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Science. 1998 Jul 31;281(5377):703-6.

Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.

Author information

1
Department of Pathology, Tufts University, Boston, MA 02111 USA.

Abstract

Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.

PMID:
9685265
DOI:
10.1126/science.281.5377.703
[Indexed for MEDLINE]
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