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Items: 1 to 50 of 122

1.

Multi-functional roles of the N-terminal region of HIV-1SF2Nef are mediated by three independent protein interaction sites.

Ananth S, Morath K, Trautz B, Tibroni N, Shytaj IL, Obermaier B, Stolp B, Lusic M, Fackler OT.

J Virol. 2019 Oct 9. pii: JVI.01398-19. doi: 10.1128/JVI.01398-19. [Epub ahead of print]

PMID:
31597760
2.

FAMoS: A Flexible and dynamic Algorithm for Model Selection to analyse complex systems dynamics.

Gabel M, Hohl T, Imle A, Fackler OT, Graw F.

PLoS Comput Biol. 2019 Aug 16;15(8):e1007230. doi: 10.1371/journal.pcbi.1007230. eCollection 2019 Aug.

3.

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.

Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D.

Cell Rep. 2019 May 14;27(7):2092-2104.e10. doi: 10.1016/j.celrep.2019.04.063.

4.

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures.

Imle A, Kumberger P, Schnellbächer ND, Fehr J, Carrillo-Bustamante P, Ales J, Schmidt P, Ritter C, Godinez WJ, Müller B, Rohr K, Hamprecht FA, Schwarz US, Graw F, Fackler OT.

Nat Commun. 2019 May 13;10(1):2144. doi: 10.1038/s41467-019-09879-3.

5.

T cell receptor-triggered nuclear actin network formation drives CD4+ T cell effector functions.

Tsopoulidis N, Kaw S, Laketa V, Kutscheidt S, Baarlink C, Stolp B, Grosse R, Fackler OT.

Sci Immunol. 2019 Jan 4;4(31). pii: eaav1987. doi: 10.1126/sciimmunol.aav1987.

PMID:
30610013
6.

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists.

de Sousa-Pereira P, Abrantes J, Bauernfried S, Pierini V, Esteves PJ, Keppler OT, Pizzato M, Hornung V, Fackler OT, Baldauf HM.

J Gen Virol. 2019 Feb;100(2):278-288. doi: 10.1099/jgv.0.001201. Epub 2018 Dec 19.

PMID:
30566072
7.

HIV-1 Nef Disrupts CD4+ T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface.

Lamas-Murua M, Stolp B, Kaw S, Thoma J, Tsopoulidis N, Trautz B, Ambiel I, Reif T, Arora S, Imle A, Tibroni N, Wu J, Cui G, Stein JV, Tanaka M, Lyck R, Fackler OT.

J Immunol. 2018 Nov 1;201(9):2731-2743. doi: 10.4049/jimmunol.1701420. Epub 2018 Sep 26.

PMID:
30257886
8.

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

Kmiec D, Akbil B, Ananth S, Hotter D, Sparrer KMJ, Stürzel CM, Trautz B, Ayouba A, Peeters M, Yao Z, Stagljar I, Passos V, Zillinger T, Goffinet C, Sauter D, Fackler OT, Kirchhoff F.

PLoS Pathog. 2018 Aug 20;14(8):e1007269. doi: 10.1371/journal.ppat.1007269. eCollection 2018 Aug.

9.

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.

Chase AJ, Wombacher R, Fackler OT.

J Biol Chem. 2018 May 18;293(20):7824-7840. doi: 10.1074/jbc.RA118.002794. Epub 2018 Mar 27.

10.

Tailored environments to study motile cells and pathogens.

Muthinja JM, Ripp J, Krüger T, Imle A, Haraszti T, Fackler OT, Spatz JP, Engstler M, Frischknecht F.

Cell Microbiol. 2018 Mar;20(3). doi: 10.1111/cmi.12820. Epub 2018 Jan 29. Review.

PMID:
29316156
11.

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles.

Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, Kräusslich HG, Brocker T, Pizzato M, Ruggieri A, Brügger B, Fackler OT.

J Biol Chem. 2017 Aug 18;292(33):13702-13713. doi: 10.1074/jbc.M117.797332. Epub 2017 Jun 28.

12.

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A.

MBio. 2017 Apr 18;8(2). pii: e00488-17. doi: 10.1128/mBio.00488-17. No abstract available.

13.

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2729-2734. doi: 10.1073/pnas.1613635114. Epub 2017 Feb 22.

14.

Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites.

Muthinja MJ, Ripp J, Hellmann JK, Haraszti T, Dahan N, Lemgruber L, Battista A, Schütz L, Fackler OT, Schwarz US, Spatz JP, Frischknecht F.

Adv Healthc Mater. 2017 Mar;6(6). doi: 10.1002/adhm.201601178. Epub 2017 Jan 24.

PMID:
28117558
15.

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.

Roth H, Magg V, Uch F, Mutz P, Klein P, Haneke K, Lohmann V, Bartenschlager R, Fackler OT, Locker N, Stoecklin G, Ruggieri A.

MBio. 2017 Jan 10;8(1). pii: e02150-16. doi: 10.1128/mBio.02150-16. Erratum in: MBio. 2017 Apr 18;8(2):.

16.

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection.

Ostalecki C, Wittki S, Lee JH, Geist MM, Tibroni N, Harrer T, Schuler G, Fackler OT, Baur AS.

EBioMedicine. 2016 Nov;13:294-304. doi: 10.1016/j.ebiom.2016.10.027. Epub 2016 Oct 19.

17.

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.

Trautz B, Pierini V, Wombacher R, Stolp B, Chase AJ, Pizzato M, Fackler OT.

J Virol. 2016 Nov 14;90(23):10915-10927. doi: 10.1128/JVI.01246-16. Print 2016 Dec 1.

18.

D186/D190 is an allele-dependent determinant of HIV-1 Nef function.

Imle A, Stolp B, Böhmer V, Geyer M, Raz E, Fackler OT.

Virology. 2016 Nov;498:44-56. doi: 10.1016/j.virol.2016.08.012. Epub 2016 Aug 24.

19.

Integrative analysis of pathogen replication and spread: zooming into increasing complexity.

Fackler OT, Kräusslich HG.

FEBS Lett. 2016 Jul;590(13):1855-7. doi: 10.1002/1873-3468.12253. No abstract available.

20.

Hydrophilic trans-Cyclooctenylated Noncanonical Amino Acids for Fast Intracellular Protein Labeling.

Kozma E, Nikić I, Varga BR, Aramburu IV, Kang JH, Fackler OT, Lemke EA, Kele P.

Chembiochem. 2016 Aug 17;17(16):1518-24. doi: 10.1002/cbic.201600284. Epub 2016 Jul 7.

PMID:
27223658
21.

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection.

Lee JH, Schierer S, Blume K, Dindorf J, Wittki S, Xiang W, Ostalecki C, Koliha N, Wild S, Schuler G, Fackler OT, Saksela K, Harrer T, Baur AS.

EBioMedicine. 2016 Apr;6:103-113. doi: 10.1016/j.ebiom.2016.03.004. Epub 2016 Mar 3.

22.

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites.

Pujol FM, Laketa V, Schmidt F, Mukenhirn M, Müller B, Boulant S, Grimm D, Keppler OT, Fackler OT.

J Virol. 2016 Jul 11;90(15):6709-6723. doi: 10.1128/JVI.00504-16. Print 2016 Aug 1.

23.

Experimental systems for studying Plasmodium/HIV coinfection.

Frischknecht F, Fackler OT.

FEBS Lett. 2016 Jul;590(13):2000-13. doi: 10.1002/1873-3468.12151. Epub 2016 Apr 15. Review.

24.
25.

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.

Martínez-Bonet M, Palladino C, Briz V, Rudolph JM, Fackler OT, Relloso M, Muñoz-Fernandez MA, Madrid R.

PLoS One. 2015 Dec 23;10(12):e0145239. doi: 10.1371/journal.pone.0145239. eCollection 2015.

26.

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles.

Galaski J, Ahmad F, Tibroni N, Pujol FM, Müller B, Schmidt RE, Fackler OT.

J Acquir Immune Defic Syndr. 2016 May 1;72(1):1-10. doi: 10.1097/QAI.0000000000000917. Erratum in: J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):e66.

PMID:
26656785
27.

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.

Trotard M, Tsopoulidis N, Tibroni N, Willemsen J, Binder M, Ruggieri A, Fackler OT.

J Virol. 2015 Dec 9;90(4):2064-76. doi: 10.1128/JVI.02966-15. Print 2016 Feb 15.

28.

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.

Imle A, Abraham L, Tsopoulidis N, Hoflack B, Saksela K, Fackler OT.

MBio. 2015 Sep 8;6(5):e01309-15. doi: 10.1128/mBio.01309-15.

29.

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.

Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, Fackler OT, Ivaska J, Grosse R.

Dev Cell. 2015 Aug 24;34(4):475-83. doi: 10.1016/j.devcel.2015.06.015. Epub 2015 Aug 6.

30.

Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement.

Antoku S, Zhu R, Kutscheidt S, Fackler OT, Gundersen GG.

Cell Cycle. 2015;14(14):2200-5. doi: 10.1080/15384101.2015.1053665. Epub 2015 Jun 17.

31.

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.

Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, Mueller B, Haller C, Walker BD, Kirchhoff F, Brumme ZL, Ueno T, Fackler OT.

PLoS One. 2015 Mar 20;10(3):e0120434. doi: 10.1371/journal.pone.0120434. eCollection 2015.

32.

SAMHD1's protein expression profile in humans.

Schmidt S, Schenkova K, Adam T, Erikson E, Lehmann-Koch J, Sertel S, Verhasselt B, Fackler OT, Lasitschka F, Keppler OT.

J Leukoc Biol. 2015 Jul;98(1):5-14. doi: 10.1189/jlb.4HI0714-338RR. Epub 2015 Feb 2.

PMID:
25646359
33.

HIV-1 reprograms the migration of macrophages.

Vérollet C, Souriant S, Bonnaud E, Jolicoeur P, Raynaud-Messina B, Kinnaer C, Fourquaux I, Imle A, Benichou S, Fackler OT, Poincloux R, Maridonneau-Parini I.

Blood. 2015 Mar 5;125(10):1611-22. doi: 10.1182/blood-2014-08-596775. Epub 2014 Dec 19.

PMID:
25527710
34.

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin.

Kluge SF, Mack K, Iyer SS, Pujol FM, Heigele A, Learn GH, Usmani SM, Sauter D, Joas S, Hotter D, Bibollet-Ruche F, Plenderleith LJ, Peeters M, Geyer M, Sharp PM, Fackler OT, Hahn BH, Kirchhoff F.

Cell Host Microbe. 2014 Nov 12;16(5):639-50. doi: 10.1016/j.chom.2014.10.002. Epub 2014 Nov 12.

35.

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.

Haller C, Müller B, Fritz JV, Lamas-Murua M, Stolp B, Pujol FM, Keppler OT, Fackler OT.

J Virol. 2014 Dec;88(24):14241-57. doi: 10.1128/JVI.02333-14. Epub 2014 Oct 1.

36.

Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins.

Lee JY, Acosta EG, Stoeck IK, Long G, Hiet MS, Mueller B, Fackler OT, Kallis S, Bartenschlager R.

J Virol. 2014 Nov;88(21):12422-37. doi: 10.1128/JVI.01660-14. Epub 2014 Aug 13.

37.

Adding new dimensions: towards an integrative understanding of HIV-1 spread.

Fackler OT, Murooka TT, Imle A, Mempel TR.

Nat Rev Microbiol. 2014 Aug;12(8):563-74. doi: 10.1038/nrmicro3309. Review.

38.

FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.

Kutscheidt S, Zhu R, Antoku S, Luxton GW, Stagljar I, Fackler OT, Gundersen GG.

Nat Cell Biol. 2014 Jul;16(7):708-15. doi: 10.1038/ncb2981. Epub 2014 Jun 1.

39.

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef.

Geist MM, Pan X, Bender S, Bartenschlager R, Nickel W, Fackler OT.

J Biol Chem. 2014 May 16;289(20):14030-44. doi: 10.1074/jbc.M114.563528. Epub 2014 Apr 4.

40.

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.

Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, Kirchhoff F, Verhasselt B.

Retrovirology. 2013 Nov 15;10:137. doi: 10.1186/1742-4690-10-137.

41.

MxB/Mx2: the latest piece in HIV's interferon puzzle.

Fackler OT, Keppler OT.

EMBO Rep. 2013 Dec;14(12):1028-9. doi: 10.1038/embor.2013.172. Epub 2013 Nov 1. No abstract available.

42.

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes.

Pan X, Baldauf HM, Keppler OT, Fackler OT.

Cell Res. 2013 Jul;23(7):876-85. doi: 10.1038/cr.2013.74. Epub 2013 Jun 4. Review.

43.

Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.

Floyd S, Whiffin N, Gavilan MP, Kutscheidt S, De Luca M, Marcozzi C, Min M, Watkins J, Chung K, Fackler OT, Lindon C.

J Cell Sci. 2013 Jul 1;126(Pt 13):2845-56. doi: 10.1242/jcs.123232. Epub 2013 Apr 23.

44.

HIV-1 Nef disrupts membrane-microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases.

Pan X, Geist MM, Rudolph JM, Nickel W, Fackler OT.

Cell Microbiol. 2013 Oct;15(10):1605-21. doi: 10.1111/cmi.12148. Epub 2013 May 3.

PMID:
23601552
45.

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

Bolduan S, Hubel P, Reif T, Lodermeyer V, Höhne K, Fritz JV, Sauter D, Kirchhoff F, Fackler OT, Schindler M, Schubert U.

Virology. 2013 Jun 5;440(2):190-203. doi: 10.1016/j.virol.2013.02.021. Epub 2013 Mar 22.

46.

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers.

Schönichen A, Mannherz HG, Behrmann E, Mazur AJ, Kühn S, Silván U, Schoenenberger CA, Fackler OT, Raunser S, Dehmelt L, Geyer M.

J Cell Sci. 2013 Apr 15;126(Pt 8):1891-901. doi: 10.1242/jcs.126706. Epub 2013 Feb 26.

47.

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.

Sauter D, Unterweger D, Vogl M, Usmani SM, Heigele A, Kluge SF, Hermkes E, Moll M, Barker E, Peeters M, Learn GH, Bibollet-Ruche F, Fritz JV, Fackler OT, Hahn BH, Kirchhoff F.

PLoS Pathog. 2012 Dec;8(12):e1003093. doi: 10.1371/journal.ppat.1003093. Epub 2012 Dec 20.

48.

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.

Abraham L, Fackler OT.

Cell Commun Signal. 2012 Dec 10;10(1):39. doi: 10.1186/1478-811X-10-39.

49.

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo.

Stolp B, Imle A, Coelho FM, Hons M, Gorina R, Lyck R, Stein JV, Fackler OT.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18541-6. doi: 10.1073/pnas.1204322109. Epub 2012 Oct 23.

50.

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host.

Götz N, Sauter D, Usmani SM, Fritz JV, Goffinet C, Heigele A, Geyer M, Bibollet-Ruche F, Learn GH, Fackler OT, Hahn BH, Kirchhoff F.

Cell Host Microbe. 2012 Sep 13;12(3):373-80. doi: 10.1016/j.chom.2012.07.008.

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