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Items: 19


Urogenital schistosomiasis is associated with signatures of microbiome dysbiosis in Nigerian adolescents.

Ajibola O, Rowan AD, Ogedengbe CO, Mshelia MB, Cabral DJ, Eze AA, Obaro S, Belenky P.

Sci Rep. 2019 Jan 29;9(1):829. doi: 10.1038/s41598-018-36709-1.


The individual components of commercial isometamidium do not possess stronger trypanocidal activity than the mixture, nor bypass isometamidium resistance.

Eze AA, Igoli J, Gray AI, Skellern GG, De Koning HP.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:54-58. doi: 10.1016/j.ijpddr.2019.01.003. Epub 2019 Jan 21.


Typhoid Fever Diagnosis in Endemic Countries: A Clog in the Wheel of Progress?

Ajibola O, Mshelia MB, Gulumbe BH, Eze AA.

Medicina (Kaunas). 2018 Apr 25;54(2). pii: E23. doi: 10.3390/medicina54020023. Review.


Tools for Detection of Schistosomiasis in Resource Limited Settings.

Ajibola O, Gulumbe BH, Eze AA, Obishakin E.

Med Sci (Basel). 2018 May 23;6(2). pii: E39. doi: 10.3390/medsci6020039. Review.


Self-Medication with Antibiotics, Attitude and Knowledge of Antibiotic Resistance among Community Residents and Undergraduate Students in Northwest Nigeria.

Ajibola O, Omisakin OA, Eze AA, Omoleke SA.

Diseases. 2018 Apr 27;6(2). pii: E32. doi: 10.3390/diseases6020032.


Prevalence of trypanosome infection in tsetse flies from Oji River and Emene axis of Enugu State, Nigeria: A preliminary report.

Onyekwelu KC, Ejezie FE, Eze AA, Ikekpeazu JE, Ezeh RC, Edeh GC.

Trop Parasitol. 2017 Jul-Dec;7(2):98-102. doi: 10.4103/tp.TP_14_17.


Monotherapy with amlodipine or hydrochlorothiazide in patients with mild to moderate hypertension: Comparison of their efficacy and effects on electrolytes.

Nwachukwu DC, Eze AA, Nwachukwu NZ, Aneke EI, Agu PU, Azubike NC, Obika LF, Okoye OI.

Malawi Med J. 2017 Jun;29(2):108-112.


Animal African Trypanosomiasis in Nigeria: A long way from elimination/eradication.

Isaac C, Ohiolei JA, Ebhodaghe F, Igbinosa IB, Eze AA.

Acta Trop. 2017 Dec;176:323-331. doi: 10.1016/j.actatropica.2017.08.032. Epub 2017 Sep 8. Review.


Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.

Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20.


Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

Eze AA, Gould MK, Munday JC, Tagoe DN, Stelmanis V, Schnaufer A, De Koning HP.

PLoS Negl Trop Dis. 2016 Aug 12;10(8):e0004791. doi: 10.1371/journal.pntd.0004791. eCollection 2016 Aug.


Effect of Hibiscus sabdariffaon blood pressure and electrolyte profile of mild to moderate hypertensive Nigerians: A comparative study with hydrochlorothiazide.

Nwachukwu DC, Aneke E, Nwachukwu NZ, Obika LF, Nwagha UI, Eze AA.

Niger J Clin Pract. 2015 Nov-Dec;18(6):762-70. doi: 10.4103/1119-3077.163278.


Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.

Munday JC, Tagoe DN, Eze AA, Krezdorn JA, Rojas López KE, Alkhaldi AA, McDonald F, Still J, Alzahrani KJ, Settimo L, De Koning HP.

Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21.


Protocols for the routine screening of drug sensitivity in the human parasite Trichomonas vaginalis.

Natto MJ, Eze AA, de Koning HP.

Methods Mol Biol. 2015;1263:103-10. doi: 10.1007/978-1-4939-2269-7_8.


A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines.

Ríos Martínez CH, Miller F, Ganeshamoorthy K, Glacial F, Kaiser M, de Koning HP, Eze AA, Lagartera L, Herraiz T, Dardonville C.

Antimicrob Agents Chemother. 2015 Feb;59(2):890-904. doi: 10.1128/AAC.03958-14. Epub 2014 Nov 24.


Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.

Munday JC, Rojas López KE, Eze AA, Delespaux V, Van Den Abbeele J, Rowan T, Barrett MP, Morrison LJ, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2013 Feb 10;3:69-76. doi: 10.1016/j.ijpddr.2013.01.004. eCollection 2013 Dec.


Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.

Vodnala SK, Lundbäck T, Yeheskieli E, Sjöberg B, Gustavsson AL, Svensson R, Olivera GC, Eze AA, de Koning HP, Hammarström LG, Rottenberg ME.

J Med Chem. 2013 Dec 27;56(24):9861-73. doi: 10.1021/jm401530a. Epub 2013 Dec 10.


Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP.

J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13.


Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes.

Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C.

J Med Chem. 2012 Mar 22;55(6):2606-22. doi: 10.1021/jm2014259. Epub 2012 Mar 6.


The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.

Teka IA, Kazibwe AJ, El-Sabbagh N, Al-Salabi MI, Ward CP, Eze AA, Munday JC, Mäser P, Matovu E, Barrett MP, de Koning HP.

Mol Pharmacol. 2011 Jul;80(1):110-6. doi: 10.1124/mol.111.071555. Epub 2011 Mar 24.

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