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Items: 19


TGFβ receptor inhibitor galunisertib is linked to inflammation- and remodeling-related proteins in patients with pancreatic cancer.

Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplanque G, Fuchs M, Trojan J, Kozloff M, Simionato F, Cleverly A, Smith C, Wang S, Man M, Driscoll KE, Estrem ST, Lahn MMF, Benhadji KA, Tabernero J.

Cancer Chemother Pharmacol. 2019 May;83(5):975-991. doi: 10.1007/s00280-019-03807-4. Epub 2019 Mar 18.


Galunisertib plus gemcitabine vs. gemcitabine for first-line treatment of patients with unresectable pancreatic cancer.

Melisi D, Garcia-Carbonero R, Macarulla T, Pezet D, Deplanque G, Fuchs M, Trojan J, Oettle H, Kozloff M, Cleverly A, Smith C, Estrem ST, Gueorguieva I, Lahn MMF, Blunt A, Benhadji KA, Tabernero J.

Br J Cancer. 2018 Nov;119(10):1208-1214. doi: 10.1038/s41416-018-0246-z. Epub 2018 Oct 15.


Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine.

Capper D, von Deimling A, Brandes AA, Carpentier AF, Kesari S, Sepulveda-Sanchez JM, Wheeler HR, Chinot O, Cher L, Steinbach JP, Specenier P, Rodon J, Cleverly A, Smith C, Gueorguieva I, Miles C, Guba SC, Desaiah D, Estrem ST, Lahn MM, Wick W.

Int J Mol Sci. 2017 May 6;18(5). pii: E995. doi: 10.3390/ijms18050995.


Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway.

Herbertz S, Sawyer JS, Stauber AJ, Gueorguieva I, Driscoll KE, Estrem ST, Cleverly AL, Desaiah D, Guba SC, Benhadji KA, Slapak CA, Lahn MM.

Drug Des Devel Ther. 2015 Aug 10;9:4479-99. doi: 10.2147/DDDT.S86621. eCollection 2015. Review.


Pharmacokinetic, pharmacodynamic and biomarker evaluation of transforming growth factor-β receptor I kinase inhibitor, galunisertib, in phase 1 study in patients with advanced cancer.

Rodón J, Carducci M, Sepulveda-Sánchez JM, Azaro A, Calvo E, Seoane J, Braña I, Sicart E, Gueorguieva I, Cleverly A, Pillay NS, Desaiah D, Estrem ST, Paz-Ares L, Holdhoff M, Blakeley J, Lahn MM, Baselga J.

Invest New Drugs. 2015 Apr;33(2):357-70. doi: 10.1007/s10637-014-0192-4. Epub 2014 Dec 23.


First-in-human dose study of the novel transforming growth factor-β receptor I kinase inhibitor LY2157299 monohydrate in patients with advanced cancer and glioma.

Rodon J, Carducci MA, Sepulveda-Sánchez JM, Azaro A, Calvo E, Seoane J, Braña I, Sicart E, Gueorguieva I, Cleverly AL, Pillay NS, Desaiah D, Estrem ST, Paz-Ares L, Holdhoff M, Blakeley J, Lahn MM, Baselga J.

Clin Cancer Res. 2015 Feb 1;21(3):553-60. doi: 10.1158/1078-0432.CCR-14-1380. Epub 2014 Nov 25.


Transcriptome signature of resistance exercise adaptations: mixed muscle and fiber type specific profiles in young and old adults.

Raue U, Trappe TA, Estrem ST, Qian HR, Helvering LM, Smith RC, Trappe S.

J Appl Physiol (1985). 2012 May;112(10):1625-36. doi: 10.1152/japplphysiol.00435.2011. Epub 2012 Feb 2.


Assessment of diet-induced obese rats as an obesity model by comparative functional genomics.

Li S, Zhang HY, Hu CC, Lawrence F, Gallagher KE, Surapaneni A, Estrem ST, Calley JN, Varga G, Dow ER, Chen Y.

Obesity (Silver Spring). 2008 Apr;16(4):811-8. doi: 10.1038/oby.2007.116. Epub 2008 Jan 24.


Data-driven analysis approach for biomarker discovery using molecular-profiling technologies.

Wei T, Liao B, Ackermann BL, Jolly RA, Eckstein JA, Kulkarni NH, Helvering LM, Goldstein KM, Shou J, Estrem ST, Ryan TP, Colet JM, Thomas CE, Stevens JL, Onyia JE.

Biomarkers. 2005 Mar-Jun;10(2-3):153-72.


Pooling samples within microarray studies: a comparative analysis of rat liver transcription response to prototypical toxicants.

Jolly RA, Goldstein KM, Wei T, Gao H, Chen P, Huang S, Colet JM, Ryan TP, Thomas CE, Estrem ST.

Physiol Genomics. 2005 Aug 11;22(3):346-55. Epub 2005 May 24.


Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus.

Helvering LM, Adrian MD, Geiser AG, Estrem ST, Wei T, Huang S, Chen P, Dow ER, Calley JN, Dodge JA, Grese TA, Jones SA, Halladay DL, Miles RR, Onyia JE, Ma YL, Sato M, Bryant HU.

Biol Reprod. 2005 Apr;72(4):830-41. Epub 2004 Dec 1.


Old and new approaches used to identify gene products important for Saccharomyces cerevisiae cell wall biology.

Estrem ST, Skatrud PL.

J Ind Microbiol Biotechnol. 2001 Dec;27(6):357-9. Review. No abstract available.


Promoter recognition and discrimination by EsigmaS RNA polymerase.

Gaal T, Ross W, Estrem ST, Nguyen LH, Burgess RR, Gourse RL.

Mol Microbiol. 2001 Nov;42(4):939-54.


Genome of the bacterium Streptococcus pneumoniae strain R6.

Hoskins J, Alborn WE Jr, Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR Jr, Skatrud PL, Glass JI.

J Bacteriol. 2001 Oct;183(19):5709-17.


Strength and regulation without transcription factors: lessons from bacterial rRNA promoters.

Gourse RL, Gaal T, Aiyar SE, Barker MM, Estrem ST, Hirvonen CA, Ross W.

Cold Spring Harb Symp Quant Biol. 1998;63:131-9. Review. No abstract available.


Identification of an UP element consensus sequence for bacterial promoters.

Estrem ST, Gaal T, Ross W, Gourse RL.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9761-6.


The chicken malic enzyme gene: structural organization and identification of triiodothyronine response elements in the 5'-flanking DNA.

Hodnett DW, Fantozzi DA, Thurmond DC, Klautky SA, MacPhee KG, Estrem ST, Xu G, Goodridge AG.

Arch Biochem Biophys. 1996 Oct 15;334(2):309-24.


Localization of the intrinsically bent DNA region upstream of the E.coli rrnB P1 promoter.

Gaal T, Rao L, Estrem ST, Yang J, Wartell RM, Gourse RL.

Nucleic Acids Res. 1994 Jun 25;22(12):2344-50.

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