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Items: 1 to 50 of 112

1.

Molecular Origins of Functional Diversity in Benzylisoquinoline Alkaloid Methyltransferases.

Facchini PJ, Morris JS.

Front Plant Sci. 2019 Aug 30;10:1058. doi: 10.3389/fpls.2019.01058. eCollection 2019. Review.

2.

Purine permease-type benzylisoquinoline alkaloid transporters in opium poppy.

Dastmalchi M, Chang L, Chen R, Yu L, Chen X, Hagel J, Facchini PJ.

Plant Physiol. 2019 Aug 29. pii: pp.00565.2019. doi: 10.1104/pp.19.00565. [Epub ahead of print]

PMID:
31467164
3.

Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition.

Lang DE, Morris JS, Rowley M, Torres MA, Maksimovich VA, Facchini PJ, Ng KKS.

J Biol Chem. 2019 Oct 4;294(40):14482-14498. doi: 10.1074/jbc.RA119.009214. Epub 2019 Aug 7.

PMID:
31395658
4.

Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy.

Dastmalchi M, Chen X, Hagel JM, Chang L, Chen R, Ramasamy S, Yeaman S, Facchini PJ.

Nat Chem Biol. 2019 Apr;15(4):384-390. doi: 10.1038/s41589-019-0247-0. Epub 2019 Mar 18.

PMID:
30886433
5.

Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus.

Menéndez-Perdomo IM, Facchini PJ.

Molecules. 2018 Nov 6;23(11). pii: E2899. doi: 10.3390/molecules23112899. Review.

6.

Production of methylparaben in Escherichia coli.

Hagel JM, Chen X, Facchini PJ.

J Ind Microbiol Biotechnol. 2019 Jan;46(1):91-99. doi: 10.1007/s10295-018-2102-9. Epub 2018 Nov 3.

PMID:
30392093
7.

An N-methyltransferase from Ephedra sinica catalyzing the formation of ephedrine and pseudoephedrine enables microbial phenylalkylamine production.

Morris JS, Groves RA, Hagel JM, Facchini PJ.

J Biol Chem. 2018 Aug 31;293(35):13364-13376. doi: 10.1074/jbc.RA118.004067. Epub 2018 Jun 21.

8.

A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis.

Chen X, Hagel JM, Chang L, Tucker JE, Shiigi SA, Yelpaala Y, Chen HY, Estrada R, Colbeck J, Enquist-Newman M, Ibáñez AB, Cottarel G, Vidanes GM, Facchini PJ.

Nat Chem Biol. 2018 Jul;14(7):738-743. doi: 10.1038/s41589-018-0059-7. Epub 2018 May 28.

PMID:
29807982
9.

Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy.

Dastmalchi M, Chang L, Torres MA, Ng KKS, Facchini PJ.

Plant J. 2018 May 19. doi: 10.1111/tpj.13975. [Epub ahead of print]

10.

Heterodimeric O-methyltransferases involved in the biosynthesis of noscapine in opium poppy.

Park MR, Chen X, Lang DE, Ng KKS, Facchini PJ.

Plant J. 2018 Jul;95(2):252-267. doi: 10.1111/tpj.13947. Epub 2018 Jun 8.

11.

Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism.

Hagel JM, Facchini PJ.

Nat Prod Rep. 2018 Aug 15;35(8):721-734. doi: 10.1039/c7np00060j. Review.

PMID:
29488530
12.

Tying the knot: occurrence and possible significance of gene fusions in plant metabolism and beyond.

Hagel JM, Facchini PJ.

J Exp Bot. 2017 Jul 10;68(15):4029-4043. doi: 10.1093/jxb/erx152. Review.

PMID:
28521055
13.

Genes encoding norcoclaurine synthase occur as tandem fusions in the Papaveraceae.

Li J, Lee EJ, Chang L, Facchini PJ.

Sci Rep. 2016 Dec 19;6:39256. doi: 10.1038/srep39256.

14.

Plant metabolons assembled on demand.

Dastmalchi M, Facchini PJ.

Science. 2016 Nov 18;354(6314):829-830. No abstract available.

PMID:
27856864
15.
16.

Structural and Functional Studies of Pavine N-Methyltransferase from Thalictrum flavum Reveal Novel Insights into Substrate Recognition and Catalytic Mechanism.

Torres MA, Hoffarth E, Eugenio L, Savtchouk J, Chen X, Morris JS, Facchini PJ, Ng KK.

J Biol Chem. 2016 Nov 4;291(45):23403-23415. Epub 2016 Aug 29.

17.

Plug-and-Play Benzylisoquinoline Alkaloid Biosynthetic Gene Discovery in Engineered Yeast.

Morris JS, Dastmalchi M, Li J, Chang L, Chen X, Hagel JM, Facchini PJ.

Methods Enzymol. 2016;575:143-78. doi: 10.1016/bs.mie.2016.03.023. Epub 2016 Apr 25.

PMID:
27417928
18.

Characterization of aromatic aminotransferases from Ephedra sinica Stapf.

Kilpatrick K, Pajak A, Hagel JM, Sumarah MW, Lewinsohn E, Facchini PJ, Marsolais F.

Amino Acids. 2016 May;48(5):1209-20. doi: 10.1007/s00726-015-2156-1. Epub 2016 Feb 1.

PMID:
26832171
19.

Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants.

Hagel JM, Morris JS, Lee EJ, Desgagné-Penix I, Bross CD, Chang L, Chen X, Farrow SC, Zhang Y, Soh J, Sensen CW, Facchini PJ.

BMC Plant Biol. 2015 Sep 18;15:227. doi: 10.1186/s12870-015-0596-0.

20.

Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants.

Hagel JM, Mandal R, Han B, Han J, Dinsmore DR, Borchers CH, Wishart DS, Facchini PJ.

BMC Plant Biol. 2015 Sep 15;15:220. doi: 10.1186/s12870-015-0594-2.

21.

Isolation and Characterization of O-methyltransferases Involved in the Biosynthesis of Glaucine in Glaucium flavum.

Chang L, Hagel JM, Facchini PJ.

Plant Physiol. 2015 Oct;169(2):1127-40. doi: 10.1104/pp.15.01240. Epub 2015 Aug 21.

22.

Papaverine 7-O-demethylase, a novel 2-oxoglutarate/Fe(2+)-dependent dioxygenase from opium poppy.

Farrow SC, Facchini PJ.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2701-6. doi: 10.1016/j.febslet.2015.07.042. Epub 2015 Aug 8.

23.

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy.

Farrow SC, Hagel JM, Beaudoin GA, Burns DC, Facchini PJ.

Nat Chem Biol. 2015 Sep;11(9):728-32. doi: 10.1038/nchembio.1879. Epub 2015 Jul 1.

PMID:
26147354
24.

Transcriptome profiling of khat (Catha edulis) and Ephedra sinica reveals gene candidates potentially involved in amphetamine-type alkaloid biosynthesis.

Groves RA, Hagel JM, Zhang Y, Kilpatrick K, Levy A, Marsolais F, Lewinsohn E, Sensen CW, Facchini PJ.

PLoS One. 2015 Mar 25;10(3):e0119701. doi: 10.1371/journal.pone.0119701. eCollection 2015.

25.

Noscapine comes of age.

Chen X, Dang TT, Facchini PJ.

Phytochemistry. 2015 Mar;111:7-13. doi: 10.1016/j.phytochem.2014.09.008. Epub 2015 Jan 9. Review.

PMID:
25583437
26.

Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.

Dang TT, Chen X, Facchini PJ.

Nat Chem Biol. 2015 Feb;11(2):104-6. doi: 10.1038/nchembio.1717. Epub 2014 Dec 8.

PMID:
25485687
27.

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism.

Farrow SC, Facchini PJ.

Front Plant Sci. 2014 Oct 9;5:524. doi: 10.3389/fpls.2014.00524. eCollection 2014. Review.

29.

Benzylisoquinoline alkaloid biosynthesis in opium poppy.

Beaudoin GA, Facchini PJ.

Planta. 2014 Jul;240(1):19-32. doi: 10.1007/s00425-014-2056-8. Epub 2014 Mar 27. Review.

PMID:
24671624
30.

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae.

Fossati E, Ekins A, Narcross L, Zhu Y, Falgueyret JP, Beaudoin GA, Facchini PJ, Martin VJ.

Nat Commun. 2014;5:3283. doi: 10.1038/ncomms4283.

PMID:
24513861
31.

CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy.

Dang TT, Facchini PJ.

J Biol Chem. 2014 Jan 24;289(4):2013-26. doi: 10.1074/jbc.M113.505099. Epub 2013 Dec 9.

32.

Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy.

Dang TT, Facchini PJ.

FEBS Lett. 2014 Jan 3;588(1):198-204. doi: 10.1016/j.febslet.2013.11.037. Epub 2013 Dec 4.

33.

Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers.

Onoyovwe A, Hagel JM, Chen X, Khan MF, Schriemer DC, Facchini PJ.

Plant Cell. 2013 Oct;25(10):4110-22. doi: 10.1105/tpc.113.115113. Epub 2013 Oct 8.

34.

Dioxygenases catalyze O-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy.

Farrow SC, Facchini PJ.

J Biol Chem. 2013 Oct 4;288(40):28997-9012. doi: 10.1074/jbc.M113.488585. Epub 2013 Aug 8.

35.

Role of the phloem in the biochemistry and ecophysiology of benzylisoquinoline alkaloid metabolism.

Lee EJ, Hagel JM, Facchini PJ.

Front Plant Sci. 2013 Jun 11;4:182. doi: 10.3389/fpls.2013.00182. eCollection 2013.

36.

Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest.

Xiao M, Zhang Y, Chen X, Lee EJ, Barber CJ, Chakrabarty R, Desgagné-Penix I, Haslam TM, Kim YB, Liu E, MacNevin G, Masada-Atsumi S, Reed DW, Stout JM, Zerbe P, Zhang Y, Bohlmann J, Covello PS, De Luca V, Page JE, Ro DK, Martin VJ, Facchini PJ, Sensen CW.

J Biotechnol. 2013 Jul 10;166(3):122-34. doi: 10.1016/j.jbiotec.2013.04.004. Epub 2013 Apr 16.

37.

Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world.

Hagel JM, Facchini PJ.

Plant Cell Physiol. 2013 May;54(5):647-72. doi: 10.1093/pcp/pct020. Epub 2013 Feb 5. Review.

PMID:
23385146
38.

Isolation and characterization of a cDNA encoding (S)-cis-N-methylstylopine 14-hydroxylase from opium poppy, a key enzyme in sanguinarine biosynthesis.

Beaudoin GA, Facchini PJ.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):597-603. doi: 10.1016/j.bbrc.2012.12.129. Epub 2013 Jan 9.

PMID:
23313486
39.

Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis.

Hagel JM, Beaudoin GA, Fossati E, Ekins A, Martin VJ, Facchini PJ.

J Biol Chem. 2012 Dec 14;287(51):42972-83. doi: 10.1074/jbc.M112.420414. Epub 2012 Nov 1.

40.

Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species.

Dang TT, Onoyovwi A, Farrow SC, Facchini PJ.

Methods Enzymol. 2012;515:231-66. doi: 10.1016/B978-0-12-394290-6.00011-2.

PMID:
22999177
41.

Benzaldehyde is a precursor of phenylpropylamino alkaloids as revealed by targeted metabolic profiling and comparative biochemical analyses in Ephedra spp.

Krizevski R, Bar E, Shalit OR, Levy A, Hagel JM, Kilpatrick K, Marsolais F, Facchini PJ, Ben-Shabat S, Sitrit Y, Lewinsohn E.

Phytochemistry. 2012 Sep;81:71-9. doi: 10.1016/j.phytochem.2012.05.018. Epub 2012 Jun 21.

PMID:
22727117
42.

Systematic silencing of benzylisoquinoline alkaloid biosynthetic genes reveals the major route to papaverine in opium poppy.

Desgagné-Penix I, Facchini PJ.

Plant J. 2012 Oct;72(2):331-44. doi: 10.1111/j.1365-313X.2012.05084.x. Epub 2012 Aug 9.

43.

Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy.

Dang TT, Facchini PJ.

Plant Physiol. 2012 Jun;159(2):618-31. doi: 10.1104/pp.112.194886. Epub 2012 Apr 25.

44.

Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy.

Desgagné-Penix I, Farrow SC, Cram D, Nowak J, Facchini PJ.

Plant Mol Biol. 2012 Jun;79(3):295-313. doi: 10.1007/s11103-012-9913-2. Epub 2012 Apr 24.

PMID:
22527754
45.

Biosynthesis of amphetamine analogs in plants.

Hagel JM, Krizevski R, Marsolais F, Lewinsohn E, Facchini PJ.

Trends Plant Sci. 2012 Jul;17(7):404-12. doi: 10.1016/j.tplants.2012.03.004. Epub 2012 Apr 11. Review.

PMID:
22502775
46.

Transcript and metabolite profiling in cell cultures of 18 plant species that produce benzylisoquinoline alkaloids.

Farrow SC, Hagel JM, Facchini PJ.

Phytochemistry. 2012 May;77:79-88. doi: 10.1016/j.phytochem.2012.02.014. Epub 2012 Mar 14.

PMID:
22424601
47.

Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids.

Hagel JM, Krizevski R, Kilpatrick K, Sitrit Y, Marsolais F, Lewinsohn E, Facchini PJ.

Genet Mol Biol. 2011 Oct;34(4):640-6. doi: 10.1590/S1415-47572011000400017. Epub 2011 Oct 1.

48.

Synthetic biosystems for the production of high-value plant metabolites.

Facchini PJ, Bohlmann J, Covello PS, De Luca V, Mahadevan R, Page JE, Ro DK, Sensen CW, Storms R, Martin VJ.

Trends Biotechnol. 2012 Mar;30(3):127-31. doi: 10.1016/j.tibtech.2011.10.001. Epub 2011 Dec 29.

PMID:
22209518
49.

Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing.

Wijekoon CP, Facchini PJ.

Plant J. 2012 Mar;69(6):1052-63. doi: 10.1111/j.1365-313X.2011.04855.x. Epub 2011 Dec 28.

50.

Tyrosine aminotransferase contributes to benzylisoquinoline alkaloid biosynthesis in opium poppy.

Lee EJ, Facchini PJ.

Plant Physiol. 2011 Nov;157(3):1067-78. doi: 10.1104/pp.111.185512. Epub 2011 Sep 23.

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