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Best matches for Fässler R[au]:

Integrin-mediated mechanotransduction. Sun Z et al. J Cell Biol. (2016)

Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. Volckaert T et al. Dev Cell. (2017)

Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading. Böttcher RT et al. J Cell Biol. (2017)

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Items: 1 to 50 of 357


Hippo signaling promotes lung epithelial lineage commitment by curbing Fgf10 and β-catenin signaling.

Volckaert T, Yuan T, Yuan J, Boateng E, Hopkins S, Zhang JS, Thannickal VJ, Fässler R, De Langhe SP.

Development. 2019 Jan 16;146(2). pii: dev166454. doi: 10.1242/dev.166454.


Microenvironment-derived ADAM28 prevents cancer dissemination.

Gérard C, Hubeau C, Carnet O, Bellefroid M, Sounni NE, Blacher S, Bendavid G, Moser M, Fässler R, Noel A, Cataldo D, Rocks N.

Oncotarget. 2018 Dec 14;9(98):37185-37199. doi: 10.18632/oncotarget.26449. eCollection 2018 Dec 14.


Integrin activation by talin, kindlin and mechanical forces.

Sun Z, Costell M, Fässler R.

Nat Cell Biol. 2019 Jan;21(1):25-31. doi: 10.1038/s41556-018-0234-9. Epub 2019 Jan 2. Review.


LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT.

J Cell Sci. 2018 Nov 21;131(22). pii: jcs218214. doi: 10.1242/jcs.218214.


Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.

Moretti FA, Klapproth S, Ruppert R, Margraf A, Weber J, Pick R, Scheiermann C, Sperandio M, Fässler R, Moser M.

Elife. 2018 Sep 6;7. pii: e35816. doi: 10.7554/eLife.35816.


The Kank family proteins in adhesion dynamics.

Chen NP, Sun Z, Fässler R.

Curr Opin Cell Biol. 2018 Oct;54:130-136. doi: 10.1016/ Epub 2018 Jun 14. Review.


Temporal profiling of redox-dependent heterogeneity in single cells.

Radzinski M, Fassler R, Yogev O, Breuer W, Shai N, Gutin J, Ilyas S, Geffen Y, Tsytkin-Kirschenzweig S, Nahmias Y, Ravid T, Friedman N, Schuldiner M, Reichmann D.

Elife. 2018 Jun 5;7. pii: e37623. doi: 10.7554/eLife.37623.


Corrigendum: Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.

Strohmeyer N, Bharadwaj M, Costell M, Fässler R, Müller DJ.

Nat Mater. 2017 Dec 19;17(1):103. doi: 10.1038/nmat5054.


Low density lipoprotein receptor-related protein 1 couples β1 integrin activation to degradation.

Wujak L, Böttcher RT, Pak O, Frey H, El Agha E, Chen Y, Schmitt S, Bellusci S, Schaefer L, Weissmann N, Fässler R, Wygrecka M.

Cell Mol Life Sci. 2018 May;75(9):1671-1685. doi: 10.1007/s00018-017-2707-6. Epub 2017 Nov 7.


Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.

Strohmeyer N, Bharadwaj M, Costell M, Fässler R, Müller DJ.

Nat Mater. 2017 Dec;16(12):1262-1270. doi: 10.1038/nmat5023. Epub 2017 Nov 6. Erratum in: Nat Mater. 2017 Dec 19;17 (1):103.


Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells.

Volckaert T, Yuan T, Chao CM, Bell H, Sitaula A, Szimmtenings L, El Agha E, Chanda D, Majka S, Bellusci S, Thannickal VJ, Fässler R, De Langhe SP.

Dev Cell. 2017 Oct 9;43(1):48-59.e5. doi: 10.1016/j.devcel.2017.09.003.


Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.

Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R.

Development. 2017 Nov 15;144(22):4148-4158. doi: 10.1242/dev.149914. Epub 2017 Oct 9.


Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading.

Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R.

J Cell Biol. 2017 Nov 6;216(11):3785-3798. doi: 10.1083/jcb.201701176. Epub 2017 Sep 14.


Lucky kindlin: A cloverleaf at the integrin tail.

Kammerer P, Aretz J, Fässler R.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9234-9236. doi: 10.1073/pnas.1712471114. Epub 2017 Aug 22. No abstract available.


A forceful connection: mechanoregulation of oncogenic YAP.

Böttcher RT, Sun Z, Fässler R.

EMBO J. 2017 Sep 1;36(17):2467-2469. doi: 10.15252/embj.201797527. Epub 2017 Jul 19. No abstract available.


A Role of Metastable Regions and Their Connectivity in the Inactivation of a Redox-Regulated Chaperone and Its Inter-Chaperone Crosstalk.

Rimon O, Suss O, Goldenberg M, Fassler R, Yogev O, Amartely H, Propper G, Friedler A, Reichmann D.

Antioxid Redox Signal. 2017 Nov 20;27(15):1252-1267. doi: 10.1089/ars.2016.6900. Epub 2017 Apr 10.


Sensing the mechano-chemical properties of the extracellular matrix.

Ringer P, Colo G, Fässler R, Grashoff C.

Matrix Biol. 2017 Dec;64:6-16. doi: 10.1016/j.matbio.2017.03.004. Epub 2017 Apr 4. Review.


β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain.

Fujioka T, Kaneko N, Ajioka I, Nakaguchi K, Omata T, Ohba H, Fässler R, García-Verdugo JM, Sekiguchi K, Matsukawa N, Sawamoto K.

EBioMedicine. 2017 Feb;16:195-203. doi: 10.1016/j.ebiom.2017.01.005. Epub 2017 Jan 9.


αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.

Bharadwaj M, Strohmeyer N, Colo GP, Helenius J, Beerenwinkel N, Schiller HB, Fässler R, Müller DJ.

Nat Commun. 2017 Jan 27;8:14348. doi: 10.1038/ncomms14348.


Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.

Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R.

Elife. 2016 Dec 8;5. pii: e18633. doi: 10.7554/eLife.18633.


Integrin-mediated mechanotransduction.

Sun Z, Guo SS, Fässler R.

J Cell Biol. 2016 Nov 21;215(4):445-456. Epub 2016 Nov 8. Review.


Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.

Cerikan B, Shaheen R, Colo GP, Gläßer C, Hata S, Knobeloch KP, Alkuraya FS, Fässler R, Schiebel E.

Dev Cell. 2016 Oct 10;39(1):28-43. doi: 10.1016/j.devcel.2016.08.020. Epub 2016 Sep 29.


Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation.

Sun Z, Tseng HY, Tan S, Senger F, Kurzawa L, Dedden D, Mizuno N, Wasik AA, Thery M, Dunn AR, Fässler R.

Nat Cell Biol. 2016 Sep;18(9):941-53. doi: 10.1038/ncb3402. Epub 2016 Aug 22.


Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.

Cheah M, Andrews MR, Chew DJ, Moloney EB, Verhaagen J, Fässler R, Fawcett JW.

J Neurosci. 2016 Jul 6;36(27):7283-97. doi: 10.1523/JNEUROSCI.0901-16.2016.


Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice.

Lukjanenko L, Jung MJ, Hegde N, Perruisseau-Carrier C, Migliavacca E, Rozo M, Karaz S, Jacot G, Schmidt M, Li L, Metairon S, Raymond F, Lee U, Sizzano F, Wilson DH, Dumont NA, Palini A, Fässler R, Steiner P, Descombes P, Rudnicki MA, Fan CM, von Maltzahn J, Feige JN, Bentzinger CF.

Nat Med. 2016 Aug;22(8):897-905. doi: 10.1038/nm.4126. Epub 2016 Jul 4.


Integrins synergise to induce expression of the MRTF-A-SRF target gene ISG15 for promoting cancer cell invasion.

Hermann MR, Jakobson M, Colo GP, Rognoni E, Jakobson M, Kupatt C, Posern G, Fässler R.

J Cell Sci. 2016 Apr 1;129(7):1391-403. doi: 10.1242/jcs.177592. Epub 2016 Feb 12.


Introduction to the ECR special issue, "Mechanosensing via Cell-Matrix Adhesions".

Geiger B, Fässler R.

Exp Cell Res. 2016 Apr 10;343(1):1-2. doi: 10.1016/j.yexcr.2016.01.016. Epub 2016 Jan 27. Review. No abstract available.


Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.

Theodosiou M, Widmaier M, Böttcher RT, Rognoni E, Veelders M, Bharadwaj M, Lambacher A, Austen K, Müller DJ, Zent R, Fässler R.

Elife. 2016 Jan 27;5:e10130. doi: 10.7554/eLife.10130.


The kindlin family: functions, signaling properties and implications for human disease.

Rognoni E, Ruppert R, Fässler R.

J Cell Sci. 2016 Jan 1;129(1):17-27. doi: 10.1242/jcs.161190. Review.


Guido Tarone, Ph.D. (1951-2015).

Giancotti FG, Fässler R.

J Cell Sci. 2015 Aug 15;128(16):2955-6. No abstract available.


Minimal amounts of kindlin-3 suffice for basal platelet and leukocyte functions in mice.

Klapproth S, Moretti FA, Zeiler M, Ruppert R, Breithaupt U, Mueller S, Haas R, Mann M, Sperandio M, Fässler R, Moser M.

Blood. 2015 Dec 10;126(24):2592-600. doi: 10.1182/blood-2015-04-639310. Epub 2015 Oct 5.


Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice.

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M.

Blood. 2015 Dec 17;126(25):2704-12. doi: 10.1182/blood-2015-05-647453. Epub 2015 Sep 3.


Kindlin-3-mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells.

Ruppert R, Moser M, Sperandio M, Rognoni E, Orban M, Liu WH, Schulz AS, Oostendorp RA, Massberg S, Fässler R.

J Exp Med. 2015 Aug 24;212(9):1415-32. doi: 10.1084/jem.20150269. Epub 2015 Aug 17.


The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites.

Karaköse E, Geiger T, Flynn K, Lorenz-Baath K, Zent R, Mann M, Fässler R.

J Cell Sci. 2015 Mar 1;128(5):1023-33. doi: 10.1242/jcs.162545. Epub 2015 Jan 20.


Membrane tension drives ligand-independent integrin signaling.

Böttcher RT, Fässler R.

EMBO J. 2014 Nov 3;33(21):2439-41. doi: 10.15252/embj.201489886. Epub 2014 Sep 17. No abstract available.


Nascent adhesions: from fluctuations to a hierarchical organization.

Sun Z, Lambacher A, Fässler R.

Curr Biol. 2014 Sep 8;24(17):R801-3. doi: 10.1016/j.cub.2014.07.061.


Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Tseng HY, Thorausch N, Ziegler T, Meves A, Fässler R, Böttcher RT.

J Mol Biol. 2014 Sep 9;426(18):3180-3194. doi: 10.1016/j.jmb.2014.07.003. Epub 2014 Jul 11.


Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.

Chen X, Wang H, Liao HJ, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang ZY, Vega-Montoto L, Vanacore RM, Fässler R, Zent R, Pozzi A.

J Clin Invest. 2014 Aug;124(8):3295-310. doi: 10.1172/JCI71668. Epub 2014 Jul 1.


Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling.

Speicher T, Siegenthaler B, Bogorad RL, Ruppert R, Petzold T, Padrissa-Altes S, Bachofner M, Anderson DG, Koteliansky V, Fässler R, Werner S.

Nat Commun. 2014 May 21;5:3862. doi: 10.1038/ncomms4862.


The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.

Schiefermeier N, Scheffler JM, de Araujo ME, Stasyk T, Yordanov T, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, Lange A, Wunderlich W, Fässler R, Teis D, Huber LA.

J Cell Biol. 2014 May 26;205(4):525-40. doi: 10.1083/jcb.201310043. Epub 2014 May 19.


Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation.

Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, Böttcher RT, Lai-Cheong JE, Rifkin DB, McGrath JA, Fässler R.

Nat Med. 2014 Apr;20(4):350-9. doi: 10.1038/nm.3490. Epub 2014 Mar 30.


The integrin adhesome: from genes and proteins to human disease.

Winograd-Katz SE, Fässler R, Geiger B, Legate KR.

Nat Rev Mol Cell Biol. 2014 Apr;15(4):273-88. doi: 10.1038/nrm3769. Review.


Biological role of prolyl 3-hydroxylation in type IV collagen.

Pokidysheva E, Boudko S, Vranka J, Zientek K, Maddox K, Moser M, Fässler R, Ware J, Bächinger HP.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):161-6. doi: 10.1073/pnas.1307597111. Epub 2013 Dec 24.


Cre recombinase induces DNA damage and tetraploidy in the absence of loxP sites.

Janbandhu VC, Moik D, Fässler R.

Cell Cycle. 2014;13(3):462-70. doi: 10.4161/cc.27271. Epub 2013 Nov 26.


The mechanism of kindlin-mediated activation of integrin αIIbβ3.

Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH.

Curr Biol. 2013 Nov 18;23(22):2288-2295. doi: 10.1016/j.cub.2013.09.050. Epub 2013 Nov 7.


Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells.

Moretti FA, Moser M, Lyck R, Abadier M, Ruppert R, Engelhardt B, Fässler R.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17005-10. doi: 10.1073/pnas.1316032110. Epub 2013 Oct 2.


The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis.

Cohen SJ, Gurevich I, Feigelson SW, Petrovich E, Moser M, Shakhar G, Fassler R, Alon R.

Blood. 2013 Oct 10;122(15):2609-17. doi: 10.1182/blood-2013-04-495036. Epub 2013 Aug 26.


Ten-m2 is required for the generation of binocular visual circuits.

Young TR, Bourke M, Zhou X, Oohashi T, Sawatari A, Fässler R, Leamey CA.

J Neurosci. 2013 Jul 24;33(30):12490-509. doi: 10.1523/JNEUROSCI.4708-12.2013.


Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis.

Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG, Fässler R, Deutsch U, Kupatt C.

J Clin Invest. 2013 Jul 1. pii: 66549. doi: 10.1172/JCI66549. [Epub ahead of print]

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