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Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery.

Dovc K, Boughton C, Tauschmann M, Thabit H, Bally L, Allen JM, Acerini CL, Arnolds S, de Beaufort C, Bergenstal RM, Campbell F, Criego A, Dunger DB, Elleri D, Evans ML, Fröhlich-Reiterer E, Hofer S, Kapellen T, Leelarathna L, Pieber TR, Rami-Merhar B, Shah VN, Sibayan J, Wilinska ME, Hovorka R; APCam11, AP@Home, and KidsAP Consortia.

Diabetes Care. 2019 Jul;42(7):1344-1347. doi: 10.2337/dc18-2625. Epub 2019 May 21.


Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis.

Bally L, Gubler P, Thabit H, Hartnell S, Ruan Y, Wilinska ME, Evans ML, Semmo M, Vogt B, Coll AP, Stettler C, Hovorka R.

Kidney Int. 2019 Mar 20. pii: S0085-2538(19)30322-9. doi: 10.1016/j.kint.2019.03.006. [Epub ahead of print]


Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial.

Boughton CK, Bally L, Martignoni F, Hartnell S, Herzig D, Vogt A, Wertli MM, Wilinska ME, Evans ML, Coll AP, Stettler C, Hovorka R.

Lancet Diabetes Endocrinol. 2019 May;7(5):368-377. doi: 10.1016/S2213-8587(19)30061-0. Epub 2019 Mar 29.


Evaluating Glucose Control With a Novel Composite Continuous Glucose Monitoring Index.

Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R.

J Diabetes Sci Technol. 2019 Mar 31:1932296819838525. doi: 10.1177/1932296819838525. [Epub ahead of print]


Technology to overcome clinical inertia in insulin therapy.

Evans ML, Golubic R.

Lancet. 2019 Mar 16;393(10176):1078-1080. doi: 10.1016/S0140-6736(19)30416-7. Epub 2019 Feb 23. No abstract available.


A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabetes (onset 5).

Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, DeVries JH, Graungaard T, Hyseni A, Gondolf T, Battelino T.

Diabetes Obes Metab. 2018 Dec 9. doi: 10.1111/dom.13610. [Epub ahead of print]


Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial.

Tauschmann M, Thabit H, Bally L, Allen JM, Hartnell S, Wilinska ME, Ruan Y, Sibayan J, Kollman C, Cheng P, Beck RW, Acerini CL, Evans ML, Dunger DB, Elleri D, Campbell F, Bergenstal RM, Criego A, Shah VN, Leelarathna L, Hovorka R; APCam11 Consortium.

Lancet. 2018 Oct 13;392(10155):1321-1329. doi: 10.1016/S0140-6736(18)31947-0. Epub 2018 Oct 3. Erratum in: Lancet. 2018 Oct 13;392(10155):1310.


Parental consent: an unnecessary barrier to adolescent obstetrical care.

Bortoletto P, Dethier D, Evans ML, Tracy EE.

Am J Obstet Gynecol. 2018 Nov;219(5):451.e1-451.e5. doi: 10.1016/j.ajog.2018.08.029. Epub 2018 Aug 28.


Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes.

Chakera AJ, Hurst PS, Spyer G, Ogunnowo-Bada EO, Marsh WJ, Riches CH, Yueh CY, Markkula SP, Dalley JW, Cox RD, Macdonald IA, Amiel SA, MacLeod KM, Heisler LK, Hattersley AT, Evans ML.

Mol Metab. 2018 Nov;17:17-27. doi: 10.1016/j.molmet.2018.08.001. Epub 2018 Aug 13.


Amyloid by Design: Intrinsic Regulation of Microbial Amyloid Assembly.

Deshmukh M, Evans ML, Chapman MR.

J Mol Biol. 2018 Oct 12;430(20):3631-3641. doi: 10.1016/j.jmb.2018.07.007. Epub 2018 Jul 12. Review.


Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care.

Bally L, Thabit H, Hartnell S, Andereggen E, Ruan Y, Wilinska ME, Evans ML, Wertli MM, Coll AP, Stettler C, Hovorka R.

N Engl J Med. 2018 Aug 9;379(6):547-556. doi: 10.1056/NEJMoa1805233. Epub 2018 Jun 25.


Sodiation and Desodiation via Helical Phosphorus Intermediates in High-Capacity Anodes for Sodium-Ion Batteries.

Marbella LE, Evans ML, Groh MF, Nelson J, Griffith KJ, Morris AJ, Grey CP.

J Am Chem Soc. 2018 Jun 27;140(25):7994-8004. doi: 10.1021/jacs.8b04183. Epub 2018 Jun 19.


Bacterial Amyloids.

Evans ML, Gichana E, Zhou Y, Chapman MR.

Methods Mol Biol. 2018;1779:267-288. doi: 10.1007/978-1-4939-7816-8_17.


Heliox Adjunct Therapy for Neonates With Congenital Diaphragmatic Hernia.

Wise AC, Boutin MA, Knodel EM, Proudfoot JA, Lane BP, Evans ML, Suttner DM, Kimball AL.

Respir Care. 2018 Sep;63(9):1147-1153. doi: 10.4187/respcare.06079. Epub 2018 May 22.


Community-based pre-pregnancy care programme improves pregnancy preparation in women with pregestational diabetes.

Yamamoto JM, Hughes DJF, Evans ML, Karunakaran V, Clark JDA, Morrish NJ, Rayman GA, Winocour PH, Hambling C, Harries AW, Sampson MJ, Murphy HR.

Diabetologia. 2018 Jul;61(7):1528-1537. doi: 10.1007/s00125-018-4613-3. Epub 2018 May 9.


Sustained Reduction in Severe Hypoglycemia in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: Two-Year Follow-up in the HypoCOMPaSS Randomized Clinical Trial.

Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Lubina-Solomon A, Chadwick TJ, Stocken DD, Brennand C, Marshall SM, Wood R, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM.

Diabetes Care. 2018 Aug;41(8):1600-1607. doi: 10.2337/dc17-2682. Epub 2018 Apr 16.


Hypoglycaemia incidence and recovery during home use of hybrid closed-loop insulin delivery in adults with type 1 diabetes.

Ruan Y, Bally L, Thabit H, Leelarathna L, Hartnell S, Tauschmann M, Wilinska ME, Evans ML, Mader JK, Kojzar H, Dellweg S, Benesch C, Arnolds S, Pieber TR, Hovorka R.

Diabetes Obes Metab. 2018 Aug;20(8):2004-2008. doi: 10.1111/dom.13304. Epub 2018 Apr 16.


Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C.

Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. Epub 2018 Feb 7.


Use of Long-Acting Reversible Contraception by Obstetrics and Gynecology Residents: An Examination of Access for All Women.

Evans ML, Espey E, Ogburn T, Zite NB.

Obstet Gynecol. 2018 Mar;131(3):538-541. doi: 10.1097/AOG.0000000000002489.


Training Physicians in Advocacy: Why It Matters.

Aksel S, Evans ML, Gellhaus TM.

Obstet Gynecol. 2017 Dec;130(6):1334-1337. doi: 10.1097/AOG.0000000000002335.


Inhibition of curli assembly and Escherichia coli biofilm formation by the human systemic amyloid precursor transthyretin.

Jain N, Ådén J, Nagamatsu K, Evans ML, Li X, McMichael B, Ivanova MI, Almqvist F, Buxbaum JN, Chapman MR.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12184-12189. doi: 10.1073/pnas.1708805114. Epub 2017 Oct 30.


Lorcaserin improves glycemic control via a melanocortin neurocircuit.

Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, Heisler LK.

Mol Metab. 2017 Oct;6(10):1092-1102. doi: 10.1016/j.molmet.2017.07.004. Epub 2017 Jul 21.


A new integrated care pathway for ambulance attended severe hypoglycaemia in the East of England: The Eastern Academic Health Science Network (EAHSN) model.

Sampson M, Bailey M, Clark J, Evans ML, Fong R, Hall H, Hambling C, Hadley-Brown M, Morrish N, Murphy H, Rayman GA, Vithian K, Winocour P, Harries A.

Diabetes Res Clin Pract. 2017 Nov;133:50-59. doi: 10.1016/j.diabres.2017.08.017. Epub 2017 Sep 1.


Bolusing frequency and amount impacts glucose control during hybrid closed-loop.

Bally L, Thabit H, Ruan Y, Mader JK, Kojzar H, Dellweg S, Benesch C, Hartnell S, Leelarathna L, Wilinska ME, Evans ML, Arnolds S, Pieber TR, Hovorka R.

Diabet Med. 2018 Mar;35(3):347-351. doi: 10.1111/dme.13436. Epub 2017 Aug 19.


Assessing the effectiveness of a 3-month day-and-night home closed-loop control combined with pump suspend feature compared with sensor-augmented pump therapy in youths and adults with suboptimally controlled type 1 diabetes: a randomised parallel study protocol.

Bally L, Thabit H, Tauschmann M, Allen JM, Hartnell S, Wilinska ME, Exall J, Huegel V, Sibayan J, Borgman S, Cheng P, Blackburn M, Lawton J, Elleri D, Leelarathna L, Acerini CL, Campbell F, Shah VN, Criego A, Evans ML, Dunger DB, Kollman C, Bergenstal RM, Hovorka R.

BMJ Open. 2017 Jul 13;7(7):e016738. doi: 10.1136/bmjopen-2017-016738.


Revolving Loan Fund: A Novel Approach to Increasing Access to Long-Acting Reversible Contraception Methods in Community Health Centers.

Evans ML, Breeze JL, Paulus JK, Meadows A.

J Public Health Manag Pract. 2017 Nov/Dec;23(6):684-689. doi: 10.1097/PHH.0000000000000607.


Behavioral Patterns and Associations with Glucose Control During 12-Week Randomized Free-Living Clinical Trial of Day and Night Hybrid Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes.

Emami A, Willinska ME, Thabit H, Leelarathna L, Hartnell S, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Pieber TR, Arnolds S, Evans ML, Hovorka R.

Diabetes Technol Ther. 2017 Jul;19(7):433-437. doi: 10.1089/dia.2016.0307. Epub 2017 May 2.


Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.

Ruan Y, Thabit H, Leelarathna L, Hartnell S, Wilinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home consortium.

Diabetes Obes Metab. 2017 Oct;19(10):1485-1489. doi: 10.1111/dom.12956. Epub 2017 Jun 23.


Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy.

Barnard KD, Wysocki T, Ully V, Mader JK, Pieber TR, Thabit H, Tauschmann M, Leelarathna L, Hartnell S, Acerini CL, Wilinska ME, Dellweg S, Benesch C, Arnolds S, Holzer M, Kojzar H, Campbell F, Yong J, Pichierri J, Hindmarsh P, Heinemann L, Evans ML, Hovorka R.

J Diabetes Sci Technol. 2017 Nov;11(6):1080-1088. doi: 10.1177/1932296817702656. Epub 2017 Apr 3.


Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study.

Bally L, Thabit H, Kojzar H, Mader JK, Qerimi-Hyseni J, Hartnell S, Tauschmann M, Allen JM, Wilinska ME, Pieber TR, Evans ML, Hovorka R.

Lancet Diabetes Endocrinol. 2017 Apr;5(4):261-270. doi: 10.1016/S2213-8587(17)30001-3. Epub 2017 Jan 14.


Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial.

Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R.

Lancet Diabetes Endocrinol. 2017 Feb;5(2):117-124. doi: 10.1016/S2213-8587(16)30280-7. Epub 2016 Nov 9.


Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats.

Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML.

Endocrinology. 2016 Dec;157(12):4669-4676. Epub 2016 Oct 14.


The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli.

Hufnagel DA, Evans ML, Greene SE, Pinkner JS, Hultgren SJ, Chapman MR.

J Bacteriol. 2016 Nov 18;198(24):3329-3334. Print 2016 Dec 15.


Exhaled Breath Isoprene Rises During Hypoglycemia in Type 1 Diabetes.

Neupane S, Peverall R, Richmond G, Blaikie TP, Taylor D, Hancock G, Evans ML.

Diabetes Care. 2016 Jul;39(7):e97-8. doi: 10.2337/dc16-0461. No abstract available.


Rapid Benefits of Structured Optimization and Sensor-Augmented Insulin Pump Therapy in Adults With Type 1 Diabetes.

Leelarathna L, Thabit H, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R; AP@home Consortium.

J Diabetes Sci Technol. 2017 Jan;11(1):180-181. doi: 10.1177/1932296816654715. Epub 2016 Jul 9. No abstract available.


Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons.

Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, Low MJ, Rochford JJ, Myers MG, Evans ML, Heisler LK.

Mol Metab. 2016 Jan 22;5(3):245-252. doi: 10.1016/j.molmet.2016.01.005. eCollection 2016 Mar.


Variability of Insulin Requirements Over 12 Weeks of Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes.

Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home Consortium.

Diabetes Care. 2016 May;39(5):830-2. doi: 10.2337/dc15-2623. Epub 2016 Mar 10.


Low-Blood Glucose Avoidance Training Improves Glycemic Variability in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: HypoCOMPaSS Trial.

Tan HK, Little SA, Leelarathna L, Walkinshaw E, Lubina-Solomon A, Hosking J, Speight J, Kerr D, Heller SR, Evans ML, Shaw JA, Flanagan D.

Diabetes Care. 2016 Apr;39(4):e56-8. doi: 10.2337/dc15-2431. Epub 2016 Mar 7. No abstract available.


Connect the Dots-January 2016.

Chescheir NC, Zeligs KP, Easter SR, Evans ML.

Obstet Gynecol. 2016 Jan;127(1):159-60. doi: 10.1097/AOG.0000000000001216. No abstract available.


Bacterial Chaperones CsgE and CsgC Differentially Modulate Human α-Synuclein Amyloid Formation via Transient Contacts.

Chorell E, Andersson E, Evans ML, Jain N, Götheson A, Åden J, Chapman MR, Almqvist F, Wittung-Stafshede P.

PLoS One. 2015 Oct 14;10(10):e0140194. doi: 10.1371/journal.pone.0140194. eCollection 2015.


Balancing Life and Work in a 2-Physician Relationship: Redefining the "Power Couple".

Ryan SP, Evans ML.

J Orthop Trauma. 2015 Nov;29 Suppl 11:S21-2. doi: 10.1097/BOT.0000000000000432. Review.


Factors Associated With Glycemic Control During Free-Living Overnight Closed-Loop Insulin Delivery in Children and Adults With Type 1 Diabetes.

Tauschmann M, Thabit H, Leelarathna L, Elleri D, Allen JM, Lubina-Solomon A, Stadler M, Walkinshaw E, Iqbal A, Choudhary P, Wilinska ME, Heller SR, Amiel SA, Evans ML, Dunger DB, Hovorka R.

J Diabetes Sci Technol. 2015 Oct 7;9(6):1346-7. doi: 10.1177/1932296815604439. No abstract available.


Too Much or Too Little? The Double Jeopardy of Subcutaneous Insulin Therapy in Diabetes.

Evans ML.

Diabetes. 2015 Oct;64(10):3353-4. doi: 10.2337/dbi15-0003. No abstract available.


Home Use of an Artificial Beta Cell in Type 1 Diabetes.

Thabit H, Tauschmann M, Allen JM, Leelarathna L, Hartnell S, Wilinska ME, Acerini CL, Dellweg S, Benesch C, Heinemann L, Mader JK, Holzer M, Kojzar H, Exall J, Yong J, Pichierri J, Barnard KD, Kollman C, Cheng P, Hindmarsh PC, Campbell FM, Arnolds S, Pieber TR, Evans ML, Dunger DB, Hovorka R.

N Engl J Med. 2015 Nov 26;373(22):2129-2140. doi: 10.1056/NEJMoa1509351. Epub 2015 Sep 17.


Accuracy of Continuous Glucose Monitoring During Three Closed-Loop Home Studies Under Free-Living Conditions.

Thabit H, Leelarathna L, Wilinska ME, Elleri D, Allen JM, Lubina-Solomon A, Walkinshaw E, Stadler M, Choudhary P, Mader JK, Dellweg S, Benesch C, Pieber TR, Arnolds S, Heller SR, Amiel SA, Dunger D, Evans ML, Hovorka R.

Diabetes Technol Ther. 2015 Nov;17(11):801-7. doi: 10.1089/dia.2015.0062. Epub 2015 Aug 4.


Holistic Impact of Closed-Loop Technology on People With Type 1 Diabetes.

Young AJ, Thabit H, Heller SR, Evans ML, Amiel SA, Hovorka R, Barnard KD.

J Diabetes Sci Technol. 2015 Jul;9(4):932-3. doi: 10.1177/1932296815580162. Epub 2015 Apr 7. No abstract available.


Predicting risk of severe hypoglycaemia in type 2 diabetes.

Neupane S, Evans ML.

Diabetologia. 2015 Jun;58(6):1143-5. doi: 10.1007/s00125-015-3550-7. Epub 2015 Mar 21.


Transcriptomic responses of Atlantic salmon (Salmo salar) to environmental enrichment during juvenile rearing.

Evans ML, Hori TS, Rise ML, Fleming IA.

PLoS One. 2015 Mar 5;10(3):e0118378. doi: 10.1371/journal.pone.0118378. eCollection 2015.


The bacterial curli system possesses a potent and selective inhibitor of amyloid formation.

Evans ML, Chorell E, Taylor JD, Åden J, Götheson A, Li F, Koch M, Sefer L, Matthews SJ, Wittung-Stafshede P, Almqvist F, Chapman MR.

Mol Cell. 2015 Feb 5;57(3):445-55. doi: 10.1016/j.molcel.2014.12.025. Epub 2015 Jan 22.


Psychosocial aspects of closed- and open-loop insulin delivery: closing the loop in adults with Type 1 diabetes in the home setting.

Barnard KD, Wysocki T, Thabit H, Evans ML, Amiel S, Heller S, Young A, Hovorka R; Angela Consortium.

Diabet Med. 2015 May;32(5):601-8. doi: 10.1111/dme.12706. Epub 2015 Feb 20.


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