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Items: 26

1.

MinION sequencing of Streptococcus suis allows for functional characterization of bacteria by multilocus sequence typing and antimicrobial resistance profiling.

Tan S, Dvorak CMT, Estrada AA, Gebhart C, Marthaler DG, Murtaugh MP.

J Microbiol Methods. 2020 Feb;169:105817. doi: 10.1016/j.mimet.2019.105817. Epub 2019 Dec 24.

PMID:
31881288
2.

Serotype and Genotype (Multilocus Sequence Type) of Streptococcus suis Isolates from the United States Serve as Predictors of Pathotype.

Estrada AA, Gottschalk M, Rossow S, Rendahl A, Gebhart C, Marthaler DG.

J Clin Microbiol. 2019 Aug 26;57(9). pii: e00377-19. doi: 10.1128/JCM.00377-19. Print 2019 Sep.

3.

Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond - Part 2.

Shore DGM, Sweeney ZK, Beresford A, Chan BK, Chen H, Drummond J, Gill A, Kleinheinz T, Liu X, Medhurst AD, McIver EG, Moffat JG, Zhu H, Estrada AA.

Bioorg Med Chem Lett. 2019 Feb 15;29(4):674-680. doi: 10.1016/j.bmcl.2018.10.017. Epub 2018 Oct 12.

PMID:
30522953
4.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

Chen H, Volgraf M, Do S, Kolesnikov A, Shore DG, Verma VA, Villemure E, Wang L, Chen Y, Hu B, Lu AJ, Wu G, Xu X, Yuen PW, Zhang Y, Erickson SD, Dahl M, Brotherton-Pleiss C, Tay S, Ly JQ, Murray LJ, Chen J, Amm D, Lange W, Hackos DH, Reese RM, Shields SD, Lyssikatos JP, Safina BS, Estrada AA.

J Med Chem. 2018 Apr 26;61(8):3641-3659. doi: 10.1021/acs.jmedchem.8b00117. Epub 2018 Apr 12.

PMID:
29590749
5.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Patel S, Meilandt WJ, Erickson RI, Chen J, Deshmukh G, Estrada AA, Fuji RN, Gibbons P, Gustafson A, Harris SF, Imperio J, Liu W, Liu X, Liu Y, Lyssikatos JP, Ma C, Yin J, Lewcock JW, Siu M.

J Med Chem. 2017 Oct 12;60(19):8083-8102. doi: 10.1021/acs.jmedchem.7b00843. Epub 2017 Sep 20.

PMID:
28929759
6.

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.

Verma VA, Shore DGM, Chen H, Chen J, Do S, Hackos DH, Kolesnikov A, Lyssikatos JP, Tay S, Wang L, Estrada AA.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):495-498. doi: 10.1016/j.bmcl.2015.11.088. Epub 2015 Nov 25.

PMID:
26706172
7.

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors.

Estrada AA, Sweeney ZK.

J Med Chem. 2015 Sep 10;58(17):6733-46. doi: 10.1021/acs.jmedchem.5b00261. Epub 2015 May 14.

PMID:
25915084
8.

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung.

Fuji RN, Flagella M, Baca M, Baptista MA, Brodbeck J, Chan BK, Fiske BK, Honigberg L, Jubb AM, Katavolos P, Lee DW, Lewin-Koh SC, Lin T, Liu X, Liu S, Lyssikatos JP, O'Mahony J, Reichelt M, Roose-Girma M, Sheng Z, Sherer T, Smith A, Solon M, Sweeney ZK, Tarrant J, Urkowitz A, Warming S, Yaylaoglu M, Zhang S, Zhu H, Estrada AA, Watts RJ.

Sci Transl Med. 2015 Feb 4;7(273):273ra15. doi: 10.1126/scitranslmed.aaa3634.

PMID:
25653221
9.

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, Ly CQ, Lyssikatos JP, Ma C, Scearce-Levie K, Shin YG, Solanoy H, Stark KL, Wang J, Wang B, Zhao X, Lewcock JW, Siu M.

J Med Chem. 2015 Jan 8;58(1):401-18. doi: 10.1021/jm5013984. Epub 2014 Oct 23.

PMID:
25341110
10.

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Estrada AA, Chan BK, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chen H, Dominguez SL, Dotson J, Drummond J, Flagella M, Fuji R, Gill A, Halladay J, Harris SF, Heffron TP, Kleinheinz T, Lee DW, Le Pichon CE, Liu X, Lyssikatos JP, Medhurst AD, Moffat JG, Nash K, Scearce-Levie K, Sheng Z, Shore DG, Wong S, Zhang S, Zhang X, Zhu H, Sweeney ZK.

J Med Chem. 2014 Feb 13;57(3):921-36. doi: 10.1021/jm401654j. Epub 2014 Jan 15.

PMID:
24354345
11.

Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).

Estrada AA, Shore DG, Blackwood E, Chen YH, Deshmukh G, Ding X, Dipasquale AG, Epler JA, Friedman LS, Koehler MF, Liu L, Malek S, Nonomiya J, Ortwine DF, Pei Z, Sideris S, St-Jean F, Trinh L, Truong T, Lyssikatos JP.

J Med Chem. 2013 Apr 11;56(7):3090-101. doi: 10.1021/jm400194n. Epub 2013 Mar 29.

PMID:
23473235
12.

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

Pei Z, Blackwood E, Liu L, Malek S, Belvin M, Koehler MF, Ortwine DF, Chen H, Cohen F, Kenny JR, Bergeron P, Lau K, Ly C, Zhao X, Estrada AA, Truong T, Epler JA, Nonomiya J, Trinh L, Sideris S, Lesnick J, Bao L, Vijapurkar U, Mukadam S, Tay S, Deshmukh G, Chen YH, Ding X, Friedman LS, Lyssikatos JP.

ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. doi: 10.1021/ml3003132. eCollection 2013 Jan 10.

13.

Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor.

Chan BK, Estrada AA, Chen H, Atherall J, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Dominguez SL, Drummond J, Gill A, Kleinheinz T, Le Pichon CE, Medhurst AD, Liu X, Moffat JG, Nash K, Scearce-Levie K, Sheng Z, Shore DG, Van de Poël H, Zhang S, Zhu H, Sweeney ZK.

ACS Med Chem Lett. 2012 Nov 23;4(1):85-90. doi: 10.1021/ml3003007. eCollection 2013 Jan 10.

14.

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JG, Kirkpatrick DS, Zhu H.

Sci Transl Med. 2012 Dec 12;4(164):164ra161. doi: 10.1126/scitranslmed.3004485.

15.

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

Estrada AA, Liu X, Baker-Glenn C, Beresford A, Burdick DJ, Chambers M, Chan BK, Chen H, Ding X, DiPasquale AG, Dominguez SL, Dotson J, Drummond J, Flagella M, Flynn S, Fuji R, Gill A, Gunzner-Toste J, Harris SF, Heffron TP, Kleinheinz T, Lee DW, Le Pichon CE, Lyssikatos JP, Medhurst AD, Moffat JG, Mukund S, Nash K, Scearce-Levie K, Sheng Z, Shore DG, Tran T, Trivedi N, Wang S, Zhang S, Zhang X, Zhao G, Zhu H, Sweeney ZK.

J Med Chem. 2012 Nov 26;55(22):9416-33. doi: 10.1021/jm301020q. Epub 2012 Oct 15.

PMID:
22985112
16.

Discovery of selective LRRK2 inhibitors guided by computational analysis and molecular modeling.

Chen H, Chan BK, Drummond J, Estrada AA, Gunzner-Toste J, Liu X, Liu Y, Moffat J, Shore D, Sweeney ZK, Tran T, Wang S, Zhao G, Zhu H, Burdick DJ.

J Med Chem. 2012 Jun 14;55(11):5536-45. doi: 10.1021/jm300452p. Epub 2012 Jun 1.

PMID:
22591441
17.

Recent advances in the chemistry and biology of naturally occurring antibiotics.

Nicolaou KC, Chen JS, Edmonds DJ, Estrada AA.

Angew Chem Int Ed Engl. 2009;48(4):660-719. doi: 10.1002/anie.200801695. Review.

18.

New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems.

Nicolaou KC, Estrada AA, Freestone GC, Lee SH, Alvarez-Mico X.

Tetrahedron. 2007 Jul 2;63(27):6088-6114.

19.

Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones.

Nicolaou KC, Estrada AA, Lee SH, Freestone GC.

Angew Chem Int Ed Engl. 2006 Aug 11;45(32):5364-8. No abstract available.

PMID:
16847981
20.

Discovery of a biologically active thiostrepton fragment.

Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR.

J Am Chem Soc. 2005 Nov 2;127(43):15042-4.

PMID:
16248640
21.

Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis.

Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M.

J Am Chem Soc. 2005 Aug 10;127(31):11176-83.

PMID:
16076225
22.

Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks.

Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S.

J Am Chem Soc. 2005 Aug 10;127(31):11159-75.

PMID:
16076224
23.

Construction of substituted N-hydroxyindoles: synthesis of a nocathiacin I model system.

Nicolaou KC, Lee SH, Estrada AA, Zak M.

Angew Chem Int Ed Engl. 2005 Jun 13;44(24):3736-40. No abstract available.

PMID:
15892095
24.

A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide.

Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS.

Angew Chem Int Ed Engl. 2005 Feb 18;44(9):1378-82. No abstract available.

PMID:
15674985
25.

Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle.

Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH.

Angew Chem Int Ed Engl. 2004 Sep 27;43(38):5087-92. No abstract available.

PMID:
15372631
26.

Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis.

Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA.

Angew Chem Int Ed Engl. 2004 Sep 27;43(38):5092-7. No abstract available.

PMID:
15372630

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