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Organization of ATP-gated P2X1 receptor intracellular termini in apo and desensitized states.

Fryatt AG, Dayl S, Stavrou A, Schmid R, Evans RJ.

J Gen Physiol. 2019 Feb 4;151(2):146-155. doi: 10.1085/jgp.201812108. Epub 2019 Jan 9.


Spread Spectrum Steganographic Capacity Improvement for Medical Image Security in Teleradiology.

Eze PU, Parampalli U, Evans RJ, Liu D.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8512344.


ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles.

Schmid R, Evans RJ.

Annu Rev Physiol. 2019 Feb 10;81:43-62. doi: 10.1146/annurev-physiol-020518-114259. Epub 2018 Oct 24.


The Interplay of Host Autophagy and Eukaryotic Pathogens.

Evans RJ, Sundaramurthy V, Frickel EM.

Front Cell Dev Biol. 2018 Sep 13;6:118. doi: 10.3389/fcell.2018.00118. eCollection 2018. Review.


Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region.

Huo H, Fryatt AG, Farmer LK, Schmid R, Evans RJ.

J Biol Chem. 2018 Aug 17;293(33):12820-12831. doi: 10.1074/jbc.RA118.003737. Epub 2018 Jul 11.


Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.

Allsopp RC, Dayl S, Bin Dayel A, Schmid R, Evans RJ.

Mol Pharmacol. 2018 May;93(5):553-562. doi: 10.1124/mol.117.111021. Epub 2018 Mar 13.


A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5.

van Leeuwen LM, Evans RJ, Jim KK, Verboom T, Fang X, Bojarczuk A, Malicki J, Johnston SA, van der Sar AM.

Biol Open. 2018 Feb 2;7(2). pii: bio030494. doi: 10.1242/bio.030494.


Impact of Cystectomy With Urinary Diversion Upon Tracked Receipt of Opioid Prescriptions Among Patients With Interstitial Cystitis/Bladder Pain Syndrome.

Koslov DS, Vilson F, Colaco M, Terlecki RP, Evans RJ.

Urology. 2018 Apr;114:83-86. doi: 10.1016/j.urology.2017.11.009. Epub 2017 Nov 20.


P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli.

Greve AS, Skals M, Fagerberg SK, Tonnus W, Ellermann-Eriksen S, Evans RJ, Linkermann A, Praetorius HA.

Front Cell Infect Microbiol. 2017 Apr 6;7:113. doi: 10.3389/fcimb.2017.00113. eCollection 2017.


Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.

Allsopp RC, Dayl S, Schmid R, Evans RJ.

Sci Rep. 2017 Apr 7;7(1):725. doi: 10.1038/s41598-017-00732-5.


Application of DRIFTS, 13C NMR, and py-MBMS to Characterize the Effects of Soil Science Oxidation Assays on Soil Organic Matter Composition in a Mollic Xerofluvent.

Margenot AJ, Calderón FJ, Magrini KA, Evans RJ.

Appl Spectrosc. 2017 Jul;71(7):1506-1518. doi: 10.1177/0003702817691776. Epub 2017 Mar 31.


Bladder Capacity is a Biomarker for a Bladder Centric versus Systemic Manifestation in Interstitial Cystitis/Bladder Pain Syndrome.

Walker SJ, Zambon J, Andersson KE, Langefeld CD, Matthews CA, Badlani G, Bowman H, Evans RJ.

J Urol. 2017 Aug;198(2):369-375. doi: 10.1016/j.juro.2017.02.022. Epub 2017 Feb 12.


Using Flow Cytometry to Analyze Cryptococcus Infection of Macrophages.

Evans RJ, Voelz K, Johnston SA, May RC.

Methods Mol Biol. 2017;1519:349-357.


Mechanistic insights from resolving ligand-dependent kinetics of conformational changes at ATP-gated P2X1R ion channels.

Fryatt AG, Dayl S, Cullis PM, Schmid R, Evans RJ.

Sci Rep. 2016 Sep 12;6:32918. doi: 10.1038/srep32918.


Calcium Signalling through Ligand-Gated Ion Channels such as P2X1 Receptors in the Platelet and other Non-Excitable Cells.

Mahaut-Smith MP, Taylor KA, Evans RJ.

Adv Exp Med Biol. 2016;898:305-29. doi: 10.1007/978-3-319-26974-0_13. Review.


Transcriptome analysis of bladder biopsy from interstitial cystitis/bladder pain syndrome patients.

Walker SJ, Colaco M, Koslov DS, Keys T, Evans RJ, Badlani GH, Andersson KE.

Genom Data. 2014 Oct 20;2:366-8. doi: 10.1016/j.gdata.2014.10.009. eCollection 2014 Dec.


Separation of Doppler radar-based respiratory signatures.

Lee YS, Pathirana PN, Evans RJ, Steinfort CL.

Med Biol Eng Comput. 2016 Aug;54(8):1169-79. doi: 10.1007/s11517-015-1379-3. Epub 2015 Sep 10.


Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels.

Allsopp RC, Evans RJ.

J Biol Chem. 2015 Jun 5;290(23):14556-66. doi: 10.1074/jbc.M115.642033. Epub 2015 Apr 22.


Cryptococcal phospholipase B1 is required for intracellular proliferation and control of titan cell morphology during macrophage infection.

Evans RJ, Li Z, Hughes WS, Djordjevic JT, Nielsen K, May RC.

Infect Immun. 2015 Apr;83(4):1296-304. doi: 10.1128/IAI.03104-14. Epub 2015 Jan 20.


The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice.

Maître B, Magnenat S, Heim V, Ravanat C, Evans RJ, de la Salle H, Gachet C, Hechler B.

J Immunol. 2015 Jan 15;194(2):739-49. doi: 10.4049/jimmunol.1401786. Epub 2014 Dec 5.


Kinetics of conformational changes revealed by voltage-clamp fluorometry give insight to desensitization at ATP-gated human P2X1 receptors.

Fryatt AG, Evans RJ.

Mol Pharmacol. 2014 Dec;86(6):707-15. doi: 10.1124/mol.114.095307. Epub 2014 Oct 8.


P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice.

Darbousset R, Delierneux C, Mezouar S, Hego A, Lecut C, Guillaumat I, Riederer MA, Evans RJ, Dignat-George F, Panicot-Dubois L, Oury C, Dubois C.

Blood. 2014 Oct 16;124(16):2575-85. doi: 10.1182/blood-2014-04-571679. Epub 2014 Aug 22.


Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation.

Jones S, Evans RJ, Mahaut-Smith MP.

Mol Pharmacol. 2014 Sep;86(3):243-51. doi: 10.1124/mol.114.092528. Epub 2014 Jun 12.


Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome.

Colaco M, Koslov DS, Keys T, Evans RJ, Badlani GH, Andersson KE, Walker SJ.

J Urol. 2014 Oct;192(4):1123-9. doi: 10.1016/j.juro.2014.05.047. Epub 2014 May 17.


Amplification of human platelet activation by surface pannexin-1 channels.

Taylor KA, Wright JR, Vial C, Evans RJ, Mahaut-Smith MP.

J Thromb Haemost. 2014 Jun;12(6):987-98. doi: 10.1111/jth.12566.


Dynamics of Ebola epidemics in West Africa 2014.

Evans RJ, Mammadov M.

Version 2. F1000Res. 2014 Dec 31 [revised 2015 Jan 1];3:319. doi: 10.12688/f1000research.5941.2. eCollection 2014.


Rural general practice placements: alignment with the Australian Curriculum Framework for Junior Doctors.

Young L, Larkins SL, Sen Gupta TK, McKenzie SH, Evans RJ, Crowe MJ, Ware EJ.

Med J Aust. 2013 Dec 16;199(11):787-91. Review.


Male contraception via simultaneous knockout of α1A-adrenoceptors and P2X1-purinoceptors in mice.

White CW, Choong YT, Short JL, Exintaris B, Malone DT, Allen AM, Evans RJ, Ventura S.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20825-30. doi: 10.1073/pnas.1318624110. Epub 2013 Dec 2.


Development of a P2X1-purinoceptor mediated contractile response in the aged mouse prostate gland through slowing down of ATP breakdown.

White CW, Short JL, Evans RJ, Ventura S.

Neurourol Urodyn. 2015 Mar;34(3):292-8. doi: 10.1002/nau.22519. Epub 2013 Nov 19.


Current recommendations for bladder instillation therapy in the treatment of interstitial cystitis/bladder pain syndrome.

Colaco MA, Evans RJ.

Curr Urol Rep. 2013 Oct;14(5):442-7. doi: 10.1007/s11934-013-0369-y. Review.


Marginal log-linear parameters for graphical Markov models.

Evans RJ, Richardson TS.

J R Stat Soc Series B Stat Methodol. 2013 Sep 1;75(4):743-768.


Two algorithms for fitting constrained marginal models.

Evans RJ, Forcina A.

Comput Stat Data Anal. 2013 Oct 1;66:1-7.


Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F.

Ma L, Clayton JR, Walgren RA, Zhao B, Evans RJ, Smith MC, Heinz-Taheny KM, Kreklau EL, Bloem L, Pitou C, Shen W, Strelow JM, Halstead C, Rempala ME, Parthasarathy S, Gillig JR, Heinz LJ, Pei H, Wang Y, Stancato LF, Dowless MS, Iversen PW, Burkholder TP.

Blood Cancer J. 2013 Apr 12;3:e109. doi: 10.1038/bcj.2013.6.


Sacral neuromodulation is an effective treatment for interstitial cystitis/bladder pain syndrome: con.

Evans RJ.

J Urol. 2012 Dec;188(6):2044-5. doi: 10.1016/j.juro.2012.09.073. Epub 2012 Sep 20. No abstract available.


Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes.

Roberts JA, Bottrill AR, Mistry S, Evans RJ.

J Neurochem. 2012 Dec;123(5):725-35. doi: 10.1111/jnc.12012. Epub 2012 Oct 11.


Massive localized lymphedema: A case series and literature review.

Evans RJ, Scilley C.

Can J Plast Surg. 2011 Fall;19(3):e30-1.


Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.

Lalo U, Jones S, Roberts JA, Mahaut-Smith MP, Evans RJ.

J Biol Chem. 2012 Sep 21;287(39):32747-54. Epub 2012 Jul 31.


The hot foot syndrome: Evans' sign and the old way.

Evans RJ, Watson CP.

Pain Res Manag. 2012 Jan-Feb;17(1):31-4.


In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system.

Jardé T, Evans RJ, McQuillan KL, Parry L, Feng GJ, Alvares B, Clarke AR, Dale TC.

Oncogene. 2013 Feb 14;32(7):883-93. doi: 10.1038/onc.2012.103. Epub 2012 Apr 2.


A collaboratively-derived science-policy research agenda.

Sutherland WJ, Bellingan L, Bellingham JR, Blackstock JJ, Bloomfield RM, Bravo M, Cadman VM, Cleevely DD, Clements A, Cohen AS, Cope DR, Daemmrich AA, Devecchi C, Anadon LD, Denegri S, Doubleday R, Dusic NR, Evans RJ, Feng WY, Godfray HC, Harris P, Hartley SE, Hester AJ, Holmes J, Hughes A, Hulme M, Irwin C, Jennings RC, Kass GS, Littlejohns P, Marteau TM, McKee G, Millstone EP, Nuttall WJ, Owens S, Parker MM, Pearson S, Petts J, Ploszek R, Pullin AS, Reid G, Richards KS, Robinson JG, Shaxson L, Sierra L, Smith BG, Spiegelhalter DJ, Stilgoe J, Stirling A, Tyler CP, Winickoff DE, Zimmern RL.

PLoS One. 2012;7(3):e31824. doi: 10.1371/journal.pone.0031824. Epub 2012 Mar 9.


Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.

Roberts JA, Allsopp RC, El Ajouz S, Vial C, Schmid R, Young MT, Evans RJ.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4663-7. doi: 10.1073/pnas.1201872109. Epub 2012 Mar 5.


ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation.

Lecut C, Faccinetto C, Delierneux C, van Oerle R, Spronk HM, Evans RJ, El Benna J, Bours V, Oury C.

J Thromb Haemost. 2012 Mar;10(3):453-65. doi: 10.1111/j.1538-7836.2011.04606.x.


The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.

Allsopp RC, Evans RJ.

J Biol Chem. 2011 Dec 30;286(52):44691-701. doi: 10.1074/jbc.M111.303917. Epub 2011 Oct 25.


Identification of human P2X1 receptor-interacting proteins reveals a role of the cytoskeleton in receptor regulation.

Lalo U, Roberts JA, Evans RJ.

J Biol Chem. 2011 Sep 2;286(35):30591-9. doi: 10.1074/jbc.M111.253153. Epub 2011 Jul 7.


Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating.

Allsopp RC, El Ajouz S, Schmid R, Evans RJ.

J Biol Chem. 2011 Aug 19;286(33):29207-17. doi: 10.1074/jbc.M111.260364. Epub 2011 Jun 20.


Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop.

El-Ajouz S, Ray D, Allsopp RC, Evans RJ.

Br J Pharmacol. 2012 Jan;165(2):390-400. doi: 10.1111/j.1476-5381.2011.01534.x.


The P2X1 receptor and platelet function.

Mahaut-Smith MP, Jones S, Evans RJ.

Purinergic Signal. 2011 Sep;7(3):341-56. doi: 10.1007/s11302-011-9224-0. Epub 2011 Mar 22.


Proof of concept trial of tanezumab for the treatment of symptoms associated with interstitial cystitis.

Evans RJ, Moldwin RM, Cossons N, Darekar A, Mills IW, Scholfield D.

J Urol. 2011 May;185(5):1716-21. doi: 10.1016/j.juro.2010.12.088. Epub 2011 Mar 21.


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