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Items: 30


CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization.

Watanabe R, Hara M, Okumura EI, Hervé S, Fachinetti D, Ariyoshi M, Fukagawa T.

J Cell Biol. 2019 Nov 1. pii: jcb.201907006. doi: 10.1083/jcb.201907006. [Epub ahead of print]


Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity.

Gemble S, Simon A, Pennetier C, Dumont M, Hervé S, Meitinger F, Oegema K, Rodriguez R, Almouzni G, Fachinetti D, Basto R.

Curr Biol. 2019 Sep 23;29(18):3072-3080.e5. doi: 10.1016/j.cub.2019.07.052. Epub 2019 Sep 5.


Plk1 protects kinetochore-centromere architecture against microtubule pulling forces.

Lera RF, Norman RX, Dumont M, Dennee A, Martin-Koob J, Fachinetti D, Burkard ME.

EMBO Rep. 2019 Oct 4;20(10):e48711. doi: 10.15252/embr.201948711. Epub 2019 Aug 30.


Keeping the Centromere under Control: A Promising Role for DNA Methylation.

Scelfo A, Fachinetti D.

Cells. 2019 Aug 16;8(8). pii: E912. doi: 10.3390/cells8080912. Review.


DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres.

Nechemia-Arbely Y, Miga KH, Shoshani O, Aslanian A, McMahon MA, Lee AY, Fachinetti D, Yates JR 3rd, Ren B, Cleveland DW.

Nat Cell Biol. 2019 Jun;21(6):743-754. doi: 10.1038/s41556-019-0331-4. Epub 2019 Jun 3.


The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

Gentili M, Lahaye X, Nadalin F, Nader GPF, Lombardi EP, Herve S, De Silva NS, Rookhuizen DC, Zueva E, Goudot C, Maurin M, Bochnakian A, Amigorena S, Piel M, Fachinetti D, Londoño-Vallejo A, Manel N.

Cell Rep. 2019 Mar 26;26(13):3798. doi: 10.1016/j.celrep.2019.03.049. No abstract available.


The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

Gentili M, Lahaye X, Nadalin F, Nader GPF, Puig Lombardi E, Herve S, De Silva NS, Rookhuizen DC, Zueva E, Goudot C, Maurin M, Bochnakian A, Amigorena S, Piel M, Fachinetti D, Londoño-Vallejo A, Manel N.

Cell Rep. 2019 Feb 26;26(9):2377-2393.e13. doi: 10.1016/j.celrep.2019.01.105. Erratum in: Cell Rep. 2019 Mar 26;26(13):3798.


Phosphorylation of CENP-A on serine 7 does not control centromere function.

Barra V, Logsdon GA, Scelfo A, Hoffmann S, Hervé S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D.

Nat Commun. 2019 Jan 11;10(1):175. doi: 10.1038/s41467-018-08073-1.


The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA.

Barra V, Fachinetti D.

Nat Commun. 2018 Oct 18;9(1):4340. doi: 10.1038/s41467-018-06545-y. Review.


Real-Time De Novo Deposition of Centromeric Histone-Associated Proteins Using the Auxin-Inducible Degradation System.

Hoffmann S, Fachinetti D.

Methods Mol Biol. 2018;1832:223-241. doi: 10.1007/978-1-4939-8663-7_12.


DNA Sequences in Centromere Formation and Function.

Dumont M, Fachinetti D.

Prog Mol Subcell Biol. 2017;56:305-336. doi: 10.1007/978-3-319-58592-5_13. Review.


A time out for CENP-A.

Hoffmann S, Fachinetti D.

Mol Cell Oncol. 2017 Feb 17;4(3):e1293596. doi: 10.1080/23723556.2017.1293596. eCollection 2017.


Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome transition.

Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE.

Nat Commun. 2017 Jun 9;8:15775. doi: 10.1038/ncomms15775.


α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere.

Sathyan KM, Fachinetti D, Foltz DR.

Nat Commun. 2017 Mar 7;8:14678. doi: 10.1038/ncomms14678.


Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points.

Nechemia-Arbely Y, Fachinetti D, Miga KH, Sekulic N, Soni GV, Kim DH, Wong AK, Lee AY, Nguyen K, Dekker C, Ren B, Black BE, Cleveland DW.

J Cell Biol. 2017 Mar 6;216(3):607-621. doi: 10.1083/jcb.201608083. Epub 2017 Feb 24.


CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres.

Fachinetti D, Logsdon GA, Abdullah A, Selzer EB, Cleveland DW, Black BE.

Dev Cell. 2017 Jan 9;40(1):104-113. doi: 10.1016/j.devcel.2016.12.014.


Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.

Ly P, Teitz LS, Kim DH, Shoshani O, Skaletsky H, Fachinetti D, Page DC, Cleveland DW.

Nat Cell Biol. 2017 Jan;19(1):68-75. doi: 10.1038/ncb3450. Epub 2016 Dec 5.


CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly.

Hoffmann S, Dumont M, Barra V, Ly P, Nechemia-Arbely Y, McMahon MA, Hervé S, Cleveland DW, Fachinetti D.

Cell Rep. 2016 Nov 22;17(9):2394-2404. doi: 10.1016/j.celrep.2016.10.084.


DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.

Fachinetti D, Han JS, McMahon MA, Ly P, Abdullah A, Wong AJ, Cleveland DW.

Dev Cell. 2015 May 4;33(3):314-27. doi: 10.1016/j.devcel.2015.03.020.


Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.

Han JS, Vitre B, Fachinetti D, Cleveland DW.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4185-93. doi: 10.1073/pnas.1416277111. Epub 2014 Sep 22.


A two-step mechanism for epigenetic specification of centromere identity and function.

Fachinetti D, Folco HD, Nechemia-Arbely Y, Valente LP, Nguyen K, Wong AJ, Zhu Q, Holland AJ, Desai A, Jansen LE, Cleveland DW.

Nat Cell Biol. 2013 Sep;15(9):1056-66. doi: 10.1038/ncb2805. Epub 2013 Jul 21.


Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20.

Han JS, Holland AJ, Fachinetti D, Kulukian A, Cetin B, Cleveland DW.

Mol Cell. 2013 Jul 11;51(1):92-104. doi: 10.1016/j.molcel.2013.05.019. Epub 2013 Jun 20.


The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.

Holland AJ, Fachinetti D, Zhu Q, Bauer M, Verma IM, Nigg EA, Cleveland DW.

Genes Dev. 2012 Dec 15;26(24):2684-9. doi: 10.1101/gad.207027.112.


Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells.

Holland AJ, Fachinetti D, Han JS, Cleveland DW.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):E3350-7. doi: 10.1073/pnas.1216880109. Epub 2012 Nov 12.


Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly.

Nechemia-Arbely Y, Fachinetti D, Cleveland DW.

Exp Cell Res. 2012 Jul 15;318(12):1353-60. doi: 10.1016/j.yexcr.2012.04.007. Epub 2012 Apr 27. Review.


Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.

Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland DW.

Mol Biol Cell. 2012 May;23(10):1838-45. doi: 10.1091/mbc.E11-12-1043. Epub 2012 Mar 28.


Topoisomerase I poisoning results in PARP-mediated replication fork reversal.

Ray Chaudhuri A, Hashimoto Y, Herrador R, Neelsen KJ, Fachinetti D, Bermejo R, Cocito A, Costanzo V, Lopes M.

Nat Struct Mol Biol. 2012 Mar 4;19(4):417-23. doi: 10.1038/nsmb.2258.


Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.

Fachinetti D, Bermejo R, Cocito A, Minardi S, Katou Y, Kanoh Y, Shirahige K, Azvolinsky A, Zakian VA, Foiani M.

Mol Cell. 2010 Aug 27;39(4):595-605. doi: 10.1016/j.molcel.2010.07.024.


Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

Bermejo R, Capra T, Gonzalez-Huici V, Fachinetti D, Cocito A, Natoli G, Katou Y, Mori H, Kurokawa K, Shirahige K, Foiani M.

Cell. 2009 Sep 4;138(5):870-84. doi: 10.1016/j.cell.2009.06.022.


Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells.

Cotta-Ramusino C, Fachinetti D, Lucca C, Doksani Y, Lopes M, Sogo J, Foiani M.

Mol Cell. 2005 Jan 7;17(1):153-9.

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