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Items: 1 to 50 of 52

1.

GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis.

Planas R, Santos R, Tomas-Ojer P, Cruciani C, Lutterotti A, Faigle W, Schaeren-Wiemers N, Espejo C, Eixarch H, Pinilla C, Martin R, Sospedra M.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat4301. doi: 10.1126/scitranslmed.aat4301.

PMID:
30305453
2.

The value of oligoclonal bands in the multiple sclerosis diagnostic criteria.

Arrambide G, Tintore M, Espejo C, Auger C, Castillo M, Río J, Castilló J, Vidal-Jordana A, Galán I, Nos C, Mitjana R, Mulero P, de Barros A, Rodríguez-Acevedo B, Midaglia L, Sastre-Garriga J, Rovira A, Comabella M, Montalban X.

Brain. 2018 Apr 1;141(4):1075-1084. doi: 10.1093/brain/awy006.

PMID:
29462277
3.

Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis.

Calvo-Barreiro L, Eixarch H, Montalban X, Espejo C.

Autoimmun Rev. 2018 Feb;17(2):165-174. doi: 10.1016/j.autrev.2017.11.019. Epub 2017 Nov 28. Review.

PMID:
29191793
4.

Correction to: Blood lymphocyte subsets identify optimal responders to IFN-beta in MS.

Alenda R, Costa-Frossard L, Alvarez-Lafuente R, Espejo C, Rodríguez-Martín E, Sainz de la Maza S, Villarrubia N, Río J, Domínguez-Mozo MI, Montalban X, Álvarez-Cermeño JC, Villar LM.

J Neurol. 2018 Jan;265(1):32. doi: 10.1007/s00415-017-8679-5.

PMID:
29177546
5.

Blood lymphocyte subsets identify optimal responders to IFN-beta in MS.

Alenda R, Costa-Frossard L, Alvarez-Lafuente R, Espejo C, Rodríguez-Martín E, de la Maza SS, Villarrubia N, Río J, Domínguez-Mozo MI, Montalban X, Álvarez-Cermeño JC, Villar LM.

J Neurol. 2018 Jan;265(1):24-31. doi: 10.1007/s00415-017-8625-6. Epub 2017 Oct 12. Erratum in: J Neurol. 2017 Nov 24;:.

PMID:
29027004
6.

Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.

Miralles M, Eixarch H, Tejero M, Costa C, Hirota K, Castaño AR, Puig M, Stockinger G, Montalban X, Bosch A, Espejo C, Chillon M.

Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8.

7.

Gut dysbiosis and neuroimmune responses to brain infection with Theiler's murine encephalomyelitis virus.

Carrillo-Salinas FJ, Mestre L, Mecha M, Feliú A, Del Campo R, Villarrubia N, Espejo C, Montalbán X, Álvarez-Cermeño JC, Villar LM, Guaza C.

Sci Rep. 2017 Mar 14;7:44377. doi: 10.1038/srep44377.

8.

Bone morphogenetic proteins in multiple sclerosis: Role in neuroinflammation.

Eixarch H, Calvo-Barreiro L, Montalban X, Espejo C.

Brain Behav Immun. 2018 Feb;68:1-10. doi: 10.1016/j.bbi.2017.02.019. Epub 2017 Feb 27. Review.

PMID:
28249802
9.

Myeloid-derived suppressor cells can be efficiently generated from human hematopoietic progenitors and peripheral blood monocytes.

Casacuberta-Serra S, Parés M, Golbano A, Coves E, Espejo C, Barquinero J.

Immunol Cell Biol. 2017 Jul;95(6):538-548. doi: 10.1038/icb.2017.4. Epub 2017 Jan 21.

PMID:
28108746
10.

Myeloid-derived suppressor cells expressing a self-antigen ameliorate experimental autoimmune encephalomyelitis.

Casacuberta-Serra S, Costa C, Eixarch H, Mansilla MJ, López-Estévez S, Martorell L, Parés M, Montalban X, Espejo C, Barquinero J.

Exp Neurol. 2016 Dec;286:50-60. doi: 10.1016/j.expneurol.2016.09.012. Epub 2016 Sep 28.

PMID:
27693617
11.

Semaphorin 7A as a Potential Therapeutic Target for Multiple Sclerosis.

Gutiérrez-Franco A, Eixarch H, Costa C, Gil V, Castillo M, Calvo-Barreiro L, Montalban X, Del Río JA, Espejo C.

Mol Neurobiol. 2017 Aug;54(6):4820-4831. doi: 10.1007/s12035-016-0154-2. Epub 2016 Oct 6.

PMID:
27714632
12.

Neurofilament light chain level is a weak risk factor for the development of MS.

Arrambide G, Espejo C, Eixarch H, Villar LM, Alvarez-Cermeño JC, Picón C, Kuhle J, Disanto G, Kappos L, Sastre-Garriga J, Pareto D, Simon E, Comabella M, Río J, Nos C, Tur C, Castilló J, Vidal-Jordana A, Galán I, Arévalo MJ, Auger C, Rovira A, Montalban X, Tintore M.

Neurology. 2016 Sep 13;87(11):1076-84. doi: 10.1212/WNL.0000000000003085. Epub 2016 Aug 12. Erratum in: Neurology. 2016 Nov 8;87(19):2068.

13.

Differential expression of sema3A and sema7A in a murine model of multiple sclerosis: Implications for a therapeutic design.

Gutiérrez-Franco A, Costa C, Eixarch H, Castillo M, Medina-Rodríguez EM, Bribián A, de Castro F, Montalban X, Espejo C.

Clin Immunol. 2016 Feb;163:22-33. doi: 10.1016/j.clim.2015.12.005. Epub 2015 Dec 10.

PMID:
26686462
14.

Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.

Costa C, Martínez-Sáez E, Gutiérrez-Franco A, Eixarch H, Castro Z, Ortega-Aznar A, Ramón Y Cajal S, Montalban X, Espejo C.

Mult Scler. 2015 Nov;21(13):1632-43. doi: 10.1177/1352458515599848. Epub 2015 Oct 2.

PMID:
26432853
15.

The only certain measure of the effectiveness of multiple sclerosis therapy is cerebrospinal neurofilament level-NO.

Arrambide G, Espejo C, Tintore M.

Mult Scler. 2015 Sep;21(10):1240-2. doi: 10.1177/1352458515589774. Epub 2015 Aug 4. No abstract available.

PMID:
26242692
16.

Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.

Cantó E, Espejo C, Costa C, Montalban X, Comabella M.

Clin Immunol. 2015 Oct;160(2):133-41. doi: 10.1016/j.clim.2015.06.004. Epub 2015 Jun 12.

PMID:
26079949
17.

Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab.

Villar LM, Costa-Frossard L, Masterman T, Fernandez O, Montalban X, Casanova B, Izquierdo G, Coret F, Tumani H, Saiz A, Arroyo R, Fink K, Leyva L, Espejo C, Simó-Castelló M, García-Sánchez MI, Lauda F, Llufriú S, Álvarez-Lafuente R, Olascoaga J, Prada A, Oterino A, de Andrés C, Tintoré M, Ramió-Torrentà L, Rodríguez-Martín E, Picón C, Comabella M, Quintana E, Agüera E, Díaz S, Fernandez-Bolaños R, García-Merino JA, Landete L, Menéndez-González M, Navarro L, Pérez D, Sánchez-López F, Serrano-Castro PJ, Tuñón A, Espiño M, Muriel A, Bar-Or A, Álvarez-Cermeño JC.

Ann Neurol. 2015 Mar;77(3):447-57. doi: 10.1002/ana.24345. Epub 2015 Jan 30.

PMID:
25581547
18.

Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.

Mansilla MJ, Costa C, Eixarch H, Tepavcevic V, Castillo M, Martin R, Lubetzki C, Aigrot MS, Montalban X, Espejo C.

PLoS One. 2014 Aug 25;9(8):e105737. doi: 10.1371/journal.pone.0105737. eCollection 2014.

19.

Assessment of the reproducibility of oligoclonal IgM band detection for its application in daily clinical practice.

Espiño M, Abraira V, Arroyo R, Bau L, Cámara C, Campos-Ruiz L, Casanova B, Espejo C, Fernández O, García-Merino A, García-Sánchez MI, Gómez M, Gosis A, Izquierdo G, Meca J, Montalban X, Morandeira F, Olascoaga J, Prada A, Quintana E, Ramió-Torrentà L, Rodríguez-Antigüedad A, Salgado G, Santiago JL, Sarasola E, Simó-Castelló M, Alvarez-Cermeño JC, Villar LM.

Clin Chim Acta. 2015 Jan 1;438:67-9. doi: 10.1016/j.cca.2014.08.004. Epub 2014 Aug 8.

PMID:
25110815
20.

Regulatory lymphocytes are key factors in MHC-independent resistance to EAE.

Marín N, Mecha M, Espejo C, Mestre L, Eixarch H, Montalban X, Álvarez-Cermeño JC, Guaza C, Villar LM.

J Immunol Res. 2014;2014:156380. doi: 10.1155/2014/156380. Epub 2014 Apr 27.

21.

Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.

Mansilla MJ, Comabella M, Río J, Castilló J, Castillo M, Martin R, Montalban X, Espejo C.

Autoimmunity. 2014 Mar;47(2):127-33. doi: 10.3109/08916934.2013.866104. Epub 2013 Dec 12.

22.

Anti-myelin antibodies play an important role in the susceptibility to develop proteolipid protein-induced experimental autoimmune encephalomyelitis.

Marín N, Eixarch H, Mansilla MJ, Rodríguez-Martín E, Mecha M, Guaza C, Álvarez-Cermeño JC, Montalban X, Villar LM, Espejo C.

Clin Exp Immunol. 2014 Feb;175(2):202-7. doi: 10.1111/cei.12233.

23.

Serum biomarker gMS-Classifier2: predicting conversion to clinically definite multiple sclerosis.

Arrambide G, Espejo C, Yarden J, Fire E, Spector L, Dotan N, Dukler A, Rovira A, Montalban X, Tintore M.

PLoS One. 2013;8(3):e59953. doi: 10.1371/journal.pone.0059953. Epub 2013 Mar 28.

24.

Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis.

Eixarch H, Mansilla MJ, Costa C, Kunkel SL, Montalban X, Godessart N, Espejo C.

Neurosci Lett. 2013 Apr 29;541:161-6. doi: 10.1016/j.neulet.2013.02.038. Epub 2013 Mar 1.

PMID:
23466692
25.

Semaphorins 3A and 7A: potential immune and neuroregenerative targets in multiple sclerosis.

Eixarch H, Gutiérrez-Franco A, Montalban X, Espejo C.

Trends Mol Med. 2013 Mar;19(3):157-64. doi: 10.1016/j.molmed.2013.01.003. Epub 2013 Feb 16.

PMID:
23419749
26.

Myeloid-derived suppressor cells are generated during retroviral transduction of murine bone marrow.

Gomez A, Espejo C, Eixarch H, Casacuberta-Serra S, Mansilla MJ, Sanchez R, Pereira S, Lopez-Estevez S, Gimeno R, Montalban X, Barquinero J.

Cell Transplant. 2014 Jan;23(1):73-85. doi: 10.3727/096368912X658971. Epub 2012 Nov 27.

PMID:
23192196
27.

Treatment with MOG-DNA vaccines induces CD4+CD25+FoxP3+ regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis.

Fissolo N, Costa C, Nurtdinov RN, Bustamante MF, Llombart V, Mansilla MJ, Espejo C, Montalban X, Comabella M.

J Neuroinflammation. 2012 Jun 22;9:139. doi: 10.1186/1742-2094-9-139.

28.

Heat shock protein 70: roles in multiple sclerosis.

Mansilla MJ, Montalban X, Espejo C.

Mol Med. 2012 Sep 7;18:1018-28. doi: 10.2119/molmed.2012.00119. Review.

29.

[Guidelines on the appropriate use of animal models for developing therapies in multiple sclerosis].

Moreno B, Espejo C, Mestre L, Suardiaz M, Clemente D, de Castro F, Fernández-Fernández Ó, Montalban X, Villoslada P, Guaza C; Spanish Network for MS.

Rev Neurol. 2012 Jan 16;54(2):114-24. Spanish.

30.

Implication of the Toll-like receptor 4 pathway in the response to interferon-β in multiple sclerosis.

Bustamante MF, Fissolo N, Río J, Espejo C, Costa C, Mansilla MJ, Lizasoain I, Moro MA, Carmen Edo M, Montalban X, Comabella M.

Ann Neurol. 2011 Oct;70(4):634-45. doi: 10.1002/ana.22511.

PMID:
22028223
31.

Dalfampridine in multiple sclerosis: from symptomatic treatment to immunomodulation.

Espejo C, Montalban X.

Clin Immunol. 2012 Jan;142(1):84-92. doi: 10.1016/j.clim.2011.06.004. Epub 2011 Jun 25. Review.

PMID:
21742559
32.

Utility of oligoclonal IgG band detection for MS diagnosis in daily clinical practice.

Abraira V, Alvarez-Cermeño JC, Arroyo R, Cámara C, Casanova B, Cubillo S, de Andrés C, Espejo C, Fernández O, Ferrer J, Figueredo MA, García-Merino A, García-Sánchez MI, García-Trujillo JA, Gómez M, González-Oria C, Gosis A, Izquierdo G, Jímenez J, López-Trascasa M, Montalbán X, Moreno MJ, Muñoz D, Nuñez V, Muriel A, Navarro J, Olascoaga J, Oreja-Guevara C, Prada A, Ramil E, Ramo-Tello C, Rodríguez C, Rodríguez E, Rodríguez-Frías F, Rodríguez-Antigüedad A, Rodríguez-Molina JJ, Ruiz E, Saiz A, Sarasola E, Simó M, Yagüe J, Villar LM.

J Immunol Methods. 2011 Aug 31;371(1-2):170-3. doi: 10.1016/j.jim.2011.06.009. Epub 2011 Jun 17.

PMID:
21704629
33.

Transgene expression levels determine the immunogenicity of transduced hematopoietic grafts in partially myeloablated mice.

Eixarch H, Gómez A, Kádár E, George M, Martínez N, Espejo C, Pétriz J, Gimeno R, Barquinero J.

Mol Ther. 2009 Nov;17(11):1904-9. doi: 10.1038/mt.2009.198. Epub 2009 Aug 25.

34.

Tolerance induction in experimental autoimmune encephalomyelitis using non-myeloablative hematopoietic gene therapy with autoantigen.

Eixarch H, Espejo C, Gómez A, Mansilla MJ, Castillo M, Mildner A, Vidal F, Gimeno R, Prinz M, Montalban X, Barquinero J.

Mol Ther. 2009 May;17(5):897-905. doi: 10.1038/mt.2009.42. Epub 2009 Mar 10. Erratum in: Mol Ther. 2009 Jul;17(7):1303.

35.

Plasma chitotriosidase activity in multiple sclerosis.

Comabella M, Domínguez C, Rio J, Martín-Gallán P, Vilches A, Vilarrasa N, Espejo C, Montalban X.

Clin Immunol. 2009 May;131(2):216-22. doi: 10.1016/j.clim.2008.12.004. Epub 2009 Jan 26.

PMID:
19176289
36.

Changes in matrix metalloproteinases and their inhibitors during interferon-beta treatment in multiple sclerosis.

Comabella M, Río J, Espejo C, Ruiz de Villa M, Al-Zayat H, Nos C, Deisenhammer F, Baranzini SE, Nonell L, López C, Julià E, Oksenberg JR, Montalban X.

Clin Immunol. 2009 Feb;130(2):145-50. doi: 10.1016/j.clim.2008.09.010. Epub 2008 Oct 21.

PMID:
18945642
37.

Antimyelin antibodies with no progression to multiple sclerosis.

Pelayo R, Tintoré M, Montalban X, Rovira A, Espejo C, Reindl M, Berger T.

N Engl J Med. 2007 Jan 25;356(4):426-8. No abstract available.

38.

Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation.

Hidalgo J, Penkowa M, Espejo C, Martínez-Cáceres EM, Carrasco J, Quintana A, Molinero A, Florit S, Giralt M, Ortega-Aznar A.

Exp Biol Med (Maywood). 2006 Oct;231(9):1450-8.

PMID:
17018866
39.

The role of methallothioneins in experimental autoimmune encephalomyelitis and multiple sclerosis.

Espejo C, Martínez-Cáceres EM.

Ann N Y Acad Sci. 2005 Jun;1051:88-96. Review.

PMID:
16126947
40.

Time-course expression of CNS inflammatory, neurodegenerative tissue repair markers and metallothioneins during experimental autoimmune encephalomyelitis.

Espejo C, Penkowa M, Demestre M, Montalban X, Martínez-Cáceres EM.

Neuroscience. 2005;132(4):1135-49.

PMID:
16078373
41.

IFN-beta treatment modulates the CD28/CTLA-4-mediated pathway for IL-2 production in patients with relapsing-remitting multiple sclerosis.

Espejo C, Brieva L, Ruggiero G, Río J, Montalban X, Martínez-Cáceres EM.

Mult Scler. 2004 Dec;10(6):630-5.

PMID:
15584487
42.

CD4-CD8 and CD28 expression in T cells infiltrating the vitreous fluid in patients with proliferative diabetic retinopathy: a flow cytometric analysis.

Cantón A, Martinez-Cáceres EM, Hernández C, Espejo C, García-Arumí J, Simó R.

Arch Ophthalmol. 2004 May;122(5):743-9.

PMID:
15136323
43.

Metallothionein expression in the central nervous system of multiple sclerosis patients.

Penkowa M, Espejo C, Ortega-Aznar A, Hidalgo J, Montalban X, Martínez Cáceres EM.

Cell Mol Life Sci. 2003 Jun;60(6):1258-66.

PMID:
12861391
44.

Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis.

Penkowa M, Espejo C, Martínez-Cáceres EM, Montalban X, Hidalgo J.

Cell Mol Life Sci. 2003 Jan;60(1):185-97.

PMID:
12613667
45.

Interferon-gamma regulates oxidative stress during experimental autoimmune encephalomyelitis.

Espejo C, Penkowa M, Sáez-Torres I, Hidalgo J, García A, Montalban X, Martínez-Cáceres EM.

Exp Neurol. 2002 Sep;177(1):21-31.

PMID:
12429207
46.

Expression of chemokine receptors in the different clinical forms of multiple sclerosis.

Martínez-Cáceres EM, Espejo C, Brieva L, Pericot I, Tintoré M, Sáez-Torres I, Montalban X.

Mult Scler. 2002 Oct;8(5):390-5.

PMID:
12356205
47.

Specific proliferation towards myelin antigens in patients with multiple sclerosis during a relapse.

Sáez-Torres I, Brieva L, Espejo C, Barrau MA, Montalban X, Martínez-Caceres EM.

Autoimmunity. 2002 Feb;35(1):45-50.

PMID:
11908706
48.

Treatment with methylprednisolone in relapses of multiple sclerosis patients: immunological evidence of immediate and short-term but not long-lasting effects.

Martínez-Cáceres EM, Barrau MA, Brieva L, Espejo C, Barberà N, Montalban X.

Clin Exp Immunol. 2002 Jan;127(1):165-71.

49.

Treatment with anti-interferon-gamma monoclonal antibodies modifies experimental autoimmune encephalomyelitis in interferon-gamma receptor knockout mice.

Espejo C, Penkowa M, Sáez-Torres I, Xaus J, Celada A, Montalban X, Martínez-Cáceres EM.

Exp Neurol. 2001 Dec;172(2):460-8.

PMID:
11716570
50.

Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.

Penkowa M, Espejo C, Martínez-Cáceres EM, Poulsen CB, Montalban X, Hidalgo J.

J Neuroimmunol. 2001 Oct 1;119(2):248-60.

PMID:
11585628

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