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Items: 13

1.

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.

Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, Vints K, Baatsen P, Munck S, Derua R, Waelkens E, Basi GS, Mercken M, Vooijs M, Bollen M, Schymkowitz J, Rousseau F, Bonifacino JS, Van Niel G, De Strooper B, Annaert W.

Cell. 2016 Jun 30;166(1):193-208. doi: 10.1016/j.cell.2016.05.020. Epub 2016 Jun 9.

2.

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain.

Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De Strooper B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W.

FASEB J. 2012 Sep;26(9):3765-78. doi: 10.1096/fj.11-201368. Epub 2012 Jun 1.

PMID:
22661005
3.

ADAM17 (TACE) regulates TGFβ signaling through the cleavage of vasorin.

Malapeira J, Esselens C, Bech-Serra JJ, Canals F, Arribas J.

Oncogene. 2011 Apr 21;30(16):1912-22. doi: 10.1038/onc.2010.565. Epub 2010 Dec 20.

PMID:
21170088
4.

The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration.

Esselens C, Malapeira J, Colomé N, Casal C, Rodríguez-Manzaneque JC, Canals F, Arribas J.

J Biol Chem. 2010 Jan 22;285(4):2463-73. doi: 10.1074/jbc.M109.055129. Epub 2009 Nov 13.

5.

ADAM17 as a therapeutic target in multiple diseases.

Arribas J, Esselens C.

Curr Pharm Des. 2009;15(20):2319-35. Review.

PMID:
19601834
6.

Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.

Esselens CW, Malapeira J, Colomé N, Moss M, Canals F, Arribas J.

Biol Chem. 2008 Aug;389(8):1075-84.

PMID:
18979631
7.

Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors.

Santiago-Josefat B, Esselens C, Bech-Serra JJ, Arribas J.

J Biol Chem. 2007 Mar 16;282(11):8325-31. Epub 2007 Jan 16.

8.

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.

Bech-Serra JJ, Santiago-Josefat B, Esselens C, Saftig P, Baselga J, Arribas J, Canals F.

Mol Cell Biol. 2006 Jul;26(13):5086-95.

9.

Presenilin 1: more than just gamma-secretase.

Raemaekers T, Esselens C, Annaert W.

Biochem Soc Trans. 2005 Aug;33(Pt 4):559-62. Review.

PMID:
16042544
10.

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway.

Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W.

J Cell Biol. 2004 Sep 27;166(7):1041-54.

11.

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.

Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B.

Neuron. 2001 Nov 20;32(4):579-89.

12.

A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32.

Veugelers M, De Cat B, Delande N, Esselens C, Bonk I, Vermeesch J, Marynen P, Fryns JP, David G.

Matrix Biol. 2001 Sep;20(5-6):375-85.

PMID:
11566272
13.

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B.

Hum Mol Genet. 2001 Aug 1;10(16):1665-71.

PMID:
11487570

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