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Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.

Bazin HG, Bess LS, Livesay MT, Li Y, Cybulski V, Miller SM, Johnson DA, Evans JT.

Bioorg Med Chem Lett. 2020 Mar 15;30(6):126984. doi: 10.1016/j.bmcl.2020.126984. Epub 2020 Jan 22.


Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis.

Ryter KT, Ettenger G, Rasheed OK, Buhl C, Child R, Miller SM, Holley D, Smith AJ, Evans JT.

J Med Chem. 2020 Jan 9;63(1):309-320. doi: 10.1021/acs.jmedchem.9b01598. Epub 2019 Dec 20.


Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity.

Short KK, Miller SM, Walsh L, Cybulski V, Bazin H, Evans JT, Burkhart D.

J Control Release. 2019 Dec 10;315:186-196. doi: 10.1016/j.jconrel.2019.10.025. Epub 2019 Oct 22.


Synthetic Toll-like Receptors 7 and 8 Agonists: Structure-Activity Relationship in the Oxoadenine Series.

Evans JT, Bess LS, Mwakwari SC, Livesay MT, Li Y, Cybulski V, Johnson DA, Bazin HG.

ACS Omega. 2019 Sep 10;4(13):15665-15677. doi: 10.1021/acsomega.9b02138. eCollection 2019 Sep 24.


Knee and hip replacements and the risk of revision - Authors' reply.

Evans JT, Blom AW, Sayers A, Whitehouse MR.

Lancet. 2019 Aug 31;394(10200):e31. doi: 10.1016/S0140-6736(19)31827-6. No abstract available.


How might the longer-than-expected lifetimes of hip and knee replacements affect clinical practice?

Fowler TJ, Blom AW, Sayers A, Whitehouse MR, Evans JT.

Expert Rev Med Devices. 2019 Sep;16(9):753-755. doi: 10.1080/17434440.2019.1654857. Epub 2019 Aug 14. No abstract available.


Genome evolution and host-microbiome shifts correspond with intraspecific niche divergence within harmful algal bloom-forming Microcystis aeruginosa.

Jackrel SL, White JD, Evans JT, Buffin K, Hayden K, Sarnelle O, Denef VJ.

Mol Ecol. 2019 Sep;28(17):3994-4011. doi: 10.1111/mec.15198. Epub 2019 Aug 22.


Interprofessional Coaches: Preparing Faculty to Facilitate Interprofessional Education.

Evans JT, Rock M, Delp J.

Nurse Educ. 2019 Jul 13. doi: 10.1097/NNE.0000000000000706. [Epub ahead of print] No abstract available.


Partial versus total knee replacement for knee osteoarthritis.

Evans JT, Whitehouse MR.

Lancet. 2019 Aug 31;394(10200):712-713. doi: 10.1016/S0140-6736(19)31612-5. Epub 2019 Jul 17. No abstract available.


Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study.

Primrose JN, Fox RP, Palmer DH, Malik HZ, Prasad R, Mirza D, Anthony A, Corrie P, Falk S, Finch-Jones M, Wasan H, Ross P, Wall L, Wadsley J, Evans JTR, Stocken D, Praseedom R, Ma YT, Davidson B, Neoptolemos JP, Iveson T, Raftery J, Zhu S, Cunningham D, Garden OJ, Stubbs C, Valle JW, Bridgewater J; BILCAP study group.

Lancet Oncol. 2019 May;20(5):663-673. doi: 10.1016/S1470-2045(18)30915-X. Epub 2019 Mar 25. Erratum in: Lancet Oncol. 2019 Apr 2;:.


Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists.

Smith AJ, Miller SM, Buhl C, Child R, Whitacre M, Schoener R, Ettenger G, Burkhart D, Ryter K, Evans JT.

Front Immunol. 2019 Feb 28;10:338. doi: 10.3389/fimmu.2019.00338. eCollection 2019.


How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up.

Evans JT, Walker RW, Evans JP, Blom AW, Sayers A, Whitehouse MR.

Lancet. 2019 Feb 16;393(10172):655-663. doi: 10.1016/S0140-6736(18)32531-5. Epub 2019 Feb 14. Erratum in: Lancet. 2019 Feb 20;:.


How long does a hip replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up.

Evans JT, Evans JP, Walker RW, Blom AW, Whitehouse MR, Sayers A.

Lancet. 2019 Feb 16;393(10172):647-654. doi: 10.1016/S0140-6736(18)31665-9. Epub 2019 Feb 14.


Mycobacterium tuberculosis transmission in an ethnically-diverse high incidence region in England, 2007-11.

Vynnycky E, Keen AR, Evans JT, Khanom S, Hawkey PM, White RG, Abubakar I.

BMC Infect Dis. 2019 Jan 7;19(1):26. doi: 10.1186/s12879-018-3585-8.


Are competing risks models appropriate to describe implant failure?

Sayers A, Evans JT, Whitehouse MR, Blom AW.

Acta Orthop. 2018 Jun;89(3):256-258. doi: 10.1080/17453674.2018.1444876. Epub 2018 Mar 9.


Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties.

Smith AJ, Graves B, Child R, Rice PJ, Ma Z, Lowman DW, Ensley HE, Ryter KT, Evans JT, Williams DL.

J Immunol. 2018 Jan 15;200(2):788-799. doi: 10.4049/jimmunol.1701258. Epub 2017 Dec 15.


Clinical features of serous retinopathy observed with cobimetinib in patients with BRAF-mutated melanoma treated in the randomized coBRIM study.

de la Cruz-Merino L, Di Guardo L, Grob JJ, Venosa A, Larkin J, McArthur GA, Ribas A, Ascierto PA, Evans JTR, Gomez-Escobar A, Barteselli G, Eng S, Hsu JJ, Uyei A, Dréno B.

J Transl Med. 2017 Jun 24;15(1):146. doi: 10.1186/s12967-017-1246-0.


Evaluation of three sample preparation methods for the direct identification of bacteria in positive blood cultures by MALDI-TOF.

Tanner H, Evans JT, Gossain S, Hussain A.

BMC Res Notes. 2017 Jan 18;10(1):48. doi: 10.1186/s13104-016-2366-y.


Leg injuries and wound repair among cosmetid harvestmen (Arachnida, Opiliones, Laniatores).

Townsend VR Jr, Schaus MH, Zvonareva T, Illinik JJ, Evans JT.

J Morphol. 2017 Jan;278(1):73-88. doi: 10.1002/jmor.20620. Epub 2016 Nov 8.


Programmatic utility of tuberculosis cluster investigation using a social network approach in Birmingham, United Kingdom.

Munang ML, Browne C, Evans JT, Smith EG, Hawkey PM, Welch SB, Kaur H, Dedicoat MJ.

Int J Tuberc Lung Dis. 2016 Oct;20(10):1300-1305.


Enhanced Electrical Resistivity and Properties via Ion Bombardment of Ferroelectric Thin Films.

Saremi S, Xu R, Dedon LR, Mundy JA, Hsu SL, Chen Z, Damodaran AR, Chapman SP, Evans JT, Martin LW.

Adv Mater. 2016 Dec;28(48):10750-10756. doi: 10.1002/adma.201603968. Epub 2016 Oct 10.


Improve manager competency with experiential learning.

McKinney P, Evans JT, McKay R.

Nurs Manage. 2016 Oct;47(10):46-9. doi: 10.1097/01.NUMA.0000499568.02763.1b. No abstract available.


Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants.

Smith AJ, Li Y, Bazin HG, St-Jean JR, Larocque D, Evans JT, Baldridge JR.

Vaccine. 2016 Aug 5;34(36):4304-12. doi: 10.1016/j.vaccine.2016.06.080. Epub 2016 Jul 9.


Complications associated with opening wedge high tibial osteotomy--A review of the literature and of 15 years of experience.

Woodacre T, Ricketts M, Evans JT, Pavlou G, Schranz P, Hockings M, Toms A.

Knee. 2016 Mar;23(2):276-82. doi: 10.1016/j.knee.2015.09.018. Epub 2015 Nov 17. Review.


PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination.

Oberoi HS, Yorgensen YM, Morasse A, Evans JT, Burkhart DJ.

J Control Release. 2016 Feb 10;223:64-74. doi: 10.1016/j.jconrel.2015.11.006. Epub 2015 Nov 6.


Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually.

Spinner JL, Oberoi HS, Yorgensen YM, Poirier DS, Burkhart DJ, Plante M, Evans JT.

Vaccine. 2015 Oct 26;33(43):5845-5853. doi: 10.1016/j.vaccine.2015.08.086. Epub 2015 Sep 21.


Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives.

Bazin HG, Li Y, Khalaf JK, Mwakwari S, Livesay MT, Evans JT, Johnson DA.

Bioorg Med Chem Lett. 2015 Mar 15;25(6):1318-23. doi: 10.1016/j.bmcl.2015.01.037. Epub 2015 Jan 31.


Tuberculosis microepidemics among dispersed migrants, Birmingham, UK, 2004-2013.

Munang ML, Browne C, Khanom S, Evans JT, Smith EG, Hawkey PM, Kunst H, Welch SB, Dedicoat MJ.

Emerg Infect Dis. 2015 Mar;21(3):524-7. doi: 10.3201/eid2103.140209.


Delaying the onset of treadmill exercise following peripheral nerve injury has different effects on axon regeneration and motoneuron synaptic plasticity.

Brandt J, Evans JT, Mildenhall T, Mulligan A, Konieczny A, Rose SJ, English AW.

J Neurophysiol. 2015 Apr 1;113(7):2390-9. doi: 10.1152/jn.00892.2014. Epub 2015 Jan 28.


Characterization of TRIF selectivity in the AGP class of lipid A mimetics: role of secondary lipid chains.

Khalaf JK, Bowen WS, Bazin HG, Ryter KT, Livesay MT, Ward JR, Evans JT, Johnson DA.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):547-53. doi: 10.1016/j.bmcl.2014.12.024. Epub 2014 Dec 17.


Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection.

Maroof A, Yorgensen YM, Li Y, Evans JT.

PLoS Pathog. 2014 Jan;10(1):e1003875. doi: 10.1371/journal.ppat.1003875. Epub 2014 Jan 23.


Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection.

Hingley-Wilson SM, Casey R, Connell D, Bremang S, Evans JT, Hawkey PM, Smith GE, Jepson A, Philip S, Kon OM, Lalvani A.

Emerg Infect Dis. 2013 Jul;19(7):1138-41. doi: 10.3201/1907.130313.


Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study.

Walker TM, Ip CL, Harrell RH, Evans JT, Kapatai G, Dedicoat MJ, Eyre DW, Wilson DJ, Hawkey PM, Crook DW, Parkhill J, Harris D, Walker AS, Bowden R, Monk P, Smith EG, Peto TE.

Lancet Infect Dis. 2013 Feb;13(2):137-46. doi: 10.1016/S1473-3099(12)70277-3. Epub 2012 Nov 15.


Displaced femoral neck stress fractures in Royal Marine recruits--management and results of operative treatment.

Evans JT, Guyver PM, Kassam AM, Hubble MJ.

J R Nav Med Serv. 2012;98(2):3-5.


Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist.

Bowen WS, Minns LA, Johnson DA, Mitchell TC, Hutton MM, Evans JT.

Sci Signal. 2012 Feb 14;5(211):ra13. doi: 10.1126/scisignal.2001963.


A geographically-restricted but prevalent Mycobacterium tuberculosis strain identified in the West Midlands Region of the UK between 1995 and 2008.

Evans JT, Serafino Wani RL, Anderson L, Gibson AL, Smith EG, Wood A, Olowokure B, Abubakar I, Mann JS, Gardiner S, Jones H, Sonnenberg P, Hawkey PM.

PLoS One. 2011 Mar 25;6(3):e17930. doi: 10.1371/journal.pone.0017930.


Investigating transmission of Mycobacterium bovis in the United Kingdom in 2005 to 2008.

Mandal S, Bradshaw L, Anderson LF, Brown T, Evans JT, Drobniewski F, Smith G, Magee JG, Barrett A, Blatchford O, Laurenson IF, Seagar AL, Ruddy M, White PL, Myers R, Hawkey P, Abubakar I.

J Clin Microbiol. 2011 May;49(5):1943-50. doi: 10.1128/JCM.02299-10. Epub 2011 Mar 23.


Intragastric balloon therapy in the management of obesity: why the bad wrap?

Evans JT, DeLegge MH.

JPEN J Parenter Enteral Nutr. 2011 Jan;35(1):25-31. doi: 10.1177/0148607110374476. Review.


Primary hepatic gastrinoma: an unusual case of zollinger-ellison syndrome.

Evans JT, Nickles S, Hoffman BJ.

Gastroenterol Hepatol (N Y). 2010 Jan;6(1):53-6. No abstract available.


Global Origin of Mycobacterium tuberculosis in the Midlands, UK.

Evans JT, Gardiner S, Smith EG, Webber R, Hawkey PM.

Emerg Infect Dis. 2010 Mar;16(3):542-5. doi: 10.3201/eid1603.090813.


Management of the trauma patient: what happens after the patient leaves Afghanistan--a 40 Commando Royal Marines perspective.

Evans JT, Wood AM, Wood IM.

J R Nav Med Serv. 2010;96(3):146-9. No abstract available.


A tale of two STAT6 knock out mice in the induction of experimental autoimmune encephalomyelitis.

Wang Y, Evans JT, Rodriguez F, Fields P, Mueller C, Chitnis T, Khoury SJ, Bynoe MS.

J Neuroimmunol. 2009 Jan 3;206(1-2):76-85. doi: 10.1016/j.jneuroim.2008.11.003. Epub 2008 Dec 18.


Predominance of CTX-M-15 extended spectrum beta-lactamases in diverse Escherichia coli and Klebsiella pneumoniae from hospital and community patients in Kuwait.

Ensor VM, Jamal W, Rotimi VO, Evans JT, Hawkey PM.

Int J Antimicrob Agents. 2009 May;33(5):487-9. doi: 10.1016/j.ijantimicag.2008.10.011. Epub 2008 Dec 20. No abstract available.


Application of denaturing HPLC to rapidly identify rifampicin-resistant Mycobacterium tuberculosis in low- and high-prevalence areas.

Evans JT, Parveen A, Smith GE, Xu L, Chan EW, Chan RC, Hawkey PM.

J Antimicrob Chemother. 2009 Feb;63(2):295-301. doi: 10.1093/jac/dkn506. Epub 2008 Dec 18.


The 'Ethereal' nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics.

Bazin HG, Murray TJ, Bowen WS, Mozaffarian A, Fling SP, Bess LS, Livesay MT, Arnold JS, Johnson CL, Ryter KT, Cluff CW, Evans JT, Johnson DA.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5350-4. doi: 10.1016/j.bmcl.2008.09.060. Epub 2008 Sep 19.


Rituximab-responsive cryoglobulinemic glomerulonephritis in a patient with autoimmune hepatitis.

Evans JT, Shepard MM, Oates JC, Self SE, Reuben A.

J Clin Gastroenterol. 2008 Aug;42(7):862-3. doi: 10.1097/MCG.0b013e3180f60b7a. No abstract available.


Genome analysis shows a common evolutionary origin for the dominant strains of Mycobacterium tuberculosis in a UK South Asian community.

Menéndez MC, Buxton RS, Evans JT, Gascoyne-Binzi D, Barlow RE, Hinds J, Hawkey PM, Colston MJ.

Tuberculosis (Edinb). 2007 Sep;87(5):426-36. Epub 2007 Aug 23. Erratum in: Tuberculosis (Edinb). 2008 Sep;88(5):503.


Cluster of human tuberculosis caused by Mycobacterium bovis: evidence for person-to-person transmission in the UK.

Evans JT, Smith EG, Banerjee A, Smith RM, Dale J, Innes JA, Hunt D, Tweddell A, Wood A, Anderson C, Hewinson RG, Smith NH, Hawkey PM, Sonnenberg P.

Lancet. 2007 Apr 14;369(9569):1270-1276. doi: 10.1016/S0140-6736(07)60598-4.


Careers in surgery.

Evans JT.

Bull Am Coll Surg. 2001 Sep;86(9):42. No abstract available.


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