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Items: 1 to 50 of 63

1.

Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in Xanthophyllomyces dendrorhous.

Gutiérrez MS, Campusano S, González AM, Gómez M, Barahona S, Sepúlveda D, Espenshade PJ, Fernández-Lobato M, Baeza M, Cifuentes V, Alcaíno J.

Front Microbiol. 2019 Mar 29;10:586. doi: 10.3389/fmicb.2019.00586. eCollection 2019.

2.

A Scientist's Oath.

Bettridge KE, Cook AL, Ziegelstein RC, Espenshade PJ.

Mol Cell. 2018 Sep 20;71(6):879-881. doi: 10.1016/j.molcel.2018.08.026.

PMID:
30241604
3.

Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation.

Clasen SJ, Shao W, Gu H, Espenshade PJ.

Elife. 2017 Oct 30;6. pii: e28563. doi: 10.7554/eLife.28563.

4.

Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.

Burr R, Espenshade PJ.

Semin Cell Dev Biol. 2018 Sep;81:110-120. doi: 10.1016/j.semcdb.2017.08.043. Epub 2017 Aug 26. Review.

PMID:
28851600
5.

Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Burr R, Ribbens D, Raychaudhuri S, Stewart EV, Ho J, Espenshade PJ.

J Biol Chem. 2017 Sep 29;292(39):16333-16350. doi: 10.1074/jbc.M117.802025. Epub 2017 Aug 18.

6.

Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors.

Burr R, Stewart EV, Espenshade PJ.

J Biol Chem. 2017 Mar 31;292(13):5311-5324. doi: 10.1074/jbc.M117.778209. Epub 2017 Feb 15.

7.

Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization.

Gong X, Qian H, Shao W, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P, Yan N.

Cell Res. 2016 Nov;26(11):1197-1211. doi: 10.1038/cr.2016.123. Epub 2016 Nov 4.

8.

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ.

EMBO J. 2016 Nov 2;35(21):2332-2349. Epub 2016 Sep 21.

9.

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.

Shao W, Machamer CE, Espenshade PJ.

J Lipid Res. 2016 Aug;57(8):1564-73. doi: 10.1194/jlr.M069583. Epub 2016 Jun 20.

10.

Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2.

Hwang J, Espenshade PJ.

Biochem J. 2016 Aug 15;473(16):2463-9. doi: 10.1042/BCJ20160106. Epub 2016 Jun 7.

11.

Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R, Stewart EV, Shao W, Zhao S, Hannibal-Bach HK, Ejsing CS, Espenshade PJ.

J Biol Chem. 2016 Jun 3;291(23):12171-83. doi: 10.1074/jbc.M116.723650. Epub 2016 Apr 6.

12.

Sugar Makes Fat by Talking to SCAP.

Shao W, Espenshade PJ.

Cancer Cell. 2015 Nov 9;28(5):548-549. doi: 10.1016/j.ccell.2015.10.011.

13.

Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.

Raychaudhuri S, Espenshade PJ.

J Biol Chem. 2015 Jun 5;290(23):14430-40. doi: 10.1074/jbc.M114.630863. Epub 2015 Apr 27.

14.

Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.

Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N.

Cell Res. 2015 Apr;25(4):401-11. doi: 10.1038/cr.2015.32. Epub 2015 Mar 13.

15.

Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast.

Tong Z, Kim MS, Pandey A, Espenshade PJ.

Mol Cell Proteomics. 2014 Nov;13(11):2871-82. doi: 10.1074/mcp.M114.040774. Epub 2014 Jul 30.

16.

Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).

Shao W, Espenshade PJ.

J Biol Chem. 2014 Mar 14;289(11):7547-57. doi: 10.1074/jbc.M113.545699. Epub 2014 Jan 29.

17.

Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.

Brookheart RT, Lee CY, Espenshade PJ.

J Biol Chem. 2014 Jan 31;289(5):2725-35. doi: 10.1074/jbc.M113.511899. Epub 2013 Dec 10.

18.

Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Lloyd SJ, Raychaudhuri S, Espenshade PJ.

J Biol Chem. 2013 Jul 19;288(29):21043-54. doi: 10.1074/jbc.M113.468215. Epub 2013 Jun 12.

19.

Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Cheung R, Espenshade PJ.

J Biol Chem. 2013 Jul 12;288(28):20351-60. doi: 10.1074/jbc.M113.482224. Epub 2013 May 31.

20.

Expanding roles for SREBP in metabolism.

Shao W, Espenshade PJ.

Cell Metab. 2012 Oct 3;16(4):414-9. doi: 10.1016/j.cmet.2012.09.002. Epub 2012 Sep 20. Review.

21.

Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.

Porter JR, Lee CY, Espenshade PJ, Iglesias PA.

Mol Biol Cell. 2012 Sep;23(18):3764-74. doi: 10.1091/mbc.E12-06-0451. Epub 2012 Jul 25.

22.

Regulation of lipid metabolism: a tale of two yeasts.

Raychaudhuri S, Young BP, Espenshade PJ, Loewen C Jr.

Curr Opin Cell Biol. 2012 Aug;24(4):502-8. Epub 2012 Jun 11. Review.

23.

Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H, Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC, Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C, Espenshade PJ, Ideker T, Krogan NJ.

Mol Cell. 2012 Jun 8;46(5):691-704. doi: 10.1016/j.molcel.2012.05.028.

24.

Identifying a static nonlinear structure in a biological system using noisy, sparse data.

Porter JR, Burg JS, Espenshade PJ, Iglesias PA.

J Theor Biol. 2012 May 7;300:232-41. doi: 10.1016/j.jtbi.2012.01.037. Epub 2012 Feb 1.

25.

Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase.

Stewart EV, Lloyd SJ, Burg JS, Nwosu CC, Lintner RE, Daza R, Russ C, Ponchner K, Nusbaum C, Espenshade PJ.

J Biol Chem. 2012 Jan 2;287(1):672-81. doi: 10.1074/jbc.M111.317370. Epub 2011 Nov 15.

26.

Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.

Lee CY, Yeh TL, Hughes BT, Espenshade PJ.

Mol Cell. 2011 Oct 21;44(2):225-34. doi: 10.1016/j.molcel.2011.08.031.

27.

Regulation of HMG-CoA reductase in mammals and yeast.

Burg JS, Espenshade PJ.

Prog Lipid Res. 2011 Oct;50(4):403-10. doi: 10.1016/j.plipres.2011.07.002. Epub 2011 Jul 23. Review.

28.
29.

Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV, Nwosu CC, Tong Z, Roguev A, Cummins TD, Kim DU, Hayles J, Park HO, Hoe KL, Powell DW, Krogan NJ, Espenshade PJ.

Mol Cell. 2011 Apr 22;42(2):160-71. doi: 10.1016/j.molcel.2011.02.035.

30.

The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.

Yeh TL, Lee CY, Amzel LM, Espenshade PJ, Bianchet MA.

Structure. 2011 Apr 13;19(4):503-14. doi: 10.1016/j.str.2011.01.017.

31.

Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.

Porter JR, Burg JS, Espenshade PJ, Iglesias PA.

J Biol Chem. 2010 Dec 24;285(52):41051-61. doi: 10.1074/jbc.M110.144337. Epub 2010 Oct 19.

32.

Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis.

Bien CM, Espenshade PJ.

Eukaryot Cell. 2010 Mar;9(3):352-9. doi: 10.1128/EC.00358-09. Epub 2010 Jan 29. Review.

33.

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.

Osborne TF, Espenshade PJ.

Genes Dev. 2009 Nov 15;23(22):2578-91. doi: 10.1101/gad.1854309. Review.

34.

Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.

Bien CM, Chang YC, Nes WD, Kwon-Chung KJ, Espenshade PJ.

Mol Microbiol. 2009 Nov;74(3):672-90. doi: 10.1111/j.1365-2958.2009.06895.x. Epub 2009 Oct 8.

35.

Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans.

Chang YC, Ingavale SS, Bien C, Espenshade P, Kwon-Chung KJ.

Eukaryot Cell. 2009 Nov;8(11):1770-9. doi: 10.1128/EC.00207-09. Epub 2009 Sep 11.

36.

Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast.

Hughes BT, Nwosu CC, Espenshade PJ.

J Biol Chem. 2009 Jul 31;284(31):20512-21. doi: 10.1074/jbc.M109.002436. Epub 2009 Jun 11.

37.

Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.

Lee CY, Stewart EV, Hughes BT, Espenshade PJ.

EMBO J. 2009 Jan 21;28(2):135-43. doi: 10.1038/emboj.2008.271.

38.

Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.

Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, Espenshade PJ.

Cell Metab. 2008 Dec;8(6):522-31. doi: 10.1016/j.cmet.2008.09.004.

39.

Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.

Hughes AL, Stewart EV, Espenshade PJ.

J Lipid Res. 2008 Sep;49(9):2001-12. doi: 10.1194/jlr.M800207-JLR200. Epub 2008 May 23.

40.

Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.

Hughes BT, Espenshade PJ.

EMBO J. 2008 May 21;27(10):1491-501. doi: 10.1038/emboj.2008.83. Epub 2008 Apr 17.

41.

Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast.

Sehgal A, Hughes BT, Espenshade PJ.

Nucleic Acids Res. 2008 Apr;36(6):2024-31. doi: 10.1093/nar/gkn027. Epub 2008 Feb 14.

42.

SREBP controls oxygen-dependent mobilization of retrotransposons in fission yeast.

Sehgal A, Lee CY, Espenshade PJ.

PLoS Genet. 2007 Aug;3(8):e131. Epub 2007 Jun 22.

43.

Regulation of sterol synthesis in eukaryotes.

Espenshade PJ, Hughes AL.

Annu Rev Genet. 2007;41:401-27. Review.

PMID:
17666007
44.

Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans.

Lee H, Bien CM, Hughes AL, Espenshade PJ, Kwon-Chung KJ, Chang YC.

Mol Microbiol. 2007 Aug;65(4):1018-33. Epub 2007 Jul 21.

45.

4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress.

Hughes AL, Lee CY, Bien CM, Espenshade PJ.

J Biol Chem. 2007 Aug 17;282(33):24388-96. Epub 2007 Jun 26.

46.

Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans.

Chang YC, Bien CM, Lee H, Espenshade PJ, Kwon-Chung KJ.

Mol Microbiol. 2007 May;64(3):614-29.

47.

Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ.

Cell Metab. 2007 Feb;5(2):143-9.

48.

Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ.

Mol Cell Biol. 2006 Apr;26(7):2817-31.

49.

SREBPs: sterol-regulated transcription factors.

Espenshade PJ.

J Cell Sci. 2006 Mar 15;119(Pt 6):973-6. Review. No abstract available.

50.

SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.

Hughes AL, Todd BL, Espenshade PJ.

Cell. 2005 Mar 25;120(6):831-42.

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