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Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients.

Brown E, Rowan C, Strowitzki MJ, Fagundes RR, Faber KN, Güntsch A, Halligan DN, Kugler J, Jones F, Lee CT, Doherty G, Taylor CT.

FASEB J. 2020 Jan 16. doi: 10.1096/fj.201902103R. [Epub ahead of print]


Riboflavin supplementation in patients with Crohn's disease (RISE-UP study).

von Martels JZH, Bourgonje AR, Klaassen MAY, Alkhalifah HAA, Sadaghian Sadabad M, Vich Vila A, Gacesa R, Gabriëls RY, Steinert RE, Jansen BH, Bulthuis MLC, van Dullemen HM, Visschedijk MC, Festen EAM, Weersma RK, de Vos P, van Goor H, Faber KN, Harmsen HJM, Dijkstra G.

J Crohns Colitis. 2019 Dec 24. pii: jjz208. doi: 10.1093/ecco-jcc/jjz208. [Epub ahead of print]


Farnesoid X receptor and bile acids regulate vitamin A storage.

Saeed A, Yang J, Heegsma J, Groen AK, van Mil SWC, Paulusma CC, Zhou L, Wang B, Faber KN.

Sci Rep. 2019 Dec 20;9(1):19493. doi: 10.1038/s41598-019-55988-w.


Glycogen storage disease type 1a is associated with disturbed vitamin A metabolism and elevated serum retinol levels.

Saeed A, Hoogerland JA, Wessel H, Heegsma J, Derks TGJ, Veer E, Mithieux G, Rajas F, Oosterveer MH, Faber KN.

Hum Mol Genet. 2019 Dec 9. pii: ddz283. doi: 10.1093/hmg/ddz283. [Epub ahead of print]


Protective effect of metformin against palmitate-induced hepatic cell death.

Geng Y, Hernández Villanueva A, Oun A, Buist-Homan M, Blokzijl H, Faber KN, Dolga A, Moshage H.

Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165621. doi: 10.1016/j.bbadis.2019.165621. Epub 2019 Nov 29.


A Combined Set of Four Serum Inflammatory Biomarkers Reliably Predicts Endoscopic Disease Activity in Inflammatory Bowel Disease.

Bourgonje AR, von Martels JZH, Gabriëls RY, Blokzijl T, Buist-Homan M, Heegsma J, Jansen BH, van Dullemen HM, Festen EAM, Ter Steege RWF, Visschedijk MC, Weersma RK, de Vos P, Faber KN, Dijkstra G.

Front Med (Lausanne). 2019 Nov 5;6:251. doi: 10.3389/fmed.2019.00251. eCollection 2019.


Plasma Levels of Retinol Binding Protein 4 Relate to Large VLDL and Small LDL Particles in Subjects with and without Type 2 Diabetes.

Wessel H, Saeed A, Heegsma J, Connelly MA, Faber KN, Dullaart RPF.

J Clin Med. 2019 Oct 25;8(11). pii: E1792. doi: 10.3390/jcm8111792.


Serum Free Thiols Are Superior to Fecal Calprotectin in Reflecting Endoscopic Disease Activity in Inflammatory Bowel Disease.

Bourgonje AR, Gabriëls RY, de Borst MH, Bulthuis MLC, Faber KN, van Goor H, Dijkstra G.

Antioxidants (Basel). 2019 Sep 1;8(9). pii: E351. doi: 10.3390/antiox8090351.


Hydrogen sulfide stimulates activation of hepatic stellate cells through increased cellular bio-energetics.

Damba T, Zhang M, Buist-Homan M, van Goor H, Faber KN, Moshage H.

Nitric Oxide. 2019 Nov 1;92:26-33. doi: 10.1016/j.niox.2019.08.004. Epub 2019 Aug 8.


Corrigendum: Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.

Parada Venegas D, De la Fuente MK, Landskron G, González MJ, Quera R, Dijkstra G, Harmsen HJM, Faber KN, Hermoso MA.

Front Immunol. 2019 Jun 28;10:1486. doi: 10.3389/fimmu.2019.01486. eCollection 2019.


Hormone-sensitive lipase is a retinyl ester hydrolase in human and rat quiescent hepatic stellate cells.

Shajari S, Saeed A, Smith-Cortinez NF, Heegsma J, Sydor S, Faber KN.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1258-1267. doi: 10.1016/j.bbalip.2019.05.012. Epub 2019 May 28.


Crohn's Disease in Clinical Remission Is Marked by Systemic Oxidative Stress.

Bourgonje AR, von Martels JZH, Bulthuis MLC, van Londen M, Faber KN, Dijkstra G, van Goor H.

Front Physiol. 2019 Apr 26;10:499. doi: 10.3389/fphys.2019.00499. eCollection 2019.


Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.

Parada Venegas D, De la Fuente MK, Landskron G, González MJ, Quera R, Dijkstra G, Harmsen HJM, Faber KN, Hermoso MA.

Front Immunol. 2019 Mar 11;10:277. doi: 10.3389/fimmu.2019.00277. eCollection 2019. Review. Erratum in: Front Immunol. 2019 Jun 28;10:1486.


Hepatitis C virus core or NS3/4A protein expression preconditions hepatocytes against oxidative stress and endoplasmic reticulum stress.

Ríos-Ocampo WA, Daemen T, Buist-Homan M, Faber KN, Navas MC, Moshage H.

Redox Rep. 2019 Dec;24(1):17-26. doi: 10.1080/13510002.2019.1596431.


Assessing intestinal permeability in Crohn's disease patients using orally administered 52Cr-EDTA.

von Martels JZH, Bourgonje AR, Harmsen HJM, Faber KN, Dijkstra G.

PLoS One. 2019 Feb 7;14(2):e0211973. doi: 10.1371/journal.pone.0211973. eCollection 2019.


The cellular stress response in hepatitis C virus infection: A balancing act to promote viral persistence and host cell survival.

Ríos-Ocampo WA, Navas MC, Faber KN, Daemen T, Moshage H.

Virus Res. 2019 Apr 2;263:1-8. doi: 10.1016/j.virusres.2018.12.013. Epub 2018 Dec 29. Review.


Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-α biologicals and an Infliximab-biosimilar.

Buurman DJ, Blokzijl T, Festen EAM, Pham BT, Faber KN, Brouwer E, Dijkstra G.

PLoS One. 2018 Dec 11;13(12):e0208922. doi: 10.1371/journal.pone.0208922. eCollection 2018.


Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.

Uniken Venema WT, Voskuil MD, Vila AV, van der Vries G, Jansen BH, Jabri B, Faber KN, Dijkstra G, Xavier RJ, Wijmenga C, Graham DB, Weersma RK, Festen EA.

Gastroenterology. 2019 Feb;156(3):812-815.e22. doi: 10.1053/j.gastro.2018.10.046. Epub 2018 Nov 2. No abstract available.


Increased fecal calprotectin levels in Crohn's disease correlate with elevated serum Th1- and Th17-associated cytokines.

Bourgonje AR, von Martels JZH, de Vos P, Faber KN, Dijkstra G.

PLoS One. 2018 Feb 21;13(2):e0193202. doi: 10.1371/journal.pone.0193202. eCollection 2018.


Disturbed Vitamin A Metabolism in Non-Alcoholic Fatty Liver Disease (NAFLD).

Saeed A, Dullaart RPF, Schreuder TCMA, Blokzijl H, Faber KN.

Nutrients. 2017 Dec 29;10(1). pii: E29. doi: 10.3390/nu10010029. Review.


Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.

Sydor S, Manka P, Best J, Jafoui S, Sowa JP, Zoubek ME, Hernandez-Gea V, Cubero FJ, Kälsch J, Vetter D, Fiel MI, Hoshida Y, Bian CB, Nelson LJ, Moshage H, Faber KN, Paul A, Baba HA, Gerken G, Friedman SL, Canbay A, Bechmann LP.

Sci Rep. 2017 Aug 14;7(1):8119. doi: 10.1038/s41598-017-08680-w.


High prevalence of apolipoprotein B dyslipoproteinemias in non-alcoholic fatty liver disease: The lifelines cohort study.

Nass KJ, van den Berg EH, Faber KN, Schreuder TCMA, Blokzijl H, Dullaart RPF.

Metabolism. 2017 Jul;72:37-46. doi: 10.1016/j.metabol.2017.04.004. Epub 2017 Apr 13.


Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine.

Klunder LJ, Faber KN, Dijkstra G, van IJzendoorn SCD.

Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7). pii: a027888. doi: 10.1101/cshperspect.a027888. Review.


Regulation of mitochondrial gene expression, the epigenetic enigma.

Mposhi A, Van der Wijst MG, Faber KN, Rots MG.

Front Biosci (Landmark Ed). 2017 Mar 1;22:1099-1113. Review.


Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort.

van den Berg EH, Amini M, Schreuder TC, Dullaart RP, Faber KN, Alizadeh BZ, Blokzijl H.

PLoS One. 2017 Feb 2;12(2):e0171502. doi: 10.1371/journal.pone.0171502. eCollection 2017.


The interrelationship between bile acid and vitamin A homeostasis.

Saeed A, Hoekstra M, Hoeke MO, Heegsma J, Faber KN.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):496-512. doi: 10.1016/j.bbalip.2017.01.007. Epub 2017 Jan 19. Review.


Targeting pathogen metabolism without collateral damage to the host.

Haanstra JR, Gerding A, Dolga AM, Sorgdrager FJH, Buist-Homan M, du Toit F, Faber KN, Holzhütter HG, Szöör B, Matthews KR, Snoep JL, Westerhoff HV, Bakker BM.

Sci Rep. 2017 Jan 13;7:40406. doi: 10.1038/srep40406.


Higher free triiodothyronine is associated with non-alcoholic fatty liver disease in euthyroid subjects: the Lifelines Cohort Study.

van den Berg EH, van Tienhoven-Wind LJ, Amini M, Schreuder TC, Faber KN, Blokzijl H, Dullaart RP.

Metabolism. 2017 Feb;67:62-71. doi: 10.1016/j.metabol.2016.11.002. Epub 2016 Nov 6.


A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis.

Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J.

Hepatology. 2017 Sep;66(3):794-808. doi: 10.1002/hep.29034. Epub 2017 Jul 18.


The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut.

von Martels JZH, Sadaghian Sadabad M, Bourgonje AR, Blokzijl T, Dijkstra G, Faber KN, Harmsen HJM.

Anaerobe. 2017 Apr;44:3-12. doi: 10.1016/j.anaerobe.2017.01.001. Epub 2017 Jan 3. Review.


Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells.

Arabpour M, Cool RH, Faber KN, Quax WJ, Haisma HJ.

J Drug Target. 2017 Apr;25(4):360-369. doi: 10.1080/1061186X.2016.1262867. Epub 2016 Dec 28.


Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage.

González-Ponce HA, Martínez-Saldaña MC, Rincón-Sánchez AR, Sumaya-Martínez MT, Buist-Homan M, Faber KN, Moshage H, Jaramillo-Juárez F.

Nutrients. 2016 Oct 4;8(10). pii: E607.


The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro.

Bai X, Yang P, Zhou Q, Cai B, Buist-Homan M, Cheng H, Jiang J, Shen D, Li L, Luo X, Faber KN, Moshage H, Shi G.

Br J Pharmacol. 2017 Jan;174(1):41-56. doi: 10.1111/bph.13645. Epub 2016 Nov 28.


Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity.

Verhaag EM, Buist-Homan M, Koehorst M, Groen AK, Moshage H, Faber KN.

PLoS One. 2016 Mar 7;11(3):e0149782. doi: 10.1371/journal.pone.0149782. eCollection 2016.


HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.

Regeling A, Imhann F, Volders HH, Blokzijl T, Bloks VW, Weersma RK, Dijkstra G, Faber KN.

Biochim Biophys Acta. 2016 Apr;1862(4):788-796. doi: 10.1016/j.bbadis.2016.01.020. Epub 2016 Jan 26.


A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells.

Sadaghian Sadabad M, von Martels JZ, Khan MT, Blokzijl T, Paglia G, Dijkstra G, Harmsen HJ, Faber KN.

Sci Rep. 2015 Dec 15;5:17906. doi: 10.1038/srep17906.


Melatonin suppresses activation of hepatic stellate cells through RORα-mediated inhibition of 5-lipoxygenase.

Shajari S, Laliena A, Heegsma J, Tuñón MJ, Moshage H, Faber KN.

J Pineal Res. 2015 Oct;59(3):391-401. doi: 10.1111/jpi.12271. Epub 2015 Sep 15.


Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis.

Conde de la Rosa L, Vrenken TE, Buist-Homan M, Faber KN, Moshage H.

Pharmacol Res Perspect. 2015 Mar;3(2):e00125. doi: 10.1002/prp2.125. Epub 2015 Mar 18.


The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.

Sadaghian Sadabad M, Regeling A, de Goffau MC, Blokzijl T, Weersma RK, Penders J, Faber KN, Harmsen HJ, Dijkstra G.

Gut. 2015 Oct;64(10):1546-52. doi: 10.1136/gutjnl-2014-307289. Epub 2014 Sep 24.


Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease.

Parikh K, Zhou L, Somasundaram R, Fuhler GM, Deuring JJ, Blokzijl T, Regeling A, Kuipers EJ, Weersma RK, Nuij VJ, Alves M, Vogelaar L, Visser L, de Haar C, Krishnadath KK, van der Woude CJ, Dijkstra G, Faber KN, Peppelenbosch MP.

Sci Transl Med. 2014 Apr 23;6(233):233ra53. doi: 10.1126/scitranslmed.3006763.


Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1.

Hoeke MO, Heegsma J, Hoekstra M, Moshage H, Faber KN.

PLoS One. 2014 Feb 3;9(2):e88011. doi: 10.1371/journal.pone.0088011. eCollection 2014.


Metformin protects rat hepatocytes against bile acid-induced apoptosis.

Woudenberg-Vrenken TE, Conde de la Rosa L, Buist-Homan M, Faber KN, Moshage H.

PLoS One. 2013 Aug 12;8(8):e71773. doi: 10.1371/journal.pone.0071773. eCollection 2013.


Glutathione and antioxidant enzymes serve complementary roles in protecting activated hepatic stellate cells against hydrogen peroxide-induced cell death.

Dunning S, Ur Rehman A, Tiebosch MH, Hannivoort RA, Haijer FW, Woudenberg J, van den Heuvel FA, Buist-Homan M, Faber KN, Moshage H.

Biochim Biophys Acta. 2013 Dec;1832(12):2027-34. doi: 10.1016/j.bbadis.2013.07.008. Epub 2013 Jul 16.


Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis.

Karimian G, Buist-Homan M, Schmidt M, Tietge UJ, de Boer JF, Klappe K, Kok JW, Combettes L, Tordjmann T, Faber KN, Moshage H.

Biochim Biophys Acta. 2013 Dec;1832(12):1922-9. doi: 10.1016/j.bbadis.2013.06.011. Epub 2013 Jun 28.


Angiotensin II protects primary rat hepatocytes against bile salt-induced apoptosis.

Karimian G, Buist-Homan M, Mikus B, Henning RH, Faber KN, Moshage H.

PLoS One. 2012;7(12):e52647. doi: 10.1371/journal.pone.0052647. Epub 2012 Dec 26.


Westernized high-fat diet accelerates weight loss in dextran sulfate sodium-induced colitis in mice, which is further aggravated by supplementation of heme.

van der Logt EM, Blokzijl T, van der Meer R, Faber KN, Dijkstra G.

J Nutr Biochem. 2013 Jun;24(6):1159-65. doi: 10.1016/j.jnutbio.2012.09.001. Epub 2012 Dec 12.


Pertussis toxin, an inhibitor of G(αi) PCR, inhibits bile acid- and cytokine-induced apoptosis in primary rat hepatocytes.

Karimian G, Buist-Homan M, Faber KN, Moshage H.

PLoS One. 2012;7(8):e43156. doi: 10.1371/journal.pone.0043156. Epub 2012 Aug 10.


Impact of human granulocyte and monocyte isolation procedures on functional studies.

Zhou L, Somasundaram R, Nederhof RF, Dijkstra G, Faber KN, Peppelenbosch MP, Fuhler GM.

Clin Vaccine Immunol. 2012 Jul;19(7):1065-74. doi: 10.1128/CVI.05715-11. Epub 2012 May 2.


Homo- and hetero-dimeric architecture of the human liver Na⁺-dependent taurocholate co-transporting protein.

Bijsmans IT, Bouwmeester RA, Geyer J, Faber KN, van de Graaf SF.

Biochem J. 2012 Feb 1;441(3):1007-15. doi: 10.1042/BJ20111234.


Haplotype-based analysis of ulcerative colitis risk loci identifies both IL2 and IL21 as susceptibility genes in Han Chinese.

Shi J, Zhou L, Zhernakova A, Qian J, Zhu F, Sun G, Zhu L, Ma X, Dijkstra G, Wijmenga C, Faber KN, Lu X, Weersma RK.

Inflamm Bowel Dis. 2011 Dec;17(12):2472-9. doi: 10.1002/ibd.21652. Epub 2011 Jun 6.


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