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Items: 50

1.

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.

Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01734-18. doi: 10.1128/AAC.01734-18. Print 2019 Jan.

2.

Aptamer Selection against a Trichomonas vaginalis Adhesion Protein for Diagnostic Applications.

Espiritu CAL, Justo CAC, Rubio MJ, Svobodova M, Bashammakh AS, Alyoubi AO, Rivera WL, Rollon AP, O'Sullivan CK.

ACS Infect Dis. 2018 Sep 14;4(9):1306-1315. doi: 10.1021/acsinfecdis.8b00065. Epub 2018 Jul 20.

PMID:
29972299
3.

Prophylactic intracameral levofloxacin in cataract surgery - an evaluation of safety.

Espiritu CRG, Bolinao JG.

Clin Ophthalmol. 2017 Dec 12;11:2199-2204. doi: 10.2147/OPTH.S144625. eCollection 2017.

4.

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.

Lam AM, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00680-17. doi: 10.1128/AAC.00680-17. Print 2017 Aug.

5.

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies.

Ramanan V, Trehan K, Ong ML, Luna JM, Hoffmann HH, Espiritu C, Sheahan TP, Chandrasekar H, Schwartz RE, Christine KS, Rice CM, van Oudenaarden A, Bhatia SN.

Virology. 2016 Jul;494:236-47. doi: 10.1016/j.virol.2016.04.020. Epub 2016 Apr 27.

6.

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.

Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15196-201. doi: 10.1073/pnas.1513803112. Epub 2015 Nov 23.

7.

SEC14L2 enables pan-genotype HCV replication in cell culture.

Saeed M, Andreo U, Chung HY, Espiritu C, Branch AD, Silva JM, Rice CM.

Nature. 2015 Aug 27;524(7566):471-5. doi: 10.1038/nature14899. Epub 2015 Aug 12.

8.

Gene therapy with neurogenin3, betacellulin and SOCS1 reverses diabetes in NOD mice.

Li R, Buras E, Lee J, Liu R, Liu V, Espiritu C, Ozer K, Thompson B, Nally L, Yuan G, Oka K, Chang B, Samson S, Yechoor V, Chan L.

Gene Ther. 2015 Nov;22(11):876-82. doi: 10.1038/gt.2015.62. Epub 2015 Jul 14.

9.

Hepatitis C virus genotype 5a subgenomic replicons for evaluation of direct-acting antiviral agents.

Wose Kinge CN, Espiritu C, Prabdial-Sing N, Sithebe NP, Saeed M, Rice CM.

Antimicrob Agents Chemother. 2014 Sep;58(9):5386-94. doi: 10.1128/AAC.03534-14. Epub 2014 Jun 30.

10.

Use of 2'-spirocyclic ethers in HCV nucleoside design.

Du J, Chun BK, Mosley RT, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Sofia MJ.

J Med Chem. 2014 Mar 13;57(5):1826-35. doi: 10.1021/jm401224y. Epub 2013 Oct 18.

PMID:
24079820
11.

Discovery of novel HCV inhibitors: synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B.

Zhang X, Zhang N, Chen G, Turpoff A, Ren H, Takasugi J, Morrill C, Zhu J, Li C, Lennox W, Paget S, Liu Y, Almstead N, Njoroge FG, Gu Z, Komatsu T, Clausen V, Espiritu C, Graci J, Colacino J, Lahser F, Risher N, Weetall M, Nomeir A, Karp GM.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3947-53. doi: 10.1016/j.bmcl.2013.04.049. Epub 2013 Apr 30.

PMID:
23683597
12.

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

Du J, Bao D, Chun BK, Jiang Y, Reddy PG, Zhang HR, Ross BS, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2012 Sep 15;22(18):5924-9. doi: 10.1016/j.bmcl.2012.07.066. Epub 2012 Jul 27.

PMID:
22892115
13.

Prognostic and predictive significance of proliferation in 867 colorectal cancers.

Fodor IK, Hutchins GG, Espiritu C, Quirke P, Jubb AM.

J Clin Pathol. 2012 Nov;65(11):989-95. doi: 10.1136/jclinpath-2012-200911. Epub 2012 Aug 2.

PMID:
22859394
14.

A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.

Liu J, Du J, Wang P, Nagarathnam D, Espiritu CL, Bao H, Murakami E, Furman PA, Sofia MJ.

Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):277-85. doi: 10.1080/15257770.2012.658131.

PMID:
22444190
15.

Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.

Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Niu C, Zennou V, Keilman M, Zhu Y, Lan S, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68. doi: 10.1128/AAC.00054-12. Epub 2012 Mar 19.

16.

Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

Chun BK, Du J, Zhang HR, Chang W, Ross BS, Jiang Y, Bao D, Espiritu CL, Keilman M, Steuer HM, Furman PA, Sofia MJ.

Nucleosides Nucleotides Nucleic Acids. 2011 Nov;30(11):886-96. doi: 10.1080/15257770.2011.614308.

PMID:
22060553
17.

Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.

Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Zennou V, Otto MJ, Furman PA.

J Virol. 2011 Dec;85(23):12334-42. doi: 10.1128/JVI.05639-11. Epub 2011 Sep 28.

18.
19.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

Furman PA, Murakami E, Niu C, Lam AM, Espiritu C, Bansal S, Bao H, Tolstykh T, Micolochick Steuer H, Keilman M, Zennou V, Bourne N, Veselenak RL, Chang W, Ross BS, Du J, Otto MJ, Sofia MJ.

Antiviral Res. 2011 Aug;91(2):120-32. doi: 10.1016/j.antiviral.2011.05.003. Epub 2011 May 12.

20.

Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.

Lam AM, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer HM, Niu C, Keilman M, Bao H, Bourne N, Veselenak RL, Reddy PG, Chang W, Du J, Nagarathnam D, Sofia MJ, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2011 Jun;55(6):2566-75. doi: 10.1128/AAC.00032-11. Epub 2011 Mar 28.

21.

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.

Chang W, Bao D, Chun BK, Naduthambi D, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ.

ACS Med Chem Lett. 2010 Dec 17;2(2):130-5. doi: 10.1021/ml100209f. eCollection 2011 Feb 10.

22.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

Reddy PG, Bao D, Chang W, Chun BK, Du J, Nagarathnam D, Rachakonda S, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7376-80. doi: 10.1016/j.bmcl.2010.10.035. Epub 2010 Oct 15.

PMID:
21050754
23.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA.

J Med Chem. 2010 Oct 14;53(19):7202-18. doi: 10.1021/jm100863x.

PMID:
20845908
24.

Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.

Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, Chang W, Espiritu C, Bansal S, Lam AM, Otto MJ, Sofia MJ, Furman PA.

J Biol Chem. 2010 Nov 5;285(45):34337-47. doi: 10.1074/jbc.M110.161802. Epub 2010 Aug 26.

25.

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1.

26.

Incision sizes at different stages of phacoemulsification with foldable intraocular lens implantation.

Espiritu CR, Bernardo JP Jr.

J Cataract Refract Surg. 2009 Dec;35(12):2115-20. doi: 10.1016/j.jcrs.2009.06.037.

PMID:
19969217
27.

Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes.

Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L.

Dev Cell. 2009 Mar;16(3):358-73. doi: 10.1016/j.devcel.2009.01.012.

28.

Safety of prophylactic intracameral moxifloxacin 0.5% ophthalmic solution in cataract surgery patients.

Espiritu CR, Caparas VL, Bolinao JG.

J Cataract Refract Surg. 2007 Jan;33(1):63-8.

PMID:
17189795
29.

Comparison of bacteriostatic normal saline and lidocaine used as intradermal anesthesia for the placement of intravenous lines.

Windle PE, Kwan ML, Warwick H, Sibayan A, Espiritu C, Vergara J.

J Perianesth Nurs. 2006 Aug;21(4):251-8.

PMID:
16935736
30.

Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly.

Yen HC, Espiritu C, Chang EC.

J Biol Chem. 2003 Aug 15;278(33):30669-76. Epub 2003 Jun 3.

31.

RL-37, an alpha-helical antimicrobial peptide of the rhesus monkey.

Zhao C, Nguyen T, Boo LM, Hong T, Espiritu C, Orlov D, Wang W, Waring A, Lehrer RI.

Antimicrob Agents Chemother. 2001 Oct;45(10):2695-702.

32.

Bactericidal activity of mammalian cathelicidin-derived peptides.

Travis SM, Anderson NN, Forsyth WR, Espiritu C, Conway BD, Greenberg EP, McCray PB Jr, Lehrer RI, Welsh MJ, Tack BF.

Infect Immun. 2000 May;68(5):2748-55.

33.

New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen.

Sheppard HM, Corneillie SI, Espiritu C, Gatti A, Liu X.

Mol Cell Biol. 1999 Apr;19(4):2746-53.

34.

Chronic anterior uveitis in leprosy: an insidious cause of blindness.

Espiritu CG, Gelber R, Ostler HB.

Br J Ophthalmol. 1991 May;75(5):273-5.

35.

Allopurinol-induced granulomatous hepatitis.

Espiritu CR, Alalu J, Glueckauf LG, Lubin J.

Am J Dig Dis. 1976 Sep;21(9):804-6. No abstract available.

PMID:
961676
36.

A severe infantile micromelic chondrodysplasia which resembles Kniest disease.

Langer LO Jr, Gonzalez-Ramos M, Chen H, Espiritu CE, Courtney NW, Opitz JM.

Eur J Pediatr. 1976 Aug 16;123(1):29-38.

PMID:
989037
37.

An extra small metacentric chromosome identified as a deleted chromosome no. 17.

Palutke W, Chen H, Woolley P Jr, Espiritu C, Vogel HL, Gohle N, Tyrkus M.

Clin Genet. 1976 May;9(5):454-58.

PMID:
1269167
38.

Chlorpropamide-induced granulomas. A probable hypersensitivity reaction in liver and bone marrow.

Rigberg LA, Robinson MJ, Espiritu CR.

JAMA. 1976 Jan 26;235(4):409-10.

PMID:
128640
39.

Mucolipidosis III (pseudo-Hurler polydystrophy): Clinical and laboratory studies in a series of 12 patients.

Kelly TE, Thomas GH, Taylor HA Jr, McKusick VA, Sly WS, Glaser JH, Robinow M, Luzzatti L, Espiritu C, Feingold M, Bull MJ, Ashenhurst EM, Ives EJ.

Johns Hopkins Med J. 1975 Oct;137(4):156-75.

PMID:
810612
40.

Mesomelic dwarfism as the homozygous expression of dyschondrosteosis.

Espiritu C, Chen H, Woolley PV Jr.

Am J Dis Child. 1975 Mar;129(3):375-7. No abstract available.

PMID:
1121969
41.

The clinical presentation of mesenteric vascular disease.

Espiritu CR, Robinson MJ.

South Med J. 1975 Feb;68(2):153-6.

PMID:
1078914
42.

Probable homozygosity for the dyschondrosteosis genes.

Espiritu CE, Chen H, Woolley PV Jr.

Birth Defects Orig Artic Ser. 1975;11(6):127-32. No abstract available.

PMID:
1201337
43.

Inter-nipple distance in normal children from birth to 14 years, and in children with Turner's, Noonan's, Down's and other aneuploides.

Chen H, Espiritu C, Casquejo C, Boriboon K, Woolley P Jr.

Growth. 1974 Dec;38(4):421-36. No abstract available.

PMID:
4282364
44.

Familial bird-headed dwarfism (Seckel's syndrome).

Sauk JJ, Litt R, Espiritu CE, Delaney JR.

J Med Genet. 1973 Jun;10(2):196-8. No abstract available.

45.

Mallory-Weiss syndrome presenting as a gastric tumor.

Espiritu CR, Mendoza J, Gratz CJ.

JFMA. 1973 Mar;60(3):24-5. No abstract available.

PMID:
4687252
46.

Effects of intravenous infusion of dopamine in cirrhotics.

Espiritu CR, Mendoza JP, Yeh BK.

Proc Soc Exp Biol Med. 1972 Oct;141(1):331-5. No abstract available.

PMID:
5082308
47.

Diagnostic accuracy of pancreatic scanning.

Espiritu CR, Rolfs HE.

Am J Dig Dis. 1972 Jun;17(6):539-43. No abstract available.

PMID:
5030746
48.

Arthrogryposis multiplex congenita and the Turner phenotype.

Krieger I, Espiritu CE.

Am J Dis Child. 1972 Feb;123(2):141-4. No abstract available.

PMID:
5025860
49.

Trisomy D1 syndrome with DqDq tandem translocation.

Chen YC, Espiritu C, Woolley PV Jr.

Am J Dis Child. 1971 Dec;122(6):535-7. No abstract available.

PMID:
5156262
50.

Granulomatous hepatitis associated with sulfadimethoxine hypersensitivity.

Espiritu CR, Kim TS, Levine RA.

JAMA. 1967 Dec 4;202(10):985-8. No abstract available.

PMID:
5630747

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