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Items: 1 to 50 of 129


Does Adaptive Protein Evolution Proceed by Large or Small Steps at the Amino Acid Level?

Bergman J, Eyre-Walker A.

Mol Biol Evol. 2019 May 1;36(5):990-998. doi: 10.1093/molbev/msz033.


Mitochondrial replacement and its effects on human health.

Eyre-Walker A.

Hum Reprod Update. 2019 May 1;25(3):392-394. doi: 10.1093/humupd/dmz009. No abstract available.


Nearly Neutral Evolution across the Drosophila melanogaster Genome.

Castellano D, James J, Eyre-Walker A.

Mol Biol Evol. 2018 Nov 1;35(11):2685-2694. doi: 10.1093/molbev/msy164.


The distribution of bacterial doubling times in the wild.

Gibson B, Wilson DJ, Feil E, Eyre-Walker A.

Proc Biol Sci. 2018 Jun 13;285(1880). pii: 20180789. doi: 10.1098/rspb.2018.0789.


Large scale variation in the rate of germ-line de novo mutation, base composition, divergence and diversity in humans.

Smith TCA, Arndt PF, Eyre-Walker A.

PLoS Genet. 2018 Mar 28;14(3):e1007254. doi: 10.1371/journal.pgen.1007254. eCollection 2018 Mar.


Are pangenomes adaptive or not?

Vos M, Eyre-Walker A.

Nat Microbiol. 2017 Dec;2(12):1576. doi: 10.1038/s41564-017-0067-5. No abstract available.


Population genomics of picophytoplankton unveils novel chromosome hypervariability.

Blanc-Mathieu R, Krasovec M, Hebrard M, Yau S, Desgranges E, Martin J, Schackwitz W, Kuo A, Salin G, Donnadieu C, Desdevises Y, Sanchez-Ferandin S, Moreau H, Rivals E, Grigoriev IV, Grimsley N, Eyre-Walker A, Piganeau G.

Sci Adv. 2017 Jul 5;3(7):e1700239. doi: 10.1126/sciadv.1700239. eCollection 2017 Jul.


Spontaneous Mutation Rate in the Smallest Photosynthetic Eukaryotes.

Krasovec M, Eyre-Walker A, Sanchez-Ferandin S, Piganeau G.

Mol Biol Evol. 2017 Jul 1;34(7):1770-1779. doi: 10.1093/molbev/msx119.


Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

Eyre-Walker A.

Genetics. 2017 Apr;205(4):1365-1372. doi: 10.1534/genetics.116.196436. Review.


DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA.

James J, Castellano D, Eyre-Walker A.

Heredity (Edinb). 2017 Jan;118(1):88-95. doi: 10.1038/hdy.2016.108. Epub 2016 Nov 9.


Are sites with multiple single nucleotide variants in cancer genomes a consequence of drivers, hypermutable sites or sequencing errors?

Smith TC, Carr AM, Eyre-Walker AC.

PeerJ. 2016 Sep 20;4:e2391. doi: 10.7717/peerj.2391. eCollection 2016.


Molecular Evolutionary Consequences of Island Colonization.

James JE, Lanfear R, Eyre-Walker A.

Genome Biol Evol. 2016 Jul 2;8(6):1876-88. doi: 10.1093/gbe/evw120.


Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.

Krasovec M, Eyre-Walker A, Grimsley N, Salmeron C, Pecqueur D, Piganeau G, Sanchez-Ferandin S.

G3 (Bethesda). 2016 Jul 7;6(7):2063-71. doi: 10.1534/g3.116.029769.


Extensive Variation in the Mutation Rate Between and Within Human Genes Associated with Mendelian Disease.

Smith T, Ho G, Christodoulou J, Price EA, Onadim Z, Gauthier-Villars M, Dehainault C, Houdayer C, Parfait B, van Minkelen R, Lohman D, Eyre-Walker A.

Hum Mutat. 2016 May;37(5):488-94. doi: 10.1002/humu.22967. Epub 2016 Mar 14.


The rate of adaptive evolution in animal mitochondria.

James JE, Piganeau G, Eyre-Walker A.

Mol Ecol. 2016 Jan;25(1):67-78. doi: 10.1111/mec.13475. Epub 2015 Dec 17. Review.


Adaptive Evolution Is Substantially Impeded by Hill-Robertson Interference in Drosophila.

Castellano D, Coronado-Zamora M, Campos JL, Barbadilla A, Eyre-Walker A.

Mol Biol Evol. 2016 Feb;33(2):442-55. doi: 10.1093/molbev/msv236. Epub 2015 Oct 22.


Rates of Lateral Gene Transfer in Prokaryotes: High but Why?

Vos M, Hesselman MC, Te Beek TA, van Passel MWJ, Eyre-Walker A.

Trends Microbiol. 2015 Oct;23(10):598-605. doi: 10.1016/j.tim.2015.07.006. Review.


Research groups: How big should they be?

Cook I, Grange S, Eyre-Walker A.

PeerJ. 2015 Jun 9;3:e989. doi: 10.7717/peerj.989. eCollection 2015.


An improved genome of the model marine alga Ostreococcus tauri unfolds by assessing Illumina de novo assemblies.

Blanc-Mathieu R, Verhelst B, Derelle E, Rombauts S, Bouget FY, Carré I, Château A, Eyre-Walker A, Grimsley N, Moreau H, Piégu B, Rivals E, Schackwitz W, Van de Peer Y, Piganeau G.

BMC Genomics. 2014 Dec 13;15:1103. doi: 10.1186/1471-2164-15-1103.


How much of the variation in the mutation rate along the human genome can be explained?

Eyre-Walker A, Eyre-Walker YC.

G3 (Bethesda). 2014 Jul 3;4(9):1667-70. doi: 10.1534/g3.114.012849.


The role of mutation rate variation and genetic diversity in the architecture of human disease.

Eyre-Walker YC, Eyre-Walker A.

PLoS One. 2014 Feb 27;9(2):e90166. doi: 10.1371/journal.pone.0090166. eCollection 2014.


Fluctuating selection models and McDonald-Kreitman type analyses.

Gossmann TI, Waxman D, Eyre-Walker A.

PLoS One. 2014 Jan 7;9(1):e84540. doi: 10.1371/journal.pone.0084540. eCollection 2014.


Population size and the rate of evolution.

Lanfear R, Kokko H, Eyre-Walker A.

Trends Ecol Evol. 2014 Jan;29(1):33-41. doi: 10.1016/j.tree.2013.09.009. Epub 2013 Oct 20. Review.


The assessment of science: the relative merits of post-publication review, the impact factor, and the number of citations.

Eyre-Walker A, Stoletzki N.

PLoS Biol. 2013 Oct;11(10):e1001675. doi: 10.1371/journal.pbio.1001675. Epub 2013 Oct 8.


Organellar inheritance in the green lineage: insights from Ostreococcus tauri.

Blanc-Mathieu R, Sanchez-Ferandin S, Eyre-Walker A, Piganeau G.

Genome Biol Evol. 2013;5(8):1503-11. doi: 10.1093/gbe/evt106.


ODoSE: a webserver for genome-wide calculation of adaptive divergence in prokaryotes.

Vos M, te Beek TA, van Driel MA, Huynen MA, Eyre-Walker A, van Passel MW.

PLoS One. 2013 May 6;8(5):e62447. doi: 10.1371/journal.pone.0062447. Print 2013.


A resolution of the mutation load paradox in humans.

Lesecque Y, Keightley PD, Eyre-Walker A.

Genetics. 2012 Aug;191(4):1321-30. doi: 10.1534/genetics.112.140343. Epub 2012 Jun 1.


A selection index for gene expression evolution and its application to the divergence between humans and chimpanzees.

Warnefors M, Eyre-Walker A.

PLoS One. 2012;7(4):e34935. doi: 10.1371/journal.pone.0034935. Epub 2012 Apr 18.


The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.

Gossmann TI, Keightley PD, Eyre-Walker A.

Genome Biol Evol. 2012;4(5):658-67. doi: 10.1093/gbe/evs027. Epub 2012 Mar 21.


Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small.

Keightley PD, Eyre-Walker A.

J Mol Evol. 2012 Feb;74(1-2):61-8. doi: 10.1007/s00239-012-9488-1. Epub 2012 Feb 12.


Hundreds of putatively functional small open reading frames in Drosophila.

Ladoukakis E, Pereira V, Magny EG, Eyre-Walker A, Couso JP.

Genome Biol. 2011 Nov 25;12(11):R118. doi: 10.1186/gb-2011-12-11-r118.


Variation in the mutation rate across mammalian genomes.

Hodgkinson A, Eyre-Walker A.

Nat Rev Genet. 2011 Oct 4;12(11):756-66. doi: 10.1038/nrg3098. Review.


Quantifying the variation in the effective population size within a genome.

Gossmann TI, Woolfit M, Eyre-Walker A.

Genetics. 2011 Dec;189(4):1389-402. doi: 10.1534/genetics.111.132654. Epub 2011 Sep 27.


A method for inferring the rate of occurrence and fitness effects of advantageous mutations.

Schneider A, Charlesworth B, Eyre-Walker A, Keightley PD.

Genetics. 2011 Dec;189(4):1427-37. doi: 10.1534/genetics.111.131730. Epub 2011 Sep 27.


The large-scale distribution of somatic mutations in cancer genomes.

Hodgkinson A, Chen Y, Eyre-Walker A.

Hum Mutat. 2012 Jan;33(1):136-43. doi: 10.1002/humu.21616. Epub 2011 Oct 20.


The accumulation of gene regulation through time.

Warnefors M, Eyre-Walker A.

Genome Biol Evol. 2011;3:667-73. doi: 10.1093/gbe/evr019. Epub 2011 Mar 11.


How and why DNA barcodes underestimate the diversity of microbial eukaryotes.

Piganeau G, Eyre-Walker A, Jancek S, Grimsley N, Moreau H.

PLoS One. 2011 Feb 10;6(2):e16342. doi: 10.1371/journal.pone.0016342. Erratum in: PLoS One. 2012;7(4): doi/10.1371/annotation/c12aac06-71d2-4749-91de-46c458e7a4eb. Jancek, Severine [added].


The positive correlation between dN/dS and dS in mammals is due to runs of adjacent substitutions.

Stoletzki N, Eyre-Walker A.

Mol Biol Evol. 2011 Apr;28(4):1371-80. doi: 10.1093/molbev/msq320. Epub 2010 Nov 29.


Evidence of selection upon genomic GC-content in bacteria.

Hildebrand F, Meyer A, Eyre-Walker A.

PLoS Genet. 2010 Sep 9;6(9):e1001107. doi: 10.1371/journal.pgen.1001107.


Estimation of the neutrality index.

Stoletzki N, Eyre-Walker A.

Mol Biol Evol. 2011 Jan;28(1):63-70. doi: 10.1093/molbev/msq249. Epub 2010 Sep 13.


Direct measure of the de novo mutation rate in autism and schizophrenia cohorts.

Awadalla P, Gauthier J, Myers RA, Casals F, Hamdan FF, Griffing AR, Côté M, Henrion E, Spiegelman D, Tarabeux J, Piton A, Yang Y, Boyko A, Bustamante C, Xiong L, Rapoport JL, Addington AM, DeLisi JL, Krebs MO, Joober R, Millet B, Fombonne E, Mottron L, Zilversmit M, Keebler J, Daoud H, Marineau C, Roy-Gagnon MH, Dubé MP, Eyre-Walker A, Drapeau P, Stone EA, Lafrenière RG, Rouleau GA.

Am J Hum Genet. 2010 Sep 10;87(3):316-24. doi: 10.1016/j.ajhg.2010.07.019.


The genomic distribution and local context of coincident SNPs in human and chimpanzee.

Hodgkinson A, Eyre-Walker A.

Genome Biol Evol. 2010;2:547-57. doi: 10.1093/gbe/evq039. Epub 2010 Jul 8.


Transposable elements: insertion pattern and impact on gene expression evolution in hominids.

Warnefors M, Pereira V, Eyre-Walker A.

Mol Biol Evol. 2010 Aug;27(8):1955-62. doi: 10.1093/molbev/msq084. Epub 2010 Mar 23.


What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

Keightley PD, Eyre-Walker A.

Philos Trans R Soc Lond B Biol Sci. 2010 Apr 27;365(1544):1187-93. doi: 10.1098/rstb.2009.0266.


Genome wide analyses reveal little evidence for adaptive evolution in many plant species.

Gossmann TI, Song BH, Windsor AJ, Mitchell-Olds T, Dixon CJ, Kapralov MV, Filatov DA, Eyre-Walker A.

Mol Biol Evol. 2010 Aug;27(8):1822-32. doi: 10.1093/molbev/msq079. Epub 2010 Mar 18.


Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies.

Eyre-Walker A.

Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1752-6. doi: 10.1073/pnas.0906182107. Epub 2010 Jan 19.


Evidence for pervasive adaptive protein evolution in wild mice.

Halligan DL, Oliver F, Eyre-Walker A, Harr B, Keightley PD.

PLoS Genet. 2010 Jan 22;6(1):e1000825. doi: 10.1371/journal.pgen.1000825.


Human triallelic sites: evidence for a new mutational mechanism?

Hodgkinson A, Eyre-Walker A.

Genetics. 2010 Jan;184(1):233-41. doi: 10.1534/genetics.109.110510. Epub 2009 Nov 2.


A problem with the correlation coefficient as a measure of gene expression divergence.

Pereira V, Waxman D, Eyre-Walker A.

Genetics. 2009 Dec;183(4):1597-600. doi: 10.1534/genetics.109.110247. Epub 2009 Oct 12.


Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.

Eyre-Walker A, Keightley PD.

Mol Biol Evol. 2009 Sep;26(9):2097-108. doi: 10.1093/molbev/msp119. Epub 2009 Jun 17.


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