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Near-Infrared Photoimmunotherapy Using a Small Protein Mimetic for HER2-Overexpressing Breast Cancer.

Yamaguchi H, Pantarat N, Suzuki T, Evdokiou A.

Int J Mol Sci. 2019 Nov 20;20(23). pii: E5835. doi: 10.3390/ijms20235835.


Clodronate-Liposome Mediated Macrophage Depletion Abrogates Multiple Myeloma Tumor Establishment In Vivo.

Opperman KS, Vandyke K, Clark KC, Coulter EA, Hewett DR, Mrozik KM, Schwarz N, Evdokiou A, Croucher PI, Psaltis PJ, Noll JE, Zannettino AC.

Neoplasia. 2019 Aug;21(8):777-787. doi: 10.1016/j.neo.2019.05.006. Epub 2019 Jun 24.


Pericytes reduce inflammation and collagen deposition in acute wounds.

Bodnar RJ, Yang T, Rigatti LH, Liu F, Evdokiou A, Kathju S, Satish L.

Cytotherapy. 2018 Aug;20(8):1046-1060. doi: 10.1016/j.jcyt.2018.06.011. Epub 2018 Aug 6.


Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size.

Kogawa M, Khalid KA, Wijenayaka AR, Ormsby RT, Evdokiou A, Anderson PH, Findlay DM, Atkins GJ.

Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C53-C61. doi: 10.1152/ajpcell.00175.2017. Epub 2017 Oct 4.


Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs.

Maher S, Kaur G, Lima-Marques L, Evdokiou A, Losic D.

ACS Appl Mater Interfaces. 2017 Sep 6;9(35):29562-29570. doi: 10.1021/acsami.7b09916. Epub 2017 Aug 24.


Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma.

Liapis V, Zysk A, DeNichilo M, Zinonos I, Hay S, Panagopoulos V, Shoubridge A, Difelice C, Ponomarev V, Ingman W, Atkins GJ, Findlay DM, Zannettino ACW, Evdokiou A.

Cancer Med. 2017 Sep;6(9):2164-2176. doi: 10.1002/cam4.1115. Epub 2017 Aug 10.


Evaluation of the combined use of metronomic zoledronic acid and Coriolus versicolor in intratibial breast cancer mouse model.

Ko CH, Yue GG, Gao S, Luo KW, Siu WS, Shum WT, Shiu HT, Lee JK, Li G, Leung PC, Evdokiou A, Lau CB.

J Ethnopharmacol. 2017 May 23;204:77-85. doi: 10.1016/j.jep.2017.04.007. Epub 2017 Apr 12.


Inflammatory peroxidases promote breast cancer progression in mice via regulation of the tumour microenvironment.

Panagopoulos V, Leach DA, Zinonos I, Ponomarev V, Licari G, Liapis V, Ingman WV, Anderson P, DeNichilo MO, Evdokiou A.

Int J Oncol. 2017 Apr;50(4):1191-1200. doi: 10.3892/ijo.2017.3883. Epub 2017 Feb 20.


CCL2-driven inflammation increases mammary gland stromal density and cancer susceptibility in a transgenic mouse model.

Sun X, Glynn DJ, Hodson LJ, Huo C, Britt K, Thompson EW, Woolford L, Evdokiou A, Pollard JW, Robertson SA, Ingman WV.

Breast Cancer Res. 2017 Jan 11;19(1):4. doi: 10.1186/s13058-016-0796-z.


Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer.

Zysk A, DeNichilo MO, Panagopoulos V, Zinonos I, Liapis V, Hay S, Ingman W, Ponomarev V, Atkins G, Findlay D, Zannettino A, Evdokiou A.

Cancer Lett. 2017 Feb 1;386:141-150. doi: 10.1016/j.canlet.2016.11.013. Epub 2016 Nov 16.


Peroxidase enzymes inhibit osteoclast differentiation and bone resorption.

Panagopoulos V, Liapis V, Zinonos I, Hay S, Leach DA, Ingman W, DeNichilo MO, Atkins GJ, Findlay DM, Zannettino ACW, Evdokiou A.

Mol Cell Endocrinol. 2017 Jan 15;440:8-15. doi: 10.1016/j.mce.2016.11.007. Epub 2016 Nov 9.


From The Mine to Cancer Therapy: Natural and Biodegradable Theranostic Silicon Nanocarriers from Diatoms for Sustained Delivery of Chemotherapeutics.

Maher S, Kumeria T, Wang Y, Kaur G, Fathalla D, Fetih G, Santos A, Habib F, Evdokiou A, Losic D.

Adv Healthc Mater. 2016 Oct;5(20):2667-2678. doi: 10.1002/adhm.201600688. Epub 2016 Sep 5.


Naturally Derived Iron Oxide Nanowires from Bacteria for Magnetically Triggered Drug Release and Cancer Hyperthermia in 2D and 3D Culture Environments: Bacteria Biofilm to Potent Cancer Therapeutic.

Kumeria T, Maher S, Wang Y, Kaur G, Wang L, Erkelens M, Forward P, Lambert MF, Evdokiou A, Losic D.

Biomacromolecules. 2016 Aug 8;17(8):2726-36. doi: 10.1021/acs.biomac.6b00786. Epub 2016 Jul 28.


Titanium wire implants with nanotube arrays: A study model for localized cancer treatment.

Kaur G, Willsmore T, Gulati K, Zinonos I, Wang Y, Kurian M, Hay S, Losic D, Evdokiou A.

Biomaterials. 2016 Sep;101:176-88. doi: 10.1016/j.biomaterials.2016.05.048. Epub 2016 Jun 2.


Pharmacological blockade of aquaporin-1 water channel by AqB013 restricts migration and invasiveness of colon cancer cells and prevents endothelial tube formation in vitro.

Dorward HS, Du A, Bruhn MA, Wrin J, Pei JV, Evdokiou A, Price TJ, Yool AJ, Hardingham JE.

J Exp Clin Cancer Res. 2016 Feb 24;35:36. doi: 10.1186/s13046-016-0310-6.


Anticancer efficacy of the hypoxia-activated prodrug evofosfamide (TH-302) in osteolytic breast cancer murine models.

Liapis V, Zinonos I, Labrinidis A, Hay S, Ponomarev V, Panagopoulos V, Zysk A, DeNichilo M, Ingman W, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A.

Cancer Med. 2016 Mar;5(3):534-45. doi: 10.1002/cam4.599. Epub 2016 Jan 9.


Peroxidase Enzymes Regulate Collagen Biosynthesis and Matrix Mineralization by Cultured Human Osteoblasts.

DeNichilo MO, Shoubridge AJ, Panagopoulos V, Liapis V, Zysk A, Zinonos I, Hay S, Atkins GJ, Findlay DM, Evdokiou A.

Calcif Tissue Int. 2016 Mar;98(3):294-305. doi: 10.1007/s00223-015-0090-6. Epub 2015 Dec 7.


Bioinert Anodic Alumina Nanotubes for Targeting of Endoplasmic Reticulum Stress and Autophagic Signaling: A Combinatorial Nanotube-Based Drug Delivery System for Enhancing Cancer Therapy.

Wang Y, Kaur G, Chen Y, Santos A, Losic D, Evdokiou A.

ACS Appl Mater Interfaces. 2015 Dec 16;7(49):27140-51. doi: 10.1021/acsami.5b07557. Epub 2015 Dec 1.


Uncovering a new role for peroxidase enzymes as drivers of angiogenesis.

Panagopoulos V, Zinonos I, Leach DA, Hay SJ, Liapis V, Zysk A, Ingman WV, DeNichilo MO, Evdokiou A.

Int J Biochem Cell Biol. 2015 Nov;68:128-38. doi: 10.1016/j.biocel.2015.09.006. Epub 2015 Sep 18.


Facile synthesis of optical microcavities by a rationally designed anodization approach: tailoring photonic signals by nanopore structure.

Wang Y, Chen Y, Kumeria T, Ding F, Evdokiou A, Losic D, Santos A.

ACS Appl Mater Interfaces. 2015 May 13;7(18):9879-88. doi: 10.1021/acsami.5b01885. Epub 2015 May 1.


Peroxidase enzymes regulate collagen extracellular matrix biosynthesis.

DeNichilo MO, Panagopoulos V, Rayner TE, Borowicz RA, Greenwood JE, Evdokiou A.

Am J Pathol. 2015 May;185(5):1372-84. doi: 10.1016/j.ajpath.2015.01.013. Epub 2015 Mar 7.


Systematic in vitro nanotoxicity study on anodic alumina nanotubes with engineered aspect ratio: understanding nanotoxicity by a nanomaterial model.

Wang Y, Kaur G, Zysk A, Liapis V, Hay S, Santos A, Losic D, Evdokiou A.

Biomaterials. 2015 Apr;46:117-30. doi: 10.1016/j.biomaterials.2014.12.008. Epub 2015 Jan 23.


Doxorubicin overcomes resistance to drozitumab by antagonizing Inhibitor of Apoptosis Proteins (IAPs).

Zinonos I, Labrinidis A, Liapis V, Hay S, Panagopoulos V, Denichilo M, Ponomarev V, Ingman W, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A.

Anticancer Res. 2014 Dec;34(12):7007-20.


Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli.

Ito N, Wijenayaka AR, Prideaux M, Kogawa M, Ormsby RT, Evdokiou A, Bonewald LF, Findlay DM, Atkins GJ.

Mol Cell Endocrinol. 2015 Jan 5;399:208-18. doi: 10.1016/j.mce.2014.10.007. Epub 2014 Oct 16.


Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma.

Liapis V, Labrinidis A, Zinonos I, Hay S, Ponomarev V, Panagopoulos V, DeNichilo M, Ingman W, Atkins GJ, Findlay DM, Zannettino ACW, Evdokiou A.

Cancer Lett. 2015 Feb 1;357(1):160-169. doi: 10.1016/j.canlet.2014.11.020. Epub 2014 Nov 15.


The combined use of Camellia sinensis and metronomic zoledronic acid in a breast cancer-induced osteolysis mouse model.

Luo KW, Ko CH, Yue GG, Gao S, Lee JK, Li G, Fung KP, Leung PC, Evdokiou A, Lau CB.

J Cancer Res Clin Oncol. 2015 Jun;141(6):1025-36. doi: 10.1007/s00432-014-1882-1. Epub 2014 Nov 28.


Hormonal regulation of the cytokine microenvironment in the mammary gland.

Dasari P, Sharkey DJ, Noordin E, Glynn DJ, Hodson LJ, Chin PY, Evdokiou A, Robertson SA, Ingman WV.

J Reprod Immunol. 2014 Dec;106:58-66. doi: 10.1016/j.jri.2014.07.002. Epub 2014 Jul 30.


SaOS2 Osteosarcoma cells as an in vitro model for studying the transition of human osteoblasts to osteocytes.

Prideaux M, Wijenayaka AR, Kumarasinghe DD, Ormsby RT, Evdokiou A, Findlay DM, Atkins GJ.

Calcif Tissue Int. 2014 Aug;95(2):183-93. doi: 10.1007/s00223-014-9879-y. Epub 2014 Jun 12.


Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer.

Zinonos I, Luo KW, Labrinidis A, Liapis V, Hay S, Panagopoulos V, Denichilo M, Ko CH, Yue GG, Lau CB, Ingman W, Ponomarev V, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A.

Int J Oncol. 2014 Aug;45(2):532-40. doi: 10.3892/ijo.2014.2468. Epub 2014 May 27.


Structurally engineered anodic alumina nanotubes as nano-carriers for delivery of anticancer therapeutics.

Wang Y, Santos A, Kaur G, Evdokiou A, Losic D.

Biomaterials. 2014 Jul;35(21):5517-26. doi: 10.1016/j.biomaterials.2014.03.059. Epub 2014 Apr 14.


Nutlin-3a efficacy in sarcoma predicted by transcriptomic and epigenetic profiling.

Pishas KI, Neuhaus SJ, Clayer MT, Schreiber AW, Lawrence DM, Perugini M, Whitfield RJ, Farshid G, Manavis J, Chryssidis S, Mayo BJ, Haycox RC, Ho K, Brown MP, D'Andrea RJ, Evdokiou A, Thomas DM, Desai J, Callen DF, Neilsen PM.

Cancer Res. 2014 Feb 1;74(3):921-31. doi: 10.1158/0008-5472.CAN-13-2424. Epub 2013 Dec 13.


Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells.

Noll JE, Williams SA, Tong CM, Wang H, Quach JM, Purton LE, Pilkington K, To LB, Evdokiou A, Gronthos S, Zannettino AC.

Haematologica. 2014 Jan;99(1):163-71. doi: 10.3324/haematol.2013.090977. Epub 2013 Aug 9.


Macrophage phenotype in the mammary gland fluctuates over the course of the estrous cycle and is regulated by ovarian steroid hormones.

Hodson LJ, Chua AC, Evdokiou A, Robertson SA, Ingman WV.

Biol Reprod. 2013 Sep 19;89(3):65. doi: 10.1095/biolreprod.113.109561. Print 2013 Sep.


Anti-tumor and anti-osteolysis effects of the metronomic use of zoledronic acid in primary and metastatic breast cancer mouse models.

Luo KW, Ko CH, Yue GG, Lee MY, Siu WS, Lee JK, Shum WT, Fung KP, Leung PC, Li G, Evdokiou A, Lau CB.

Cancer Lett. 2013 Oct 1;339(1):42-8. doi: 10.1016/j.canlet.2013.07.024. Epub 2013 Jul 26.


Calcium induces pro-anabolic effects on human primary osteoblasts associated with acquisition of mature osteocyte markers.

Welldon KJ, Findlay DM, Evdokiou A, Ormsby RT, Atkins GJ.

Mol Cell Endocrinol. 2013 Aug 25;376(1-2):85-92. doi: 10.1016/j.mce.2013.06.013. Epub 2013 Jun 18.


Pre-activation of the p53 pathway through Nutlin-3a sensitises sarcomas to drozitumab therapy.

Pishas KI, Neuhaus SJ, Clayer MT, Adwal A, Brown MP, Evdokiou A, Callen DF, Neilsen PM.

Oncol Rep. 2013 Jul;30(1):471-7. doi: 10.3892/or.2013.2454. Epub 2013 May 13.


The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis.

Endo-Munoz L, Evdokiou A, Saunders NA.

Biochim Biophys Acta. 2012 Dec;1826(2):434-42. doi: 10.1016/j.bbcan.2012.07.003. Epub 2012 Jul 27. Review.


Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells.

Nicolaou KA, Liapis V, Evdokiou A, Constantinou C, Magiatis P, Skaltsounis AL, Koumas L, Costeas PA, Constantinou AI.

Biochem Biophys Res Commun. 2012 Aug 17;425(1):76-82. doi: 10.1016/j.bbrc.2012.07.053. Epub 2012 Jul 20.


Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome.

Neilsen PM, Noll JE, Suetani RJ, Schulz RB, Al-Ejeh F, Evdokiou A, Lane DP, Callen DF.

Oncotarget. 2011 Dec;2(12):1203-17.


Myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones include double-positive CD8+CD4+ T cells: evidence from myeloma-bearing mouse model.

Freeman LM, Lam A, Petcu E, Smith R, Salajegheh A, Diamond P, Zannettino A, Evdokiou A, Luff J, Wong PF, Khalil D, Waterhouse N, Vari F, Rice AM, Catley L, Hart DN, Vuckovic S.

J Immunol. 2011 Oct 15;187(8):3987-96. doi: 10.4049/jimmunol.1101202. Epub 2011 Sep 9.


Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism.

Atkins GJ, Rowe PS, Lim HP, Welldon KJ, Ormsby R, Wijenayaka AR, Zelenchuk L, Evdokiou A, Findlay DM.

J Bone Miner Res. 2011 Jul;26(7):1425-36. doi: 10.1002/jbmr.345.


RECK in osteosarcoma: a novel role in tumour vasculature and inhibition of tumorigenesis in an orthotopic model.

Clark JC, Akiyama T, Thomas DM, Labrinidis A, Evdokiou A, Galloway SJ, Kim HS, Dass CR, Choong PF.

Cancer. 2011 Aug 1;117(15):3517-28. doi: 10.1002/cncr.25757. Epub 2011 Feb 1.


Nutlin-3a is a potential therapeutic for ewing sarcoma.

Pishas KI, Al-Ejeh F, Zinonos I, Kumar R, Evdokiou A, Brown MP, Callen DF, Neilsen PM.

Clin Cancer Res. 2011 Feb 1;17(3):494-504. doi: 10.1158/1078-0432.CCR-10-1587. Epub 2010 Nov 23.


Loss of osteoclasts contributes to development of osteosarcoma pulmonary metastases.

Endo-Munoz L, Cumming A, Rickwood D, Wilson D, Cueva C, Ng C, Strutton G, Cassady AI, Evdokiou A, Sommerville S, Dickinson I, Guminski A, Saunders NA.

Cancer Res. 2010 Sep 15;70(18):7063-72. doi: 10.1158/0008-5472.CAN-09-4291. Epub 2010 Sep 7.


Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo.

Zinonos I, Labrinidis A, Lee M, Liapis V, Hay S, Ponomarev V, Diamond P, Findlay DM, Zannettino AC, Evdokiou A.

J Bone Miner Res. 2011 Mar;26(3):630-43. doi: 10.1002/jbmr.244.


Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model.

Labrinidis A, Hay S, Liapis V, Findlay DM, Evdokiou A.

Int J Cancer. 2010 Jul 15;127(2):345-54. doi: 10.1002/ijc.25051.


A role for the phosphatidylinositol 3-kinase--protein kinase C zeta--Sp1 pathway in the 1,25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24-hydroxylase gene in human kidney cells.

Dwivedi PP, Gao XH, Tan JC, Evdokiou A, Ferrante A, Morris HA, May BK, Hii CS.

Cell Signal. 2010 Mar;22(3):543-52. doi: 10.1016/j.cellsig.2009.11.009.


Apomab, a fully human agonistic antibody to DR5, exhibits potent antitumor activity against primary and metastatic breast cancer.

Zinonos I, Labrinidis A, Lee M, Liapis V, Hay S, Ponomarev V, Diamond P, Zannettino AC, Findlay DM, Evdokiou A.

Mol Cancer Ther. 2009 Oct;8(10):2969-80. doi: 10.1158/1535-7163.MCT-09-0745. Epub 2009 Oct 6.


Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model.

Labrinidis A, Hay S, Liapis V, Ponomarev V, Findlay DM, Evdokiou A.

Clin Cancer Res. 2009 May 15;15(10):3451-61. doi: 10.1158/1078-0432.CCR-08-1616. Epub 2009 Apr 28.


Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.

Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, To LB, Fujii N, O'Loughlin PD, Evdokiou A, Zannettino AC.

J Bone Miner Res. 2009 Jul;24(7):1150-61. doi: 10.1359/jbmr.090210. Review.

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