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Profiling of RNAs from Human Islet-Derived Exosomes in a Model of Type 1 Diabetes.

Krishnan P, Syed F, Jiyun Kang N, G Mirmira R, Evans-Molina C.

Int J Mol Sci. 2019 Nov 25;20(23). pii: E5903. doi: 10.3390/ijms20235903.


The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening.

Jacobsen LM, Bocchino L, Evans-Molina C, DiMeglio L, Goland R, Wilson DM, Atkinson MA, Aye T, Russell WE, Wentworth JM, Boulware D, Geyer S, Sosenko JM.

Diabetologia. 2019 Nov 25. doi: 10.1007/s00125-019-05047-w. [Epub ahead of print]


Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, Gitelman SE, Greenbaum CJ, Gottlieb PA, Herold KC, Hessner MJ, Knip M, Jacobsen L, Krischer JP, Long SA, Lundgren M, McKinney EF, Morgan NG, Oram RA, Pastinen T, Peters MC, Petrelli A, Qian X, Redondo MJ, Roep BO, Schatz D, Skibinski D, Peakman M.

Diabetes Care. 2019 Nov 21. pii: dc190880. doi: 10.2337/dc19-0880. [Epub ahead of print]


Loss of Diurnal Oscillatory Rhythms in Gut Microbiota Correlates with Changes in Circulating Metabolites in Type 2 Diabetic db/db Mice.

Beli E, Prabakaran S, Krishnan P, Evans-Molina C, Grant MB.

Nutrients. 2019 Sep 29;11(10). pii: E2310. doi: 10.3390/nu11102310.


Abnormalities in proinsulin processing in islets from individuals with longstanding T1D.

Sims EK, Syed F, Nyalwidhe J, Bahnson HT, Haataja L, Speake C, Morris MA, Balamurugan AN, Mirmira RG, Nadler J, Mastracci TL, Arvan P, Greenbaum CJ, Evans-Molina C.

Transl Res. 2019 Nov;213:90-99. doi: 10.1016/j.trsl.2019.08.001. Epub 2019 Aug 9.


Serum miR-204 is an early biomarker of type 1 diabetes-associated pancreatic beta-cell loss.

Xu G, Thielen LA, Chen J, Grayson TB, Grimes T, Bridges SL Jr, Tse HM, Smith B, Patel R, Li P, Evans-Molina C, Ovalle F, Shalev A.

Am J Physiol Endocrinol Metab. 2019 Oct 1;317(4):E723-E730. doi: 10.1152/ajpendo.00122.2019. Epub 2019 Aug 13.


The role of proteomics in assessing beta-cell dysfunction and death in type 1 diabetes.

Nakayasu ES, Qian WJ, Evans-Molina C, Mirmira RG, Eizirik DL, Metz TO.

Expert Rev Proteomics. 2019 Jul;16(7):569-582. doi: 10.1080/14789450.2019.1634548. Epub 2019 Jun 24.


The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes.

Redondo MJ, Evans-Molina C, Steck AK, Atkinson MA, Sosenko J.

Diabetes Care. 2019 Aug;42(8):1357-1364. doi: 10.2337/dc19-0102. Epub 2019 Jun 4.


The Integrated Islet Distribution Program Answers the Call for Improved Human Islet Phenotyping and Reporting of Human Islet Characteristics in Research Articles.

Brissova M, Niland JC, Cravens J, Olack B, Sowinski J, Evans-Molina C.

Diabetes. 2019 Jul;68(7):1363-1365. doi: 10.2337/dbi19-0019. Epub 2019 May 15. No abstract available.


The Integrated Islet Distribution Program answers the call for improved human islet phenotyping and reporting of human islet characteristics in research articles.

Brissova M, Niland JC, Cravens J, Olack B, Sowinski J, Evans-Molina C.

Diabetologia. 2019 Jul;62(7):1312-1314. doi: 10.1007/s00125-019-4876-3. Epub 2019 May 15. No abstract available.


Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258-264.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C.

Diabetes Care. 2019 May;42(5):e85-e86. doi: 10.2337/dci19-0012. No abstract available.


Associations of HbA1c with the timing of C-peptide responses during the oral glucose tolerance test at the diagnosis of type 1 diabetes.

Ismail HM, Evans-Molina C, DiMeglio LA, Becker DJ, Libman I, Sims EK, Boulware D, Herold KC, Rafkin L, Skyler J, Cleves MA, Palmer J, Sosenko JM; Type 1 Diabetes Trial Net and Diabetes Prevention Trial-Type-1 (DPT-1) Study Groups.

Pediatr Diabetes. 2019 Jun;20(4):408-413. doi: 10.1111/pedi.12845. Epub 2019 Apr 15.


Beta cells in type 1 diabetes: mass and function; sleeping or dead?

Oram RA, Sims EK, Evans-Molina C.

Diabetologia. 2019 Apr;62(4):567-577. doi: 10.1007/s00125-019-4822-4. Epub 2019 Feb 14. Review.


Analysis of serum Hsp90 as a potential biomarker of β cell autoimmunity in type 1 diabetes.

Ocaña GJ, Sims EK, Watkins RA, Ragg S, Mather KJ, Oram RA, Mirmira RG, DiMeglio LA, Blum JS, Evans-Molina C.

PLoS One. 2019 Jan 10;14(1):e0208456. doi: 10.1371/journal.pone.0208456. eCollection 2019.


Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.

Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C; T1D Exchange Residual C-peptide Study Group.

Diabetes Care. 2019 Feb;42(2):258-264. doi: 10.2337/dc17-2625. Epub 2018 Dec 10.


Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell.

Yamamoto WR, Bone RN, Sohn P, Syed F, Reissaus CA, Mosley AL, Wijeratne AB, True JD, Tong X, Kono T, Evans-Molina C.

J Biol Chem. 2019 Jan 4;294(1):168-181. doi: 10.1074/jbc.RA118.005683. Epub 2018 Nov 12.


The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms.

Leete P, Mallone R, Richardson SJ, Sosenko JM, Redondo MJ, Evans-Molina C.

Curr Diab Rep. 2018 Sep 26;18(11):115. doi: 10.1007/s11892-018-1083-4. Review.


Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables.

Wentworth JM, Bediaga NG, Giles LC, Ehlers M, Gitelman SE, Geyer S, Evans-Molina C, Harrison LC; Type 1 Diabetes TrialNet Study Group; Immune Tolerance Network Study Group.

Diabetologia. 2019 Jan;62(1):33-40. doi: 10.1007/s00125-018-4722-z. Epub 2018 Aug 30. Review.


Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell.

Kono T, Tong X, Taleb S, Bone RN, Iida H, Lee CC, Sohn P, Gilon P, Roe MW, Evans-Molina C.

Diabetes. 2018 Nov;67(11):2293-2304. doi: 10.2337/db17-1351. Epub 2018 Aug 21.


Biomarkers of islet beta cell stress and death in type 1 diabetes.

Sims EK, Evans-Molina C, Tersey SA, Eizirik DL, Mirmira RG.

Diabetologia. 2018 Nov;61(11):2259-2265. doi: 10.1007/s00125-018-4712-1. Epub 2018 Aug 15. Review.


β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis.

Evans-Molina C, Sims EK, DiMeglio LA, Ismail HM, Steck AK, Palmer JP, Krischer JP, Geyer S, Xu P, Sosenko JM; Type 1 Diabetes TrialNet Study Group.

JCI Insight. 2018 Aug 9;3(15). pii: 120877. doi: 10.1172/jci.insight.120877. eCollection 2018 Aug 9.


Persistent elevations in circulating INS DNA among subjects with longstanding type 1 diabetes.

Neyman A, Nelson J, Tersey SA, Mirmira RG, Evans-Molina C, Sims EK.

Diabetes Obes Metab. 2019 Jan;21(1):95-102. doi: 10.1111/dom.13489. Epub 2018 Aug 24.


Type 1 diabetes.

DiMeglio LA, Evans-Molina C, Oram RA.

Lancet. 2018 Jun 16;391(10138):2449-2462. doi: 10.1016/S0140-6736(18)31320-5. Review.


Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice.

Beli E, Yan Y, Moldovan L, Vieira CP, Gao R, Duan Y, Prasad R, Bhatwadekar A, White FA, Townsend SD, Chan L, Ryan CN, Morton D, Moldovan EG, Chu FI, Oudit GY, Derendorf H, Adorini L, Wang XX, Evans-Molina C, Mirmira RG, Boulton ME, Yoder MC, Li Q, Levi M, Busik JV, Grant MB.

Diabetes. 2018 Sep;67(9):1867-1879. doi: 10.2337/db18-0158. Epub 2018 Apr 30.


The influence of body mass index and age on C-peptide at the diagnosis of type 1 diabetes in children who participated in the diabetes prevention trial-type 1.

Sosenko JM, Geyer S, Skyler JS, Rafkin LE, Ismail HM, Libman IM, Liu YF, DiMeglio LA, Evans-Molina C, Palmer JP.

Pediatr Diabetes. 2018 May;19(3):403-409. doi: 10.1111/pedi.12609. Epub 2017 Nov 24.


The Role of Age and Excess Body Mass Index in Progression to Type 1 Diabetes in At-Risk Adults.

Ferrara CT, Geyer SM, Evans-Molina C, Libman IM, Becker DJ, Wentworth JM, Moran A, Gitelman SE, Redondo MJ; Type 1 Diabetes TrialNet Study Group.

J Clin Endocrinol Metab. 2017 Dec 1;102(12):4596-4603. doi: 10.1210/jc.2017-01490.


Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials.

Nathan BM, Boulware D, Geyer S, Atkinson MA, Colman P, Goland R, Russell W, Wentworth JM, Wilson DM, Evans-Molina C, Wherrett D, Skyler JS, Moran A, Sosenko JM; Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups.

Diabetes Care. 2017 Nov;40(11):1494-1499. doi: 10.2337/dc17-0916. Epub 2017 Aug 31.


Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation.

Hatanaka M, Anderson-Baucum E, Lakhter A, Kono T, Maier B, Tersey SA, Tanizawa Y, Evans-Molina C, Mirmira RG, Sims EK.

Sci Rep. 2017 Jun 19;7(1):3758. doi: 10.1038/s41598-017-03869-5.


Combination Immunotherapy for Type 1 Diabetes.

Bone RN, Evans-Molina C.

Curr Diab Rep. 2017 Jul;17(7):50. doi: 10.1007/s11892-017-0878-z. Review.


STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

Gordon HM, Majithia N, MacDonald PE, Fox JEM, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS.

Endocrine. 2017 Jun;56(3):528-537. doi: 10.1007/s12020-017-1297-2. Epub 2017 Apr 12.


Smoking and the risk of type 2 diabetes.

Maddatu J, Anderson-Baucum E, Evans-Molina C.

Transl Res. 2017 Jun;184:101-107. doi: 10.1016/j.trsl.2017.02.004. Epub 2017 Mar 6. Review.


MicroRNA 21 targets BCL2 mRNA to increase apoptosis in rat and human beta cells.

Sims EK, Lakhter AJ, Anderson-Baucum E, Kono T, Tong X, Evans-Molina C.

Diabetologia. 2017 Jun;60(6):1057-1065. doi: 10.1007/s00125-017-4237-z. Epub 2017 Mar 9.


Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

Ferrara CT, Geyer SM, Liu YF, Evans-Molina C, Libman IM, Besser R, Becker DJ, Rodriguez H, Moran A, Gitelman SE, Redondo MJ; Type 1 Diabetes TrialNet Study Group.

Diabetes Care. 2017 May;40(5):698-701. doi: 10.2337/dc16-2331. Epub 2017 Feb 15.


Inflammatory stress of pancreatic beta cells drives release of extracellular heat-shock protein 90α.

Ocaña GJ, Pérez L, Guindon L, Deffit SN, Evans-Molina C, Thurmond DC, Blum JS.

Immunology. 2017 Jun;151(2):198-210. doi: 10.1111/imm.12723. Epub 2017 Mar 13.


Biomarkers of β-Cell Stress and Death in Type 1 Diabetes.

Mirmira RG, Sims EK, Syed F, Evans-Molina C.

Curr Diab Rep. 2016 Oct;16(10):95. doi: 10.1007/s11892-016-0783-x. Review.


SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity.

Tong X, Kono T, Anderson-Baucum EK, Yamamoto W, Gilon P, Lebeche D, Day RN, Shull GE, Evans-Molina C.

Diabetes. 2016 Oct;65(10):3039-52. doi: 10.2337/db16-0084. Epub 2016 Aug 3.


Elevations in the Fasting Serum Proinsulin-to-C-Peptide Ratio Precede the Onset of Type 1 Diabetes.

Sims EK, Chaudhry Z, Watkins R, Syed F, Blum J, Ouyang F, Perkins SM, Mirmira RG, Sosenko J, DiMeglio LA, Evans-Molina C.

Diabetes Care. 2016 Sep;39(9):1519-26. doi: 10.2337/dc15-2849. Epub 2016 Jul 6.


Nucleic acid biomarkers of β cell stress and death in type 1 diabetes.

Syed F, Evans-Molina C.

Curr Opin Endocrinol Diabetes Obes. 2016 Aug;23(4):312-7. doi: 10.1097/MED.0000000000000261. Review.


The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants.

Meah FA, DiMeglio LA, Greenbaum CJ, Blum JS, Sosenko JM, Pugliese A, Geyer S, Xu P, Evans-Molina C; Type 1 Diabetes TrialNet Study Group.

Diabetologia. 2016 Jun;59(6):1186-95. doi: 10.1007/s00125-016-3924-5. Epub 2016 Mar 19.


HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.

Pugliese A, Boulware D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molina C, Harrison LC, Schatz D, Palmer JP, Greenbaum C, Eisenbarth GS, Sosenko JM; Type 1 Diabetes TrialNet Study Group.

Diabetes. 2016 Apr;65(4):1109-19. doi: 10.2337/db15-1105. Epub 2016 Jan 28.


CD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity.

Morris DL, Oatmen KE, Mergian TA, Cho KW, DelProposto JL, Singer K, Evans-Molina C, O'Rourke RW, Lumeng CN.

J Leukoc Biol. 2016 Jun;99(6):1107-19. doi: 10.1189/jlb.3A0115-009R. Epub 2015 Dec 11.


Sirtuin 6 regulates glucose-stimulated insulin secretion in mouse pancreatic beta cells.

Xiong X, Wang G, Tao R, Wu P, Kono T, Li K, Ding WX, Tong X, Tersey SA, Harris RA, Mirmira RG, Evans-Molina C, Dong XC.

Diabetologia. 2016 Jan;59(1):151-160. doi: 10.1007/s00125-015-3778-2.


Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.

Watkins RA, Evans-Molina C, Terrell JK, Day KH, Guindon L, Restrepo IA, Mirmira RG, Blum JS, DiMeglio LA.

Transl Res. 2016 Feb;168:96-106.e1. doi: 10.1016/j.trsl.2015.08.010. Epub 2015 Sep 4.


Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.

Fisher MM, Watkins RA, Blum J, Evans-Molina C, Chalasani N, DiMeglio LA, Mather KJ, Tersey SA, Mirmira RG.

Diabetes. 2015 Nov;64(11):3867-72. doi: 10.2337/db15-0430. Epub 2015 Jul 27.


SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.

Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H.

J Biol Chem. 2015 Jul 3;290(27):16607-18. doi: 10.1074/jbc.M115.661777. Epub 2015 May 20.


Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes.

Filgueiras LR, Brandt SL, Wang S, Wang Z, Morris DL, Evans-Molina C, Mirmira RG, Jancar S, Serezani CH.

Sci Signal. 2015 Jan 27;8(361):ra10. doi: 10.1126/scisignal.2005568.


Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.

Mastracci TL, Evans-Molina C.

J Endocrinol Diabetes Obes. 2014;2(3). pii: 1044.

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