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Items: 14


G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors.

Wu JH, Zhang L, Fanaroff AC, Cai X, Sharma KC, Brian L, Exum ST, Shenoy SK, Peppel K, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):308-16. doi: 10.1161/ATVBAHA.111.239608. Epub 2011 Nov 17.


Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.

Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ.

Mol Pharmacol. 2009 Mar;75(3):626-36. doi: 10.1124/mol.108.050278. Epub 2008 Dec 17.


Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.

Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ.

Circ Res. 2008 Jul 3;103(1):70-9. doi: 10.1161/CIRCRESAHA.108.172338. Epub 2008 Jun 2.


Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.

Wang L, Hauser ER, Shah SH, Seo D, Sivashanmugam P, Exum ST, Gregory SG, Granger CB, Haines JL, Jones CJ, Crossman D, Haynes C, Kraus WE, Freedman NJ, Pericak-Vance MA, Goldschmidt-Clermont PJ, Vance JM.

Ann Hum Genet. 2008 Jul;72(Pt 4):443-53. doi: 10.1111/j.1469-1809.2008.00433.x. Epub 2008 Jul 3.


Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery.

Zhang L, Sivashanmugam P, Wu JH, Brian L, Exum ST, Freedman NJ, Peppel K.

Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):284-9. Epub 2007 Nov 15.


Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis.

Zhang L, Peppel K, Sivashanmugam P, Orman ES, Brian L, Exum ST, Freedman NJ.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1087-94.


Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.

Wu JH, Goswami R, Cai X, Exum ST, Huang X, Zhang L, Brian L, Premont RT, Peppel K, Freedman NJ.

J Biol Chem. 2006 Dec 8;281(49):37758-72. Epub 2006 Oct 3.


The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.

Wu JH, Peppel K, Nelson CD, Lin FT, Kohout TA, Miller WE, Exum ST, Freedman NJ.

J Biol Chem. 2003 Nov 7;278(45):44238-45. Epub 2003 Aug 27.


Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.

Peppel K, Zhang L, Huynh TT, Huang X, Jacobson A, Brian L, Exum ST, Hagen PO, Freedman NJ.

J Mol Cell Cardiol. 2002 Oct;34(10):1399-1409.


Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors.

Lin FT, Chen W, Shenoy S, Cong M, Exum ST, Lefkowitz RJ.

Biochemistry. 2002 Aug 27;41(34):10692-9.


Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.

Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ.

J Biol Chem. 1997 Jul 11;272(28):17734-43.


Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor.

Hawes BE, Luttrell LM, Exum ST, Lefkowitz RJ.

J Biol Chem. 1994 Jun 3;269(22):15776-85.

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