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Items: 35


Diversification of polyketide structures via synthase engineering.

Kornfuehrer T, Eustáquio AS.

Medchemcomm. 2019 May 10;10(8):1256-1272. doi: 10.1039/c9md00141g. eCollection 2019 Aug 1. Review.


Heterologous Production of Lasso Peptide Capistruin in a Burkholderia Host.

Kunakom S, Eustáquio AS.

ACS Synth Biol. 2020 Feb 21;9(2):241-248. doi: 10.1021/acssynbio.9b00438. Epub 2020 Jan 13.


Scytodecamide from the Cultured Scytonema sp. UIC 10036 Expands the Chemical and Genetic Diversity of Cyanobactins.

Crnkovic CM, Braesel J, Krunic A, Eustáquio AS, Orjala J.

Chembiochem. 2020 Mar 16;21(6):845-852. doi: 10.1002/cbic.201900511. Epub 2019 Nov 26.


Burkholderia as a Source of Natural Products.

Kunakom S, Eustáquio AS.

J Nat Prod. 2019 Jul 26;82(7):2018-2037. doi: 10.1021/acs.jnatprod.8b01068. Epub 2019 Jul 11.


Natural Products and Synthetic Biology: Where We Are and Where We Need To Go.

Kunakom S, Eustáquio AS.

mSystems. 2019 May 14;4(3). pii: e00113-19. doi: 10.1128/mSystems.00113-19.


Heterologous expression of the diazaquinomycin biosynthetic gene cluster.

Braesel J, Tran TA, Eustáquio AS.

J Ind Microbiol Biotechnol. 2019 Oct;46(9-10):1359-1364. doi: 10.1007/s10295-019-02187-1. Epub 2019 May 15.


Genome Sequence of Marine-Derived Streptomyces sp. Strain F001, a Producer of Akashin A and Diazaquinomycins.

Braesel J, Clark CM, Kunstman KJ, Green SJ, Maienschein-Cline M, Murphy BT, Eustáquio AS.

Microbiol Resour Announc. 2019 May 9;8(19). pii: e00165-19. doi: 10.1128/MRA.00165-19.


Diazaquinomycin Biosynthetic Gene Clusters from Marine and Freshwater Actinomycetes.

Braesel J, Lee JH, Arnould B, Murphy BT, Eustáquio AS.

J Nat Prod. 2019 Apr 26;82(4):937-946. doi: 10.1021/acs.jnatprod.8b01028. Epub 2019 Mar 21.


Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.

Braesel J, Crnkovic CM, Kunstman KJ, Green SJ, Maienschein-Cline M, Orjala J, Murphy BT, Eustáquio AS.

J Nat Prod. 2018 Sep 28;81(9):2057-2068. doi: 10.1021/acs.jnatprod.8b00394. Epub 2018 Aug 15.


Preparation, Assay, and Application of Chlorinase SalL for the Chemoenzymatic Synthesis of S-Adenosyl-l-Methionine and Analogs.

Davis TD, Kunakom S, Burkart MD, Eustaquio AS.

Methods Enzymol. 2018;604:367-388. doi: 10.1016/bs.mie.2018.02.012. Epub 2018 Apr 2.


Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges.

Nicacio KJ, Ióca LP, Fróes AM, Leomil L, Appolinario LR, Thompson CC, Thompson FL, Ferreira AG, Williams DE, Andersen RJ, Eustaquio AS, Berlinck RG.

J Nat Prod. 2017 Feb 24;80(2):235-240. doi: 10.1021/acs.jnatprod.6b00838. Epub 2017 Feb 13.


Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.

Agarwal V, Miles ZD, Winter JM, Eustáquio AS, El Gamal AA, Moore BS.

Chem Rev. 2017 Apr 26;117(8):5619-5674. doi: 10.1021/acs.chemrev.6b00571. Epub 2017 Jan 20. Review.


Biosynthetic engineering and fermentation media development leads to gram-scale production of spliceostatin natural products in Burkholderia sp.

Eustáquio AS, Chang LP, Steele GL, O Donnell CJ, Koehn FE.

Metab Eng. 2016 Jan;33:67-75. doi: 10.1016/j.ymben.2015.11.003. Epub 2015 Nov 24.


Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase.

Eustáquio AS, Janso JE, Ratnayake AS, O'Donnell CJ, Koehn FE.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):E3376-85. doi: 10.1073/pnas.1408300111. Epub 2014 Aug 5.


Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica.

Janso JE, Haltli BA, Eustáquio AS, Kulowski K, Waldman AJ, Zha L, Nakamura H, Bernan VS, He H, Carter GT, Koehn FE, Balskus EP.

Tetrahedron. 2014 Jul 8;70(27-28):4156-4164.


Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A.

Jones AC, Ottilie S, Eustáquio AS, Edwards DJ, Gerwick L, Moore BS, Gerwick WH.

FEBS J. 2012 Apr;279(7):1243-51. doi: 10.1111/j.1742-4658.2012.08517.x. Epub 2012 Mar 1.


Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.

Lechner A, Eustáquio AS, Gulder TA, Hafner M, Moore BS.

Chem Biol. 2011 Dec 23;18(12):1527-36. doi: 10.1016/j.chembiol.2011.10.014.


Discovery and assembly-line biosynthesis of the lymphostin pyrroloquinoline alkaloid family of mTOR inhibitors in Salinispora bacteria.

Miyanaga A, Janso JE, McDonald L, He M, Liu H, Barbieri L, Eustáquio AS, Fielding EN, Carter GT, Jensen PR, Feng X, Leighton M, Koehn FE, Moore BS.

J Am Chem Soc. 2011 Aug 31;133(34):13311-3. doi: 10.1021/ja205655w. Epub 2011 Aug 9.


Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses.

Udwary DW, Gontang EA, Jones AC, Jones CS, Schultz AW, Winter JM, Yang JY, Beauchemin N, Capson TL, Clark BR, Esquenazi E, Eustáquio AS, Freel K, Gerwick L, Gerwick WH, Gonzalez D, Liu WT, Malloy KL, Maloney KN, Nett M, Nunnery JK, Penn K, Prieto-Davo A, Simmons TL, Weitz S, Wilson MC, Tisa LS, Dorrestein PC, Moore BS.

Appl Environ Microbiol. 2011 Jun;77(11):3617-25. doi: 10.1128/AEM.00038-11. Epub 2011 Apr 15.


The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution.

Eustáquio AS, Nam SJ, Penn K, Lechner A, Wilson MC, Fenical W, Jensen PR, Moore BS.

Chembiochem. 2011 Jan 3;12(1):61-4. doi: 10.1002/cbic.201000564. No abstract available.


Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.

Eustáquio AS, O'Hagan D, Moore BS.

J Nat Prod. 2010 Mar 26;73(3):378-82. doi: 10.1021/np900719u.


Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).

Deng H, McMahon SA, Eustáquio AS, Moore BS, Naismith JH, O'Hagan D.

Chembiochem. 2009 Oct 12;10(15):2455-9. doi: 10.1002/cbic.200900369. No abstract available.


Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

Liu Y, Hazzard C, Eustáquio AS, Reynolds KA, Moore BS.

J Am Chem Soc. 2009 Aug 5;131(30):10376-7. doi: 10.1021/ja9042824.


Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.

Eustáquio AS, McGlinchey RP, Liu Y, Hazzard C, Beer LL, Florova G, Alhamadsheh MM, Lechner A, Kale AJ, Kobayashi Y, Reynolds KA, Moore BS.

Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12295-300. doi: 10.1073/pnas.0901237106. Epub 2009 Jul 9.


S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.

Eustáquio AS, Härle J, Noel JP, Moore BS.

Chembiochem. 2008 Sep 22;9(14):2215-9. doi: 10.1002/cbic.200800341. No abstract available.


Advances in and applications of proteasome inhibitors.

Moore BS, Eustáquio AS, McGlinchey RP.

Curr Opin Chem Biol. 2008 Aug;12(4):434-40. doi: 10.1016/j.cbpa.2008.06.033. Epub 2008 Jul 24. Review.


novE and novG act as positive regulators of novobiocin biosynthesis.

Dangel V, Eustáquio AS, Gust B, Heide L.

Arch Microbiol. 2008 Nov;190(5):509-19. doi: 10.1007/s00203-008-0396-0. Epub 2008 Jun 21.


Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors.

McGlinchey RP, Nett M, Eustáquio AS, Asolkar RN, Fenical W, Moore BS.

J Am Chem Soc. 2008 Jun 25;130(25):7822-3. doi: 10.1021/ja8029398. Epub 2008 May 31.


Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome.

Eustáquio AS, Moore BS.

Angew Chem Int Ed Engl. 2008;47(21):3936-8. doi: 10.1002/anie.200800177. No abstract available.


Discovery and characterization of a marine bacterial SAM-dependent chlorinase.

Eustáquio AS, Pojer F, Noel JP, Moore BS.

Nat Chem Biol. 2008 Jan;4(1):69-74. Epub 2007 Dec 2.


NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.

Eustáquio AS, Li SM, Heide L.

Microbiology. 2005 Jun;151(Pt 6):1949-1961. doi: 10.1099/mic.0.27669-0.


Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters.

Eustáquio AS, Gust B, Galm U, Li SM, Chater KF, Heide L.

Appl Environ Microbiol. 2005 May;71(5):2452-9.


Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

Eustáquio AS, Gust B, Li SM, Pelzer S, Wohlleben W, Chater KF, Heide L.

Chem Biol. 2004 Nov;11(11):1561-72.


Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.

Eustáquio AS, Luft T, Wang ZX, Gust B, Chater KF, Li SM, Heide L.

Arch Microbiol. 2003 Jul;180(1):25-32. Epub 2003 May 8.


Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

Eustáquio AS, Gust B, Luft T, Li SM, Chater KF, Heide L.

Chem Biol. 2003 Mar;10(3):279-88.


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