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Frequency, predictors, and prognosis of ejection fraction improvement in heart failure: an echocardiogram-based registry study.

Ghimire A, Fine N, Ezekowitz JA, Howlett J, Youngson E, McAlister FA.

Eur Heart J. 2019 Jul 1;40(26):2110-2117. doi: 10.1093/eurheartj/ehz233.


High vs. low oxygen therapy in patients with acute heart failure: HiLo-HF pilot trial.

Sepehrvand N, Alemayehu W, Rowe BH, McAlister FA, van Diepen S, Stickland M, Ezekowitz JA.

ESC Heart Fail. 2019 May 17. doi: 10.1002/ehf2.12448. [Epub ahead of print]


External Validation of the H2F-PEF Model in Diagnosing Patients With Heart Failure and Preserved Ejection Fraction.

Sepehrvand N, Alemayehu W, Dyck GJB, Dyck JRB, Anderson T, Howlett J, Paterson I, McAlister FA, Ezekowitz JA.

Circulation. 2019 May 14;139(20):2377-2379. doi: 10.1161/CIRCULATIONAHA.118.038594. No abstract available.


Incremental costs of high intensive care utilisation in patients hospitalised with heart failure.

van Diepen S, Tran DT, Ezekowitz JA, Schnell G, Wiley BM, Morrow DA, McAlister FA, Kaul P.

Eur Heart J Acute Cardiovasc Care. 2019 Apr 12:2048872619845282. doi: 10.1177/2048872619845282. [Epub ahead of print]


Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score.

O'Connor C, Fiuzat M, Mulder H, Coles A, Ahmad T, Ezekowitz JA, Adams KF, Piña IL, Anstrom KJ, Cooper LS, Mark DB, Whellan DJ, Januzzi JL Jr, Leifer ES, Felker GM.

Eur J Heart Fail. 2019 Jun;21(6):770-778. doi: 10.1002/ejhf.1450. Epub 2019 Mar 27.


The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review.

Dyck GJB, Raj P, Zieroth S, Dyck JRB, Ezekowitz JA.

Int J Mol Sci. 2019 Feb 19;20(4). pii: E904. doi: 10.3390/ijms20040904. Review.


Efficacy and Safety of Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Extremes in Body Weight.

Hohnloser SH, Fudim M, Alexander JH, Wojdyla DM, Ezekowitz JA, Hanna M, Atar D, Hijazi Z, Bahit MC, Al-Khatib SM, Lopez-Sendon JL, Wallentin L, Granger CB, Lopes RD.

Circulation. 2019 May 14;139(20):2292-2300. doi: 10.1161/CIRCULATIONAHA.118.037955.


Creating order out of chaos: quality of care in heart failure.

Ezekowitz JA.

Heart. 2019 Mar;105(6):429-430. doi: 10.1136/heartjnl-2018-314526. Epub 2019 Jan 31. No abstract available.


Update on the diagnosis and management of acute heart failure.

Gouda P, Ezekowitz JA.

Curr Opin Cardiol. 2019 Mar;34(2):202-206. doi: 10.1097/HCO.0000000000000594.


Titration and Tolerability of Sacubitril/Valsartan for Patients With Heart Failure in Clinical Practice.

Du AX, Westerhout CM, McAlister FA, Shanks M, Oudit GY, Paterson DI, Hanninen M, Thomas J, Ezekowitz JA.

J Cardiovasc Pharmacol. 2019 Mar;73(3):149-154. doi: 10.1097/FJC.0000000000000643.


Obesity paradox on outcome in atrial fibrillation maintained even considering the prognostic influence of biomarkers: insights from the ARISTOTLE trial.

Sandhu RK, Ezekowitz JA, Hijazi Z, Westerbergh J, Aulin J, Alexander JH, Granger CB, Halvorsen S, Hanna MS, Lopes RD, Siegbahn A, Wallentin L.

Open Heart. 2018 Nov 1;5(2):e000908. doi: 10.1136/openhrt-2018-000908. eCollection 2018.


Economic and Quality-of-Life Outcomes of Natriuretic Peptide-Guided Therapy for Heart Failure.

Mark DB, Cowper PA, Anstrom KJ, Sheng S, Daniels MR, Knight JD, Baloch KN, Davidson-Ray L, Fiuzat M, Januzzi JL Jr, Whellan DJ, Piña IL, Ezekowitz JA, Adams KF, Cooper LS, O'Connor CM, Felker GM.

J Am Coll Cardiol. 2018 Nov 27;72(21):2551-2562. doi: 10.1016/j.jacc.2018.08.2184.


Impact of contrast echocardiography on accurate discrimination of specific degree of left ventricular systolic dysfunction and comparison with cardiac magnetic resonance imaging.

Alherbish A, Becher H, Alemayehu W, Paterson DI, Butler CR, Anderson TJ, Ezekowitz JA, Shanks M; Alberta HEART investigators.

Echocardiography. 2018 Nov;35(11):1746-1754. doi: 10.1111/echo.14152. Epub 2018 Oct 30.


Comparison of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Management Strategies Before Cardiac Surgery: A Pilot Randomized Controlled Registry Trial.

van Diepen S, Norris CM, Zheng Y, Nagendran J, Graham MM, Gaete Ortega D, Townsend DR, Ezekowitz JA, Bagshaw SM.

J Am Heart Assoc. 2018 Oct 16;7(20):e009917. doi: 10.1161/JAHA.118.009917.


Relationship Between Enrolling Country Income Level and Patient Profile, Protocol Completion, and Trial End Points.

Greene SJ, Hernandez AF, Sun JL, Butler J, Armstrong PW, Ezekowitz JA, Zannad F, Ferreira JP, Coles A, Metra M, Voors AA, Califf RM, O'Connor CM, Mentz RJ.

Circ Cardiovasc Qual Outcomes. 2018 Oct;11(10):e004783. doi: 10.1161/CIRCOUTCOMES.118.004783.


Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update.

Tobe SW, Stone JA, Anderson T, Bacon S, Cheng AYY, Daskalopoulou SS, Ezekowitz JA, Gregoire JC, Gubitz G, Jain R, Keshavjee K, Lindsay P, L'Abbe M, Lau DCW, Leiter LA, O'Meara E, Pearson GJ, Rabi DM, Sherifali D, Selby P, Tu JV, Wharton S, Walker KM, Hua-Stewart D, Liu PP.

CMAJ. 2018 Oct 9;190(40):E1192-E1206. doi: 10.1503/cmaj.180194. No abstract available.


Acute Coronary Syndromes and Heart Failure Critical Care Units Utilization and Outcomes in Teaching and Community Hospitals: A National Population-Based Analysis.

Verma S, Kaul P, Lin M, Ezekowitz JA, Zygun DA, Fordyce CB, Wang TY, McAlister FA, van Diepen S.

Can J Cardiol. 2018 Oct;34(10):1365-1368. doi: 10.1016/j.cjca.2018.07.419. Epub 2018 Jul 29.


Oxygen therapy in acute myocardial infarctions: do we need to re-evaluate its necessity?

Sepehrvand N, Ezekowitz JA.

Expert Rev Cardiovasc Ther. 2018 Oct;16(10):693-694. doi: 10.1080/14779072.2018.1523719. Epub 2018 Sep 19. No abstract available.


Rationale and design of the Study of Dietary Intervention Under 100 MMOL in Heart Failure (SODIUM-HF).

Colin-Ramirez E, Ezekowitz JA; SODIUM-HF investigators.

Am Heart J. 2018 Nov;205:87-96. doi: 10.1016/j.ahj.2018.08.005. Epub 2018 Aug 16.


Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF).

Fudim M, Parikh KS, Dunning A, DeVore AD, Mentz RJ, Schulte PJ, Armstrong PW, Ezekowitz JA, Tang WHW, McMurray JJV, Voors AA, Drazner MH, O'Connor CM, Hernandez AF, Patel CB.

Am J Cardiol. 2018 Nov 1;122(9):1506-1512. doi: 10.1016/j.amjcard.2018.07.023. Epub 2018 Aug 3.


Initial Rhythm and Resuscitation Outcomes for Patients Developing Cardiac Arrest in Hospital: Data From Low-Middle Income Country.

Ngunga LM, Yonga G, Wachira B, Ezekowitz JA.

Glob Heart. 2018 Dec;13(4):255-260. doi: 10.1016/j.gheart.2018.07.001. Epub 2018 Aug 18.


Is incentivising stroke prevention therapy in atrial fibrillation the key?

Sandhu RK, Ezekowitz JA.

Heart. 2019 Jan;105(1):4-5. doi: 10.1136/heartjnl-2018-313402. Epub 2018 Jul 10. No abstract available.


Influence of hospital volume on outcomes for patients with heart failure: Evidence from a Canadian national cohort study.

McAlister FA, Youngson E, van Diepen S, Ezekowitz JA, Kaul P.

Am Heart J. 2018 Aug;202:148-150. doi: 10.1016/j.ahj.2018.05.014. Epub 2018 May 27.


The high cost of critical care unit over-utilization for patients with NSTE ACS.

van Diepen S, Tran DT, Ezekowitz JA, Zygun DA, Katz JN, Lopes RD, Newby LK, McAlister FA, Kaul P.

Am Heart J. 2018 Aug;202:84-88. doi: 10.1016/j.ahj.2018.05.003. Epub 2018 May 19.


Use of Biomarkers to Predict Specific Causes of Death in Patients With Atrial Fibrillation.

Sharma A, Hijazi Z, Andersson U, Al-Khatib SM, Lopes RD, Alexander JH, Held C, Hylek EM, Leonardi S, Hanna M, Ezekowitz JA, Siegbahn A, Granger CB, Wallentin L.

Circulation. 2018 Oct 16;138(16):1666-1676. doi: 10.1161/CIRCULATIONAHA.118.034125.


Examining the Influence of Component Outcomes on the Composite at the Design Stage.

Brown PM, Ezekowitz JA.

Circ Cardiovasc Qual Outcomes. 2018 Jun;11(6):e004419. doi: 10.1161/CIRCOUTCOMES.117.004419. No abstract available.


Trends in Noncardiovascular Comorbidities Among Patients Hospitalized for Heart Failure: Insights From the Get With The Guidelines-Heart Failure Registry.

Sharma A, Zhao X, Hammill BG, Hernandez AF, Fonarow GC, Felker GM, Yancy CW, Heidenreich PA, Ezekowitz JA, DeVore AD.

Circ Heart Fail. 2018 Jun;11(6):e004646. doi: 10.1161/CIRCHEARTFAILURE.117.004646.


Implantable cardioverter-defibrillators in heart failure patients with reduced ejection fraction and diabetes.

Sharma A, Al-Khatib SM, Ezekowitz JA, Cooper LB, Fordyce CB, Michael Felker G, Bardy GH, Poole JE, Thomas Bigger J, Buxton AE, Moss AJ, Friedman DJ, Lee KL, Steinman R, Dorian P, Cappato R, Kadish AH, Kudenchuk PJ, Mark DB, Peterson ED, Inoue LYT, Sanders GD.

Eur J Heart Fail. 2018 Jun;20(6):1031-1038. doi: 10.1002/ejhf.1192. Epub 2018 May 15.


Reply to McClure et al.-Reader Commentary on 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure.

Ezekowitz JA, McMurtry MS.

Can J Cardiol. 2018 Jun;34(6):813.e3. doi: 10.1016/j.cjca.2018.03.004. Epub 2018 Mar 16. No abstract available.


Ambulance use, distance and outcomes in patients with suspected cardiovascular disease: a registry-based geographic information system study.

Sepehrvand N, Alemayehu W, Kaul P, Pelletier R, Bello AK, Welsh RC, Armstrong PW, Ezekowitz JA.

Eur Heart J Acute Cardiovasc Care. 2018 Apr 1:2048872618769872. doi: 10.1177/2048872618769872. [Epub ahead of print]


Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: a meta-analysis of randomised clinical trials.

Sepehrvand N, James SK, Stub D, Khoshnood A, Ezekowitz JA, Hofmann R.

Heart. 2018 Oct;104(20):1691-1698. doi: 10.1136/heartjnl-2018-313089. Epub 2018 Mar 29. Review.


Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure: Insights From ASCEND-HF Trial.

Cerbin LP, Ambrosy AP, Greene SJ, Armstrong PW, Butler J, Coles A, DeVore AD, Ezekowitz JA, Hernandez AF, Metra M, Starling RC, Tang W, Teerlink JR, Voors AA, Wu A, O'Connor CM, Mentz RJ.

JACC Heart Fail. 2018 Apr;6(4):298-307. doi: 10.1016/j.jchf.2018.01.018. Epub 2018 Mar 7.


Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).

Bhatt AS, Cooper LB, Ambrosy AP, Clare RM, Coles A, Joyce E, Krishnamoorthy A, Butler J, Felker GM, Ezekowitz JA, Armstrong PW, Hernandez AF, O'Connor CM, Mentz RJ.

J Am Heart Assoc. 2018 Feb 3;7(3). pii: e006740. doi: 10.1161/JAHA.117.006740.


Use of Direct Oral Anticoagulants in Canadian Primary Care Practice 2010-2015: A Cohort Study From the Canadian Primary Care Sentinel Surveillance Network.

McAlister FA, Garrison S, Kosowan L, Ezekowitz JA, Singer A.

J Am Heart Assoc. 2018 Jan 26;7(3). pii: e007603. doi: 10.1161/JAHA.117.007603.


Prediction of Early Adverse Events in Emergency Department Patients With Acute Heart Failure: A Systematic Review.

Michaud AM, Parker SIA, Ganshorn H, Ezekowitz JA, McRae AD.

Can J Cardiol. 2018 Feb;34(2):168-179. doi: 10.1016/j.cjca.2017.09.004. Epub 2017 Sep 12. Review.


Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND-HF.

Pokorney SD, Al-Khatib SM, Sun JL, Schulte P, O'Connor CM, Teerlink JR, Armstrong PW, Ezekowitz JA, Starling RC, Voors AA, Velazquez EJ, Hernandez AF, Mentz RJ.

Eur J Heart Fail. 2018 Mar;20(3):525-532. doi: 10.1002/ejhf.1078. Epub 2017 Dec 20.


Impact of climate and air pollution on acute coronary syndromes: an update from the European Society of Cardiology Congress 2017.

Kaluzna-Oleksy M, Aunan K, Rao-Skirbekk S, Kjellstrom T, Ezekowitz JA, Agewall S, Atar D.

Scand Cardiovasc J. 2018 Feb;52(1):1-3. doi: 10.1080/14017431.2017.1405069. Epub 2017 Dec 4. No abstract available.


2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure.

Ezekowitz JA, O'Meara E, McDonald MA, Abrams H, Chan M, Ducharme A, Giannetti N, Grzeslo A, Hamilton PG, Heckman GA, Howlett JG, Koshman SL, Lepage S, McKelvie RS, Moe GW, Rajda M, Swiggum E, Virani SA, Zieroth S, Al-Hesayen A, Cohen-Solal A, D'Astous M, De S, Estrella-Holder E, Fremes S, Green L, Haddad H, Harkness K, Hernandez AF, Kouz S, LeBlanc MH, Masoudi FA, Ross HJ, Roussin A, Sussex B.

Can J Cardiol. 2017 Nov;33(11):1342-1433. doi: 10.1016/j.cjca.2017.08.022. Epub 2017 Sep 6.


Aetiology, timing and clinical predictors of early vs. late readmission following index hospitalization for acute heart failure: insights from ASCEND-HF.

Fudim M, O'Connor CM, Dunning A, Ambrosy AP, Armstrong PW, Coles A, Ezekowitz JA, Greene SJ, Metra M, Starling RC, Voors AA, Hernandez AF, Michael Felker G, Mentz RJ.

Eur J Heart Fail. 2018 Feb;20(2):304-314. doi: 10.1002/ejhf.1020. Epub 2017 Oct 29.


Relationship between baseline systolic blood pressure and long-term outcomes in acute heart failure patients treated with TRV027: an exploratory subgroup analysis of BLAST-AHF.

Cotter G, Davison BA, Butler J, Collins SP, Ezekowitz JA, Felker GM, Filippatos G, Levy PD, Metra M, Ponikowski P, Teerlink JR, Voors AA, Senger S, Bharucha D, Goin K, Soergel DG, Pang PS.

Clin Res Cardiol. 2018 Feb;107(2):170-181. doi: 10.1007/s00392-017-1168-0. Epub 2017 Oct 6.


Heart Failure in Young Adults Is Associated With High Mortality: A Contemporary Population-Level Analysis.

Wong CM, Hawkins NM, Ezekowitz JA, Jhund PS, Savu A, MacDonald MR, Kristensen SL, Petrie MC, McMurray JJV, McAlister FA, Kaul P.

Can J Cardiol. 2017 Nov;33(11):1472-1477. doi: 10.1016/j.cjca.2017.05.009. Epub 2017 Jun 19.


Ivabradine in Heart Failure: The Representativeness of SHIFT (Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial) in a Broad Population of Patients With Chronic Heart Failure.

Das D, Savarese G, Dahlström U, Fu M, Howlett J, Ezekowitz JA, Lund LH.

Circ Heart Fail. 2017 Sep;10(9). pii: e004112. doi: 10.1161/CIRCHEARTFAILURE.117.004112.


Letter by Kaul et al Regarding Article, "Age-Specific Trends in Incidence, Mortality, and Comorbidities of Heart Failure in Denmark, 1995 to 2012".

Kaul P, Ezekowitz JA, McAlister FA.

Circulation. 2017 Aug 29;136(9):884-885. doi: 10.1161/CIRCULATIONAHA.117.029335. No abstract available.


Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial.

Felker GM, Anstrom KJ, Adams KF, Ezekowitz JA, Fiuzat M, Houston-Miller N, Januzzi JL Jr, Mark DB, Piña IL, Passmore G, Whellan DJ, Yang H, Cooper LS, Leifer ES, Desvigne-Nickens P, O'Connor CM.

JAMA. 2017 Aug 22;318(8):713-720. doi: 10.1001/jama.2017.10565.


A prospective evaluation of the established criteria for heart failure with preserved ejection fraction using the Alberta HEART cohort.

Ezekowitz JA, McAlister FA, Howlett J, Alemayehu W, Paterson I, Belenkie I, Oudit GY, Kaul P, Dyck JR, Anderson T; Alberta HEART Investigators.

ESC Heart Fail. 2018 Feb;5(1):19-26. doi: 10.1002/ehf2.12200. Epub 2017 Jul 25.


Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial.

Greene SJ, Hernandez AF, Dunning A, Ambrosy AP, Armstrong PW, Butler J, Cerbin LP, Coles A, Ezekowitz JA, Metra M, Starling RC, Teerlink JR, Voors AA, O'Connor CM, Mentz RJ.

J Am Coll Cardiol. 2017 Jun 27;69(25):3029-3039. doi: 10.1016/j.jacc.2017.04.043.


A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure.

Sharma A, Demissei BG, Tromp J, Hillege HL, Cleland JG, O'Connor CM, Metra M, Ponikowski P, Teerlink JR, Davison BA, Givertz MM, Bloomfield DM, Dittrich H, van Veldhuisen DJ, Cotter G, Ezekowitz JA, Khan MAF, Voors AA.

Eur J Heart Fail. 2017 Oct;19(10):1310-1320. doi: 10.1002/ejhf.912. Epub 2017 Jun 21.


Multitype Events and the Analysis of Heart Failure Readmissions: Illustration of a New Modeling Approach and Comparison With Familiar Composite End Points.

Brown PM, Ezekowitz JA.

Circ Cardiovasc Qual Outcomes. 2017 Jun;10(6). pii: e003382. doi: 10.1161/CIRCOUTCOMES.116.003382.


Characterization of hemodynamically stable acute heart failure patients requiring a critical care unit admission: Derivation, validation, and refinement of a risk score.

Raslan IR, Brown P, Westerhout CM, Ezekowitz JA, Hernandez AF, Starling RC, O'Connor C, McAlister FA, Rowe BH, Armstrong PW, van Diepen S.

Am Heart J. 2017 Jun;188:127-135. doi: 10.1016/j.ahj.2017.03.014. Epub 2017 Mar 25.


Association Between Diabetes During Pregnancy and Peripartum Cardiomyopathy: A Population-Level Analysis of 309,825 Women.

Dhesi S, Savu A, Ezekowitz JA, Kaul P.

Can J Cardiol. 2017 Jul;33(7):911-917. doi: 10.1016/j.cjca.2017.02.008. Epub 2017 Feb 24.


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