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J Neuroimmunol. 2015 Nov 15;288:47-55. doi: 10.1016/j.jneuroim.2015.09.001. Epub 2015 Sep 10.

Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells.

Author information

1
Department of Clinical Neuroscience, Division of Neurosurgery, Karolinska Institutet, Stockholm, Sweden.
2
Division of Neurology, Karolinska Institutet, Stockholm, Sweden.
3
Division of Neurology, Karolinska Institutet, Stockholm, Sweden. Electronic address: lou.brundin@karolinska.se.

Abstract

Studies in multiple sclerosis have demonstrated that normal-appearing white matter can harbor pathological changes. Here we investigated the effects of neuroinflammation, modeled by experimental autoimmune encephalomyelitis (EAE) on neural stem/progenitor cells (NPCs) located distally to inflammatory foci. We observed that EAE-derived NPCs had a lower capacity to differentiate into oligodendrocytes and an increased neuronal differentiation than control NPCs. This finding was corroborated with changes in gene expression of early differentiation genes. We conclude that inflammation has a long range effect on the NPCs in the diseased central nervous system, reaching NPC populations outside the lesion sites.

KEYWORDS:

Adult neural progenitor cells; Gene expression; Gliogenesis; Neurogenesis; Neuroinflammation; Proliferation; Spinal cord

PMID:
26531694
DOI:
10.1016/j.jneuroim.2015.09.001
[Indexed for MEDLINE]
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