcbfm.2015.165. Epub 2015 Jul 8.


Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury.

Faden AI, Wu J, Stoica BA, Loane DJ.

Br J Pharmacol. 2016 Feb;173(4):681-91. doi: 10.1111/bph.13179. Epub 2015 Jun 12. Review.


Cyclopropyl-containing positive allosteric modulators of metabotropic glutamate receptor subtype 5.

Lakkaraju SK, Mbatia H, Hanscom M, Zhao Z, Wu J, Stoica B, MacKerell AD Jr, Faden AI, Xue F.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2275-9. doi: 10.1016/j.bmcl.2015.04.042. Epub 2015 Apr 20.


Neuroprotection in acute brain injury: an up-to-date review.

Stocchetti N, Taccone FS, Citerio G, Pepe PE, Le Roux PD, Oddo M, Polderman KH, Stevens RD, Barsan W, Maas AI, Meyfroidt G, Bell MJ, Silbergleit R, Vespa PM, Faden AI, Helbok R, Tisherman S, Zanier ER, Valenzuela T, Wendon J, Menon DK, Vincent JL.

Crit Care. 2015 Apr 21;19:186. doi: 10.1186/s13054-015-0887-8. Review.


Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma.

Lipinski MM, Wu J, Faden AI, Sarkar C.

Antioxid Redox Signal. 2015 Aug 20;23(6):565-77. doi: 10.1089/ars.2015.6306. Epub 2015 Apr 28. Review.


Acyl-2-aminobenzimidazoles: a novel class of neuroprotective agents targeting mGluR5.

He X, Lakkaraju SK, Hanscom M, Zhao Z, Wu J, Stoica B, MacKerell AD Jr, Faden AI, Xue F.

Bioorg Med Chem. 2015 May 1;23(9):2211-20. doi: 10.1016/j.bmc.2015.02.054. Epub 2015 Mar 6.


Neuroprotection for traumatic brain injury.

Loane DJ, Stoica BA, Faden AI.

Handb Clin Neurol. 2015;127:343-66. doi: 10.1016/B978-0-444-52892-6.00022-2. Review.


Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death.

Liu S, Sarkar C, Dinizo M, Faden AI, Koh EY, Lipinski MM, Wu J.

Cell Death Dis. 2015 Jan 8;6:e1582. doi: 10.1038/cddis.2014.527.


Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury.

Sarkar C, Zhao Z, Aungst S, Sabirzhanov B, Faden AI, Lipinski MM.

Autophagy. 2014;10(12):2208-22. doi: 10.4161/15548627.2014.981787.


Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment. Involvement of cell cycle activation.

Wu J, Stoica BA, Luo T, Sabirzhanov B, Zhao Z, Guanciale K, Nayar SK, Foss CA, Pomper MG, Faden AI.

Cell Cycle. 2014;13(15):2446-58. doi: 10.4161/cc.29420.


Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?

Faden AI, Loane DJ.

Neurotherapeutics. 2015 Jan;12(1):143-50. doi: 10.1007/s13311-014-0319-5. Review.


Voluntary Exercise Preconditioning Activates Multiple Antiapoptotic Mechanisms and Improves Neurological Recovery after Experimental Traumatic Brain Injury.

Zhao Z, Sabirzhanov B, Wu J, Faden AI, Stoica BA.

J Neurotrauma. 2015 Sep 1;32(17):1347-60. doi: 10.1089/neu.2014.3739. Epub 2015 May 7.


Selective CDK inhibitors: promising candidates for future clinical traumatic brain injury trials.

Kabadi SV, Faden AI.

Neural Regen Res. 2014 Sep 1;9(17):1578-80. doi: 10.4103/1673-5374.141779. Review.


Chronic decrease in wakefulness and disruption of sleep-wake behavior after experimental traumatic brain injury.

Skopin MD, Kabadi SV, Viechweg SS, Mong JA, Faden AI.

J Neurotrauma. 2015 Mar 1;32(5):289-96. doi: 10.1089/neu.2014.3664. Epub 2014 Dec 17.


Spinal cord injury causes brain inflammation associated with cognitive and affective changes: role of cell cycle pathways.

Wu J, Zhao Z, Sabirzhanov B, Stoica BA, Kumar A, Luo T, Skovira J, Faden AI.

J Neurosci. 2014 Aug 13;34(33):10989-1006. doi: 10.1523/JNEUROSCI.5110-13.2014.


Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury.

Loane DJ, Stoica BA, Tchantchou F, Kumar A, Barrett JP, Akintola T, Xue F, Conn PJ, Faden AI.

Neurotherapeutics. 2014 Oct;11(4):857-69. doi: 10.1007/s13311-014-0298-6.


Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins.

Sabirzhanov B, Zhao Z, Stoica BA, Loane DJ, Wu J, Borroto C, Dorsey SG, Faden AI.

J Neurosci. 2014 Jul 23;34(30):10055-71. doi: 10.1523/JNEUROSCI.1260-14.2014.


Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits.

Aungst SL, Kabadi SV, Thompson SM, Stoica BA, Faden AI.

J Cereb Blood Flow Metab. 2014 Jul;34(7):1223-32. doi: 10.1038/jcbfm.2014.75. Epub 2014 Apr 23.


Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury.

Pajoohesh-Ganji A, Burns MP, Pal-Ghosh S, Tadvalkar G, Hokenbury NG, Stepp MA, Faden AI.

Brain Res. 2014 Apr 29;1560:73-82. doi: 10.1016/j.brainres.2014.02.049. Epub 2014 Mar 11.


Boc-protected 1-(3-oxocycloalkyl)ureas via a one-step Curtius rearrangement: mechanism and scope.

Sun X, Rai R, Deschamps JR, Mackerell AD Jr, Faden AI, Xue F.

Tetrahedron Lett. 2014 Jan 22;55(4):842-844.


PARP-1 inhibition attenuates neuronal loss, microglia activation and neurological deficits after traumatic brain injury.

Stoica BA, Loane DJ, Zhao Z, Kabadi SV, Hanscom M, Byrnes KR, Faden AI.

J Neurotrauma. 2014 Apr 15;31(8):758-72. doi: 10.1089/neu.2013.3194. Epub 2014 Jan 29.


Neuroprotective strategies for traumatic brain injury: improving clinical translation.

Kabadi SV, Faden AI.

Int J Mol Sci. 2014 Jan 17;15(1):1216-36. doi: 10.3390/ijms15011216. Review.


CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury.

Kabadi SV, Stoica BA, Loane DJ, Luo T, Faden AI.

J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. doi: 10.1038/jcbfm.2013.228. Epub 2014 Jan 8.


Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation.

Loane DJ, Kumar A, Stoica BA, Cabatbat R, Faden AI.

J Neuropathol Exp Neurol. 2014 Jan;73(1):14-29. doi: 10.1097/NEN.0000000000000021.


Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) attenuate microglial activation.

Xue F, Stoica BA, Hanscom M, Kabadi SV, Faden AI.

CNS Neurol Disord Drug Targets. 2014;13(4):558-66.


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