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Items: 1 to 50 of 162

1.

ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals.

Pujantell M, Badia R, Galván-Femenía I, Garcia-Vidal E, de Cid R, Alcalde C, Tarrats A, Piñol M, Garcia F, Chamorro AM, Revollo B, Videla S, Parés D, Corral J, Tural C, Sirera G, Esté JA, Ballana E, Riveira-Muñoz E.

Sci Rep. 2019 Dec 27;9(1):19848. doi: 10.1038/s41598-019-56422-x.

2.

Meeting report: 32nd International Conference on Antiviral Research.

Tramontano E, Tarbet B, Spengler JR, Seley-Radtke K, Meier C, Jordan R, Janeba Z, Gowen B, Gentry B, Esté JA, Bray M, Andrei G, Schang LM; International Society for Antiviral Research.

Antiviral Res. 2019 Sep;169:104550. doi: 10.1016/j.antiviral.2019.104550. Epub 2019 Jul 11. Review.

3.

Dual effect of the broad spectrum kinase inhibitor midostaurin in acute and latent HIV-1 infection.

Garcia-Vidal E, Badia R, Pujantell M, Castellví M, Felip E, Clotet B, Riveira-Muñoz E, Ballana E, Esté JA.

Antiviral Res. 2019 Aug;168:18-27. doi: 10.1016/j.antiviral.2019.05.003. Epub 2019 May 8.

PMID:
31077767
4.

Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones.

Nawrozkij MB, Forgione M, Yablokov AS, Lucidi A, Tomaselli D, Patsilinakos A, Panella C, Hailu GS, Kirillov IA, Badia R, Riveira-Muñoz E, Crespan E, Armijos Rivera JI, Cirilli R, Ragno R, Esté JA, Maga G, Mai A, Rotili D.

J Med Chem. 2019 Jan 24;62(2):604-621. doi: 10.1021/acs.jmedchem.8b01238. Epub 2018 Dec 20.

PMID:
30525601
5.

Incidence of cervical high-grade squamous intraepithelial lesions in HIV-1-infected women with no history of cervical pathology: up to 17 years of follow-up.

Videla S, Tarrats A, Ornelas A, Badia R, Castella E, Alcalde C, Chamorro A, Esté JA, Clotet B, Sirera G.

Int J STD AIDS. 2019 Jan;30(1):56-63. doi: 10.1177/0956462418792653. Epub 2018 Aug 31.

PMID:
30170532
6.

Meeting report: 31st International Conference on Antiviral Research.

Bray M, Andrei G, Ballana E, Carter K, Durantel D, Gentry B, Janeba Z, Moffat J, Oomen CJ, Tarbet B, Riveira-Muñoz E, Esté JA; International Society for Antiviral Research.

Antiviral Res. 2018 Oct;158:88-102. doi: 10.1016/j.antiviral.2018.08.002. Epub 2018 Aug 4.

7.

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir.

Badia R, Ballana E, Castellví M, García-Vidal E, Pujantell M, Clotet B, Prado JG, Puig J, Martínez MA, Riveira-Muñoz E, Esté JA.

Nat Commun. 2018 Jul 16;9(1):2739. doi: 10.1038/s41467-018-05157-w.

8.

ADAR1 affects HCV infection by modulating innate immune response.

Pujantell M, Franco S, Galván-Femenía I, Badia R, Castellví M, Garcia-Vidal E, Clotet B, de Cid R, Tural C, Martínez MA, Riveira-Muñoz E, Esté JA, Ballana E.

Antiviral Res. 2018 Aug;156:116-127. doi: 10.1016/j.antiviral.2018.05.012. Epub 2018 Jun 12.

PMID:
29906476
9.

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.

Pujantell M, Riveira-Muñoz E, Badia R, Castellví M, Garcia-Vidal E, Sirera G, Puig T, Ramirez C, Clotet B, Esté JA, Ballana E.

Sci Rep. 2017 Oct 17;7(1):13339. doi: 10.1038/s41598-017-13580-0.

10.

Evaluation of the Innate Immune Modulator Acitretin as a Strategy To Clear the HIV Reservoir.

Garcia-Vidal E, Castellví M, Pujantell M, Badia R, Jou A, Gomez L, Puig T, Clotet B, Ballana E, Riveira-Muñoz E, Esté JA.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01368-17. doi: 10.1128/AAC.01368-17. Print 2017 Nov.

11.

Highlights of the 30th International Conference on Antiviral Research.

Andrei G, Carter K, Janeba Z, Sampath A, Schang LM, Tarbet EB, Vere Hodge RA, Bray M, Esté JA.

Antiviral Res. 2017 Sep;145:184-196. doi: 10.1016/j.antiviral.2017.07.017. Epub 2017 Aug 1.

PMID:
28774800
12.

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

Famiglini V, La Regina G, Coluccia A, Masci D, Brancale A, Badia R, Riveira-Muñoz E, Esté JA, Crespan E, Brambilla A, Maga G, Catalano M, Limatola C, Formica FR, Cirilli R, Novellino E, Silvestri R.

J Med Chem. 2017 Aug 10;60(15):6528-6547. doi: 10.1021/acs.jmedchem.6b01906. Epub 2017 Jul 5.

PMID:
28628334
13.

Antiviral treatment strategies based on gene silencing and genome editing.

Badia R, Ballana E, Esté JA, Riveira-Muñoz E.

Curr Opin Virol. 2017 Jun;24:46-54. doi: 10.1016/j.coviro.2017.04.001. Epub 2017 Apr 21. Review.

PMID:
28437703
14.

SAMHD1 is active in cycling cells permissive to HIV-1 infection.

Badia R, Pujantell M, Torres-Torronteras J, Menéndez-Arias L, Martí R, Ruzo A, Pauls E, Clotet B, Ballana E, Esté JA, Riveira-Muñoz E.

Antiviral Res. 2017 Jun;142:123-135. doi: 10.1016/j.antiviral.2017.03.019. Epub 2017 Mar 28.

PMID:
28359840
15.

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells.

Badia R, Pujantell M, Riveira-Muñoz E, Puig T, Torres-Torronteras J, Martí R, Clotet B, Ampudia RM, Vives-Pi M, Esté JA, Ballana E.

PLoS Pathog. 2016 Aug 19;12(8):e1005829. doi: 10.1371/journal.ppat.1005829. eCollection 2016 Aug.

16.

Long-term HIV-1 infection induces an antiviral state in primary macrophages.

Pujantell M, Badia R, Ramirez C, Puig T, Clotet B, Ballana E, Esté JA, Riveira-Muñoz E.

Antiviral Res. 2016 Sep;133:145-55. doi: 10.1016/j.antiviral.2016.08.004. Epub 2016 Aug 7.

PMID:
27510577
17.

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1.

Badia R, Angulo G, Riveira-Muñoz E, Pujantell M, Puig T, Ramirez C, Torres-Torronteras J, Martí R, Pauls E, Clotet B, Ballana E, Esté JA.

J Antimicrob Chemother. 2016 Feb;71(2):387-94. doi: 10.1093/jac/dkv363. Epub 2015 Nov 4.

18.

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

Ballana E, Esté JA.

Trends Microbiol. 2015 Nov;23(11):680-692. doi: 10.1016/j.tim.2015.08.002. Epub 2015 Oct 1. Review.

PMID:
26439297
19.

BMS-663068, a safe and effective HIV-1 attachment inhibitor.

Ballana E, Esté JA.

Lancet HIV. 2015 Oct;2(10):e404-5. doi: 10.1016/S2352-3018(15)00160-5. Epub 2015 Sep 2. No abstract available.

PMID:
26423643
20.

The thioacetate-ω(γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent.

Badia R, Grau J, Riveira-Muñoz E, Ballana E, Giannini G, Esté JA.

Antiviral Res. 2015 Nov;123:62-9. doi: 10.1016/j.antiviral.2015.09.004. Epub 2015 Sep 5.

PMID:
26348004
21.

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages.

Ruiz A, Pauls E, Badia R, Torres-Torronteras J, Riveira-Muñoz E, Clotet B, Martí R, Ballana E, Esté JA.

Cell Cycle. 2015;14(11):1657-65. doi: 10.1080/15384101.2015.1030558.

22.

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.

Famiglini V, La Regina G, Coluccia A, Pelliccia S, Brancale A, Maga G, Crespan E, Badia R, Riveira-Muñoz E, Esté JA, Ferretti R, Cirilli R, Zamperini C, Botta M, Schols D, Limongelli V, Agostino B, Novellino E, Silvestri R.

J Med Chem. 2014 Dec 11;57(23):9945-57. doi: 10.1021/jm5011622. Epub 2014 Nov 24.

PMID:
25418038
23.

Characterization of the influence of mediator complex in HIV-1 transcription.

Ruiz A, Pauls E, Badia R, Riveira-Muñoz E, Clotet B, Ballana E, Esté JA.

J Biol Chem. 2014 Oct 3;289(40):27665-76. doi: 10.1074/jbc.M114.570341. Epub 2014 Aug 6.

24.

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers.

Riveira-Muñoz E, Ruiz A, Pauls E, Permanyer M, Badia R, Mothe B, Crespo M, Clotet B, Brander C, Ballana E, Esté JA.

J Antimicrob Chemother. 2014 Nov;69(11):3057-60. doi: 10.1093/jac/dku276. Epub 2014 Jul 25.

PMID:
25063780
25.

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.

Pauls E, Badia R, Torres-Torronteras J, Ruiz A, Permanyer M, Riveira-Muñoz E, Clotet B, Marti R, Ballana E, Esté JA.

AIDS. 2014 Sep 24;28(15):2213-22. doi: 10.1097/QAD.0000000000000399.

PMID:
25036183
26.

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.

Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, Riveira-Muñoz E, Torres-Torronteras J, Alvarez M, Mothe B, Brander C, Crespo M, Menéndez-Arias L, Clotet B, Keppler OT, Martí R, Posas F, Ballana E, Esté JA.

J Immunol. 2014 Aug 15;193(4):1988-97. doi: 10.4049/jimmunol.1400873. Epub 2014 Jul 11.

27.

Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes.

Rotili D, Tarantino D, Nawrozkij MB, Babushkin AS, Botta G, Marrocco B, Cirilli R, Menta S, Badia R, Crespan E, Ballante F, Ragno R, Esté JA, Maga G, Mai A.

J Med Chem. 2014 Jun 26;57(12):5212-25. doi: 10.1021/jm500284x. Epub 2014 Jun 16.

PMID:
24933420
28.

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.

Ballana E, Badia R, Terradas G, Torres-Torronteras J, Ruiz A, Pauls E, Riveira-Muñoz E, Clotet B, Martí R, Esté JA.

Antimicrob Agents Chemother. 2014 Aug;58(8):4804-13. doi: 10.1128/AAC.03145-14. Epub 2014 Jun 9.

29.

Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.

Badia R, Pauls E, Riveira-Munoz E, Clotet B, Esté JA, Ballana E.

Antimicrob Agents Chemother. 2014 Aug;58(8):4318-27. doi: 10.1128/AAC.02690-14. Epub 2014 May 12.

30.

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.

Famiglini V, La Regina G, Coluccia A, Pelliccia S, Brancale A, Maga G, Crespan E, Badia R, Clotet B, Esté JA, Cirilli R, Novellino E, Silvestri R.

Eur J Med Chem. 2014 Jun 10;80:101-11. doi: 10.1016/j.ejmech.2014.04.027. Epub 2014 Apr 12.

PMID:
24769348
31.

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.

Badia R, Riveira-Muñoz E, Clotet B, Esté JA, Ballana E.

J Antimicrob Chemother. 2014 Jul;69(7):1755-9. doi: 10.1093/jac/dku072. Epub 2014 Mar 20.

PMID:
24651827
32.

p21 regulates the HIV-1 restriction factor SAMHD1.

Pauls E, Ruiz A, Riveira-Muñoz E, Permanyer M, Badia R, Clotet B, Keppler OT, Ballana E, Este JA.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1322-4. doi: 10.1073/pnas.1322059111. Epub 2014 Mar 7. No abstract available.

33.

The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection.

Permanyer M, Pauls E, Badia R, Esté JA, Ballana E.

PLoS One. 2013 Nov 11;8(11):e79221. doi: 10.1371/journal.pone.0079221. eCollection 2013.

34.

Insights from host genomics into HIV infection and disease: Identification of host targets for drug development.

Ballana E, Esté JA.

Antiviral Res. 2013 Nov;100(2):473-86. doi: 10.1016/j.antiviral.2013.09.017. Epub 2013 Sep 29. Review.

PMID:
24084487
35.

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.

Tintori C, Laurenzana I, La Rocca F, Falchi F, Carraro F, Ruiz A, Esté JA, Kissova M, Crespan E, Maga G, Biava M, Brullo C, Schenone S, Botta M.

ChemMedChem. 2013 Aug;8(8):1353-60. doi: 10.1002/cmdc.201300204. Epub 2013 Jun 28.

PMID:
23813855
36.

Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.

Pauls E, Jimenez E, Ruiz A, Permanyer M, Ballana E, Costa H, Nascimiento R, Parkhouse RM, Peña R, Riveiro-Muñoz E, Martinez MA, Clotet B, Esté JA, Bofill M.

J Immunol. 2013 May 1;190(9):4736-41. doi: 10.4049/jimmunol.1203226. Epub 2013 Mar 22.

37.

Computational studies identifying entry inhibitor scaffolds targeting the Phe43 cavity of HIV-1 gp120.

Tintori C, Selvaraj M, Badia R, Clotet B, Esté JA, Botta M.

ChemMedChem. 2013 Mar;8(3):475-83. doi: 10.1002/cmdc.201200584. Epub 2013 Feb 12.

PMID:
23404750
38.

Nucleotide embargo by SAMHD1: a strategy to block retroviral infection.

Pauls E, Ballana E, Esté JA.

Antiviral Res. 2013 Feb;97(2):180-2. doi: 10.1016/j.antiviral.2012.12.009. Epub 2012 Dec 21.

PMID:
23266292
39.

Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.

Permanyer M, Ballana E, Badia R, Pauls E, Clotet B, Esté JA.

J Biol Chem. 2012 Sep 14;287(38):32017-26. doi: 10.1074/jbc.M112.343293. Epub 2012 Jul 30.

40.

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.

Ballana E, Riveira-Munoz E, Pou C, Bach V, Parera M, Noguera M, Santos JR, Badia R, Casadellà M, Clotet B, Paredes R, Martínez MA, Brander C, Esté JA.

Immunobiology. 2013 Apr;218(4):543-7. doi: 10.1016/j.imbio.2012.06.012. Epub 2012 Jun 28.

PMID:
22818666
41.

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.

La Regina G, Coluccia A, Brancale A, Piscitelli F, Famiglini V, Cosconati S, Maga G, Samuele A, Gonzalez E, Clotet B, Schols D, Esté JA, Novellino E, Silvestri R.

J Med Chem. 2012 Jul 26;55(14):6634-8. doi: 10.1021/jm300477h. Epub 2012 Jul 6.

PMID:
22712652
42.

Antiretroviral agents effectively block HIV replication after cell-to-cell transfer.

Permanyer M, Ballana E, Ruiz A, Badia R, Riveira-Munoz E, Gonzalo E, Clotet B, Esté JA.

J Virol. 2012 Aug;86(16):8773-80. doi: 10.1128/JVI.01044-12. Epub 2012 Jun 13.

43.

Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors.

Puig-de-la-Bellacasa R, Giménez L, Pettersson S, Pascual R, Gonzalo E, Esté JA, Clotet B, Borrell JI, Teixidó J.

Eur J Med Chem. 2012 Aug;54:159-74. doi: 10.1016/j.ejmech.2012.04.038. Epub 2012 May 4.

PMID:
22652226
44.

Applications of 3-aminolactams: design, synthesis, and biological evaluation of a library of potential dimerisation inhibitors of HIV1-protease.

Pinyol E, Frutos S, Grillo-Bosch D, Giralt E, Clotet B, Esté JA, Diez A.

Org Biomol Chem. 2012 Jun 14;10(22):4348-54. doi: 10.1039/c2ob25291k. Epub 2012 Apr 30.

PMID:
22546925
45.

2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies.

Rotili D, Samuele A, Tarantino D, Ragno R, Musmuca I, Ballante F, Botta G, Morera L, Pierini M, Cirilli R, Nawrozkij MB, Gonzalez E, Clotet B, Artico M, Esté JA, Maga G, Mai A.

J Med Chem. 2012 Apr 12;55(7):3558-62. doi: 10.1021/jm201308v. Epub 2012 Mar 26.

PMID:
22428851
46.

Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors.

Radi M, Pagano M, Franchi L, Castagnolo D, Schenone S, Casaluce G, Zamperini C, Dreassi E, Maga G, Samuele A, Gonzalo E, Clotet B, Esté JA, Botta M.

ChemMedChem. 2012 May;7(5):883-96. doi: 10.1002/cmdc.201200056. Epub 2012 Mar 14.

PMID:
22419605
47.

Differential prevalence of the HLA-C -- 35 CC genotype among viremic long term non-progressor and elite controller HIV+ individuals.

Ballana E, Ruiz-de Andres A, Mothe B, Ramirez de Arellano E, Aguilar F, Badia R, Grau E, Clotet B, del Val M, Brander C, Esté JA.

Immunobiology. 2012 Sep;217(9):889-94. doi: 10.1016/j.imbio.2011.12.012. Epub 2012 Jan 8.

PMID:
22333575
48.

Rare LEDGF/p75 genetic variants in white long-term nonprogressor HIV+ individuals.

Ballana E, Gonzalo E, Grau E, Iribarren JA, Clotet B, Este JA.

AIDS. 2012 Feb 20;26(4):527-8. doi: 10.1097/QAD.0b013e32834fa194. No abstract available.

PMID:
22317832
49.

Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor.

Reyes-Chilpa R, Berkov S, Hernández-Ortega S, Jankowski CK, Arseneau S, Clotet-Codina I, Esté JA, Codina C, Viladomat F, Bastida J.

Molecules. 2011 Nov 15;16(11):9520-33. doi: 10.3390/molecules16119520.

50.

Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.

González-Ortega E, Ballana E, Badia R, Clotet B, Esté JA.

Antiviral Res. 2011 Dec;92(3):479-83. doi: 10.1016/j.antiviral.2011.10.010. Epub 2011 Oct 18.

PMID:
22027647

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