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Items: 1 to 50 of 257

1.

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete).

O'Callaghan-Gordo C, Kogevinas M, Pedersen M, Fthenou E, Espinosa A, Tsiapa X, Chalkiadaki G, Daraki V, Dermitzaki E, Decordier I, Farmer PB, Georgiadis P, Georgiou V, Kyrtopoulos SA, Merlo DF, Romaguera D, Roumeliotaki T, Sarri K, Törnqvist M, Loock KV, von Stedingk H, Kleinjans J, Kirsch-Volders M, Chatzi L.

Eur J Nutr. 2018 Feb;57(1):209-218. doi: 10.1007/s00394-016-1310-1. Epub 2016 Sep 21.

PMID:
27655526
2.

Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.

Stone EL, Citossi F, Singh R, Kaur B, Gaskell M, Farmer PB, Monks A, Hose C, Stevens MF, Leong CO, Stocks M, Kellam B, Marlow M, Bradshaw TD.

Bioorg Med Chem. 2015 Nov 1;23(21):6891-9. doi: 10.1016/j.bmc.2015.09.052. Epub 2015 Oct 3.

PMID:
26474663
3.

Adduct levels from benzo[a]pyrenediol epoxide: Relative formation to histidine in serum albumin and to deoxyguanosine in DNA in vitro and in vivo in mice measured by LC/MS-MS methods.

Westberg EA, Singh R, Hedebrant U, Koukouves G, Souliotis VL, Farmer PB, Segerbäck D, Kyrtopoulos S, Törnqvist MÅ.

Toxicol Lett. 2015 Jan 5;232(1):28-36. doi: 10.1016/j.toxlet.2014.09.019. Epub 2014 Sep 26.

PMID:
25261590
4.

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.

Pottenger LH, Andrews LS, Bachman AN, Boogaard PJ, Cadet J, Embry MR, Farmer PB, Himmelstein MW, Jarabek AM, Martin EA, Mauthe RJ, Persaud R, Preston RJ, Schoeny R, Skare J, Swenberg JA, Williams GM, Zeiger E, Zhang F, Kim JH.

Crit Rev Toxicol. 2014 Apr;44(4):348-91. doi: 10.3109/10408444.2013.873768. Epub 2014 Feb 4. Review.

PMID:
24494825
5.

Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.

Merlo DF, Agramunt S, Anna L, Besselink H, Botsivali M, Brady NJ, Ceppi M, Chatzi L, Chen B, Decordier I, Farmer PB, Fleming S, Fontana V, Försti A, Fthenou E, Gallo F, Georgiadis P, Gmuender H, Godschalk RW, Granum B, Hardie LJ, Hemminki K, Hochstenbach K, Knudsen LE, Kogevinas M, Kovács K, Kyrtopoulos SA, Løvik M, Nielsen JK, Nygaard UC, Pedersen M, Rydberg P, Schoket B, Segerbäck D, Singh R, Sunyer J, Törnqvist M, van Loveren H, van Schooten FJ, Vande Loock K, von Stedingk H, Wright J, Kleinjans JC, Kirsch-Volders M, van Delft JH; NewGeneris Consortium.

Environ Health Perspect. 2014 Feb;122(2):193-200. doi: 10.1289/ehp.1206324. Epub 2013 Nov 19.

6.

Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris).

Pedersen M, Schoket B, Godschalk RW, Wright J, von Stedingk H, Törnqvist M, Sunyer J, Nielsen JK, Merlo DF, Mendez MA, Meltzer HM, Lukács V, Landström A, Kyrtopoulos SA, Kovács K, Knudsen LE, Haugen M, Hardie LJ, Gützkow KB, Fleming S, Fthenou E, Farmer PB, Espinosa A, Chatzi L, Brunborg G, Brady NJ, Botsivali M, Arab K, Anna L, Alexander J, Agramunt S, Kleinjans JC, Segerbäck D, Kogevinas M.

Environ Health Perspect. 2013 Oct;121(10):1200-6. doi: 10.1289/ehp.1206333. Epub 2013 Jul 23.

7.

Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro.

Lindberg HK, Falck GC, Singh R, Suhonen S, Järventaus H, Vanhala E, Catalán J, Farmer PB, Savolainen KM, Norppa H.

Toxicology. 2013 Nov 8;313(1):24-37. doi: 10.1016/j.tox.2012.12.008. Epub 2012 Dec 21.

PMID:
23266321
8.

Urinary benzene biomarkers and DNA methylation in Bulgarian petrochemical workers: study findings and comparison of linear and beta regression models.

Seow WJ, Pesatori AC, Dimont E, Farmer PB, Albetti B, Ettinger AS, Bollati V, Bolognesi C, Roggieri P, Panev TI, Georgieva T, Merlo DF, Bertazzi PA, Baccarelli AA.

PLoS One. 2012;7(12):e50471. doi: 10.1371/journal.pone.0050471. Epub 2012 Dec 5.

9.

Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.

Barregard L, Møller P, Henriksen T, Mistry V, Koppen G, Rossner P Jr, Sram RJ, Weimann A, Poulsen HE, Nataf R, Andreoli R, Manini P, Marczylo T, Lam P, Evans MD, Kasai H, Kawai K, Li YS, Sakai K, Singh R, Teichert F, Farmer PB, Rozalski R, Gackowski D, Siomek A, Saez GT, Cerda C, Broberg K, Lindh C, Hossain MB, Haghdoost S, Hu CW, Chao MR, Wu KY, Orhan H, Senduran N, Smith RJ, Santella RM, Su Y, Cortez C, Yeh S, Olinski R, Loft S, Cooke MS.

Antioxid Redox Signal. 2013 Jun 20;18(18):2377-91. doi: 10.1089/ars.2012.4714. Epub 2013 Jan 31.

10.

Detection of acetaldehyde derived N(2)-ethyl-2'-deoxyguanosine in human leukocyte DNA following alcohol consumption.

Singh R, Gromadzinska J, Mistry Y, Cordell R, Juren T, Segerbäck D, Farmer PB.

Mutat Res. 2012 Sep 1;737(1-2):8-11. doi: 10.1016/j.mrfmmm.2012.07.001. Epub 2012 Jul 20.

PMID:
22824164
11.

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE Statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P; STROBE Statement.

PLoS Med. 2011 Oct;8(10):e1001117. doi: 10.1371/journal.pmed.1001117. Epub 2011 Oct 25. No abstract available.

12.

STrengthening the reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P.

Eur J Epidemiol. 2011 Oct;26(10):797-810. doi: 10.1007/s10654-011-9622-1. Epub 2011 Oct 29. Erratum in: Eur J Epidemiol. 2012 Feb;27(2):151.

PMID:
22037796
13.

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology STROBE-ME: an extension of the STROBE statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P.

J Clin Epidemiol. 2011 Dec;64(12):1350-63. doi: 10.1016/j.jclinepi.2011.07.010. Erratum in: J Clin Epidemiol. 2012 Jul;65(7):813.

PMID:
22030070
14.

STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P.

Prev Med. 2011 Dec;53(6):377-87. doi: 10.1016/j.ypmed.2011.08.007. Epub 2011 Oct 24. Erratum in: Prev Med. 2012 May;54(5):367.

PMID:
22029945
15.

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P.

Mutagenesis. 2012 Jan;27(1):17-29. doi: 10.1093/mutage/ger039. Epub 2011 Oct 25. Erratum in: Mutagenesis. 2012 May;27(3):383.

PMID:
22027842
16.

STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P.

J Epidemiol Community Health. 2012 Sep;66(9):844-54. doi: 10.1136/jech-2011-200318. Epub 2011 Oct 24.

PMID:
22025194
17.

STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement.

Gallo V, Egger M, McCormack V, Farmer PB, Ioannidis JP, Kirsch-Volders M, Matullo G, Phillips DH, Schoket B, Stromberg U, Vermeulen R, Wild C, Porta M, Vineis P.

Eur J Clin Invest. 2012 Jan;42(1):1-16. doi: 10.1111/j.1365-2362.2011.02561.x. Epub 2011 Oct 25. Erratum in: Eur J Clin Invest. 2012 Apr;42(4):462.

18.

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice.

Arlt VM, Singh R, Stiborová M, Gamboa da Costa G, Frei E, Evans JD, Farmer PB, Wolf CR, Henderson CJ, Phillips DH.

Drug Metab Dispos. 2011 Dec;39(12):2169-73. doi: 10.1124/dmd.111.041343. Epub 2011 Sep 22.

PMID:
21940903
19.

Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry.

Teichert F, Winkler S, Keun HC, Steward WP, Gescher AJ, Farmer PB, Singh R.

Rapid Commun Mass Spectrom. 2011 Jul 30;25(14):2071-82. doi: 10.1002/rcm.5086.

PMID:
21698690
20.

Non-invasive assessment of oxidatively damaged DNA: liquid chromatography-tandem mass spectrometry analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.

Mistry V, Teichert F, Sandhu JK, Singh R, Evans MD, Farmer PB, Cooke MS.

Methods Mol Biol. 2011;682:279-89. doi: 10.1007/978-1-60327-409-8_20.

PMID:
21057935
21.

Strategies in case of positive in vivo results in genotoxicity testing.

Thybaud V, Macgregor JT, Müller L, Crebelli R, Dearfield K, Douglas G, Farmer PB, Gocke E, Hayashi M, Lovell DP, Lutz WK, Marzin D, Moore M, Nohmi T, Phillips DH, Van Benthem J.

Mutat Res. 2011 Aug 16;723(2):121-8. doi: 10.1016/j.mrgentox.2010.09.002. Epub 2010 Sep 17.

PMID:
20854927
22.

Determination of cisplatin 1,2-intrastrand guanine-guanine DNA adducts in human leukocytes by high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry.

Harrington CF, Le Pla RC, Jones GD, Thomas AL, Farmer PB.

Chem Res Toxicol. 2010 Aug 16;23(8):1313-21. doi: 10.1021/tx100023c.

PMID:
20666396
23.

Development of a targeted adductomic method for the determination of polycyclic aromatic hydrocarbon DNA adducts using online column-switching liquid chromatography/tandem mass spectrometry.

Singh R, Teichert F, Seidel A, Roach J, Cordell R, Cheng MK, Frank H, Steward WP, Manson MM, Farmer PB.

Rapid Commun Mass Spectrom. 2010 Aug 30;24(16):2329-40. doi: 10.1002/rcm.4645.

PMID:
20658679
24.

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.

Singh R, Arlt VM, Henderson CJ, Phillips DH, Farmer PB, Gamboa da Costa G.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Aug 1;878(23):2155-62. doi: 10.1016/j.jchromb.2010.06.008. Epub 2010 Jun 11.

25.

Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.

Olsen AK, Andreassen A, Singh R, Wiger R, Duale N, Farmer PB, Brunborg G.

PLoS One. 2010 Jun 28;5(6):e11349. doi: 10.1371/journal.pone.0011349.

26.

Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.

Teichert F, Verschoyle RD, Greaves P, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gescher AJ, Keun HC.

Mol Biosyst. 2010 Oct;6(10):1911-6. doi: 10.1039/c004702c. Epub 2010 Jun 25.

PMID:
20577699
27.

Analysis of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine by liquid chromatography-tandem mass spectrometry.

Evans MD, Singh R, Mistry V, Farmer PB, Cooke MS.

Methods Mol Biol. 2010;610:341-51. doi: 10.1007/978-1-60327-029-8_20.

PMID:
20013188
28.

Phosphotriester adducts (PTEs): DNA's overlooked lesion.

Jones GD, Le Pla RC, Farmer PB.

Mutagenesis. 2010 Jan;25(1):3-16. doi: 10.1093/mutage/gep038. Epub 2009 Nov 17. Review.

PMID:
19920061
29.

Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry.

Gamboa da Costa G, Singh R, Arlt VM, Mirza A, Richards M, Takamura-Enya T, Schmeiser HH, Farmer PB, Phillips DH.

Chem Res Toxicol. 2009 Nov;22(11):1860-8. doi: 10.1021/tx900264v.

PMID:
19916526
30.

Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.

Engström KS, Vahter M, Lindh C, Teichert F, Singh R, Concha G, Nermell B, Farmer PB, Strömberg U, Broberg K.

Mutat Res. 2010 Jan 5;683(1-2):98-105. doi: 10.1016/j.mrfmmm.2009.10.014.

PMID:
19896490
31.

Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.

Yang J, Parsons J, Nicolay NH, Caporali S, Harrington CF, Singh R, Finch D, D'Atri S, Farmer PB, Johnston PG, McKenna WG, Dianov G, Sharma RA.

Oncogene. 2010 Jan 21;29(3):463-8. doi: 10.1038/onc.2009.327. Epub 2009 Oct 19.

PMID:
19838217
32.

Creating context for the use of DNA adduct data in cancer risk assessment: II. Overview of methods of identification and quantitation of DNA damage.

Himmelstein MW, Boogaard PJ, Cadet J, Farmer PB, Kim JH, Martin EA, Persaud R, Shuker DE.

Crit Rev Toxicol. 2009;39(8):679-94. doi: 10.1080/10408440903164163. Review.

PMID:
19743945
33.

Determination of 5-methyl-2'-deoxycytidine in genomic DNA using high performance liquid chromatography-ultraviolet detection.

Sandhu J, Kaur B, Armstrong C, Talbot CJ, Steward WP, Farmer PB, Singh R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 1;877(20-21):1957-61. doi: 10.1016/j.jchromb.2009.05.032. Epub 2009 May 21.

PMID:
19501556
34.

Mutagenicity of DNA adducts derived from ethylene oxide exposure in the pSP189 shuttle vector replicated in human Ad293 cells.

Tompkins EM, McLuckie KI, Jones DJ, Farmer PB, Brown K.

Mutat Res. 2009 Aug;678(2):129-37. doi: 10.1016/j.mrgentox.2009.05.011. Epub 2009 May 27.

PMID:
19477295
35.

Evaluation of the DNA damaging potential of cannabis cigarette smoke by the determination of acetaldehyde derived N2-ethyl-2'-deoxyguanosine adducts.

Singh R, Sandhu J, Kaur B, Juren T, Steward WP, Segerbäck D, Farmer PB.

Chem Res Toxicol. 2009 Jun;22(6):1181-8. doi: 10.1021/tx900106y.

PMID:
19449825
36.

First-trimester increase in oxidative stress and risk of small-for-gestational-age fetus.

Potdar N, Singh R, Mistry V, Evans MD, Farmer PB, Konje JC, Cooke MS.

BJOG. 2009 Apr;116(5):637-42. doi: 10.1111/j.1471-0528.2008.02096.x.

37.

Dose-response relationships for N7-(2-hydroxyethyl)guanine induced by low-dose [14C]ethylene oxide: evidence for a novel mechanism of endogenous adduct formation.

Marsden DA, Jones DJ, Britton RG, Ognibene T, Ubick E, Johnson GE, Farmer PB, Brown K.

Cancer Res. 2009 Apr 1;69(7):3052-9. doi: 10.1158/0008-5472.CAN-08-4233. Epub 2009 Mar 10.

38.

Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells.

Song R, Duarte TL, Almeida GM, Farmer PB, Cooke MS, Zhang W, Sheng G, Fu J, Jones GD.

Toxicol Lett. 2009 Feb 25;185(1):23-31. doi: 10.1016/j.toxlet.2008.11.011. Epub 2008 Nov 27.

PMID:
19095052
39.

Preclinical toxicokinetic evaluation of phortress [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride] in two rodent species.

Bradshaw TD, Wren JE, Bruce M, Barrett DA, Leong CO, Gaskell M, Wright EK, Farmer PB, Henderson CJ, Wolf R, Stevens MF.

Pharmacology. 2009;83(2):99-109. doi: 10.1159/000183846. Epub 2008 Dec 17.

PMID:
19088497
40.

Determination of 8-oxo-2'-deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies.

Teichert F, Verschoyle RD, Greaves P, Thorpe JF, Mellon JK, Steward WP, Farmer PB, Gescher AJ, Singh R.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):258-66. doi: 10.1002/rcm.3873. Erratum in: Rapid Commun Mass Spectrom. 2010 Jul;24(14):2175.

PMID:
19072863
41.

Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry.

Singh R, Teichert F, Verschoyle RD, Kaur B, Vives M, Sharma RA, Steward WP, Gescher AJ, Farmer PB.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):151-60. doi: 10.1002/rcm.3866.

PMID:
19065576
42.

Analysis of urinary 8-oxo-7,8-dihydro-purine-2'-deoxyribonucleosides by LC-MS/MS and improved ELISA.

Evans MD, Singh R, Mistry V, Sandhu K, Farmer PB, Cooke MS.

Free Radic Res. 2008 Oct;42(10):831-40. doi: 10.1080/10715760802506323.

PMID:
18985483
43.

Mutagenicity of tamoxifen DNA adducts in human endometrial cells and in silico prediction of p53 mutation hotspots.

Liapis E, McLuckie KI, Lewis PD, Farmer PB, Brown K.

Nucleic Acids Res. 2008 Oct;36(18):5933-45. doi: 10.1093/nar/gkn586. Epub 2008 Sep 19.

44.
45.

Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.

Teichert F, Verschoyle RD, Greaves P, Edwards RE, Teahan O, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gant TW, Gescher AJ, Keun HC.

Prostate. 2008 Jul 1;68(10):1035-47. doi: 10.1002/pros.20761.

PMID:
18459103
46.

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

Arlt VM, Stiborová M, Henderson CJ, Thiemann M, Frei E, Aimová D, Singh R, Gamboa da Costa G, Schmitz OJ, Farmer PB, Wolf CR, Phillips DH.

Carcinogenesis. 2008 Mar;29(3):656-65. doi: 10.1093/carcin/bgn002. Epub 2008 Jan 19.

PMID:
18204078
47.

Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.

Pathak S, Singh R, Verschoyle RD, Greaves P, Farmer PB, Steward WP, Mellon JK, Gescher AJ, Sharma RA.

Cancer Lett. 2008 Mar 8;261(1):74-83. Epub 2007 Dec 21.

PMID:
18096312
48.
50.

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

Ritchie KJ, Henderson CJ, Wang XJ, Vassieva O, Carrie D, Farmer PB, Gaskell M, Park K, Wolf CR.

Cancer Res. 2007 Oct 1;67(19):9248-57.

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