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Items: 1 to 50 of 122

1.

Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment.

Etrych T, Janoušková O, Chytil P.

Pharmaceutics. 2019 Sep 12;11(9). pii: E471. doi: 10.3390/pharmaceutics11090471. Review.

2.

In memory of Karel Ulbrich.

Etrych T.

J Control Release. 2019 Aug 14. pii: S0168-3659(19)30493-6. doi: 10.1016/j.jconrel.2019.08.013. [Epub ahead of print] No abstract available.

PMID:
31421158
3.

Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents.

Fang J, Islam R, Islam W, Yin H, Subr V, Etrych T, Ulbrich K, Maeda H.

Pharmaceutics. 2019 Jul 16;11(7). pii: E343. doi: 10.3390/pharmaceutics11070343.

4.

Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid.

Nakamura H, Koziolová E, Chytil P, Etrych T, Haratake M, Maeda H.

Mol Pharm. 2019 Aug 5;16(8):3452-3459. doi: 10.1021/acs.molpharmaceut.9b00248. Epub 2019 Jul 11.

PMID:
31294568
5.

Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors.

Hackbarth S, Islam W, Fang J, Šubr V, Röder B, Etrych T, Maeda H.

Photochem Photobiol Sci. 2019 Jun 12;18(6):1304-1314. doi: 10.1039/c8pp00570b.

PMID:
30994640
6.

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction.

Lynn GM, Chytil P, Francica JR, Lagová A, Kueberuwa G, Ishizuka AS, Zaidi N, Ramirez-Valdez RA, Blobel NJ, Baharom F, Leal J, Wang AQ, Gerner MY, Etrych T, Ulbrich K, Seymour LW, Seder RA, Laga R.

Biomacromolecules. 2019 Feb 11;20(2):854-870. doi: 10.1021/acs.biomac.8b01473. Epub 2019 Jan 22.

PMID:
30608149
7.

Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells.

Pola R, Král V, Filippov SK, Kaberov L, Etrych T, Sieglová I, Sedláček J, Fábry M, Pechar M.

Biomacromolecules. 2019 Jan 14;20(1):412-421. doi: 10.1021/acs.biomac.8b01616. Epub 2018 Dec 7.

PMID:
30485077
8.

Synthesis of water-soluble star polymers based on cyclodextrins.

Kotrchová L, Etrych T.

Physiol Res. 2018 Oct 30;67(Suppl 2):S357-S365.

9.

Polymeric nanogels as drug delivery systems.

Kousalová J, Etrych T.

Physiol Res. 2018 Oct 30;67(Suppl 2):S305-S317. Review.

10.

Drug carriers with star polymer structures.

Kotrchová L, Kostka L, Etrych T.

Physiol Res. 2018 Oct 30;67(Suppl 2):S293-S303. Review.

11.

Polymer-drug conjugates in inflammation treatment.

Koziolová E, Venclíková K, Etrych T.

Physiol Res. 2018 Oct 30;67(Suppl 2):S281-S292. Review.

12.

Cell-penetrating peptides: a useful tool for the delivery of various cargoes into cells.

Böhmová E, Machová D, Pechar M, Pola R, Venclíková K, Janoušková O, Etrych T.

Physiol Res. 2018 Oct 30;67(Suppl 2):S267-S279. Review.

13.

Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging.

Etrych T, Daumová L, Pokorná E, Tušková D, Lidický O, Kolářová V, Pankrác J, Šefc L, Chytil P, Klener P.

J Control Release. 2018 Nov 10;289:44-55. doi: 10.1016/j.jconrel.2018.09.018. Epub 2018 Sep 22.

PMID:
30248447
14.

Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3.

Bojarová P, Tavares MR, Laaf D, Bumba L, Petrásková L, Konefał R, Bláhová M, Pelantová H, Elling L, Etrych T, Chytil P, Křen V.

J Nanobiotechnology. 2018 Sep 20;16(1):73. doi: 10.1186/s12951-018-0399-1.

15.

Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines.

Islam W, Fang J, Imamura T, Etrych T, Subr V, Ulbrich K, Maeda H.

Mol Cancer Ther. 2018 Dec;17(12):2643-2653. doi: 10.1158/1535-7163.MCT-18-0696. Epub 2018 Sep 19.

PMID:
30232144
16.

N-(2-Hydroxypropyl)methacrylamide-Based Linear, Diblock, and Starlike Polymer Drug Carriers: Advanced Process for Their Simple Production.

Koziolová E, Kostka L, Kotrchová L, Šubr V, Konefal R, Nottelet B, Etrych T.

Biomacromolecules. 2018 Oct 8;19(10):4003-4013. doi: 10.1021/acs.biomac.8b00973. Epub 2018 Sep 19.

PMID:
30180562
17.

Nanotherapeutics with suitable properties for advanced anticancer therapy based on HPMA copolymer-bound ritonavir via pH-sensitive spacers.

Machová D, Koziolová E, Chytil P, Venclíková K, Etrych T, Janoušková O.

Eur J Pharm Biopharm. 2018 Oct;131:141-150. doi: 10.1016/j.ejpb.2018.07.023. Epub 2018 Jul 31.

PMID:
30075311
18.

Binding of HSA to Macromolecular pHPMA Based Nanoparticles for Drug Delivery: An Investigation Using Fluorescence Methods.

Zhang X, Chytil P, Etrych T, Liu W, Rodrigues L, Winter G, Filippov SK, Papadakis CM.

Langmuir. 2018 Jul 10;34(27):7998-8006. doi: 10.1021/acs.langmuir.8b01015. Epub 2018 Jun 27.

PMID:
29949376
19.

N-(2-hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging.

Fang J, Šubr V, Islam W, Hackbarth S, Islam R, Etrych T, Ulbrich K, Maeda H.

Eur J Pharm Biopharm. 2018 Sep;130:165-176. doi: 10.1016/j.ejpb.2018.06.005. Epub 2018 Jun 8.

PMID:
29885851
20.

Interaction of spin-labeled HPMA-based nanoparticles with human blood plasma proteins - the introduction of protein-corona-free polymer nanomedicine.

Klepac D, Kostková H, Petrova S, Chytil P, Etrych T, Kereïche S, Raška I, Weitz DA, Filippov SK.

Nanoscale. 2018 Mar 29;10(13):6194-6204. doi: 10.1039/C7NR09355A.

PMID:
29560983
21.

Bloodstream Stability Predetermines the Antitumor Efficacy of Micellar Polymer-Doxorubicin Drug Conjugates with pH-Triggered Drug Release.

Chytil P, Šírová M, Kudláčová J, Říhová B, Ulbrich K, Etrych T.

Mol Pharm. 2018 Sep 4;15(9):3654-3663. doi: 10.1021/acs.molpharmaceut.8b00156. Epub 2018 Mar 21.

PMID:
29543465
22.

Inhibitor-GCPII Interaction: Selective and Robust System for Targeting Cancer Cells with Structurally Diverse Nanoparticles.

Neburkova J, Sedlak F, Zackova Suchanova J, Kostka L, Sacha P, Subr V, Etrych T, Simon P, Barinkova J, Krystufek R, Spanielova H, Forstova J, Konvalinka J, Cigler P.

Mol Pharm. 2018 Aug 6;15(8):2932-2945. doi: 10.1021/acs.molpharmaceut.7b00889. Epub 2018 Feb 13.

PMID:
29389139
23.

Macromolecular pHPMA-Based Nanoparticles with Cholesterol for Solid Tumor Targeting: Behavior in HSA Protein Environment.

Zhang X, Niebuur BJ, Chytil P, Etrych T, Filippov SK, Kikhney A, Wieland DCF, Svergun DI, Papadakis CM.

Biomacromolecules. 2018 Feb 12;19(2):470-480. doi: 10.1021/acs.biomac.7b01579. Epub 2018 Jan 30.

PMID:
29381335
24.

Happy Birthday Karel!

Etrych T, Chytil P, Pechar M.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700400. No abstract available.

PMID:
29334433
25.

Intended and Unintended Targeting of Polymeric Nanocarriers: The Case of Modified Poly(glycerol adipate) Nanoparticles.

Weiss VM, Lucas H, Mueller T, Chytil P, Etrych T, Naolou T, Kressler J, Mäder K.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700240. Epub 2017 Dec 8.

PMID:
29218838
26.

Polymer nitric oxide donors potentiate the treatment of experimental solid tumours by increasing drug accumulation in the tumour tissue.

Studenovsky M, Sivak L, Sedlacek O, Konefal R, Horkova V, Etrych T, Kovar M, Rihova B, Sirova M.

J Control Release. 2018 Jan 10;269:214-224. doi: 10.1016/j.jconrel.2017.11.017. Epub 2017 Nov 16.

PMID:
29154977
27.

HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study.

Islam W, Fang J, Etrych T, Chytil P, Ulbrich K, Sakoguchi A, Kusakabe K, Maeda H.

Int J Pharm. 2018 Jan 30;536(1):108-115. doi: 10.1016/j.ijpharm.2017.11.011. Epub 2017 Nov 10.

PMID:
29133205
28.

Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems.

Samad AA, Bethry A, Janouskova O, Ciccione J, Wenk C, Coll JL, Subra G, Etrych T, Omar FE, Bakkour Y, Coudane J, Nottelet B.

Macromol Rapid Commun. 2018 Feb;39(3). doi: 10.1002/marc.201700502. Epub 2017 Nov 2.

PMID:
29094415
29.

Biological Therapy of Hematologic Malignancies: Toward a Chemotherapy- free Era.

Klener P Jr, Etrych T, Klener P.

Curr Med Chem. 2019;26(6):1002-1018. doi: 10.2174/0929867324666171006144725. Review.

PMID:
28990505
30.

Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein.

Dvořáková P, Bušek P, Knedlík T, Schimer J, Etrych T, Kostka L, Stollinová Šromová L, Šubr V, Šácha P, Šedo A, Konvalinka J.

J Med Chem. 2017 Oct 26;60(20):8385-8393. doi: 10.1021/acs.jmedchem.7b00767. Epub 2017 Oct 16.

PMID:
28953383
31.

Ability of polymer-bound P-glycoprotein inhibitor ritonavir to overcome multidrug resistance in various resistant neuroblastoma cell lines.

Koziolová E, Chytil P, Etrych T, Janoušková O.

Anticancer Drugs. 2017 Nov;28(10):1126-1130. doi: 10.1097/CAD.0000000000000553.

PMID:
28901962
32.

HPMA Copolymer-Drug Conjugates with Controlled Tumor-Specific Drug Release.

Chytil P, Koziolová E, Etrych T, Ulbrich K.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700209. Epub 2017 Aug 14. Review.

PMID:
28805040
33.

A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging.

Koziolová E, Goel S, Chytil P, Janoušková O, Barnhart TE, Cai W, Etrych T.

Nanoscale. 2017 Aug 3;9(30):10906-10918. doi: 10.1039/c7nr03306k.

34.

Polymer donors of nitric oxide improve the treatment of experimental solid tumours with nanosized polymer therapeutics.

Šírová M, Horková V, Etrych T, Chytil P, Říhová B, Studenovský M.

J Drug Target. 2017 Nov - Dec;25(9-10):796-808. doi: 10.1080/1061186X.2017.1358724. Epub 2017 Aug 7.

PMID:
28726521
35.

Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin.

Chen Y, Tezcan O, Li D, Beztsinna N, Lou B, Etrych T, Ulbrich K, Metselaar JM, Lammers T, Hennink WE.

Nanoscale. 2017 Jul 27;9(29):10404-10419. doi: 10.1039/c7nr03592f.

PMID:
28702658
36.

Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate.

Etrych T, Tsukigawa K, Nakamura H, Chytil P, Fang J, Ulbrich K, Otagiri M, Maeda H.

Eur J Pharm Sci. 2017 Aug 30;106:10-19. doi: 10.1016/j.ejps.2017.05.031. Epub 2017 May 18.

PMID:
28528285
37.

Corrigendum to "Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo" [Euro. J. Pharm. Biopharm. 105 (2016) 85-96].

Beckert L, Kostka L, Kessel E, Krhac Levacic A, Kostkova H, Etrych T, Lächelt U, Wagner E.

Eur J Pharm Biopharm. 2017 Apr;113:240. doi: 10.1016/j.ejpb.2017.01.010. Epub 2017 Jan 26. No abstract available.

PMID:
28130965
38.

The structure of polymer carriers controls the efficacy of the experimental combination treatment of tumors with HPMA copolymer conjugates carrying doxorubicin and docetaxel.

Šírová M, Strohalm J, Chytil P, Lidický O, Tomala J, Říhová B, Etrych T.

J Control Release. 2017 Jan 28;246:1-11. doi: 10.1016/j.jconrel.2016.12.004. Epub 2016 Dec 6.

PMID:
27940304
39.

Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin.

Nakamura H, Koziolová E, Chytil P, Tsukigawa K, Fang J, Haratake M, Ulbrich K, Etrych T, Maeda H.

Mol Pharm. 2016 Dec 5;13(12):4106-4115. Epub 2016 Nov 21.

PMID:
27934482
40.

Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate.

Sivak L, Subr V, Tomala J, Rihova B, Strohalm J, Etrych T, Kovar M.

Biomaterials. 2017 Jan;115:65-80. doi: 10.1016/j.biomaterials.2016.11.013. Epub 2016 Nov 12.

PMID:
27886555
41.

Tumor-targeted micelle-forming block copolymers for overcoming of multidrug resistance.

Braunová A, Kostka L, Sivák L, Cuchalová L, Hvězdová Z, Laga R, Filippov S, Černoch P, Pechar M, Janoušková O, Šírová M, Etrych T.

J Control Release. 2017 Jan 10;245:41-51. doi: 10.1016/j.jconrel.2016.11.020. Epub 2016 Nov 18.

PMID:
27871991
42.

HPMA copolymer-based polymer conjugates for the delivery and controlled release of retinoids.

Lidický O, Šírová M, Etrych T.

Physiol Res. 2016 Oct 20;65(Supplementum 2):S233-S241.

43.

The pH-dependent and enzymatic release of cytarabine from hydrophilic polymer conjugates.

Pola R, Janoušková O, Etrych T.

Physiol Res. 2016 Oct 20;65(Supplementum 2):S225-S232.

44.

Intracellular fate of polymer therapeutics investigated by fluorescence lifetime imaging and fluorescence pattern analysis.

Panek J, Koziolova E, Stepanek P, Etrych T, Janouskova O.

Physiol Res. 2016 Oct 20;65(Supplementum 2):S217-S224.

45.

High-molecular-weight HPMA-based polymer drug carriers for delivery to tumor.

Kostka L, Etrych T.

Physiol Res. 2016 Oct 20;65(Supplementum 2):S179-S190. Review.

46.

Passive Tumor Targeting of Polymer Therapeutics: In Vivo Imaging of Both the Polymer Carrier and the Enzymatically Cleavable Drug Model.

Pola R, Heinrich AK, Mueller T, Kostka L, Mäder K, Pechar M, Etrych T.

Macromol Biosci. 2016 Nov;16(11):1577-1582. doi: 10.1002/mabi.201600273. Epub 2016 Sep 22.

PMID:
27654467
47.

Biodegradable Micellar HPMA-Based Polymer-Drug Conjugates with Betulinic Acid for Passive Tumor Targeting.

Lomkova EA, Chytil P, Janoušková O, Mueller T, Lucas H, Filippov SK, Trhlíková O, Aleshunin PA, Skorik YA, Ulbrich K, Etrych T.

Biomacromolecules. 2016 Nov 14;17(11):3493-3507. Epub 2016 Sep 30.

PMID:
27636143
48.

Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications.

Hu Q, Rijcken CJ, van Gaal E, Brundel P, Kostkova H, Etrych T, Weber B, Barz M, Kiessling F, Prakash J, Storm G, Hennink WE, Lammers T.

J Control Release. 2016 Dec 28;244(Pt B):314-325. doi: 10.1016/j.jconrel.2016.07.012. Epub 2016 Jul 9.

PMID:
27401327
49.

Acid-labile pHPMA modification of four-arm oligoaminoamide pDNA polyplexes balances shielding and gene transfer activity in vitro and in vivo.

Beckert L, Kostka L, Kessel E, Krhac Levacic A, Kostkova H, Etrych T, Lächelt U, Wagner E.

Eur J Pharm Biopharm. 2016 Aug;105:85-96. doi: 10.1016/j.ejpb.2016.05.019. Epub 2016 May 25. Erratum in: Eur J Pharm Biopharm. 2017 Apr;113:240.

PMID:
27235729
50.

[Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect].

Maeda H, Fang J, Ulbrich K, Etrych T, Nakamura H.

Gan To Kagaku Ryoho. 2016 May;43(5):549-57. Japanese.

PMID:
27210083

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