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Items: 1 to 50 of 286

1.

Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.

Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GØ, Halvorsen B.

Atherosclerosis. 2019 Dec 14. pii: S0021-9150(19)31626-0. doi: 10.1016/j.atherosclerosis.2019.12.008. [Epub ahead of print]

2.

NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies.

Lau C, McAdam MB, Bergseth G, Grevys A, Bruun JA, Ludviksen JK, Fure H, Espevik T, Moen A, Andersen JT, Mollnes TE.

MAbs. 2020 Jan-Dec;12(1):1686319. doi: 10.1080/19420862.2019.1686319.

3.

Profiling of immune-related gene expression in children with familial hypercholesterolaemia.

Narverud I, Christensen JJ, Bakke SS, Ulven SM, Rundblad A, Aukrust P, Espevik T, Bogsrud MP, Retterstøl K, Ueland T, Halvorsen B, Holven KB.

J Intern Med. 2019 Oct 21. doi: 10.1111/joim.13001. [Epub ahead of print]

PMID:
31631426
4.

Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood.

Thomas AM, Gerogianni A, McAdam MB, Fløisand Y, Lau C, Espevik T, Nilsson PH, Mollnes TE, Barratt-Due A.

J Immunol. 2019 Sep 15;203(6):1571-1578. doi: 10.4049/jimmunol.1900047. Epub 2019 Aug 14.

5.

Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor.

Gravastrand CS, Steinkjer B, Halvorsen B, Landsem A, Skjelland M, Jacobsen EA, Woodruff TM, Lambris JD, Mollnes TE, Brekke OL, Espevik T, Rokstad AMA.

J Immunol. 2019 Aug 15;203(4):853-863. doi: 10.4049/jimmunol.1900503. Epub 2019 Jul 3.

6.

Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling.

Moen SH, Ehrnström B, Kojen JF, Yurchenko M, Beckwith KS, Afset JE, Damås JK, Hu Z, Yin H, Espevik T, Stenvik J.

Front Immunol. 2019 May 31;10:1209. doi: 10.3389/fimmu.2019.01209. eCollection 2019.

7.

Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.

Skjeflo EW, Christiansen D, Landsem A, Stenvik J, Woodruff TM, Espevik T, Nielsen EW, Mollnes TE.

Mol Immunol. 2019 Aug;112:131-139. doi: 10.1016/j.molimm.2019.03.014. Epub 2019 May 15.

8.

The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.

Skjesol A, Yurchenko M, Bösl K, Gravastrand C, Nilsen KE, Grøvdal LM, Agliano F, Patane F, Lentini G, Kim H, Teti G, Kumar Sharma A, Kandasamy RK, Sporsheim B, Starheim KK, Golenbock DT, Stenmark H, McCaffrey M, Espevik T, Husebye H.

PLoS Pathog. 2019 Mar 18;15(3):e1007684. doi: 10.1371/journal.ppat.1007684. eCollection 2019 Mar.

9.

Alpha-cyclodextrin inhibits cholesterol crystal-induced complement-mediated inflammation: A potential new compound for treatment of atherosclerosis.

Pilely K, Bakke SS, Palarasah Y, Skjoedt MO, Bartels ED, Espevik T, Garred P.

Atherosclerosis. 2019 Apr;283:35-42. doi: 10.1016/j.atherosclerosis.2019.01.034. Epub 2019 Feb 3.

PMID:
30772772
10.

Serum Omega-6 Fatty Acids and Immunology-Related Gene Expression in Peripheral Blood Mononuclear Cells: A Cross-Sectional Analysis in Healthy Children.

Christensen JJ, Bakke SS, Ulven SM, Retterstøl K, Henriksen T, Bollerslev J, Espevik T, Aukrust P, Halvorsen B, Holven KB.

Mol Nutr Food Res. 2019 Apr;63(7):e1800990. doi: 10.1002/mnfr.201800990. Epub 2019 Feb 11.

PMID:
30702198
11.

RORα controls inflammatory state of human macrophages.

Nejati Moharrami N, Bjørkøy Tande E, Ryan L, Espevik T, Boyartchuk V.

PLoS One. 2018 Nov 28;13(11):e0207374. doi: 10.1371/journal.pone.0207374. eCollection 2018.

12.

Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.

Landsem A, Fure H, Krey Ludviksen J, Christiansen D, Lau C, Mathisen M, Bergseth G, Nymo S, Lappegård KT, Woodruff TM, Espevik T, Mollnes TE, Brekke OL.

Clin Exp Immunol. 2019 Apr;196(1):97-110. doi: 10.1111/cei.13240. Epub 2018 Dec 19.

13.

IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.

Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE.

Front Immunol. 2018 Sep 12;9:2035. doi: 10.3389/fimmu.2018.02035. eCollection 2018.

14.

Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction.

Kleveland O, Ueland T, Kunszt G, Bratlie M, Yndestad A, Broch K, Holte E, Ryan L, Amundsen BH, Bendz B, Aakhus S, Espevik T, Halvorsen B, Mollnes TE, Wiseth R, Gullestad L, Aukrust P, Damås JK.

Int J Cardiol. 2018 Nov 15;271:1-7. doi: 10.1016/j.ijcard.2018.04.136. Epub 2018 Jun 29.

PMID:
29961572
15.

Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response.

Bösl K, Giambelluca M, Haug M, Bugge M, Espevik T, Kandasamy RK, Bergstrøm B.

Front Physiol. 2018 May 29;9:618. doi: 10.3389/fphys.2018.00618. eCollection 2018.

16.

Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.

Thomas AM, Schjalm C, Nilsson PH, Lindenskov PHH, Rørtveit R, Solberg R, Saugstad OD, Berglund MM, Strömberg P, Lau C, Espevik T, Jansen JH, Castellheim A, Mollnes TE, Barratt-Due A.

Neonatology. 2018;113(4):322-330. doi: 10.1159/000486542. Epub 2018 Feb 27.

17.

SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages.

Yurchenko M, Skjesol A, Ryan L, Richard GM, Kandasamy RK, Wang N, Terhorst C, Husebye H, Espevik T.

J Cell Biol. 2018 Apr 2;217(4):1411-1429. doi: 10.1083/jcb.201707027. Epub 2018 Feb 12.

18.

Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.

Skjeflo EW, Christiansen D, Fure H, Ludviksen JK, Woodruff TM, Espevik T, Nielsen EW, Brekke OL, Mollnes TE.

J Thromb Haemost. 2018 May;16(5):905-918. doi: 10.1111/jth.13979. Epub 2018 Mar 23.

PMID:
29437288
19.

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.

Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E.

Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013.

20.

Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.

Gregersen I, Sandanger Ø, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sørensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B.

PLoS One. 2017 Nov 27;12(11):e0188387. doi: 10.1371/journal.pone.0188387. eCollection 2017.

21.

Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages.

Ehrnström B, Beckwith KS, Yurchenko M, Moen SH, Kojen JF, Lentini G, Teti G, Damås JK, Espevik T, Stenvik J.

Front Immunol. 2017 Oct 3;8:1243. doi: 10.3389/fimmu.2017.01243. eCollection 2017.

22.

Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.

Bakke SS, Aune MH, Niyonzima N, Pilely K, Ryan L, Skjelland M, Garred P, Aukrust P, Halvorsen B, Latz E, Damås JK, Mollnes TE, Espevik T.

J Immunol. 2017 Oct 15;199(8):2910-2920. doi: 10.4049/jimmunol.1700302. Epub 2017 Aug 30.

23.

Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness.

Bugge M, Bergstrom B, Eide OK, Solli H, Kjønstad IF, Stenvik J, Espevik T, Nilsen NJ.

J Biol Chem. 2017 Sep 15;292(37):15408-15425. doi: 10.1074/jbc.M117.784090. Epub 2017 Jul 17.

24.

Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages.

Espada S, Stavik B, Holm S, Sagen EL, Bjerkeli V, Skjelland M, Dahl TB, Espevik T, Kanse S, Sandset PM, Skretting G, Halvorsen B.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):442-448. doi: 10.1016/j.bbrc.2017.07.070. Epub 2017 Jul 13.

PMID:
28712870
25.

Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.

Gravastrand C, Hamad S, Fure H, Steinkjer B, Ryan L, Oberholzer J, Lambris JD, Lacík I, Mollnes TE, Espevik T, Brekke OL, Rokstad AM.

Acta Biomater. 2017 Aug;58:158-167. doi: 10.1016/j.actbio.2017.05.052. Epub 2017 May 30.

26.

Increased expression of TFPI in human carotid stenosis.

Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, Dahl TB, Sandset PM, Skjelland M, Espevik T, Skretting G, Halvorsen B.

Thromb Res. 2017 Jul;155:31-37. doi: 10.1016/j.thromres.2017.04.024. Epub 2017 Apr 28.

PMID:
28482260
27.

Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis.

Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE.

J Intensive Care. 2017 Feb 27;5:21. doi: 10.1186/s40560-017-0217-0. eCollection 2017.

28.

Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis.

Lunde NN, Holm S, Dahl TB, Elyouncha I, Sporsheim B, Gregersen I, Abbas A, Skjelland M, Espevik T, Solberg R, Johansen HT, Halvorsen B.

Atherosclerosis. 2017 Feb;257:216-223. doi: 10.1016/j.atherosclerosis.2016.11.026. Epub 2016 Nov 28.

PMID:
27940038
29.

Complement activation by cholesterol crystals triggers a subsequent cytokine response.

Niyonzima N, Halvorsen B, Sporsheim B, Garred P, Aukrust P, Mollnes TE, Espevik T.

Mol Immunol. 2017 Apr;84:43-50. doi: 10.1016/j.molimm.2016.09.019. Epub 2016 Sep 28. Review.

PMID:
27692470
30.

Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.

Barratt-Due A, Pischke SE, Nilsson PH, Espevik T, Mollnes TE.

J Leukoc Biol. 2017 Jan;101(1):193-204. doi: 10.1189/jlb.3VMR0316-132R. Epub 2016 Aug 31. Review.

31.

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.

Paramel Varghese G, Folkersen L, Strawbridge RJ, Halvorsen B, Yndestad A, Ranheim T, Krohg-Sørensen K, Skjelland M, Espevik T, Aukrust P, Lengquist M, Hedin U, Jansson JH, Fransén K, Hansson GK, Eriksson P, Sirsjö A.

J Am Heart Assoc. 2016 May 20;5(5). pii: e003031. doi: 10.1161/JAHA.115.003031.

32.

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis.

Pilely K, Rosbjerg A, Genster N, Gal P, Pál G, Halvorsen B, Holm S, Aukrust P, Bakke SS, Sporsheim B, Nervik I, Niyonzima N, Bartels ED, Stahl GL, Mollnes TE, Espevik T, Garred P.

J Immunol. 2016 Jun 15;196(12):5064-74. doi: 10.4049/jimmunol.1502595. Epub 2016 May 16.

33.

Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis.

Malmo J, Moe N, Krokstad S, Ryan L, Loevenich S, Johnsen IB, Espevik T, Nordbø SA, Døllner H, Anthonsen MW.

PLoS One. 2016 May 12;11(5):e0155484. doi: 10.1371/journal.pone.0155484. eCollection 2016.

34.

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial.

Kleveland O, Kunszt G, Bratlie M, Ueland T, Broch K, Holte E, Michelsen AE, Bendz B, Amundsen BH, Espevik T, Aakhus S, Damås JK, Aukrust P, Wiseth R, Gullestad L.

Eur Heart J. 2016 Aug 7;37(30):2406-13. doi: 10.1093/eurheartj/ehw171. Epub 2016 May 8.

PMID:
27161611
35.

Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E.

Sci Transl Med. 2016 Apr 6;8(333):333ra50. doi: 10.1126/scitranslmed.aad6100.

36.

Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation.

Ørning P, Hoem KS, Coron AE, Skjåk-Bræk G, Mollnes TE, Brekke OL, Espevik T, Rokstad AM.

J Control Release. 2016 May 10;229:58-69. doi: 10.1016/j.jconrel.2016.03.021. Epub 2016 Mar 16.

PMID:
26993426
37.

Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.

Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE.

J Infect Dis. 2016 Jul 1;214(1):140-50. doi: 10.1093/infdis/jiw100. Epub 2016 Mar 14.

38.

Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood.

Nymo S, Gustavsen A, Nilsson PH, Lau C, Espevik T, Mollnes TE.

J Immunol. 2016 Mar 1;196(5):2293-9. doi: 10.4049/jimmunol.1502220. Epub 2016 Jan 22.

39.

Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis.

Skjeflo EW, Sagatun C, Dybwik K, Aam S, Urving SH, Nunn MA, Fure H, Lau C, Brekke OL, Huber-Lang M, Espevik T, Barratt-Due A, Nielsen EW, Mollnes TE.

Crit Care. 2015 Nov 27;19:415. doi: 10.1186/s13054-015-1129-9.

40.

Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response.

Lau C, Olstad OK, Holden M, Nygård S, Fure H, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE.

Genom Data. 2015 May 30;5:176-83. doi: 10.1016/j.gdata.2015.05.019. eCollection 2015 Sep.

41.

The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis.

Hovland A, Jonasson L, Garred P, Yndestad A, Aukrust P, Lappegård KT, Espevik T, Mollnes TE.

Atherosclerosis. 2015 Aug;241(2):480-94. doi: 10.1016/j.atherosclerosis.2015.05.038. Epub 2015 Jun 5. Review.

42.

TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway.

Bergstrøm B, Aune MH, Awuh JA, Kojen JF, Blix KJ, Ryan L, Flo TH, Mollnes TE, Espevik T, Stenvik J.

J Immunol. 2015 Aug 1;195(3):1100-11. doi: 10.4049/jimmunol.1403176. Epub 2015 Jun 17.

43.

The proportion of CD16(+)CD14(dim) monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma.

Sponaas AM, Moen SH, Liabakk NB, Feyzi E, Holien T, Kvam S, Grøseth LA, Størdal B, Buene G, Espevik T, Waage A, Standal T, Sundan A.

Immun Inflamm Dis. 2015 Jun;3(2):94-102. doi: 10.1002/iid3.53. Epub 2015 Mar 2.

44.

Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation.

Niyonzima N, Samstad EO, Aune MH, Ryan L, Bakke SS, Rokstad AM, Wright SD, Damås JK, Mollnes TE, Latz E, Espevik T.

J Immunol. 2015 Jul 1;195(1):257-64. doi: 10.4049/jimmunol.1403044. Epub 2015 May 29.

45.

The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load.

Egge KH, Barratt-Due A, Nymo S, Lindstad JK, Pharo A, Lau C, Espevik T, Thorgersen EB, Mollnes TE.

Clin Exp Immunol. 2015 Sep;181(3):457-67. doi: 10.1111/cei.12645. Epub 2015 Jul 19.

46.

CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation.

Klein DC, Skjesol A, Kers-Rebel ED, Sherstova T, Sporsheim B, Egeberg KW, Stokke BT, Espevik T, Husebye H.

Traffic. 2015 Jul;16(7):677-90. doi: 10.1111/tra.12274. Epub 2015 Mar 24.

47.

CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray.

Lau C, Nygård S, Fure H, Olstad OK, Holden M, Lappegård KT, Brekke OL, Espevik T, Hovig E, Mollnes TE.

PLoS One. 2015 Feb 23;10(2):e0117261. doi: 10.1371/journal.pone.0117261. eCollection 2015.

48.

A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.

Nilsen NJ, Vladimer GI, Stenvik J, Orning MP, Zeid-Kilani MV, Bugge M, Bergstroem B, Conlon J, Husebye H, Hise AG, Fitzgerald KA, Espevik T, Lien E.

J Biol Chem. 2015 Feb 6;290(6):3209-22. doi: 10.1074/jbc.M114.593426. Epub 2014 Dec 11.

49.

Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF.

Nymo S, Niyonzima N, Espevik T, Mollnes TE.

Immunobiology. 2014 Oct;219(10):786-92. doi: 10.1016/j.imbio.2014.06.006. Epub 2014 Jul 5.

PMID:
25053140
50.

A vital role for complement in heart disease.

Lappegård KT, Garred P, Jonasson L, Espevik T, Aukrust P, Yndestad A, Mollnes TE, Hovland A.

Mol Immunol. 2014 Oct;61(2):126-34. doi: 10.1016/j.molimm.2014.06.036. Epub 2014 Jul 16. Review.

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