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Items: 40


Is there a causal link between intracellular Na elevation and metabolic remodelling in cardiac hypertrophy?

Aksentijevic D, O'Brien BA, Eykyn TR, Shattock MJ.

Biochem Soc Trans. 2018 Aug 20;46(4):817-827. doi: 10.1042/BST20170508. Epub 2018 Jul 3. Review.


Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1.

Kavanagh Williamson M, Coombes N, Juszczak F, Athanasopoulos M, Khan MB, Eykyn TR, Srenathan U, Taams LS, Dias Zeidler J, Da Poian AT, Huthoff H.

Viruses. 2018 Mar 7;10(3). pii: E114. doi: 10.3390/v10030114.


Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.

Whittington HJ, Ostrowski PJ, McAndrew DJ, Cao F, Shaw A, Eykyn TR, Lake HA, Tyler J, Schneider JE, Neubauer S, Zervou S, Lygate CA.

Cardiovasc Res. 2018 May 1;114(6):858-869. doi: 10.1093/cvr/cvy054.


Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling.

Tsionou MI, Knapp CE, Foley CA, Munteanu CR, Cakebread A, Imberti C, Eykyn TR, Young JD, Paterson BM, Blower PJ, Ma MT.

RSC Adv. 2017 Oct 24;7(78):49586-49599. doi: 10.1039/c7ra09076e. Epub 2017 Oct 25.


Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation.

Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM.

JCI Insight. 2017 Dec 21;2(24). pii: 96184. doi: 10.1172/jci.insight.96184. [Epub ahead of print]


MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.

Beloueche-Babari M, Wantuch S, Casals Galobart T, Koniordou M, Parkes HG, Arunan V, Chung YL, Eykyn TR, Smith PD, Leach MO.

Cancer Res. 2017 Nov 1;77(21):5913-5924. doi: 10.1158/0008-5472.CAN-16-2686. Epub 2017 Sep 18.


Magnetic Resonance Spectroscopy to Study Glycolytic Metabolism During Autophagy.

Chung YL, Leach MO, Eykyn TR.

Methods Enzymol. 2017;588:133-153. doi: 10.1016/bs.mie.2016.09.078. Epub 2016 Nov 17.


Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms.

Zervou S, Yin X, Nabeebaccus AA, O'Brien BA, Cross RL, McAndrew DJ, Atkinson RA, Eykyn TR, Mayr M, Neubauer S, Lygate CA.

Amino Acids. 2016 Aug;48(8):1969-81. doi: 10.1007/s00726-016-2236-x. Epub 2016 May 3.


Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart.

Mariotti E, Orton MR, Eerbeek O, Ashruf JF, Zuurbier CJ, Southworth R, Eykyn TR.

NMR Biomed. 2016 Apr;29(4):377-86. doi: 10.1002/nbm.3464. Epub 2016 Jan 18.


Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation.

Wilder CD, Masoud R, Yazar D, O'Brien BA, Eykyn TR, Curtis MJ.

Br J Pharmacol. 2016 Jan;173(1):39-52. doi: 10.1111/bph.13332. Epub 2015 Dec 4.


Multiple quantum filtered (23)Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i.

Eykyn TR, Aksentijević D, Aughton KL, Southworth R, Fuller W, Shattock MJ.

J Mol Cell Cardiol. 2015 Sep;86:95-101. doi: 10.1016/j.yjmcc.2015.07.009. Epub 2015 Jul 18.


Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM).

Shaughnessy F, Mariotti E, Shaw KP, Eykyn TR, Blower PJ, Siow R, Southworth R.

EJNMMI Res. 2014 Dec;4(1):40. doi: 10.1186/s13550-014-0040-8. Epub 2014 Aug 1.


64Cu-CTS: A Promising Radiopharmaceutical for the Identification of Low-Grade Cardiac Hypoxia by PET.

Medina RA, Mariotti E, Pavlovic D, Shaw KP, Eykyn TR, Blower PJ, Southworth R.

J Nucl Med. 2015 Jun;56(6):921-6. doi: 10.2967/jnumed.114.148353. Epub 2015 Apr 16.


Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma.

Al-Saffar NM, Marshall LV, Jackson LE, Balarajah G, Eykyn TR, Agliano A, Clarke PA, Jones C, Workman P, Pearson AD, Leach MO.

PLoS One. 2014 Aug 1;9(8):e103835. doi: 10.1371/journal.pone.0103835. eCollection 2014.


Kinetic analysis of hyperpolarized data with minimum a priori knowledge: Hybrid maximum entropy and nonlinear least squares method (MEM/NLS).

Mariotti E, Veronese M, Dunn JT, Southworth R, Eykyn TR.

Magn Reson Med. 2015 Jun;73(6):2332-42. doi: 10.1002/mrm.25362. Epub 2014 Jul 15.


Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

Lin G, Hill DK, Andrejeva G, Boult JK, Troy H, Fong AC, Orton MR, Panek R, Parkes HG, Jafar M, Koh DM, Robinson SP, Judson IR, Griffiths JR, Leach MO, Eykyn TR, Chung YL.

Br J Cancer. 2014 Jul 15;111(2):375-85. doi: 10.1038/bjc.2014.281. Epub 2014 Jun 3.


Reduced Warburg effect in cancer cells undergoing autophagy: steady- state 1H-MRS and real-time hyperpolarized 13C-MRS studies.

Lin G, Andrejeva G, Wong Te Fong AC, Hill DK, Orton MR, Parkes HG, Koh DM, Robinson SP, Leach MO, Eykyn TR, Chung YL.

PLoS One. 2014 Mar 25;9(3):e92645. doi: 10.1371/journal.pone.0092645. eCollection 2014.


Cardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.

Handley MG, Medina RA, Mariotti E, Kenny GD, Shaw KP, Yan R, Eykyn TR, Blower PJ, Southworth R.

J Nucl Med. 2014 Mar;55(3):488-94. doi: 10.2967/jnumed.113.129015. Epub 2014 Jan 13.


Assessing radiotracer kinetics in the Langendorff perfused heart.

Mariotti E, Veronese M, Dunn JT, Medina RA, Blower PJ, Southworth R, Eykyn TR.

EJNMMI Res. 2013 Nov 14;3(1):74. doi: 10.1186/2191-219X-3-74.


Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data.

Hill DK, Orton MR, Mariotti E, Boult JK, Panek R, Jafar M, Parkes HG, Jamin Y, Miniotis MF, Al-Saffar NM, Beloueche-Babari M, Robinson SP, Leach MO, Chung YL, Eykyn TR.

PLoS One. 2013 Sep 4;8(9):e71996. doi: 10.1371/journal.pone.0071996. eCollection 2013.


Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance.

Jamin Y, Eykyn TR, Poon E, Springer CJ, Robinson SP.

Mol Imaging Biol. 2014 Apr;16(2):152-7. doi: 10.1007/s11307-013-0680-5.


¹H NMR and hyperpolarized ¹³C NMR assays of pyruvate-lactate: a comparative study.

Hill DK, Jamin Y, Orton MR, Tardif N, Parkes HG, Robinson SP, Leach MO, Chung YL, Eykyn TR.

NMR Biomed. 2013 Oct;26(10):1321-1325. doi: 10.1002/nbm.2957. Epub 2013 May 27.


MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells.

Falck Miniotis M, Arunan V, Eykyn TR, Marais R, Workman P, Leach MO, Beloueche-Babari M.

Cancer Res. 2013 Jul 1;73(13):4039-49. doi: 10.1158/0008-5472.CAN-12-1969. Epub 2013 May 2.


Noninvasive detection of carboxypeptidase G2 activity in vivo.

Jamin Y, Smyth L, Robinson SP, Poon ES, Eykyn TR, Springer CJ, Leach MO, Payne GS.

NMR Biomed. 2011 May;24(4):343-50. doi: 10.1002/nbm.1597. Epub 2010 Oct 3.


Detection of cancer in cervical tissue biopsies using mobile lipid resonances measured with diffusion-weighted (1)H magnetic resonance spectroscopy.

Zietkowski D, Davidson RL, Eykyn TR, De Silva SS, Desouza NM, Payne GS.

NMR Biomed. 2010 May;23(4):382-90. doi: 10.1002/nbm.1472. Epub 2009 Dec 15.


Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity.

Jamin Y, Gabellieri C, Smyth L, Reynolds S, Robinson SP, Springer CJ, Leach MO, Payne GS, Eykyn TR.

Magn Reson Med. 2009 Nov;62(5):1300-4. doi: 10.1002/mrm.22049.


The effect of experimental conditions on the detection of spermine in cell extracts and tissues.

Spencer NG, Eykyn TR, deSouza NM, Payne GS.

NMR Biomed. 2010 Feb;23(2):163-9. doi: 10.1002/nbm.1438.


Modulating the relaxivity of hyperpolarized substrates with gadolinium contrast agents.

Gabellieri C, Leach MO, Eykyn TR.

Contrast Media Mol Imaging. 2009 May-Jun;4(3):143-7. doi: 10.1002/cmmi.272.


Modulation of choline kinase activity in human cancer cells observed by dynamic 31P NMR.

Gabellieri C, Beloueche-Babari M, Jamin Y, Payne GS, Leach MO, Eykyn TR.

NMR Biomed. 2009 May;22(4):456-61. doi: 10.1002/nbm.1361.


Therapeutic target metabolism observed using hyperpolarized 15N choline.

Gabellieri C, Reynolds S, Lavie A, Payne GS, Leach MO, Eykyn TR.

J Am Chem Soc. 2008 Apr 9;130(14):4598-9. doi: 10.1021/ja8001293. Epub 2008 Mar 18.


Conformational exchange in pimonidazole--a hypoxia marker.

Gabellieri C, Eykyn TR, Leach MO.

Magn Reson Chem. 2007 Aug;45(8):621-3.


Frequency-switched single-transition cross-polarization: a tool for selective experiments in biomolecular NMR.

Ferrage F, Eykyn TR, Bodenhausen G.

Chemphyschem. 2004 Jan 23;5(1):76-84.


Highly selective excitation in biomolecular NMR by frequency-switched single-transition cross-polarization.

Ferrage F, Eykyn TR, Bodenhausen G.

J Am Chem Soc. 2002 Mar 13;124(10):2076-7.


Single-transition coherence transfer by adiabatic cross polarization in NMR.

Eykyn TR, Ferrage F, Winterfors E, Bodenhausen G.

Chemphyschem. 2000 Dec 15;1(4):217-21. doi: 10.1002/1439-7641(20001215)1:4<217::AID-CPHC217>3.0.CO;2-V.


Identification of spin diffusion pathways in isotopically labeled biomolecules.

Eykyn TR, Früh D, Bodenhausen G.

J Magn Reson. 1999 Jun;138(2):330-3.


Offset profiles of selective pulses in isotopically labeled macromolecules.

Eykyn TR, Ghose R, Bodenhausen G.

J Magn Reson. 1999 Feb;136(2):211-3.


Normalized one-dimensional NOE measurements in isotopically labeled macromolecules using two-way cross-polarization.

Chiarparin E, Pelupessy P, Cutting B, Eykyn TR, Bodenhausen G.

J Biomol NMR. 1999 Jan;13(1):61-5. doi: 10.1023/A:1008307012647.


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