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Items: 21


Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation.

Young RM, Ewan KB, Ferrer VP, Allende ML, Godovac-Zimmermann J, Dale TC, Wilson SW.

Elife. 2019 Dec 12;8. pii: e51447. doi: 10.7554/eLife.51447.


Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions.

Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale TC, Schade D, Grossmann TN.

Cell Chem Biol. 2017 Aug 17;24(8):958-968.e5. doi: 10.1016/j.chembiol.2017.06.013. Epub 2017 Jul 27.


Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, Mallinger A, Raynaud F, Roe T, Rohdich F, Schiemann K, Simon S, Schneider R, Valenti M, Weigt S, Blagg J, Blaukat A, Dale TC, Eccles SA, Hecht S, Urbahns K, Workman P, Wienke D.

Elife. 2016 Dec 9;5. pii: e20722. doi: 10.7554/eLife.20722.


Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

Jardé T, Lloyd-Lewis B, Thomas M, Kendrick H, Melchor L, Bougaret L, Watson PD, Ewan K, Smalley MJ, Dale TC.

Nat Commun. 2016 Oct 26;7:13207. doi: 10.1038/ncomms13207.


A functional connectome: regulation of Wnt/TCF-dependent transcription by pairs of pathway activators.

Freeman J, Smith D, Latinkic B, Ewan K, Samuel L, Zollo M, Marino N, Tyas L, Jones N, Dale TC.

Mol Cancer. 2015 Dec 8;14:206. doi: 10.1186/s12943-015-0475-1.


A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, TePoele R, Court W, Box G, Valenti M, de Haven Brandon A, Gowan S, Rohdich F, Raynaud F, Schneider R, Poeschke O, Blaukat A, Workman P, Schiemann K, Eccles SA, Wienke D, Blagg J.

Nat Chem Biol. 2015 Dec;11(12):973-980. doi: 10.1038/nchembio.1952. Epub 2015 Oct 26.


A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.

Ewan K, Pajak B, Stubbs M, Todd H, Barbeau O, Quevedo C, Botfield H, Young R, Ruddle R, Samuel L, Battersby A, Raynaud F, Allen N, Wilson S, Latinkic B, Workman P, McDonald E, Blagg J, Aherne W, Dale T.

Cancer Res. 2010 Jul 15;70(14):5963-73. doi: 10.1158/0008-5472.CAN-10-1028. Epub 2010 Jul 7.


The potential for targeting oncogenic WNT/beta-catenin signaling in therapy.

Ewan KB, Dale TC.

Curr Drug Targets. 2008 Jul;9(7):532-47. Review.


Deficiency of Mbd2 attenuates Wnt signaling.

Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, Sansom OJ, Clarke AR.

Mol Cell Biol. 2008 Oct;28(19):6094-103. doi: 10.1128/MCB.00539-08. Epub 2008 Jul 21.


The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior.

Shimshoni JA, Dalton EC, Jenkins A, Eyal S, Ewan K, Williams RS, Pessah N, Yagen B, Harwood AJ, Bialer M.

Mol Pharmacol. 2007 Mar;71(3):884-92. Epub 2006 Dec 13.


Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta.

Smalley MJ, Signoret N, Robertson D, Tilley A, Hann A, Ewan K, Ding Y, Paterson H, Dale TC.

J Cell Sci. 2005 Nov 15;118(Pt 22):5279-89. Epub 2005 Nov 1.


Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice.

Ewan KB, Oketch-Rabah HA, Ravani SA, Shyamala G, Moses HL, Barcellos-Hoff MH.

Am J Pathol. 2005 Aug;167(2):409-17.


Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH.

Cancer Res. 2002 Oct 15;62(20):5627-31.


Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.

Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH.

Am J Pathol. 2002 Jun;160(6):2081-93.


Transforming growth factor-beta and breast cancer: Mammary gland development.

Barcellos-Hoff MH, Ewan KB.

Breast Cancer Res. 2000;2(2):92-9. Epub 2000 Feb 21. Review.


Molecular regulators involved in vertebrate eye development.

Jean D, Ewan K, Gruss P.

Mech Dev. 1998 Aug;76(1-2):3-18. Review.


Gender differences in the uptake of inorganic mercury by motor neurons.

Pamphlett R, Ewan KB, McQuilty R, Waley P.

Neurotoxicol Teratol. 1997 Jul-Aug;19(4):287-93.


Increased inorganic mercury in spinal motor neurons following chelating agents.

Ewan KB, Pamphlett R.

Neurotoxicology. 1996 Summer;17(2):343-9.


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