Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 108

1.

HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.

Collier MP, Alderson TR, de Villiers CP, Nicholls D, Gastall HY, Allison TM, Degiacomi MT, Jiang H, Mlynek G, Fürst DO, van der Ven PFM, Djinovic-Carugo K, Baldwin AJ, Watkins H, Gehmlich K, Benesch JLP.

Sci Adv. 2019 May 22;5(5):eaav8421. doi: 10.1126/sciadv.aav8421. eCollection 2019 May.

2.

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.

Klein S, Frohn F, Magdaleno F, Reker-Smit C, Schierwagen R, Schierwagen I, Uschner FE, van Dijk F, Fürst DO, Djudjaj S, Boor P, Poelstra K, Beljaars L, Trebicka J.

Sci Rep. 2019 Feb 19;9(1):2256. doi: 10.1038/s41598-019-38678-5.

3.

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.

Unger A, Beckendorf L, Böhme P, Kley R, von Frieling-Salewsky M, Lochmüller H, Schröder R, Fürst DO, Vorgerd M, Linke WA.

Acta Neuropathol Commun. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0.

4.

The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling.

Dierck F, Kuhn C, Rohr C, Hille S, Braune J, Sossalla S, Molt S, van der Ven PFM, Fürst DO, Frey N.

J Biol Chem. 2017 Sep 15;292(37):15180-15191. doi: 10.1074/jbc.M117.786764. Epub 2017 Jul 17.

5.

Myofibrillar Z-discs Are a Protein Phosphorylation Hot Spot with Protein Kinase C (PKCα) Modulating Protein Dynamics.

Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke AL, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PF, Radziwill G, Fürst DO, Warscheid B.

Mol Cell Proteomics. 2017 Mar;16(3):346-367. doi: 10.1074/mcp.M116.065425. Epub 2016 Dec 27.

6.

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15.

7.

Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy.

Kebir S, Orfanos Z, Schuld J, Linhart M, Lamberz C, van der Ven PF, Schrickel J, Kirfel G, Fürst DO, Meyer R.

Exp Cell Res. 2016 Oct 15;348(1):95-105. doi: 10.1016/j.yexcr.2016.09.008. Epub 2016 Sep 14.

PMID:
27639425
8.

Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.

Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel R, Bryson-Richardson RJ, Fürst DO.

Hum Mol Genet. 2016 Jul 1;25(13):2776-2788. Epub 2016 May 19.

PMID:
27206985
9.

New insights into the protein aggregation pathology in myotilinopathy by combined proteomic and immunolocalization analyses.

Maerkens A, Olivé M, Schreiner A, Feldkirchner S, Schessl J, Uszkoreit J, Barkovits K, Güttsches AK, Theis V, Eisenacher M, Tegenthoff M, Goldfarb LG, Schröder R, Schoser B, van der Ven PF, Fürst DO, Vorgerd M, Marcus K, Kley RA.

Acta Neuropathol Commun. 2016 Feb 3;4:8. doi: 10.1186/s40478-016-0280-0.

10.

Breaking sarcomeres by in vitro exercise.

Orfanos Z, Gödderz MP, Soroka E, Gödderz T, Rumyantseva A, van der Ven PF, Hawke TJ, Fürst DO.

Sci Rep. 2016 Jan 25;6:19614. doi: 10.1038/srep19614.

11.

Interplay of Matrix Stiffness and c-SRC in Hepatic Fibrosis.

Görtzen J, Schierwagen R, Bierwolf J, Klein S, Uschner FE, van der Ven PF, Fürst DO, Strassburg CP, Laleman W, Pollok JM, Trebicka J.

Front Physiol. 2015 Dec 2;6:359. doi: 10.3389/fphys.2015.00359. eCollection 2015.

12.

Myofibrillar instability exacerbated by acute exercise in filaminopathy.

Chevessier F, Schuld J, Orfanos Z, Plank AC, Wolf L, Maerkens A, Unger A, Schlötzer-Schrehardt U, Kley RA, Von Hörsten S, Marcus K, Linke WA, Vorgerd M, van der Ven PF, Fürst DO, Schröder R.

Hum Mol Genet. 2015 Dec 20;24(25):7207-20. doi: 10.1093/hmg/ddv421. Epub 2015 Oct 15.

PMID:
26472074
13.

Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.

Uschner FE, Ranabhat G, Choi SS, Granzow M, Klein S, Schierwagen R, Raskopf E, Gautsch S, van der Ven PF, Fürst DO, Strassburg CP, Sauerbruch T, Diehl AM, Trebicka J.

Sci Rep. 2015 Sep 28;5:14573. doi: 10.1038/srep14573.

14.

New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.

Olivé M, Abdul-Hussein S, Oldfors A, González-Costello J, van der Ven PF, Fürst DO, González L, Moreno D, Torrejón-Escribano B, Alió J, Pou A, Ferrer I, Tajsharghi H.

Hum Mol Genet. 2015 Nov 1;24(21):6264. doi: 10.1093/hmg/ddv311. Epub 2015 Sep 7. No abstract available.

PMID:
26345447
15.

In vivo characterization of human myofibrillar myopathy genes in zebrafish.

Bührdel JB, Hirth S, Kessler M, Westphal S, Forster M, Manta L, Wiche G, Schoser B, Schessl J, Schröder R, Clemen CS, Eichinger L, Fürst DO, van der Ven PF, Rottbauer W, Just S.

Biochem Biophys Res Commun. 2015 May 29;461(2):217-23. doi: 10.1016/j.bbrc.2015.03.149. Epub 2015 Apr 9.

16.

New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.

Olivé M, Abdul-Hussein S, Oldfors A, González-Costello J, van der Ven PF, Fürst DO, González L, Moreno D, Torrejón-Escribano B, Alió J, Pou A, Ferrer I, Tajsharghi H.

Hum Mol Genet. 2015 Jul 1;24(13):3638-50. doi: 10.1093/hmg/ddv108. Epub 2015 Mar 23. Erratum in: Hum Mol Genet. 2015 Nov 1;24(21):6264.

PMID:
25801283
17.

Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.

Molt S, Bührdel JB, Yakovlev S, Schein P, Orfanos Z, Kirfel G, Winter L, Wiche G, van der Ven PF, Rottbauer W, Just S, Belkin AM, Fürst DO.

J Cell Sci. 2014 Aug 15;127(Pt 16):3578-92. doi: 10.1242/jcs.152157. Epub 2014 Jun 24.

18.

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.

Granzow M, Schierwagen R, Klein S, Kowallick B, Huss S, Linhart M, Mazar IG, Görtzen J, Vogt A, Schildberg FA, Gonzalez-Carmona MA, Wojtalla A, Krämer B, Nattermann J, Siegmund SV, Werner N, Fürst DO, Laleman W, Knolle P, Shah VH, Sauerbruch T, Trebicka J.

Hepatology. 2014 Jul;60(1):334-48. doi: 10.1002/hep.27117. Epub 2014 May 6.

19.

Xin is a marker of skeletal muscle damage severity in myopathies.

Nilsson MI, Nissar AA, Al-Sajee D, Tarnopolsky MA, Parise G, Lach B, Fürst DO, van der Ven PFM, Kley RA, Hawke TJ.

Am J Pathol. 2013 Dec;183(6):1703-1709. doi: 10.1016/j.ajpath.2013.08.010. Epub 2013 Nov 11.

PMID:
24225086
20.

Identification of Xin-repeat proteins as novel ligands of the SH3 domains of nebulin and nebulette and analysis of their interaction during myofibril formation and remodeling.

Eulitz S, Sauer F, Pelissier MC, Boisguerin P, Molt S, Schuld J, Orfanos Z, Kley RA, Volkmer R, Wilmanns M, Kirfel G, van der Ven PF, Fürst DO.

Mol Biol Cell. 2013 Oct;24(20):3215-26. doi: 10.1091/mbc.E13-04-0202. Epub 2013 Aug 28.

21.

Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathy.

Maerkens A, Kley RA, Olivé M, Theis V, van der Ven PF, Reimann J, Milting H, Schreiner A, Uszkoreit J, Eisenacher M, Barkovits K, Güttsches AK, Tonillo J, Kuhlmann K, Meyer HE, Schröder R, Tegenthoff M, Fürst DO, Müller T, Goldfarb LG, Vorgerd M, Marcus K.

J Proteomics. 2013 Sep 2;90:14-27. doi: 10.1016/j.jprot.2013.04.026. Epub 2013 Apr 30.

22.

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

Ulbricht A, Eppler FJ, Tapia VE, van der Ven PF, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J.

Curr Biol. 2013 Mar 4;23(5):430-5. doi: 10.1016/j.cub.2013.01.064. Epub 2013 Feb 21.

23.

Impairment of protein degradation in myofibrillar myopathy caused by FLNC/filamin C mutations.

Kley RA, van der Ven PF, Olivé M, Höhfeld J, Goldfarb LG, Fürst DO, Vorgerd M.

Autophagy. 2013 Mar;9(3):422-3. doi: 10.4161/auto.22921. Epub 2012 Dec 13.

24.

Myopodin is an F-actin bundling protein with multiple independent actin-binding regions.

Linnemann A, Vakeel P, Bezerra E, Orfanos Z, Djinović-Carugo K, van der Ven PF, Kirfel G, Fürst DO.

J Muscle Res Cell Motil. 2013 Feb;34(1):61-9. doi: 10.1007/s10974-012-9334-5. Epub 2012 Dec 9.

PMID:
23225103
25.

A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.

Kley RA, Maerkens A, Leber Y, Theis V, Schreiner A, van der Ven PF, Uszkoreit J, Stephan C, Eulitz S, Euler N, Kirschner J, Müller K, Meyer HE, Tegenthoff M, Fürst DO, Vorgerd M, Müller T, Marcus K.

Mol Cell Proteomics. 2013 Jan;12(1):215-27. doi: 10.1074/mcp.M112.023176. Epub 2012 Oct 31.

26.

Filamin C-related myopathies: pathology and mechanisms.

Fürst DO, Goldfarb LG, Kley RA, Vorgerd M, Olivé M, van der Ven PF.

Acta Neuropathol. 2013 Jan;125(1):33-46. doi: 10.1007/s00401-012-1054-9. Epub 2012 Oct 30.

27.

Pathophysiology of protein aggregation and extended phenotyping in filaminopathy.

Kley RA, Serdaroglu-Oflazer P, Leber Y, Odgerel Z, van der Ven PF, Olivé M, Ferrer I, Onipe A, Mihaylov M, Bilbao JM, Lee HS, Höhfeld J, Djinović-Carugo K, Kong K, Tegenthoff M, Peters SA, Stenzel W, Vorgerd M, Goldfarb LG, Fürst DO.

Brain. 2012 Sep;135(Pt 9):2642-60. doi: 10.1093/brain/aws200.

28.

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats.

Klein S, Klösel J, Schierwagen R, Körner C, Granzow M, Huss S, Mazar IG, Weber S, van den Ven PF, Pieper-Fürst U, Fürst DO, Nattermann J, Lammert F, Sauerbruch T, Trebicka J.

Lab Invest. 2012 Oct;92(10):1440-50. doi: 10.1038/labinvest.2012.106. Epub 2012 Aug 13.

29.

Xirp proteins mark injured skeletal muscle in zebrafish.

Otten C, van der Ven PF, Lewrenz I, Paul S, Steinhagen A, Busch-Nentwich E, Eichhorst J, Wiesner B, Stemple D, Strähle U, Fürst DO, Abdelilah-Seyfried S.

PLoS One. 2012;7(2):e31041. doi: 10.1371/journal.pone.0031041. Epub 2012 Feb 15.

30.

Distal myopathy with upper limb predominance caused by filamin C haploinsufficiency.

Guergueltcheva V, Peeters K, Baets J, Ceuterick-de Groote C, Martin JJ, Suls A, De Vriendt E, Mihaylova V, Chamova T, Almeida-Souza L, Ydens E, Tzekov C, Hadjidekov G, Gospodinova M, Storm K, Reyniers E, Bichev S, van der Ven PF, Fürst DO, Mitev V, Lochmüller H, Timmerman V, Tournev I, De Jonghe P, Jordanova A.

Neurology. 2011 Dec 13;77(24):2105-14. doi: 10.1212/WNL.0b013e31823dc51e. Epub 2011 Nov 30.

PMID:
22131542
31.

Skeletal muscle regeneration is delayed by reduction in Xin expression: consequence of impaired satellite cell activation?

Nissar AA, Zemanek B, Labatia R, Atkinson DJ, van der Ven PF, Fürst DO, Hawke TJ.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C220-7. doi: 10.1152/ajpcell.00298.2011. Epub 2011 Oct 5.

32.

Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.

Duff RM, Tay V, Hackman P, Ravenscroft G, McLean C, Kennedy P, Steinbach A, Schöffler W, van der Ven PFM, Fürst DO, Song J, Djinović-Carugo K, Penttilä S, Raheem O, Reardon K, Malandrini A, Gambelli S, Villanova M, Nowak KJ, Williams DR, Landers JE, Brown RH Jr, Udd B, Laing NG.

Am J Hum Genet. 2011 Jun 10;88(6):729-740. doi: 10.1016/j.ajhg.2011.04.021. Epub 2011 May 27.

33.

Lysophosphatidylcholine pretreatment reduces VLA-4 and P-Selectin-mediated b16.f10 melanoma cell adhesion in vitro and inhibits metastasis-like lung invasion in vivo.

Jantscheff P, Schlesinger M, Fritzsche J, Taylor LA, Graeser R, Kirfel G, Fürst DO, Massing U, Bendas G.

Mol Cancer Ther. 2011 Jan;10(1):186-97. doi: 10.1158/1535-7163.MCT-10-0474.

34.

Dominant-negative effects of a novel mutation in the filamin myopathy.

van der Ven PF, Odgerel Z, Fürst DO, Goldfarb LG, Kono S, Miyajima H.

Neurology. 2010 Dec 7;75(23):2137-8. doi: 10.1212/WNL.0b013e3182031bb3. No abstract available.

PMID:
21135393
35.

Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury.

Becher UM, Ghanem A, Tiyerili V, Fürst DO, Nickenig G, Mueller CF.

J Mol Cell Cardiol. 2011 Mar;50(3):570-7. doi: 10.1016/j.yjmcc.2010.11.013. Epub 2010 Nov 26.

PMID:
21112334
36.

DNA sequencing errors in molecular diagnostics of filamin myopathy.

Odgerel Z, van der Ven PF, Fürst DO, Goldfarb LG.

Clin Chem Lab Med. 2010 Oct;48(10):1409-14. doi: 10.1515/CCLM.2010.272. Epub 2010 Jun 27.

PMID:
20578970
37.

The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin.

Linnemann A, van der Ven PF, Vakeel P, Albinus B, Simonis D, Bendas G, Schenk JA, Micheel B, Kley RA, Fürst DO.

Eur J Cell Biol. 2010 Sep;89(9):681-92. doi: 10.1016/j.ejcb.2010.04.004. Epub 2010 May 31.

PMID:
20554076
38.

Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells.

Gehmlich K, Hayess K, Legler C, Haebel S, Van der Ven PF, Ehler E, Fürst DO.

Eur J Cell Biol. 2010 May;89(5):351-64. doi: 10.1016/j.ejcb.2009.10.019. Epub 2010 Feb 2.

PMID:
20129698
39.

Chaperone-assisted selective autophagy is essential for muscle maintenance.

Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J.

Curr Biol. 2010 Jan 26;20(2):143-8. doi: 10.1016/j.cub.2009.11.022. Epub 2010 Jan 7.

40.

"MLP: A Stress Sensor Goes Nuclear" by Sylvia Gunkel, Jörg Heineke, Denise Hilfiker-Kleiner, Ralph Knöll, J Mol Cell Cardiol. 2009;47(4):423-5.

Gehmlich K, Ehler E, Perrot A, Fürst DO, Geier C.

J Mol Cell Cardiol. 2010 Feb;48(2):424-5; author reply 426-7. doi: 10.1016/j.yjmcc.2009.10.021. Epub 2009 Oct 30. No abstract available.

PMID:
19879879
41.

Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.

Otten J, van der Ven PF, Vakeel P, Eulitz S, Kirfel G, Brandau O, Boesl M, Schrickel JW, Linhart M, Hayess K, Naya FJ, Milting H, Meyer R, Fürst DO.

Cardiovasc Res. 2010 Mar 1;85(4):739-50. doi: 10.1093/cvr/cvp345. Epub 2009 Oct 19.

PMID:
19843512
42.

Multipurpose modular lentiviral vectors for RNA interference and transgene expression.

Kesireddy V, van der Ven PF, Fürst DO.

Mol Biol Rep. 2010 Jul;37(6):2863-70. doi: 10.1007/s11033-009-9840-8. Epub 2009 Oct 2.

PMID:
19798586
43.

Enrichment and terminal differentiation of striated muscle progenitors in vitro.

Becher UM, Breitbach M, Sasse P, Garbe S, van der Ven PF, Fürst DO, Fleischmann BK.

Exp Cell Res. 2009 Oct 1;315(16):2741-51. doi: 10.1016/j.yexcr.2009.07.005. Epub 2009 Jul 15.

PMID:
19615359
44.

Differential involvement of sarcomeric proteins in myofibrillar myopathies: a morphological and immunohistochemical study.

Claeys KG, van der Ven PF, Behin A, Stojkovic T, Eymard B, Dubourg O, Laforêt P, Faulkner G, Richard P, Vicart P, Romero NB, Stoltenburg G, Udd B, Fardeau M, Voit T, Fürst DO.

Acta Neuropathol. 2009 Mar;117(3):293-307. doi: 10.1007/s00401-008-0479-7. Epub 2009 Jan 17.

PMID:
19151983
45.

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy.

Geier C, Gehmlich K, Ehler E, Hassfeld S, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch MG, Osterziel KJ, Bublak A, Nägele H, Scheffold T, Dietz R, Chien KR, Spuler S, Fürst DO, Nürnberg P, Ozcelik C.

Hum Mol Genet. 2008 Sep 15;17(18):2753-65. doi: 10.1093/hmg/ddn160. Epub 2008 May 27. Erratum in: Hum Mol Genet. 2008 Nov 1;17(21):3436. Osterziel, Karl J [added].

PMID:
18505755
46.

Clinical and morphological phenotype of the filamin myopathy: a study of 31 German patients.

Kley RA, Hellenbroich Y, van der Ven PF, Fürst DO, Huebner A, Bruchertseifer V, Peters SA, Heyer CM, Kirschner J, Schröder R, Fischer D, Müller K, Tolksdorf K, Eger K, Germing A, Brodherr T, Reum C, Walter MC, Lochmüller H, Ketelsen UP, Vorgerd M.

Brain. 2007 Dec;130(Pt 12):3250-64. Review.

PMID:
18055494
47.

Paxillin and ponsin interact in nascent costameres of muscle cells.

Gehmlich K, Pinotsis N, Hayess K, van der Ven PF, Milting H, El Banayosy A, Körfer R, Wilmanns M, Ehler E, Fürst DO.

J Mol Biol. 2007 Jun 8;369(3):665-82. Epub 2007 Mar 24.

PMID:
17462669
48.

The pathomechanism of filaminopathy: altered biochemical properties explain the cellular phenotype of a protein aggregation myopathy.

Löwe T, Kley RA, van der Ven PF, Himmel M, Huebner A, Vorgerd M, Fürst DO.

Hum Mol Genet. 2007 Jun 1;16(11):1351-8. Epub 2007 Apr 5.

PMID:
17412757
49.

Constitutive upregulations of titin-based signalling proteins in KY deficient muscles.

Beatham J, Gehmlich K, van der Ven PF, Sarparanta J, Williams D, Underhill P, Geier C, Fürst DO, Udd B, Blanco G.

Neuromuscul Disord. 2006 Jul;16(7):437-45. Epub 2006 Jun 30.

PMID:
16806927
50.

Different early pathogenesis in myotilinopathy compared to primary desminopathy.

Fischer D, Clemen CS, Olivé M, Ferrer I, Goudeau B, Roth U, Badorf P, Wattjes MP, Lutterbey G, Kral T, van der Ven PF, Fürst DO, Vicart P, Goldfarb LG, Moza M, Carpen O, Reichelt J, Schröder R.

Neuromuscul Disord. 2006 Jun;16(6):361-7. Epub 2006 May 8.

PMID:
16684602

Supplemental Content

Loading ...
Support Center