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Items: 34

1.

The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers.

Bartneck M, Schrammen PL, Möckel D, Govaere O, Liepelt A, Krenkel O, Ergen C, McCain MV, Eulberg D, Luedde T, Trautwein C, Kiessling F, Reeves H, Lammers T, Tacke F.

Cell Mol Gastroenterol Hepatol. 2018 Oct 18;7(2):371-390. doi: 10.1016/j.jcmgh.2018.10.007. [Epub ahead of print]

2.

CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism.

Romoli S, Angelotti ML, Antonelli G, Kumar Vr S, Mulay SR, Desai J, Anguiano Gomez L, Thomasova D, Eulberg D, Klussmann S, Melica ME, Conte C, Lombardi D, Lasagni L, Anders HJ, Romagnani P.

Kidney Int. 2018 Dec;94(6):1111-1126. doi: 10.1016/j.kint.2018.08.013. Epub 2018 Oct 29.

3.

Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition.

Weisberg EL, Sattler M, Azab AK, Eulberg D, Kruschinski A, Manley PW, Stone R, Griffin JD.

Oncotarget. 2017 Nov 6;8(66):109973-109984. doi: 10.18632/oncotarget.22409. eCollection 2017 Dec 15.

4.

Reprint of "Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis".

Devarapu SK, Kumar Vr S, Rupanagudi KV, Kulkarni OP, Eulberg D, Klussmann S, Anders HJ.

Clin Immunol. 2017 Dec;185:119-127. doi: 10.1016/j.clim.2017.10.011. Epub 2017 Oct 28.

PMID:
29111236
5.

Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade.

Zboralski D, Hoehlig K, Eulberg D, Frömming A, Vater A.

Cancer Immunol Res. 2017 Nov;5(11):950-956. doi: 10.1158/2326-6066.CIR-16-0303. Epub 2017 Sep 28.

6.

Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.

Boels MGS, Koudijs A, Avramut MC, Sol WMPJ, Wang G, van Oeveren-Rietdijk AM, van Zonneveld AJ, de Boer HC, van der Vlag J, van Kooten C, Eulberg D, van den Berg BM, IJpelaar DHT, Rabelink TJ.

Am J Pathol. 2017 Nov;187(11):2430-2440. doi: 10.1016/j.ajpath.2017.07.020. Epub 2017 Aug 22.

7.

C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria.

Menne J, Eulberg D, Beyer D, Baumann M, Saudek F, Valkusz Z, Więcek A, Haller H; Emapticap Study Group.

Nephrol Dial Transplant. 2017 Feb 1;32(2):307-315. doi: 10.1093/ndt/gfv459.

8.

Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury.

Mossanen JC, Krenkel O, Ergen C, Govaere O, Liepelt A, Puengel T, Heymann F, Kalthoff S, Lefebvre E, Eulberg D, Luedde T, Marx G, Strassburg CP, Roskams T, Trautwein C, Tacke F.

Hepatology. 2016 Nov;64(5):1667-1682. doi: 10.1002/hep.28682. Epub 2016 Jul 22.

PMID:
27302828
9.

Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis.

Devarapu SK, Kumar Vr S, Rupanagudi KV, Kulkarni OP, Eulberg D, Klussmann S, Anders HJ.

Clin Immunol. 2016 Aug;169:139-147. doi: 10.1016/j.clim.2016.07.003. Epub 2016 Jul 5.

PMID:
27392463
10.

Gene redundancy of two-component (chloro)phenol hydroxylases in Rhodococcus opacus 1CP.

Gröning JA, Eulberg D, Tischler D, Kaschabek SR, Schlömann M.

FEMS Microbiol Lett. 2014 Dec;361(1):68-75. Epub 2015 Jan 8.

11.

SDF-1 inhibition targets the bone marrow niche for cancer therapy.

Roccaro AM, Sacco A, Purschke WG, Moschetta M, Buchner K, Maasch C, Zboralski D, Zöllner S, Vonhoff S, Mishima Y, Maiso P, Reagan MR, Lonardi S, Ungari M, Facchetti F, Eulberg D, Kruschinski A, Vater A, Rossi G, Klussmann S, Ghobrial IM.

Cell Rep. 2014 Oct 9;9(1):118-128. doi: 10.1016/j.celrep.2014.08.042. Epub 2014 Sep 25.

12.

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis.

Ehling J, Bartneck M, Wei X, Gremse F, Fech V, Möckel D, Baeck C, Hittatiya K, Eulberg D, Luedde T, Kiessling F, Trautwein C, Lammers T, Tacke F.

Gut. 2014 Dec;63(12):1960-1971. doi: 10.1136/gutjnl-2013-306294. Epub 2014 Feb 21.

13.

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C(+) macrophage infiltration in mice.

Baeck C, Wei X, Bartneck M, Fech V, Heymann F, Gassler N, Hittatiya K, Eulberg D, Luedde T, Trautwein C, Tacke F.

Hepatology. 2014 Mar;59(3):1060-72. doi: 10.1002/hep.26783. Epub 2014 Jan 30.

PMID:
24481979
14.

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

Schwoebel F, van Eijk LT, Zboralski D, Sell S, Buchner K, Maasch C, Purschke WG, Humphrey M, Zöllner S, Eulberg D, Morich F, Pickkers P, Klussmann S.

Blood. 2013 Mar 21;121(12):2311-5. doi: 10.1182/blood-2012-09-456756. Epub 2013 Jan 24.

15.

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, Gassler N, Huss S, Klussmann S, Eulberg D, Luedde T, Trautwein C, Tacke F.

Gut. 2012 Mar;61(3):416-26. doi: 10.1136/gutjnl-2011-300304. Epub 2011 Aug 3.

PMID:
21813474
16.

Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease.

Darisipudi MN, Kulkarni OP, Sayyed SG, Ryu M, Migliorini A, Sagrinati C, Parente E, Vater A, Eulberg D, Klussmann S, Romagnani P, Anders HJ.

Am J Pathol. 2011 Jul;179(1):116-24. doi: 10.1016/j.ajpath.2011.03.004. Epub 2011 Apr 30.

17.

Polyetheylenimine-polyplexes of Spiegelmer NOX-A50 directed against intracellular high mobility group protein A1 (HMGA1) reduce tumor growth in vivo.

Maasch C, Vater A, Buchner K, Purschke WG, Eulberg D, Vonhoff S, Klussmann S.

J Biol Chem. 2010 Dec 17;285(51):40012-8. doi: 10.1074/jbc.M110.178533. Epub 2010 Oct 20.

18.

Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.

Sayyed SG, Gaikwad AB, Lichtnekert J, Kulkarni O, Eulberg D, Klussmann S, Tikoo K, Anders HJ.

Nephrol Dial Transplant. 2010 Jun;25(6):1811-7. doi: 10.1093/ndt/gfp730. Epub 2010 Jan 12.

19.

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.

Sayyed SG, Hägele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ.

Diabetologia. 2009 Nov;52(11):2445-54. doi: 10.1007/s00125-009-1493-6. Epub 2009 Aug 26.

PMID:
19707743
20.

Identification of a novel self-sufficient styrene monooxygenase from Rhodococcus opacus 1CP.

Tischler D, Eulberg D, Lakner S, Kaschabek SR, van Berkel WJ, Schlömann M.

J Bacteriol. 2009 Aug;191(15):4996-5009. doi: 10.1128/JB.00307-09. Epub 2009 May 29.

21.

Ccl2/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy.

Clauss S, Gross O, Kulkarni O, Avila-Ferrufino A, Radomska E, Segerer S, Eulberg D, Klussmann S, Anders HJ.

J Pathol. 2009 May;218(1):40-7. doi: 10.1002/path.2505.

PMID:
19156777
22.

Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice.

Kulkarni O, Eulberg D, Selve N, Zöllner S, Allam R, Pawar RD, Pfeiffer S, Segerer S, Klussmann S, Anders HJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):371-7. doi: 10.1124/jpet.108.142711. Epub 2008 Nov 7.

PMID:
18997060
23.

Physicochemical stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for therapeutic applications.

Maasch C, Buchner K, Eulberg D, Vonhoff S, Klussmann S.

Nucleic Acids Symp Ser (Oxf). 2008;(52):61-2. doi: 10.1093/nass/nrn031.

PMID:
18776253
24.

Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice.

Ninichuk V, Clauss S, Kulkarni O, Schmid H, Segerer S, Radomska E, Eulberg D, Buchner K, Selve N, Klussmann S, Anders HJ.

Am J Pathol. 2008 Mar;172(3):628-37. doi: 10.2353/ajpath.2008.070601. Epub 2008 Feb 7.

25.

Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice.

Kulkarni O, Pawar RD, Purschke W, Eulberg D, Selve N, Buchner K, Ninichuk V, Segerer S, Vielhauer V, Klussmann S, Anders HJ.

J Am Soc Nephrol. 2007 Aug;18(8):2350-8. Epub 2007 Jul 11.

26.

An L-RNA-based aquaretic agent that inhibits vasopressin in vivo.

Purschke WG, Eulberg D, Buchner K, Vonhoff S, Klussmann S.

Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5173-8. Epub 2006 Mar 17.

27.
28.

A linear megaplasmid, p1CP, carrying the genes for chlorocatechol catabolism of Rhodococcus opacus 1CP.

König C, Eulberg D, Gröning J, Lakner S, Seibert V, Kaschabek SR, Schlömann M.

Microbiology. 2004 Sep;150(Pt 9):3075-87.

PMID:
15347765
29.

Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer.

Helmling S, Maasch C, Eulberg D, Buchner K, Schröder W, Lange C, Vonhoff S, Wlotzka B, Tschöp MH, Rosewicz S, Klussmann S.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13174-9. Epub 2004 Aug 25.

30.

Spiegelmers: biostable aptamers.

Eulberg D, Klussmann S.

Chembiochem. 2003 Oct 6;4(10):979-83. Review. No abstract available.

PMID:
14523914
31.
34.

Characterization of catechol catabolic genes from Rhodococcus erythropolis 1CP.

Eulberg D, Golovleva LA, Schlömann M.

J Bacteriol. 1997 Jan;179(2):370-81.

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