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Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.

Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G.

Sci Rep. 2018 Jul 9;8(1):10341. doi: 10.1038/s41598-018-28754-7.


High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors.

Germann AL, Shin DJ, Kuhrau CR, Johnson AD, Evers AS, Akk G.

Mol Pharmacol. 2018 May;93(5):468-476. doi: 10.1124/mol.117.111435. Epub 2018 Feb 8.


SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain.

Orser BA, Suresh S, Evers AS.

Anesth Analg. 2018 Apr;126(4):1393-1396. doi: 10.1213/ANE.0000000000002833.


Mapping two neurosteroid-modulatory sites in the prototypic pentameric ligand-gated ion channel GLIC.

Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS.

J Biol Chem. 2018 Feb 23;293(8):3013-3027. doi: 10.1074/jbc.RA117.000359. Epub 2018 Jan 4.


Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1.

Budelier MM, Cheng WWL, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS.

J Biol Chem. 2017 Jun 2;292(22):9294-9304. doi: 10.1074/jbc.M116.773069. Epub 2017 Apr 10.


Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS.

Anal Chem. 2017 Feb 21;89(4):2636-2644. doi: 10.1021/acs.analchem.6b05003. Epub 2017 Feb 9.


Anesthetic Neurotoxicity: New Findings and Future Directions.

Montana MC, Evers AS.

J Pediatr. 2017 Feb;181:279-285. doi: 10.1016/j.jpeds.2016.10.049. Epub 2016 Nov 8. No abstract available.


Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G.

Br J Pharmacol. 2016 Nov;173(21):3110-3120. doi: 10.1111/bph.13566. Epub 2016 Sep 6.


In Reply.

Avidan MS, Evers AS.

Anesthesiology. 2016 Aug;125(2):428-9. doi: 10.1097/ALN.0000000000001181. No abstract available.


The GAS trial.

Orser BA, Evers AS, Suresh S, Hertz S.

Lancet. 2016 Apr 16;387(10028):1613-4. doi: 10.1016/S0140-6736(16)30199-4. Epub 2016 Apr 14. No abstract available.


Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G.

Curr Neuropharmacol. 2016;14(7):772-80. Review.


The Fallacy of Persistent Postoperative Cognitive Decline.

Avidan MS, Evers AS.

Anesthesiology. 2016 Feb;124(2):255-8. doi: 10.1097/ALN.0000000000000958. No abstract available.


Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.

Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G.

Mol Pharmacol. 2015 Oct;88(4):736-45. doi: 10.1124/mol.115.100347. Epub 2015 Jul 23.


Anesthetic neurotoxicity--clinical implications of animal models.

Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA.

N Engl J Med. 2015 Feb 26;372(9):796-7. doi: 10.1056/NEJMp1414786.


The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors.

Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G.

Br J Pharmacol. 2014 Dec;171(23):5446-57. doi: 10.1111/bph.12861.


Surgical safety checklists in ontario, Canada.

Avidan MS, Evers AS.

N Engl J Med. 2014 Jun 12;370(24):2350-1. doi: 10.1056/NEJMc1404583. No abstract available.


11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors.

Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS.

Psychopharmacology (Berl). 2014 Sep;231(17):3479-91. doi: 10.1007/s00213-014-3568-4. Epub 2014 Apr 23.


Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone.

Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2014 Jan 9;57(1):171-90. doi: 10.1021/jm401577c. Epub 2013 Dec 24.


Increased risk of intraoperative awareness in patients with a history of awareness.

Aranake A, Gradwohl S, Ben-Abdallah A, Lin N, Shanks A, Helsten DL, Glick DB, Jacobsohn E, Villafranca AJ, Evers AS, Avidan MS, Mashour GA.

Anesthesiology. 2013 Dec;119(6):1275-83. doi: 10.1097/ALN.0000000000000023.


A propofol binding site on mammalian GABAA receptors identified by photolabeling.

Yip GM, Chen ZW, Edge CJ, Smith EH, Dickinson R, Hohenester E, Townsend RR, Fuchs K, Sieghart W, Evers AS, Franks NP.

Nat Chem Biol. 2013 Nov;9(11):715-20. doi: 10.1038/nchembio.1340. Epub 2013 Sep 22.


In reply.

Fleisher LA, Evers AS, Wiener-Kronish J, Ulatowski JA.

Anesthesiology. 2013 Mar;118(3):759-60. doi: 10.1097/ALN.0b013e3182838bb4. No abstract available.


Sexual dysfunction in women on adjuvant endocrine therapy after breast cancer.

Baumgart J, Nilsson K, Evers AS, Kallak TK, Poromaa IS.

Menopause. 2013 Feb;20(2):162-8. doi: 10.1097/gme.0b013e31826560da.


What are we looking for? The question of resident selection.

Fleisher LA, Evers AS, Wiener-Kronish J, Ulatowski JA.

Anesthesiology. 2012 Aug;117(2):230-1. No abstract available.


Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS.

Mol Pharmacol. 2012 Sep;82(3):408-19. doi: 10.1124/mol.112.078410. Epub 2012 May 30.


A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.

Chen ZW, Chen LH, Akentieva N, Lichti CF, Darbandi R, Hastings R, Covey DF, Reichert DE, Townsend RR, Evers AS.

Electrophoresis. 2012 Feb;33(4):666-74. doi: 10.1002/elps.201100434.


Perspective: Hospital support for anesthesiology departments: aligning incentives and improving productivity.

Hill LL, Evers AS.

Acad Med. 2012 Mar;87(3):348-55. doi: 10.1097/ACM.0b013e318244c36e.


Deep amino acid sequencing of native brain GABAA receptors using high-resolution mass spectrometry.

Chen ZW, Fuchs K, Sieghart W, Townsend RR, Evers AS.

Mol Cell Proteomics. 2012 Jan;11(1):M111.011445.


Ketamine-induced neuroapoptosis in the fetal and neonatal rhesus macaque brain.

Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Martin LD, Dissen GA, Creeley CE, Olney JW.

Anesthesiology. 2012 Feb;116(2):372-84. doi: 10.1097/ALN.0b013e318242b2cd.


Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.

Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2012 Feb 9;55(3):1334-45. doi: 10.1021/jm2014925. Epub 2012 Jan 18.


Relationship between bispectral index values and volatile anesthetic concentrations during the maintenance phase of anesthesia in the B-Unaware trial.

Whitlock EL, Villafranca AJ, Lin N, Palanca BJ, Jacobsohn E, Finkel KJ, Zhang L, Burnside BA, Kaiser HA, Evers AS, Avidan MS.

Anesthesiology. 2011 Dec;115(6):1209-18. doi: 10.1097/ALN.0b013e3182395dcb.


Memories and dreams: building an academic department at Washington University in St. Louis.

Evers AS, Owens WD.

Anesthesiology. 2011 Dec;115(6):1147-8. doi: 10.1097/ALN.0b013e318238bd12. No abstract available.


Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.

Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S.

Br J Pharmacol. 2012 Apr;165(7):2228-43. doi: 10.1111/j.1476-5381.2011.01690.x.


Prevention of intraoperative awareness in a high-risk surgical population.

Avidan MS, Jacobsohn E, Glick D, Burnside BA, Zhang L, Villafranca A, Karl L, Kamal S, Torres B, O'Connor M, Evers AS, Gradwohl S, Lin N, Palanca BJ, Mashour GA; BAG-RECALL Research Group.

N Engl J Med. 2011 Aug 18;365(7):591-600. doi: 10.1056/NEJMoa1100403.


Congratulations from the IARS!

Evers AS, Van Aken H.

Anesthesiology. 2011 Oct;115(4):679-80. doi: 10.1097/ALN.0b013e31822ea349. No abstract available.


Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.

Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2011 Jun 9;54(11):3926-34. doi: 10.1021/jm2002487. Epub 2011 May 6.


Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia.

Avidan MS, Evers AS.

J Alzheimers Dis. 2011;24(2):201-16. doi: 10.3233/JAD-2011-101680. Review.


Postoperative cognitive decline: the unsubstantiated phenotype.

Avidan MS, Xiong C, Evers AS.

Anesthesiology. 2010 Nov;113(5):1246-8; author reply 1248-50. doi: 10.1097/ALN.0b013e3181f696f5. No abstract available.


Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.

Bandyopadhyaya AK, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6680-4. doi: 10.1016/j.bmcl.2010.09.008. Epub 2010 Sep 15.


Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.

Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH.

Curr Neuropharmacol. 2010 Mar;8(1):18-25. doi: 10.2174/157015910790909458.


Leadership in postgraduate medical education.

Cox TE, Evers AS, Murray DJ.

Anesthesiology. 2010 Sep;113(3):754; author reply 754-5. doi: 10.1097/ALN.0b013e3181eab59e. No abstract available.


Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain.

Brambrink AM, Evers AS, Avidan MS, Farber NB, Smith DJ, Zhang X, Dissen GA, Creeley CE, Olney JW.

Anesthesiology. 2010 Apr;112(4):834-41. doi: 10.1097/ALN.0b013e3181d049cd.


A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.

Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF.

J Pharmacol Exp Ther. 2010 May;333(2):404-13. doi: 10.1124/jpet.109.164079. Epub 2010 Feb 2.


Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness.

Avidan MS, Searleman AC, Storandt M, Barnett K, Vannucci A, Saager L, Xiong C, Grant EA, Kaiser D, Morris JC, Evers AS.

Anesthesiology. 2009 Nov;111(5):964-70. doi: 10.1097/ALN.0b013e3181bc9719.


Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.

Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S.

Mol Pharmacol. 2009 Oct;76(4):754-65. doi: 10.1124/mol.109.057687. Epub 2009 Jul 13.


The influence of the membrane on neurosteroid actions at GABA(A) receptors.

Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S.

Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S59-66. doi: 10.1016/j.psyneuen.2009.05.020. Review.


Performance of certified registered nurse anesthetists and anesthesiologists in a simulation-based skills assessment.

Henrichs BM, Avidan MS, Murray DJ, Boulet JR, Kras J, Krause B, Snider R, Evers AS.

Anesth Analg. 2009 Jan;108(1):255-62. doi: 10.1213/ane.0b013e31818e3d58.


Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain.

Cattano D, Williamson P, Fukui K, Avidan M, Evers AS, Olney JW, Young C.

Can J Anaesth. 2008 Jul;55(7):429-36. doi: 10.1007/BF03016309.


Anesthesia awareness and the bispectral index.

Avidan MS, Zhang L, Burnside BA, Finkel KJ, Searleman AC, Selvidge JA, Saager L, Turner MS, Rao S, Bottros M, Hantler C, Jacobsohn E, Evers AS.

N Engl J Med. 2008 Mar 13;358(11):1097-108. doi: 10.1056/NEJMoa0707361.


Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.

Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF.

J Med Chem. 2008 Mar 13;51(5):1309-18. doi: 10.1021/jm701128r. Epub 2008 Feb 15.


Performance of residents and anesthesiologists in a simulation-based skill assessment.

Murray DJ, Boulet JR, Avidan M, Kras JF, Henrichs B, Woodhouse J, Evers AS.

Anesthesiology. 2007 Nov;107(5):705-13.


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