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Items: 1 to 50 of 161

1.

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.

Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, Drennan CL, Essigmann JM, Wetmore SD, Li D.

Nucleic Acids Res. 2019 Jun 20;47(11):5522-5529. doi: 10.1093/nar/gkz395.

2.

Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2-/- Il10-/- gpt delta mice is influenced by sex.

Ge Z, Feng Y, Sheh A, Muthupalani S, Gong G, Chawanthayatham S, Essigmann JM, Fox JG.

Int J Cancer. 2019 Aug 15;145(4):1042-1054. doi: 10.1002/ijc.32332. Epub 2019 May 7.

PMID:
30977112
3.

Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study.

Fedeles BI, Essigmann JM.

DNA Repair (Amst). 2018 Nov;71:12-22. doi: 10.1016/j.dnarep.2018.08.008. Epub 2018 Aug 25. Review.

4.

An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity.

Tajai P, Fedeles BI, Suriyo T, Navasumrit P, Kanitwithayanun J, Essigmann JM, Satayavivad J.

Free Radic Biol Med. 2018 Feb 20;116:64-72. doi: 10.1016/j.freeradbiomed.2017.12.035. Epub 2017 Dec 28.

5.

Editor's Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver.

Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM.

Toxicol Sci. 2017 Nov 1;160(1):173-179. doi: 10.1093/toxsci/kfx171.

6.

Early detection of the aflatoxin B1 mutational fingerprint: A diagnostic tool for liver cancer.

Fedeles BI, Chawanthayatham S, Croy RG, Wogan GN, Essigmann JM.

Mol Cell Oncol. 2017 May 19;4(4):e1329693. doi: 10.1080/23723556.2017.1329693. eCollection 2017.

7.

1,3-Butadiene-Induced Adenine DNA Adducts Are Genotoxic but Only Weakly Mutagenic When Replicated in Escherichia coli of Various Repair and Replication Backgrounds.

Chang SC, Seneviratne UI, Wu J, Tretyakova N, Essigmann JM.

Chem Res Toxicol. 2017 May 15;30(5):1230-1239. doi: 10.1021/acs.chemrestox.7b00064. Epub 2017 Apr 17.

8.

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice.

Vartanian V, Minko IG, Chawanthayatham S, Egner PA, Lin YC, Earley LF, Makar R, Eng JR, Camp MT, Li L, Stone MP, Lasarev MR, Groopman JD, Croy RG, Essigmann JM, McCullough AK, Lloyd RS.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):4207-4212. doi: 10.1073/pnas.1620932114. Epub 2017 Apr 3.

9.

Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma.

Chawanthayatham S, Valentine CC 3rd, Fedeles BI, Fox EJ, Loeb LA, Levine SS, Slocum SL, Wogan GN, Croy RG, Essigmann JM.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3101-E3109. doi: 10.1073/pnas.1700759114. Epub 2017 Mar 28.

10.

Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions.

Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D.

Chem Res Toxicol. 2017 Apr 17;30(4):1102-1110. doi: 10.1021/acs.chemrestox.7b00009. Epub 2017 Mar 24.

11.

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA.

Chen F, Tang Q, Bian K, Humulock ZT, Yang X, Jost M, Drennan CL, Essigmann JM, Li D.

Chem Res Toxicol. 2016 Apr 18;29(4):687-93. doi: 10.1021/acs.chemrestox.5b00522. Epub 2016 Mar 15.

12.

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer.

Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang SC, Li D, Delaney JC, Wilson SH, Essigmann JM.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4571-80. doi: 10.1073/pnas.1507709112. Epub 2015 Aug 4.

13.

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond.

Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM.

J Biol Chem. 2015 Aug 21;290(34):20734-42. doi: 10.1074/jbc.R115.656462. Epub 2015 Jul 7. Review.

14.

Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo.

Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM.

Nucleic Acids Res. 2015 Jun 23;43(11):5489-500. doi: 10.1093/nar/gkv243. Epub 2015 Apr 2.

15.

Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity.

Peng CS, Fedeles BI, Singh V, Li D, Amariuta T, Essigmann JM, Tokmakoff A.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3229-34. doi: 10.1073/pnas.1415974112. Epub 2015 Mar 2.

16.

Role of tautomerism in RNA biochemistry.

Singh V, Fedeles BI, Essigmann JM.

RNA. 2015 Jan;21(1):1-13. doi: 10.1261/rna.048371.114. Review.

17.

Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1.

Techapiesancharoenkij N, Fiala JL, Navasumrit P, Croy RG, Wogan GN, Groopman JD, Ruchirawat M, Essigmann JM.

Toxicol Appl Pharmacol. 2015 Jan 1;282(1):52-60. doi: 10.1016/j.taap.2014.11.004. Epub 2014 Nov 18.

18.

Mechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB.

Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM.

Chem Res Toxicol. 2014 Sep 15;27(9):1619-31. doi: 10.1021/tx5002817. Epub 2014 Aug 26.

19.

Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine.

Li D, Fedeles BI, Singh V, Peng CS, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):E3252-9. doi: 10.1073/pnas.1405635111. Epub 2014 Jul 28.

20.

Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change.

Chawanthayatham S, Thiantanawat A, Egner PA, Groopman JD, Wogan GN, Croy RG, Essigmann JM.

Int J Cancer. 2015 Mar 15;136(6):1254-62. doi: 10.1002/ijc.29102. Epub 2014 Aug 7.

21.

A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo.

Shrivastav N, Fedeles BI, Li D, Delaney JC, Frick LE, Foti JJ, Walker GC, Essigmann JM.

PLoS One. 2014 Apr 14;9(4):e94716. doi: 10.1371/journal.pone.0094716. eCollection 2014.

22.

Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes.

Zhang J, Landry MP, Barone PW, Kim JH, Lin S, Ulissi ZW, Lin D, Mu B, Boghossian AA, Hilmer AJ, Rwei A, Hinckley AC, Kruss S, Shandell MA, Nair N, Blake S, Şen F, Şen S, Croy RG, Li D, Yum K, Ahn JH, Jin H, Heller DA, Essigmann JM, Blankschtein D, Strano MS.

Nat Nanotechnol. 2013 Dec;8(12):959-68. doi: 10.1038/nnano.2013.236. Epub 2013 Nov 24.

23.

Direct observation of multiple tautomers of oxythiamine and their recognition by the thiamine pyrophosphate riboswitch.

Singh V, Peng CS, Li D, Mitra K, Silvestre KJ, Tokmakoff A, Essigmann JM.

ACS Chem Biol. 2014 Jan 17;9(1):227-36. doi: 10.1021/cb400581f. Epub 2013 Nov 19.

24.

Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB.

Li D, Fedeles BI, Shrivastav N, Delaney JC, Yang X, Wong C, Drennan CL, Essigmann JM.

Chem Res Toxicol. 2013 Aug 19;26(8):1182-7. doi: 10.1021/tx400096m. Epub 2013 Jul 10.

25.

Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using "click" chemistry.

Hanson RN, Hua E, Labaree D, Hochberg RB, Proffitt K, Essigmann JM, Croy RG.

Org Biomol Chem. 2012 Nov 14;10(42):8501-8. doi: 10.1039/c2ob25902h. Epub 2012 Sep 25.

26.

AFB(1) -induced mutagenesis of the gpt gene in AS52 cells.

Wattanawaraporn R, Kim MY, Adams J, Trudel LJ, Woo LL, Croy RG, Essigmann JM, Wogan GN.

Environ Mol Mutagen. 2012 Aug;53(7):567-73. doi: 10.1002/em.21711. Epub 2012 Jun 26.

27.

A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver.

Wattanawaraporn R, Woo LL, Belanger C, Chang SC, Adams JE, Trudel LJ, Bouhenguel JT, Egner PA, Groopman JD, Croy RG, Essigmann JM, Wogan GN.

Toxicol Sci. 2012 Aug;128(2):326-33. doi: 10.1093/toxsci/kfs151. Epub 2012 Apr 26.

28.

Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB.

Li D, Delaney JC, Page CM, Yang X, Chen AS, Wong C, Drennan CL, Essigmann JM.

J Am Chem Soc. 2012 May 30;134(21):8896-901. doi: 10.1021/ja3010094. Epub 2012 May 21.

29.

Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target.

Fedeles BI, Zhu AY, Young KS, Hillier SM, Proffitt KD, Essigmann JM, Croy RG.

J Biol Chem. 2011 Sep 30;286(39):33910-20. doi: 10.1074/jbc.M111.278390. Epub 2011 Aug 10.

30.

Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions.

Rechkoblit O, Delaney JC, Essigmann JM, Patel DJ.

Structure. 2011 Jun 8;19(6):821-32. doi: 10.1016/j.str.2011.03.020.

31.

Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.

Woo LL, Egner PA, Belanger CL, Wattanawaraporn R, Trudel LJ, Croy RG, Groopman JD, Essigmann JM, Wogan GN, Bouhenguel JT.

Toxicol Sci. 2011 Jul;122(1):38-44. doi: 10.1093/toxsci/kfr087. Epub 2011 Apr 19. Erratum in: Toxicol Sci. 2012 Jan;125(1):326. Bouhenguel, Jason T [added].

32.

Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.

Fiala JL, Egner PA, Wiriyachan N, Ruchirawat M, Kensler KH, Wogan GN, Groopman JD, Croy RG, Essigmann JM.

Toxicol Sci. 2011 May;121(1):57-62. doi: 10.1093/toxsci/kfr026. Epub 2011 Jan 28.

33.

Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461.

Mullins JI, Heath L, Hughes JP, Kicha J, Styrchak S, Wong KG, Rao U, Hansen A, Harris KS, Laurent JP, Li D, Simpson JH, Essigmann JM, Loeb LA, Parkins J.

PLoS One. 2011 Jan 14;6(1):e15135. doi: 10.1371/journal.pone.0015135.

34.

Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry.

Li D, Delaney JC, Page CM, Chen AS, Wong C, Drennan CL, Essigmann JM.

J Nucleic Acids. 2010 Oct 27;2010:369434. doi: 10.4061/2010/369434.

35.

A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase.

Jarosz DF, Cohen SE, Delaney JC, Essigmann JM, Walker GC.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21137-42. doi: 10.1073/pnas.0907257106. Epub 2009 Nov 30.

36.

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation.

Shrivastav N, Li D, Essigmann JM.

Carcinogenesis. 2010 Jan;31(1):59-70. doi: 10.1093/carcin/bgp262. Epub 2009 Oct 29. Review.

37.

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens.

Fox JG, Feng Y, Theve EJ, Raczynski AR, Fiala JL, Doernte AL, Williams M, McFaline JL, Essigmann JM, Schauer DB, Tannenbaum SR, Dedon PC, Weinman SA, Lemon SM, Fry RC, Rogers AB.

Gut. 2010 Jan;59(1):88-97. doi: 10.1136/gut.2009.183749.

38.

Efficient replication bypass of size-expanded DNA base pairs in bacterial cells.

Delaney JC, Gao J, Liu H, Shrivastav N, Essigmann JM, Kool ET.

Angew Chem Int Ed Engl. 2009;48(25):4524-7. doi: 10.1002/anie.200805683.

39.

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG).

Lee CY, Delaney JC, Kartalou M, Lingaraju GM, Maor-Shoshani A, Essigmann JM, Samson LD.

Biochemistry. 2009 Mar 10;48(9):1850-61. doi: 10.1021/bi8018898.

40.

Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate.

Mundle ST, Delaney JC, Essigmann JM, Strauss PR.

Biochemistry. 2009 Jan 13;48(1):19-26. doi: 10.1021/bi8016137.

41.

A bifunctional platinum(II) antitumor agent that forms DNA adducts with affinity for the estrogen receptor.

Kim E, Rye PT, Essigmann JM, Croy RG.

J Inorg Biochem. 2009 Feb;103(2):256-61. doi: 10.1016/j.jinorgbio.2008.10.013. Epub 2008 Oct 26.

42.

Biological properties of single chemical-DNA adducts: a twenty year perspective.

Delaney JC, Essigmann JM.

Chem Res Toxicol. 2008 Jan;21(1):232-52. Epub 2007 Dec 12. Review.

43.

Mismatch repair proteins collaborate with methyltransferases in the repair of O(6)-methylguanine.

Rye PT, Delaney JC, Netirojjanakul C, Sun DX, Liu JZ, Essigmann JM.

DNA Repair (Amst). 2008 Feb 1;7(2):170-6. Epub 2007 Oct 24.

44.

Chemical-biological fingerprinting: probing the properties of DNA lesions formed by peroxynitrite.

Delaney S, Delaney JC, Essigmann JM.

Chem Res Toxicol. 2007 Nov;20(11):1718-29. Epub 2007 Oct 18.

45.

Studies on the replication of the ring opened formamidopyrimidine, Fapy.dG in Escherichia coli.

Patro JN, Wiederholt CJ, Jiang YL, Delaney JC, Essigmann JM, Greenberg MM.

Biochemistry. 2007 Sep 4;46(35):10202-12. Epub 2007 Aug 11.

PMID:
17691820
46.

AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector.

Kim MY, Zhou X, Delaney JC, Taghizadeh K, Dedon PC, Essigmann JM, Wogan GN.

Chem Res Toxicol. 2007 Aug;20(8):1075-83. Epub 2007 Jul 20.

PMID:
17658757
47.

DNA polymerase V allows bypass of toxic guanine oxidation products in vivo.

Neeley WL, Delaney S, Alekseyev YO, Jarosz DF, Delaney JC, Walker GC, Essigmann JM.

J Biol Chem. 2007 Apr 27;282(17):12741-8. Epub 2007 Feb 24.

48.

The substrate specificity of MutY for hyperoxidized guanine lesions in vivo.

Delaney S, Neeley WL, Delaney JC, Essigmann JM.

Biochemistry. 2007 Feb 6;46(5):1448-55.

PMID:
17260974
49.

Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB.

Frick LE, Delaney JC, Wong C, Drennan CL, Essigmann JM.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):755-60. Epub 2007 Jan 9.

50.

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