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Items: 16

1.

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism.

Huang Z, Zhang M, Plec AA, Estill SJ, Cai L, Repa JJ, McKnight SL, Tu BP.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9499-E9506. doi: 10.1073/pnas.1806635115. Epub 2018 Sep 18.

2.

Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.

Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP.

Cell Rep. 2015 Jul 21;12(3):371-9. doi: 10.1016/j.celrep.2015.06.042. Epub 2015 Jul 9.

3.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.

Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM.

Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34. Epub 2014 Apr 22.

4.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.

De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. doi: 10.1073/pnas.1213956109. Epub 2012 Oct 1.

5.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. doi: 10.1073/pnas.1213960109. Epub 2012 Oct 1.

6.

Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.

Aqul A, Liu B, Ramirez CM, Pieper AA, Estill SJ, Burns DK, Liu B, Repa JJ, Turley SD, Dietschy JM.

J Neurosci. 2011 Jun 22;31(25):9404-13. doi: 10.1523/JNEUROSCI.1317-11.2011.

7.

Development of proneurogenic, neuroprotective small molecules.

MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM.

J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6.

8.

Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL.

Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018.

9.

Acid promoted cinnamyl ion mobility within peptide derived macrocycles.

Zhao H, Negash L, Wei Q, LaCour TG, Estill SJ, Capota E, Pieper AA, Harran PG.

J Am Chem Soc. 2008 Oct 22;130(42):13864-6. doi: 10.1021/ja803299h. Epub 2008 Sep 24.

PMID:
18811162
10.

NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions.

Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O'Hara BF, McKnight SL.

Proc Natl Acad Sci U S A. 2006 May 2;103(18):7118-23. Epub 2006 Apr 24.

11.

The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.

Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC, Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ, McKnight SL.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14052-7. Epub 2005 Sep 19.

12.

Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.

Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, Diaz-Arrastia R, Brunskill EW, Potter SS, McKnight SL.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13648-53. Epub 2004 Sep 3.

13.

Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice.

Dudley CA, Erbel-Sieler C, Estill SJ, Reick M, Franken P, Pitts S, McKnight SL.

Science. 2003 Jul 18;301(5631):379-83. Epub 2003 Jul 3.

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16.

Impaired cued and contextual memory in NPAS2-deficient mice.

Garcia JA, Zhang D, Estill SJ, Michnoff C, Rutter J, Reick M, Scott K, Diaz-Arrastia R, McKnight SL.

Science. 2000 Jun 23;288(5474):2226-30.

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