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Items: 1 to 50 of 79

1.

A combined miRNA-piRNA signature to detect Alzheimer's disease.

Jain G, Stuendl A, Rao P, Berulava T, Pena Centeno T, Kaurani L, Burkhardt S, Delalle I, Kornhuber J, Hüll M, Maier W, Peters O, Esselmann H, Schulte C, Deuschle C, Synofzik M, Wiltfang J, Mollenhauer B, Maetzler W, Schneider A, Fischer A.

Transl Psychiatry. 2019 Oct 7;9(1):250. doi: 10.1038/s41398-019-0579-2.

2.

CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer's disease.

Teuber-Hanselmann S, Rekowski J, Vogelgsang J, von Arnim C, Reetz K, Stang A, Jöckel KH, Wiltfang J, Esselmann H, Otto M, Tumani H, Herring A, Keyvani K.

J Neurol Neurosurg Psychiatry. 2019 Aug 1. pii: jnnp-2019-321073. doi: 10.1136/jnnp-2019-321073. [Epub ahead of print]

3.

Correction to: Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer's, but not in frontotemporal dementia.

Bibl M, Gallus M, Welge V, Esselmann H, Wolf S, Rüther E, Wiltfang J.

J Neural Transm (Vienna). 2018 Oct;125(10):1515-1516. doi: 10.1007/s00702-018-1914-0.

4.

[Guideline-adherent inpatient psychiatric psychotherapeutic treatment of behavioral and psychological symptoms of dementia : Normative definition of personnel requirements].

Radenbach K, Retzlik J, Meyer-Rötz SH, Wolff-Menzler C, Wolff J, Esselmann H, Godemann F, Riemenschneider M, Wiltfang J, Jessen F.

Nervenarzt. 2017 Sep;88(9):1010-1019. doi: 10.1007/s00115-016-0195-9. German.

PMID:
27581115
5.

A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques.

Moreno F, Rabinovici GD, Karydas A, Miller Z, Hsu SC, Legati A, Fong J, Schonhaut D, Esselmann H, Watson C, Stephens ML, Kramer J, Wiltfang J, Seeley WW, Miller BL, Coppola G, Grinberg LT.

Acta Neuropathol Commun. 2015 Apr 3;3:19. doi: 10.1186/s40478-015-0190-6.

6.

Hypocretin in cerebrospinal fluid is positively correlated with Tau and pTau.

Deuschle M, Schilling C, Leweke FM, Enning F, Pollmächer T, Esselmann H, Wiltfang J, Frölich L, Heuser I.

Neurosci Lett. 2014 Feb 21;561:41-5. doi: 10.1016/j.neulet.2013.12.036. Epub 2013 Dec 25.

PMID:
24373987
7.

Challenges in modern biomarker discovery--17th HUPO BPP workshop: May 24-25, 2012, Sao Paulo, Brazil.

Gröttrup B, Esselmann H, May C, Schrötter A, Woitalla D, Heinsen H, Marcus K, Wiltfang J, Meyer HE, Grinberg LT, Park YM.

Proteomics. 2013 Jan;13(2):210-6. doi: 10.1002/pmic.201370025.

8.

Neurochemical biomarkers in Alzheimer's disease and related disorders.

Bibl M, Esselmann H, Wiltfang J.

Ther Adv Neurol Disord. 2012 Nov;5(6):335-48. doi: 10.1177/1756285612455367.

9.

Current application of neurochemical biomarkers in the prediction and differential diagnosis of Alzheimer's disease and other neurodegenerative dementias.

Genius J, Klafki H, Benninghoff J, Esselmann H, Wiltfang J.

Eur Arch Psychiatry Clin Neurosci. 2012 Nov;262 Suppl 2:S71-7. doi: 10.1007/s00406-012-0362-3. Epub 2012 Sep 18. Review.

PMID:
22986448
10.

Plasma amyloid-beta peptides in acute cerebral ischemia: a pilot study.

Bibl M, Welge V, Schmidt H, Esselmann H, Mollenhauer B, Lewczuk P, Otto M, Kornhuber J, Wiltfang J.

J Clin Lab Anal. 2012 Jul;26(4):238-45. doi: 10.1002/jcla.21511.

11.

Development of a magnetic immunosorbent for on-chip preconcentration of amyloid β isoforms: Representatives of Alzheimer's disease biomarkers.

Svobodova Z, Reza Mohamadi M, Jankovicova B, Esselmann H, Verpillot R, Otto M, Taverna M, Wiltfang J, Viovy JL, Bilkova Z.

Biomicrofluidics. 2012 Jun;6(2):24126-2412612. doi: 10.1063/1.4722588. Epub 2012 May 24.

12.

Characterization of cerebrospinal fluid aminoterminally truncated and oxidized amyloid-β peptides.

Bibl M, Gallus M, Welge V, Lehmann S, Sparbier K, Esselmann H, Wiltfang J.

Proteomics Clin Appl. 2012 Apr;6(3-4):163-9. doi: 10.1002/prca.201100082.

PMID:
22532452
13.

Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer's, but not in frontotemporal dementia.

Bibl M, Gallus M, Welge V, Esselmann H, Wolf S, Rüther E, Wiltfang J.

J Neural Transm (Vienna). 2012 Jul;119(7):805-13. doi: 10.1007/s00702-012-0801-3. Epub 2012 Apr 19. Erratum in: J Neural Transm (Vienna). 2018 Oct;125(10):1515-1516.

14.

Presenilin-1 L166P mutant human pluripotent stem cell-derived neurons exhibit partial loss of γ-secretase activity in endogenous amyloid-β generation.

Koch P, Tamboli IY, Mertens J, Wunderlich P, Ladewig J, Stüber K, Esselmann H, Wiltfang J, Brüstle O, Walter J.

Am J Pathol. 2012 Jun;180(6):2404-16. doi: 10.1016/j.ajpath.2012.02.012. Epub 2012 Apr 14.

PMID:
22510327
15.

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, Rousseau F, Broersen K, De Strooper B.

EMBO J. 2012 May 16;31(10):2261-74. doi: 10.1038/emboj.2012.79. Epub 2012 Apr 13.

16.

Aminoterminally truncated and oxidized amyloid-β peptides in the cerebrospinal fluid of Alzheimer's disease patients.

Bibl M, Gallus M, Welge V, Esselmann H, Wiltfang J.

J Alzheimers Dis. 2012;29(4):809-16. doi: 10.3233/JAD-2012-111796.

PMID:
22460324
17.

Stability of amyloid-β peptides in plasma and serum.

Bibl M, Welge V, Esselmann H, Wiltfang J.

Electrophoresis. 2012 Feb;33(3):445-50. doi: 10.1002/elps.201100455.

PMID:
22287174
18.

Polymeric complements to the Alzheimer's disease biomarker β-amyloid isoforms Aβ1-40 and Aβ1-42 for blood serum analysis under denaturing conditions.

Urraca JL, Aureliano CS, Schillinger E, Esselmann H, Wiltfang J, Sellergren B.

J Am Chem Soc. 2011 Jun 22;133(24):9220-3. doi: 10.1021/ja202908z. Epub 2011 Jun 1.

PMID:
21630636
19.

Long-term stability of Alzheimer's disease biomarker proteins in cerebrospinal fluid.

Schipke CG, Jessen F, Teipel S, Luckhaus C, Wiltfang J, Esselmann H, Frölich L, Maier W, Rüther E, Heppner FL, Prokop S, Heuser I, Peters O.

J Alzheimers Dis. 2011;26(2):255-62. doi: 10.3233/JAD-2011-110329.

PMID:
21606567
20.

Analysis of amyloid-β peptides in cerebrospinal fluid samples by capillary electrophoresis coupled with LIF detection.

Verpillot R, Esselmann H, Mohamadi MR, Klafki H, Poirier F, Lehnert S, Otto M, Wiltfang J, Jean-Louis V, Taverna M.

Anal Chem. 2011 Mar 1;83(5):1696-703. doi: 10.1021/ac102828f. Epub 2011 Feb 11.

PMID:
21314132
21.

CSF amyloid-β peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.

Mollenhauer B, Esselmann H, Trenkwalder C, Schulz-Schaeffer W, Kretzschmar H, Otto M, Wiltfang J, Bibl M.

J Alzheimers Dis. 2011;24(2):383-91. doi: 10.3233/JAD-2011-101551.

PMID:
21297274
22.

Different CSF β-amyloid processing in Alzheimer's and Creutzfeldt-Jakob disease.

Mollenhauer B, Esselmann H, Roeber S, Schulz-Schaeffer WJ, Trenkwalder C, Bibl M, Steinacker P, Kretzschmar HA, Wiltfang J, Otto M.

J Neural Transm (Vienna). 2011 May;118(5):691-7. doi: 10.1007/s00702-010-0543-z. Epub 2011 Jan 6. Erratum in: J Neural Transm. 2011 Aug;118(8):1261-2.

PMID:
21210287
23.

Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias.

Bibl M, Mollenhauer B, Lewczuk P, Esselmann H, Wolf S, Otto M, Kornhuber J, Rüther E, Wiltfang J.

Dement Geriatr Cogn Disord. 2011;31(1):37-44. doi: 10.1159/000322370. Epub 2010 Dec 7.

PMID:
21135556
24.

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated.

Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz E Silva EF, da Cruz E Silva OA.

Mol Neurodegener. 2010 Oct 11;5:40. doi: 10.1186/1750-1326-5-40.

25.

cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases.

Spitzer P, Klafki HW, Blennow K, Buée L, Esselmann H, Herruka SK, Jimenez C, Klivenyi P, Lewczuk P, Maler JM, Markus K, Meyer HE, Morris C, Müller T, Otto M, Parnetti L, Soininen H, Schraen S, Teunissen C, Vecsei L, Zetterberg H, Wiltfang J.

Int J Alzheimers Dis. 2010 Sep 19;2010. pii: 548145. doi: 10.4061/2010/548145.

26.

Combined Analysis of CSF Tau, Aβ42, Aβ1-42% and Aβ1-40% in Alzheimer's Disease, Dementia with Lewy Bodies and Parkinson's Disease Dementia.

Bibl M, Esselmann H, Lewczuk P, Trenkwalder C, Otto M, Kornhuber J, Wiltfang J, Mollenhauer B.

Int J Alzheimers Dis. 2010 Aug 24;2010. pii: 761571. doi: 10.4061/2010/761571.

27.

Microchip electrophoresis profiling of Aβ peptides in the cerebrospinal fluid of patients with Alzheimer's disease.

Mohamadi MR, Svobodova Z, Verpillot R, Esselmann H, Wiltfang J, Otto M, Taverna M, Bilkova Z, Viovy JL.

Anal Chem. 2010 Sep 15;82(18):7611-7. doi: 10.1021/ac101337n.

PMID:
20722394
28.

Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases.

Ebert S, Goos M, Rollwagen L, Baake D, Zech WD, Esselmann H, Wiltfang J, Mollenhauer B, Schliebs R, Gerber J, Nau R.

J Neurosci Res. 2010 Apr;88(5):1124-36. doi: 10.1002/jnr.22270.

PMID:
19859962
29.

Measurement of ERK 1/2 in CSF from patients with neuropsychiatric disorders and evidence for the presence of the activated form.

Klafki HW, Lewczuk P, Kamrowski-Kruck H, Maler JM, Müller K, Peters O, Heuser I, Jessen F, Popp J, Frölich L, Wolf S, Prinz B, Luckhaus C, Schröder J, Pantel J, Gertz HJ, Kölsch H, Müller BW, Esselmann H, Bibl M, Kornhuber J, Wiltfang J.

J Alzheimers Dis. 2009;18(3):613-22. doi: 10.3233/JAD-2009-1167.

PMID:
19625747
30.

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B.

Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19.

31.

[Physical activity and prevention of Alzheimer's dementia: current evidence and feasibility of an interventional trial].

Weih M, Abu-Omar K, Esselmann H, Gelbrich G, Lewczuk P, Rütten A, Wiltfang J, Kornhuber J.

Fortschr Neurol Psychiatr. 2009 Mar;77(3):146-51. doi: 10.1055/s-0028-1109068. Epub 2009 Mar 12. Review. German.

PMID:
19283649
32.

Exposure to allergens of different cattle breeds and their relevance in occupational allergy.

Heutelbeck AR, Junghans C, Esselmann H, Hallier E, Schulz TG.

Int Arch Occup Environ Health. 2009 Oct;82(9):1123-31. doi: 10.1007/s00420-009-0400-2. Epub 2009 Feb 24.

33.

Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease.

Welge V, Fiege O, Lewczuk P, Mollenhauer B, Esselmann H, Klafki HW, Wolf S, Trenkwalder C, Otto M, Kornhuber J, Wiltfang J, Bibl M.

J Neural Transm (Vienna). 2009 Feb;116(2):203-12. doi: 10.1007/s00702-008-0177-6. Epub 2009 Jan 14.

PMID:
19142572
34.

Distinct fractional Abeta release patterns in human mononuclear phagocytes.

Maler JM, Spitzer P, Klafki HW, Esselmann H, Lewczuk P, Kornhuber J, Herrmann M, Wiltfang J.

J Neuroimmunol. 2009 Jan 3;206(1-2):1-4. doi: 10.1016/j.jneuroim.2008.08.010. Epub 2008 Sep 27.

PMID:
18824266
35.

CSF amyloid-β 1-38 and 1-42 in FTD and AD: Biomarker performance critically depends on the detergent accessible fraction.

Bibl M, Lewczuk P, Esselmann H, Mollenhauer B, Klafki HW, Welge V, Wolf S, Trenkwalder C, Otto M, Kornhuber J, Wiltfang J.

Proteomics Clin Appl. 2008 Oct;2(10-11):1548-56. doi: 10.1002/prca.200800006. Epub 2008 Sep 10.

PMID:
21136802
36.

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study.

Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H, Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus Ch, Perneczky R, Hüll M, Schröder J, Kessler H, Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J.

Mol Psychiatry. 2010 Feb;15(2):138-45. doi: 10.1038/mp.2008.84. Epub 2008 Jul 29.

PMID:
18663368
37.

Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment.

Mamo JC, Jian L, James AP, Flicker L, Esselmann H, Wiltfang J.

Ann Clin Biochem. 2008 Jul;45(Pt 4):395-403. doi: 10.1258/acb.2008.007214.

PMID:
18583625
38.

Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes.

Maler JM, Spitzer P, Klafki HW, Esselmann H, Bibl M, Lewczuk P, Kornhuber J, Herrmann M, Wiltfang J.

Brain Behav Immun. 2008 Oct;22(7):1044-8. doi: 10.1016/j.bbi.2008.04.003. Epub 2008 Jun 3.

PMID:
18511234
39.

Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S.

J Biol Chem. 2008 Jun 20;283(25):17049-54. doi: 10.1074/jbc.M802912200. Epub 2008 Apr 21.

40.

Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.

Leuchtenberger S, Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S.

Neurodegener Dis. 2009;6(1-2):1-8. doi: 10.1159/000121391. Epub 2008 Mar 18.

PMID:
18349521
41.

Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review.

Bibl M, Mollenhauer B, Esselmann H, Schneider M, Lewczuk P, Welge V, Gross M, Falkai P, Kornhuber J, Wiltfang J.

Dement Geriatr Cogn Disord. 2008;25(3):256-65. doi: 10.1159/000115975. Epub 2008 Feb 13. Review.

PMID:
18270488
42.

Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species.

Maler JM, Klafki HW, Paul S, Spitzer P, Groemer TW, Henkel AW, Esselmann H, Lewczuk P, Kornhuber J, Wiltfang J.

Proteomics. 2007 Oct;7(20):3815-20.

PMID:
17924594
43.

Tyr687 dependent APP endocytosis and Abeta production.

Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF, da Cruz e Silva OA.

J Mol Neurosci. 2007;32(1):1-8.

PMID:
17873282
44.

Blood-based neurochemical diagnosis of vascular dementia: a pilot study.

Bibl M, Esselmann H, Mollenhauer B, Weniger G, Welge V, Liess M, Lewczuk P, Otto M, Schulz JB, Trenkwalder C, Kornhuber J, Wiltfang J.

J Neurochem. 2007 Oct;103(2):467-74. Epub 2007 Jul 27.

45.

Tyrosine 687 phosphorylated Alzheimer's amyloid precursor protein is retained intracellularly and exhibits a decreased turnover rate.

Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF, da Cruz e Silva OA.

Neurodegener Dis. 2007;4(2-3):78-87.

PMID:
17596701
46.

Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias.

Bibl M, Mollenhauer B, Lewczuk P, Esselmann H, Wolf S, Trenkwalder C, Otto M, Stiens G, Rüther E, Kornhuber J, Wiltfang J.

Mol Psychiatry. 2007 Jul;12(7):671-80. Epub 2007 Mar 6.

PMID:
17339876
47.

Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?

Mollenhauer B, Bibl M, Esselmann H, Steinacker P, Trenkwalder C, Wiltfang J, Otto M.

J Neural Transm (Vienna). 2007 Jul;114(7):919-27. Epub 2007 Feb 22.

PMID:
17318305
48.

Aminoterminally truncated and oxidized amyloid-beta peptide species in Alzheimer's disease.

Bibl M, Esselmann H, Mollenhauer B, Wiltfang J.

Neuroscience. 2007 Apr 25;146(1):17-8. Epub 2007 Feb 20. No abstract available.

PMID:
17317020
49.

Immune complexes of auto-antibodies against A beta 1-42 peptides patrol cerebrospinal fluid of non-Alzheimer's patients.

Henkel AW, Dittrich PS, Groemer TW, Lemke EA, Klingauf J, Klafki HW, Lewczuk P, Esselmann H, Schwille P, Kornhuber J, Wiltfang J.

Mol Psychiatry. 2007 Jun;12(6):601-10. Epub 2007 Feb 6.

PMID:
17279093
50.

Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load.

Wiltfang J, Esselmann H, Bibl M, Hüll M, Hampel H, Kessler H, Frölich L, Schröder J, Peters O, Jessen F, Luckhaus C, Perneczky R, Jahn H, Fiszer M, Maler JM, Zimmermann R, Bruckmoser R, Kornhuber J, Lewczuk P.

J Neurochem. 2007 May;101(4):1053-9. Epub 2007 Jan 24.

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