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CFTR structure, stability, function and regulation.

Meng X, Clews J, Ciuta AD, Martin ER, Ford RC.

Biol Chem. 2019 Sep 25;400(10):1359-1370. doi: 10.1515/hsz-2018-0470.


Learning the ABCs one at a time: structure and mechanism of ABC transporters.

Ford RC, Beis K.

Biochem Soc Trans. 2019 Feb 28;47(1):23-36. doi: 10.1042/BST20180147. Epub 2019 Jan 9. Review.


Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9 Å resolution.

Thonghin N, Collins RF, Barbieri A, Shafi T, Siebert A, Ford RC.

BMC Struct Biol. 2018 Dec 13;18(1):17. doi: 10.1186/s12900-018-0098-z.


The structural basis of cystic fibrosis.

Meng X, Clews J, Martin ER, Ciuta AD, Ford RC.

Biochem Soc Trans. 2018 Oct 19;46(5):1093-1098. doi: 10.1042/BST20180296. Epub 2018 Aug 28. Review.


Cryo-electron microscopy of membrane proteins.

Thonghin N, Kargas V, Clews J, Ford RC.

Methods. 2018 Sep 1;147:176-186. doi: 10.1016/j.ymeth.2018.04.018. Epub 2018 Apr 25. Review.


Investigation of the effects of the CFTR potentiator ivacaftor on human P-glycoprotein (ABCB1).

Lingam S, Thonghin N, Ford RC.

Sci Rep. 2017 Dec 13;7(1):17481. doi: 10.1038/s41598-017-17773-5.


A polar SxxS motif drives assembly of the transmembrane domains of Toll-like receptor 4.

Kargas V, Marzinek JK, Holdbrook DA, Yin H, Ford RC, Bond PJ.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):2086-2095. doi: 10.1016/j.bbamem.2017.07.010. Epub 2017 Jul 22.


Molecular Dynamics Flexible Fitting Simulations Identify New Models of the Closed State of the Cystic Fibrosis Transmembrane Conductance Regulator Protein.

Simhaev L, McCarty NA, Ford RC, Senderowitz H.

J Chem Inf Model. 2017 Aug 28;57(8):1932-1946. doi: 10.1021/acs.jcim.7b00091. Epub 2017 Jul 18.


Full-length, Oligomeric Structure of Wzz Determined by Cryoelectron Microscopy Reveals Insights into Membrane-Bound States.

Collins RF, Kargas V, Clarke BR, Siebert CA, Clare DK, Bond PJ, Whitfield C, Ford RC.

Structure. 2017 May 2;25(5):806-815.e3. doi: 10.1016/j.str.2017.03.017. Epub 2017 Apr 20.


Two Small Molecules Restore Stability to a Subpopulation of the Cystic Fibrosis Transmembrane Conductance Regulator with the Predominant Disease-causing Mutation.

Meng X, Wang Y, Wang X, Wrennall JA, Rimington TL, Li H, Cai Z, Ford RC, Sheppard DN.

J Biol Chem. 2017 Mar 3;292(9):3706-3719. doi: 10.1074/jbc.M116.751537. Epub 2017 Jan 13.


The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability.

Meng X, Clews J, Kargas V, Wang X, Ford RC.

Cell Mol Life Sci. 2017 Jan;74(1):23-38. doi: 10.1007/s00018-016-2386-8. Epub 2016 Oct 12. Review.


The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.

Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD.

Nat Commun. 2016 Aug 10;7:12353. doi: 10.1038/ncomms12353.


Structure of wild type and mutant F508del CFTR: A small-angle X-ray scattering study of the protein-detergent complexes.

Pollock NL, Satriano L, Zegarra-Moran O, Ford RC, Moran O.

J Struct Biol. 2016 Apr;194(1):102-11. doi: 10.1016/j.jsb.2016.02.004. Epub 2016 Feb 3.


Characterizing diverse orthologues of the cystic fibrosis transmembrane conductance regulator protein for structural studies.

Pollock NL, Rimington TL, Ford RC.

Biochem Soc Trans. 2015 Oct;43(5):894-900. doi: 10.1042/BST20150081. Review.


Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation.

Rosenberg MF, Bikadi Z, Hazai E, Starborg T, Kelley L, Chayen NE, Ford RC, Mao Q.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1725-35. doi: 10.1107/S1399004715010676. Epub 2015 Jul 31.


The Cryo-EM structure of the CorA channel from Methanocaldococcus jannaschii in low magnesium conditions.

Cleverley RM, Kean J, Shintre CA, Baldock C, Derrick JP, Ford RC, Prince SM.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2206-15. doi: 10.1016/j.bbamem.2015.06.002. Epub 2015 Jun 4.


Purification of the cystic fibrosis transmembrane conductance regulator protein expressed in Saccharomyces cerevisiae.

Pollock N, Cant N, Rimington T, Ford RC.

J Vis Exp. 2014 May 10;(87). doi: 10.3791/51447.


Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Gulati S, Jamshad M, Knowles TJ, Morrison KA, Downing R, Cant N, Collins R, Koenderink JB, Ford RC, Overduin M, Kerr ID, Dafforn TR, Rothnie AJ.

Biochem J. 2014 Jul 15;461(2):269-78. doi: 10.1042/BJ20131477.


CFTR structure and cystic fibrosis.

Cant N, Pollock N, Ford RC.

Int J Biochem Cell Biol. 2014 Jul;52:15-25. doi: 10.1016/j.biocel.2014.02.004. Epub 2014 Feb 15. Review.


Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.

Bozoky Z, Krzeminski M, Muhandiram R, Birtley JR, Al-Zahrani A, Thomas PJ, Frizzell RA, Ford RC, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4427-36. doi: 10.1073/pnas.1315104110. Epub 2013 Nov 4.


Functional and structural study of the dimeric inner membrane protein SbmA.

Corbalan N, Runti G, Adler C, Covaceuszach S, Ford RC, Lamba D, Beis K, Scocchi M, Vincent PA.

J Bacteriol. 2013 Dec;195(23):5352-61. doi: 10.1128/JB.00824-13. Epub 2013 Sep 27.


Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation.

Venerando A, Franchin C, Cant N, Cozza G, Pagano MA, Tosoni K, Al-Zahrani A, Arrigoni G, Ford RC, Mehta A, Pinna LA.

PLoS One. 2013 Sep 18;8(9):e74232. doi: 10.1371/journal.pone.0074232. eCollection 2013.


Improving the stability and function of purified ABCB1 and ABCA4: the influence of membrane lipids.

Pollock NL, McDevitt CA, Collins R, Niesten PH, Prince S, Kerr ID, Ford RC, Callaghan R.

Biochim Biophys Acta. 2014 Jan;1838(1 Pt B):134-47. doi: 10.1016/j.bbamem.2013.09.001. Epub 2013 Sep 12.


Cystic fibrosis transmembrane conductance regulator (ABCC7) structure.

Hunt JF, Wang C, Ford RC.

Cold Spring Harb Perspect Med. 2013 Feb 1;3(2):a009514. doi: 10.1101/cshperspect.a009514. Review.


Structure and assembly of a trans-periplasmic channel for type IV pili in Neisseria meningitidis.

Berry JL, Phelan MM, Collins RF, Adomavicius T, Tønjum T, Frye SA, Bird L, Owens R, Ford RC, Lian LY, Derrick JP.

PLoS Pathog. 2012 Sep;8(9):e1002923. doi: 10.1371/journal.ppat.1002923. Epub 2012 Sep 13.


A cationic lumen in the Wzx flippase mediates anionic O-antigen subunit translocation in Pseudomonas aeruginosa PAO1.

Islam ST, Fieldhouse RJ, Anderson EM, Taylor VL, Keates RA, Ford RC, Lam JS.

Mol Microbiol. 2012 Jun;84(6):1165-76. doi: 10.1111/j.1365-2958.2012.08084.x. Epub 2012 May 23.


Expression and purification of the cystic fibrosis transmembrane conductance regulator protein in Saccharomyces cerevisiae.

O'Ryan L, Rimington T, Cant N, Ford RC.

J Vis Exp. 2012 Mar 10;(61). pii: 3860. doi: 10.3791/3860.


The cystic fibrosis transmembrane conductance regulator (CFTR): three-dimensional structure and localization of a channel gate.

Rosenberg MF, O'Ryan LP, Hughes G, Zhao Z, Aleksandrov LA, Riordan JR, Ford RC.

J Biol Chem. 2011 Dec 9;286(49):42647-54. doi: 10.1074/jbc.M111.292268. Epub 2011 Sep 19.


Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA.

Valente M, Watterson SJ, Parker MD, Ford RC, Young MT.

Biochim Biophys Acta. 2011 Dec;1808(12):2859-66. doi: 10.1016/j.bbamem.2011.08.025. Epub 2011 Aug 26.


CFTR three-dimensional structure.

Ford RC, Birtley J, Rosenberg MF, Zhang L.

Methods Mol Biol. 2011;741:329-46. doi: 10.1007/978-1-61779-117-8_22.


Dual conserved periplasmic loops possess essential charge characteristics that support a catch-and-release mechanism of O-antigen polymerization by Wzy in Pseudomonas aeruginosa PAO1.

Islam ST, Gold AC, Taylor VL, Anderson EM, Ford RC, Lam JS.

J Biol Chem. 2011 Jun 10;286(23):20600-5. doi: 10.1074/jbc.C110.204651. Epub 2011 Apr 15.


Functional and structural characterization of polysaccharide co-polymerase proteins required for polymer export in ATP-binding cassette transporter-dependent capsule biosynthesis pathways.

Larue K, Ford RC, Willis LM, Whitfield C.

J Biol Chem. 2011 May 13;286(19):16658-68. doi: 10.1074/jbc.M111.228221. Epub 2011 Mar 18.


Domain location within the cystic fibrosis transmembrane conductance regulator protein investigated by electron microscopy and gold labelling.

Zhang L, Aleksandrov LA, Riordan JR, Ford RC.

Biochim Biophys Acta. 2011 Jan;1808(1):399-404. doi: 10.1016/j.bbamem.2010.08.012. Epub 2010 Aug 19.


The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone.

Rosenberg MF, Bikadi Z, Chan J, Liu X, Ni Z, Cai X, Ford RC, Mao Q.

Structure. 2010 Mar 14;18(4):482-93. doi: 10.1016/j.str.2010.01.017. Erratum in: Structure. 2010 Dec 8;18(12):1688-9.


Structure of a human multidrug transporter in an inward-facing conformation.

Rosenberg MF, Oleschuk CJ, Wu P, Mao Q, Deeley RG, Cole SP, Ford RC.

J Struct Biol. 2010 Jun;170(3):540-7. doi: 10.1016/j.jsb.2010.01.011. Epub 2010 Jan 28.


The ATP-binding cassette family: a structural perspective.

Kos V, Ford RC.

Cell Mol Life Sci. 2009 Oct;66(19):3111-26. doi: 10.1007/s00018-009-0064-9. Epub 2009 Jun 21. Review.


Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding.

Zhang L, Aleksandrov LA, Zhao Z, Birtley JR, Riordan JR, Ford RC.

J Struct Biol. 2009 Sep;167(3):242-51. doi: 10.1016/j.jsb.2009.06.004. Epub 2009 Jun 12.


Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis.

Ford RC, Brunkan-LaMontagne AL, Collins RF, Clarke BR, Harris R, Naismith JH, Whitfield C.

J Struct Biol. 2009 May;166(2):172-82. doi: 10.1016/j.jsb.2009.02.005. Epub 2009 Feb 21.


Characterization of a CorA Mg2+ transport channel from Methanococcus jannaschii using a Thermofluor-based stability assay.

Kean J, Cleverley RM, O'Ryan L, Ford RC, Prince SM, Derrick JP.

Mol Membr Biol. 2008 Dec;25(8):653-63. doi: 10.1080/09687680802541169.


Selection of membrane protein targets for crystallization using PFO-PAGE electrophoresis.

Cleverley RM, Saleem M, Kean J, Ford RC, Derrick JP, Prince SM.

Mol Membr Biol. 2008 Dec;25(8):625-30. doi: 10.1080/09687680802448530.


Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.

McDevitt CA, Shintre CA, Grossmann JG, Pollock NL, Prince SM, Callaghan R, Ford RC.

FEBS Lett. 2008 Aug 20;582(19):2950-6. doi: 10.1016/j.febslet.2008.07.022. Epub 2008 Jul 25.


Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy.

Young MT, Fisher JA, Fountain SJ, Ford RC, North RA, Khakh BS.

J Biol Chem. 2008 Sep 19;283(38):26241-51. doi: 10.1074/jbc.M804458200. Epub 2008 Jul 17.


Electron crystallography of biomolecules: mysterious membranes and missing cones.

Ford RC, Holzenburg A.

Trends Biochem Sci. 2008 Jan;33(1):38-43. Epub 2007 Nov 28. Review.


The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli.

Collins RF, Beis K, Dong C, Botting CH, McDonnell C, Ford RC, Clarke BR, Whitfield C, Naismith JH.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2390-5. Epub 2007 Feb 5.


Topology of the outer-membrane secretin PilQ from Neisseria meningitidis.

Frye SA, Assalkhou R, Collins RF, Ford RC, Petersson C, Derrick JP, Tønjum T.

Microbiology. 2006 Dec;152(Pt 12):3751-64.


Purification and 3D structural analysis of oligomeric human multidrug transporter ABCG2.

McDevitt CA, Collins RF, Conway M, Modok S, Storm J, Kerr ID, Ford RC, Callaghan R.

Structure. 2006 Nov;14(11):1623-32.


Quantifying the effects of melittin on liposomes.

Popplewell JF, Swann MJ, Freeman NJ, McDonnell C, Ford RC.

Biochim Biophys Acta. 2007 Jan;1768(1):13-20. Epub 2006 May 23.


Aligning internal organizational factors with a service excellence mission: an exploratory investigation in health care.

Ford RC, Sivo SA, Fottler MD, Dickson D, Bradley K, Johnson L.

Health Care Manage Rev. 2006 Oct-Dec;31(4):259-69.


Inelastic neutron scattering studies of the interaction between water and some amino acids.

Zhang Y, Zhang P, Ford RC, Han S, Li J.

J Phys Chem B. 2005 Sep 29;109(38):17784-6.


Vibrational spectroscopic studies of the interaction of water with serine.

Zhang P, Zhang Y, Han S, Yan Q, Ford RC, Li J.

J Phys Chem A. 2006 Apr 20;110(15):5000-3.


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