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Items: 25

1.

In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.

Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Núñez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC.

Cell. 2017 Dec 14;171(7):1495-1507.e15. doi: 10.1016/j.cell.2017.10.025. Epub 2017 Dec 7.

2.

Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells.

Takahashi Y, Wu J, Suzuki K, Martinez-Redondo P, Li M, Liao HK, Wu MZ, Hernández-Benítez R, Hishida T, Shokhirev MN, Esteban CR, Sancho-Martinez I, Belmonte JCI.

Science. 2017 May 5;356(6337):503-508. doi: 10.1126/science.aag3260.

3.

Interspecies Chimerism with Mammalian Pluripotent Stem Cells.

Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilariño M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sánchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nuñez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC.

Cell. 2017 Jan 26;168(3):473-486.e15. doi: 10.1016/j.cell.2016.12.036.

4.

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.

Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC.

Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16.

5.

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells.

Sancho-Martinez I, Nivet E, Xia Y, Hishida T, Aguirre A, Ocampo A, Ma L, Morey R, Krause MN, Zembrzycki A, Ansorge O, Vazquez-Ferrer E, Dubova I, Reddy P, Lam D, Hishida Y, Wu MZ, Esteban CR, O'Leary D, Wahl GM, Verma IM, Laurent LC, Izpisua Belmonte JC.

Nat Commun. 2016 Feb 22;7:10743. doi: 10.1038/ncomms10743.

6.

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.

Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH.

Nat Commun. 2015 Dec 3;6:10068. doi: 10.1038/ncomms10068.

7.

An alternative pluripotent state confers interspecies chimaeric competency.

Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC.

Nature. 2015 May 21;521(7552):316-21. doi: 10.1038/nature14413. Epub 2015 May 6.

8.

Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.

Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC.

Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356. Epub 2015 Apr 30.

9.

Selective elimination of mitochondrial mutations in the germline by genome editing.

Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, Sancho-Martinez I, Manau D, Civico S, Cardellach F, Del Mar O'Callaghan M, Campistol J, Zhao H, Campistol JM, Moraes CT, Izpisua Belmonte JC.

Cell. 2015 Apr 23;161(3):459-469. doi: 10.1016/j.cell.2015.03.051.

10.

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.

Liao HK, Gu Y, Diaz A, Marlett J, Takahashi Y, Li M, Suzuki K, Xu R, Hishida T, Chang CJ, Esteban CR, Young J, Izpisua Belmonte JC.

Nat Commun. 2015 Mar 10;6:6413. doi: 10.1038/ncomms7413.

PMID:
25752527
11.

Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development.

Kurian L, Aguirre A, Sancho-Martinez I, Benner C, Hishida T, Nguyen TB, Reddy P, Nivet E, Krause MN, Nelles DA, Esteban CR, Campistol JM, Yeo GW, Belmonte JCI.

Circulation. 2015 Apr 7;131(14):1278-1290. doi: 10.1161/CIRCULATIONAHA.114.013303. Epub 2015 Mar 4.

12.

A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells.

Ding Z, Sui L, Ren R, Liu Y, Xu X, Fu L, Bai R, Yuan T, Hao Y, Zhang W, Pan H, Liu W, Yu H, Esteban CR, Yu X, Yang Z, Li J, Wang X, Izpisua Belmonte JC, Liu GH, Yi F, Qu J.

Protein Cell. 2015 May;6(5):386-9. doi: 10.1007/s13238-014-0117-1. No abstract available.

13.

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs.

Liu GH, Suzuki K, Li M, Qu J, Montserrat N, Tarantino C, Gu Y, Yi F, Xu X, Zhang W, Ruiz S, Plongthongkum N, Zhang K, Masuda S, Nivet E, Tsunekawa Y, Soligalla RD, Goebl A, Aizawa E, Kim NY, Kim J, Dubova I, Li Y, Ren R, Benner C, Del Sol A, Bueren J, Trujillo JP, Surralles J, Cappelli E, Dufour C, Esteban CR, Belmonte JCI.

Nat Commun. 2014 Jul 7;5:4330. doi: 10.1038/ncomms5330.

14.

Targeted gene correction minimally impacts whole-genome mutational load in human-disease-specific induced pluripotent stem cell clones.

Suzuki K, Yu C, Qu J, Li M, Yao X, Yuan T, Goebl A, Tang S, Ren R, Aizawa E, Zhang F, Xu X, Soligalla RD, Chen F, Kim J, Kim NY, Liao HK, Benner C, Esteban CR, Jin Y, Liu GH, Li Y, Izpisua Belmonte JC.

Cell Stem Cell. 2014 Jul 3;15(1):31-6. doi: 10.1016/j.stem.2014.06.016.

15.

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.

Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Izpisua Belmonte JC.

Protein Cell. 2014 Jan;5(1):59-68. doi: 10.1007/s13238-013-0016-x. Epub 2014 Jan 29.

16.

Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors.

Zhang K, Liu GH, Yi F, Montserrat N, Hishida T, Esteban CR, Izpisua Belmonte JC.

Protein Cell. 2014 Jan;5(1):48-58. doi: 10.1007/s13238-013-0011-2. Epub 2014 Jan 29.

17.

Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.

Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM, Izpisua Belmonte JC.

Nat Cell Biol. 2013 Dec;15(12):1507-15. doi: 10.1038/ncb2872. Epub 2013 Nov 17.

PMID:
24240476
18.

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes.

Gu Y, Liu GH, Plongthongkum N, Benner C, Yi F, Qu J, Suzuki K, Yang J, Zhang W, Li M, Montserrat N, Crespo I, Del Sol A, Esteban CR, Zhang K, Belmonte JC.

Protein Cell. 2013 Aug 27. [Epub ahead of print]

PMID:
23982742
19.

Reprogramming of human fibroblasts to pluripotency with lineage specifiers.

Montserrat N, Nivet E, Sancho-Martinez I, Hishida T, Kumar S, Miquel L, Cortina C, Hishida Y, Xia Y, Esteban CR, Izpisua Belmonte JC.

Cell Stem Cell. 2013 Sep 5;13(3):341-50. doi: 10.1016/j.stem.2013.06.019. Epub 2013 Jul 18.

20.

Characterization of pluripotent stem cells.

Martí M, Mulero L, Pardo C, Morera C, Carrió M, Laricchia-Robbio L, Esteban CR, Izpisua Belmonte JC.

Nat Protoc. 2013 Feb;8(2):223-53. doi: 10.1038/nprot.2012.154. Epub 2013 Jan 10.

PMID:
23306458
21.

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2.

Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J 3rd, Esteban CR, Sancho-Martinez I, Izpisua Belmonte JC.

Nature. 2012 Nov 22;491(7425):603-7. doi: 10.1038/nature11557. Epub 2012 Oct 17.

22.

Cre-LoxP-regulated expression of monoclonal antibodies driven by an ovalbumin promoter in primary oviduct cells.

Oishi I, Kim S, Yoshii K, Esteban CR, Izpisua Belmonte JC.

BMC Biotechnol. 2011 Jan 14;11:5. doi: 10.1186/1472-6750-11-5.

23.

Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9.

Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, Lotz M, Izpisúa Belmonte JC, Asahara H.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2414-9. Epub 2005 Feb 7.

24.

Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.

Kawakami Y, Esteban CR, Matsui T, Rodríguez-León J, Kato S, Izpisúa Belmonte JC.

Development. 2004 Oct;131(19):4763-74.

25.

MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb.

Kawakami Y, Rodríguez-León J, Koth CM, Büscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, Schwarz MF, Asahara H, Izpisúa Belmonte JC.

Nat Cell Biol. 2003 Jun;5(6):513-9.

PMID:
12766772

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