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Items: 27


Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo.

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U.

Cell Rep. 2017 Jun 13;19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063.


Human haematopoietic stem cell lineage commitment is a continuous process.

Velten L, Haas SF, Raffel S, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MA, Steinmetz LM.

Nat Cell Biol. 2017 Apr;19(4):271-281. doi: 10.1038/ncb3493. Epub 2017 Mar 20.


IFNα-mediated remodeling of endothelial cells in the bone marrow niche.

Prendergast ÁM, Kuck A, van Essen M, Haas S, Blaszkiewicz S, Essers MA.

Haematologica. 2017 Mar;102(3):445-453. doi: 10.3324/haematol.2016.151209. Epub 2016 Oct 14.


Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4.

Uckelmann H, Blaszkiewicz S, Nicolae C, Haas S, Schnell A, Wurzer S, Wagener R, Aszodi A, Essers MA.

J Exp Med. 2016 Sep 19;213(10):1961-71. doi: 10.1084/jem.20151713. Epub 2016 Aug 29.


Stressed-Out HSCs Turn Up p38α and Purine to Proliferate.

Essers MAG.

Cell Stem Cell. 2016 Aug 4;19(2):143-144. doi: 10.1016/j.stem.2016.07.013.


A role for IFN during embryonic hematopoiesis.

Essers MA.

Blood. 2016 Jul 14;128(2):150-2. doi: 10.1182/blood-2016-05-713024. No abstract available.


Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.

Scognamiglio R, Cabezas-Wallscheid N, Thier MC, Altamura S, Reyes A, Prendergast ÁM, Baumgärtner D, Carnevalli LS, Atzberger A, Haas S, von Paleske L, Boroviak T, Wörsdörfer P, Essers MA, Kloz U, Eisenman RN, Edenhofer F, Bertone P, Huber W, van der Hoeven F, Smith A, Trumpp A.

Cell. 2016 Feb 11;164(4):668-80. doi: 10.1016/j.cell.2015.12.033.


Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions.

Weisser M, Demel UM, Stein S, Chen-Wichmann L, Touzot F, Santilli G, Sujer S, Brendel C, Siler U, Cavazzana M, Thrasher AJ, Reichenbach J, Essers MAG, Schwäble J, Grez M.

J Allergy Clin Immunol. 2016 Jul;138(1):219-228.e9. doi: 10.1016/j.jaci.2015.11.028. Epub 2016 Feb 4.


Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Haas S, Hansson J, Klimmeck D, Loeffler D, Velten L, Uckelmann H, Wurzer S, Prendergast ÁM, Schnell A, Hexel K, Santarella-Mellwig R, Blaszkiewicz S, Kuck A, Geiger H, Milsom MD, Steinmetz LM, Schroeder T, Trumpp A, Krijgsveld J, Essers MA.

Cell Stem Cell. 2015 Oct 1;17(4):422-34. doi: 10.1016/j.stem.2015.07.007. Epub 2015 Aug 20.


Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD.

Nature. 2015 Apr 23;520(7548):549-52. doi: 10.1038/nature14131. Epub 2015 Feb 18.


Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.

Lipka DB, Wang Q, Cabezas-Wallscheid N, Klimmeck D, Weichenhan D, Herrmann C, Lier A, Brocks D, von Paleske L, Renders S, Wünsche P, Zeisberger P, Gu L, Haas S, Essers MA, Brors B, Eils R, Trumpp A, Milsom MD, Plass C.

Cell Cycle. 2014;13(22):3476-87. doi: 10.4161/15384101.2014.973334.


Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

Cabezas-Wallscheid N, Klimmeck D, Hansson J, Lipka DB, Reyes A, Wang Q, Weichenhan D, Lier A, von Paleske L, Renders S, Wünsche P, Zeisberger P, Brocks D, Gu L, Herrmann C, Haas S, Essers MAG, Brors B, Eils R, Huber W, Milsom MD, Plass C, Krijgsveld J, Trumpp A.

Cell Stem Cell. 2014 Oct 2;15(4):507-522. doi: 10.1016/j.stem.2014.07.005. Epub 2014 Aug 21.


Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response.

Ehninger A, Boch T, Uckelmann H, Essers MA, Müdder K, Sleckman BP, Trumpp A.

Blood. 2014 Jun 19;123(25):3909-13. doi: 10.1182/blood-2013-10-531038. Epub 2014 May 2.


Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.

Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A.

J Exp Med. 2014 May 5;211(5):769-79. doi: 10.1084/jem.20131072. Epub 2014 Apr 21.


Hematopoietic stem cells, infection, and the niche.

Prendergast AM, Essers MA.

Ann N Y Acad Sci. 2014 Mar;1310:51-7. doi: 10.1111/nyas.12400. Epub 2014 Mar 10.


The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Becker MS, Schmezer P, Breuer R, Haas SF, Essers MA, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Jan 16;5:e1000. doi: 10.1038/cddis.2013.528.


Therapy of chronic myeloid leukaemia can benefit from the activation of stem cells: simulation studies of different treatment combinations.

Glauche I, Horn K, Horn M, Thielecke L, Essers MA, Trumpp A, Roeder I.

Br J Cancer. 2012 May 22;106(11):1742-52. doi: 10.1038/bjc.2012.142. Epub 2012 Apr 26.


Targeting leukemic stem cells by breaking their dormancy.

Essers MA, Trumpp A.

Mol Oncol. 2010 Oct;4(5):443-50. doi: 10.1016/j.molonc.2010.06.001. Epub 2010 Jun 9. Review.


IFNalpha activates dormant haematopoietic stem cells in vivo.

Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA, Trumpp A.

Nature. 2009 Apr 16;458(7240):904-8. doi: 10.1038/nature07815. Epub 2009 Feb 11.


Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity.

Hoogeboom D, Essers MA, Polderman PE, Voets E, Smits LM, Burgering BM.

J Biol Chem. 2008 Apr 4;283(14):9224-30. doi: 10.1074/jbc.M706638200. Epub 2008 Feb 4.


Dormant and self-renewing hematopoietic stem cells and their niches.

Wilson A, Oser GM, Jaworski M, Blanco-Bose WE, Laurenti E, Adolphe C, Essers MA, Macdonald HR, Trumpp A.

Ann N Y Acad Sci. 2007 Jun;1106:64-75. Epub 2007 Apr 18. Review.


Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene.

Oskarsson T, Essers MA, Dubois N, Offner S, Dubey C, Roger C, Metzger D, Chambon P, Hummler E, Beard P, Trumpp A.

Genes Dev. 2006 Aug 1;20(15):2024-9.


Functional interaction between beta-catenin and FOXO in oxidative stress signaling.

Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC.

Science. 2005 May 20;308(5725):1181-4.


FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, Burgering BM.

EMBO J. 2004 Dec 8;23(24):4802-12. Epub 2004 Nov 11.


Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors.

Kops GJ, Medema RH, Glassford J, Essers MA, Dijkers PF, Coffer PJ, Lam EW, Burgering BM.

Mol Cell Biol. 2002 Apr;22(7):2025-36.


Negative growth regulation of SK-N-MC cells by bFGF defines a growth factor-sensitive point in G2.

Smits VA, van Peer MA, Essers MA, Klompmaker R, Rijksen G, Medema RH.

J Biol Chem. 2000 Jun 23;275(25):19375-81.


Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation.

Smits VA, Essers MA, Loomans DS, Klompmaker R, Rijksen G, Medema RH.

FEBS Lett. 1999 Aug 20;457(1):23-7.

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