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Items: 1 to 50 of 143

1.

Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters.

Giménez-Bastida JA, Ávila-Gálvez MÁ, Espín JC, González-Sarrías A.

Mol Nutr Food Res. 2019 Aug 22:e1900629. doi: 10.1002/mnfr.201900629. [Epub ahead of print]

PMID:
31441212
2.

Tissue deconjugation of urolithin A glucuronide to free urolithin A in systemic inflammation.

Ávila-Gálvez MA, Giménez-Bastida JA, González-Sarrías A, Espín JC.

Food Funct. 2019 Jun 19;10(6):3135-3141. doi: 10.1039/c9fo00298g.

PMID:
31041969
3.

Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite.

Beltrán D, Frutos-Lisón MD, Espín JC, García-Villalba R.

Food Funct. 2019 Apr 17;10(4):1787-1791. doi: 10.1039/c8fo02594k.

PMID:
30882807
4.

Differential miRNA expression profile and proteome in plasma exosomes from patients with paroxysmal nocturnal hemoglobinuria.

Teruel-Montoya R, Luengo-Gil G, Vallejo F, Yuste JE, Bohdan N, García-Barberá N, Espín S, Martínez C, Espín JC, Vicente V, Martínez-Martínez I.

Sci Rep. 2019 Mar 5;9(1):3611. doi: 10.1038/s41598-019-40453-5.

5.

Metabolic Profiling of Dietary Polyphenols and Methylxanthines in Normal and Malignant Mammary Tissues from Breast Cancer Patients.

Ávila-Gálvez MÁ, García-Villalba R, Martínez-Díaz F, Ocaña-Castillo B, Monedero-Saiz T, Torrecillas-Sánchez A, Abellán B, González-Sarrías A, Espín JC.

Mol Nutr Food Res. 2019 May;63(9):e1801239. doi: 10.1002/mnfr.201801239. Epub 2019 Feb 4.

PMID:
30690879
6.

Effect of Food Structure and Processing on (Poly)phenol-Gut Microbiota Interactions and the Effects on Human Health.

Tomás-Barberán FA, Espín JC.

Annu Rev Food Sci Technol. 2019 Mar 25;10:221-238. doi: 10.1146/annurev-food-032818-121615. Epub 2019 Jan 11.

PMID:
30633563
7.

Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist.

Muku GE, Murray IA, Espín JC, Perdew GH.

Metabolites. 2018 Nov 29;8(4). pii: E86. doi: 10.3390/metabo8040086.

8.

Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications.

Romo-Vaquero M, Cortés-Martín A, Loria-Kohen V, Ramírez-de-Molina A, García-Mantrana I, Collado MC, Espín JC, Selma MV.

Mol Nutr Food Res. 2019 Feb;63(4):e1800958. doi: 10.1002/mnfr.201800958. Epub 2018 Dec 3.

PMID:
30471188
9.

The Human Metabolism of Nuts Proanthocyanidins does not Reveal Urinary Metabolites Consistent with Distinctive Gut Microbiota Metabotypes.

Cortés-Martín A, Selma MV, Espín JC, García-Villalba R.

Mol Nutr Food Res. 2019 Jan;63(2):e1800819. doi: 10.1002/mnfr.201800819. Epub 2018 Nov 26.

PMID:
30444059
10.

Physiological Relevance of the Antiproliferative and Estrogenic Effects of Dietary Polyphenol Aglycones versus Their Phase-II Metabolites on Breast Cancer Cells: A Call of Caution.

Ávila-Gálvez MÁ, Espín JC, González-Sarrías A.

J Agric Food Chem. 2018 Aug 15;66(32):8547-8555. doi: 10.1021/acs.jafc.8b03100. Epub 2018 Aug 1.

PMID:
30025453
11.

In Vitro Research on Dietary Polyphenols and Health: A Call of Caution and a Guide on How To Proceed.

Ávila-Gálvez MÁ, González-Sarrías A, Espín JC.

J Agric Food Chem. 2018 Aug 1;66(30):7857-7858. doi: 10.1021/acs.jafc.8b03377. Epub 2018 Jul 19. No abstract available.

PMID:
30024157
12.

The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging.

Cortés-Martín A, García-Villalba R, González-Sarrías A, Romo-Vaquero M, Loria-Kohen V, Ramírez-de-Molina A, Tomás-Barberán FA, Selma MV, Espín JC.

Food Funct. 2018 Aug 15;9(8):4100-4106. doi: 10.1039/c8fo00956b.

PMID:
30004553
13.

Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial.

González-Sarrías A, Núñez-Sánchez MA, Ávila-Gálvez MA, Monedero-Saiz T, Rodríguez-Gil FJ, Martínez-Díaz F, Selma MV, Espín JC.

Food Funct. 2018 May 23;9(5):2617-2622. doi: 10.1039/c8fo00264a.

PMID:
29770393
14.

The Endotoxemia Marker Lipopolysaccharide-Binding Protein is Reduced in Overweight-Obese Subjects Consuming Pomegranate Extract by Modulating the Gut Microbiota: A Randomized Clinical Trial.

González-Sarrías A, Romo-Vaquero M, García-Villalba R, Cortés-Martín A, Selma MV, Espín JC.

Mol Nutr Food Res. 2018 Jun;62(11):e1800160. doi: 10.1002/mnfr.201800160. Epub 2018 May 17.

PMID:
29665619
15.

Ellagibacter isourolithinifaciens gen. nov., sp. nov., a new member of the family Eggerthellaceae, isolated from human gut.

Beltrán D, Romo-Vaquero M, Espín JC, Tomás-Barberán FA, Selma MV.

Int J Syst Evol Microbiol. 2018 May;68(5):1707-1712. doi: 10.1099/ijsem.0.002735. Epub 2018 Mar 27.

PMID:
29583112
16.

Polyphenols' Gut Microbiota Metabolites: Bioactives or Biomarkers?

Tomas-Barberan FA, Selma MV, Espín JC.

J Agric Food Chem. 2018 Apr 11;66(14):3593-3594. doi: 10.1021/acs.jafc.8b00827. Epub 2018 Mar 20. No abstract available.

PMID:
29558130
17.

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.

García-Conesa MT, Chambers K, Combet E, Pinto P, Garcia-Aloy M, Andrés-Lacueva C, de Pascual-Teresa S, Mena P, Konic Ristic A, Hollands WJ, Kroon PA, Rodríguez-Mateos A, Istas G, Kontogiorgis CA, Rai DK, Gibney ER, Morand C, Espín JC, González-Sarrías A.

Int J Mol Sci. 2018 Feb 28;19(3). pii: E694. doi: 10.3390/ijms19030694. Review.

18.

Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep.

Otero JA, García-Mateos D, Alvarez-Fernández I, García-Villalba R, Espín JC, Álvarez AI, Merino G.

BMC Vet Res. 2018 Jan 15;14(1):14. doi: 10.1186/s12917-018-1341-3.

19.

An altered tissue distribution of flaxseed lignans and their metabolites in Abcg2 knockout mice.

García-Mateos D, García-Villalba R, Otero JA, Marañón JA, Espín JC, Álvarez AI, Merino G.

Food Funct. 2018 Jan 24;9(1):636-642. doi: 10.1039/c7fo01549f.

PMID:
29292449
20.

Complete Genome Sequence of the New Urolithin-Producing Bacterium Gordonibacter urolithinfaciens DSM 27213T.

Martinez-Blanch JF, Ramón D, Beltrán D, Romo-Vaquero M, García-Villalba R, Espín JC, Tomás-Barberán FA, Codoñer FM, Selma MV.

Genome Announc. 2017 Dec 14;5(50). pii: e01120-17. doi: 10.1128/genomeA.01120-17.

21.

Isolation of Human Intestinal Bacteria Capable of Producing the Bioactive Metabolite Isourolithin A from Ellagic Acid.

Selma MV, Beltrán D, Luna MC, Romo-Vaquero M, García-Villalba R, Mira A, Espín JC, Tomás-Barberán FA.

Front Microbiol. 2017 Aug 7;8:1521. doi: 10.3389/fmicb.2017.01521. eCollection 2017.

22.

Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.

García-Villalba R, Vissenaekens H, Pitart J, Romo-Vaquero M, Espín JC, Grootaert C, Selma MV, Raes K, Smagghe G, Possemiers S, Van Camp J, Tomas-Barberan FA.

J Agric Food Chem. 2017 Jul 12;65(27):5480-5493. doi: 10.1021/acs.jafc.7b02049. Epub 2017 Jun 28.

23.

The gut microbiota: A key factor in the therapeutic effects of (poly)phenols.

Espín JC, González-Sarrías A, Tomás-Barberán FA.

Biochem Pharmacol. 2017 Sep 1;139:82-93. doi: 10.1016/j.bcp.2017.04.033. Epub 2017 May 6. Review.

PMID:
28483461
24.

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome.

Selma MV, González-Sarrías A, Salas-Salvadó J, Andrés-Lacueva C, Alasalvar C, Örem A, Tomás-Barberán FA, Espín JC.

Clin Nutr. 2018 Jun;37(3):897-905. doi: 10.1016/j.clnu.2017.03.012. Epub 2017 Mar 16.

PMID:
28347564
25.

Gene expression changes in colon tissues from colorectal cancer patients following the intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial.

Nuñez-Sánchez MA, González-Sarrías A, García-Villalba R, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, Martínez-Díaz F, Tomás-Barberán FA, Espín JC, García-Conesa MT.

J Nutr Biochem. 2017 Apr;42:126-133. doi: 10.1016/j.jnutbio.2017.01.014. Epub 2017 Jan 27.

PMID:
28183047
26.

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells.

González-Sarrías A, Núñez-Sánchez MÁ, Tomás-Barberán FA, Espín JC.

J Agric Food Chem. 2017 Feb 1;65(4):752-758. doi: 10.1021/acs.jafc.6b04538. Epub 2016 Dec 2.

PMID:
28142243
27.

Gut Microbiota, Diet and Health. (We and our gut microbes).

Espín JC.

Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201770015. No abstract available.

PMID:
28044428
28.

Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial.

González-Sarrías A, García-Villalba R, Romo-Vaquero M, Alasalvar C, Örem A, Zafrilla P, Tomás-Barberán FA, Selma MV, Espín JC.

Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600830.

PMID:
27879044
29.

Interactions of gut microbiota with dietary polyphenols and consequences to human health.

Tomás-Barberán FA, Selma MV, Espín JC.

Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):471-476. Review.

PMID:
27490306
30.

Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status.

Tomás-Barberán FA, González-Sarrías A, García-Villalba R, Núñez-Sánchez MA, Selma MV, García-Conesa MT, Espín JC.

Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201500901. Epub 2016 Jun 20. Review.

PMID:
27158799
31.

Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation.

Kang I, Espín JC, Carr TP, Tomás-Barberán FA, Chung S.

J Nutr Biochem. 2016 Jun;32:64-72. doi: 10.1016/j.jnutbio.2016.02.006. Epub 2016 Mar 12.

PMID:
27142738
32.

In vivo relevant mixed urolithins and ellagic acid inhibit phenotypic and molecular colon cancer stem cell features: A new potentiality for ellagitannin metabolites against cancer.

Núñez-Sánchez MÁ, Karmokar A, González-Sarrías A, García-Villalba R, Tomás-Barberán FA, García-Conesa MT, Brown K, Espín JC.

Food Chem Toxicol. 2016 Jun;92:8-16. doi: 10.1016/j.fct.2016.03.011. Epub 2016 Mar 16.

PMID:
26995228
33.

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes.

Kang I, Kim Y, Tomás-Barberán FA, Espín JC, Chung S.

Mol Nutr Food Res. 2016 May;60(5):1129-38. doi: 10.1002/mnfr.201500796. Epub 2016 Apr 13.

PMID:
26872561
34.

Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.

González-Sarrías A, Núñez-Sánchez MÁ, García-Villalba R, Tomás-Barberán FA, Espín JC.

Eur J Nutr. 2017 Mar;56(2):831-841. doi: 10.1007/s00394-015-1131-7. Epub 2015 Dec 17.

PMID:
26680596
35.

Comprehensive characterization of the effects of ellagic acid and urolithins on colorectal cancer and key-associated molecular hallmarks: MicroRNA cell specific induction of CDKN1A (p21) as a common mechanism involved.

González-Sarrías A, Núñez-Sánchez MÁ, Tomé-Carneiro J, Tomás-Barberán FA, García-Conesa MT, Espín JC.

Mol Nutr Food Res. 2016 Apr;60(4):701-16. doi: 10.1002/mnfr.201500780. Epub 2015 Dec 29.

PMID:
26634414
36.

The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism.

Selma MV, Romo-Vaquero M, García-Villalba R, González-Sarrías A, Tomás-Barberán FA, Espín JC.

Food Funct. 2016 Apr;7(4):1769-74. doi: 10.1039/c5fo01100k.

PMID:
26597167
37.

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid.

Otero JA, Miguel V, González-Lobato L, García-Villalba R, Espín JC, Prieto JG, Merino G, Álvarez AI.

Animal. 2016 Feb;10(2):238-47. doi: 10.1017/S1751731115002141. Epub 2015 Oct 29.

PMID:
26510964
38.

Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-α induced human aortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1) levels.

Giménez-Bastida JA, González-Sarrías A, Vallejo F, Espín JC, Tomás-Barberán FA.

Food Funct. 2016 Jan;7(1):118-26. doi: 10.1039/c5fo00771b.

PMID:
26456097
39.

Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid.

García-Villalba R, Espín JC, Tomás-Barberán FA.

J Chromatogr A. 2016 Jan 8;1428:162-75. doi: 10.1016/j.chroma.2015.08.044. Epub 2015 Aug 28.

PMID:
26341594
40.

Validated Method for the Characterization and Quantification of Extractable and Nonextractable Ellagitannins after Acid Hydrolysis in Pomegranate Fruits, Juices, and Extracts.

García-Villalba R, Espín JC, Aaby K, Alasalvar C, Heinonen M, Jacobs G, Voorspoels S, Koivumäki T, Kroon PA, Pelvan E, Saha S, Tomás-Barberán FA.

J Agric Food Chem. 2015 Jul 29;63(29):6555-66. doi: 10.1021/acs.jafc.5b02062. Epub 2015 Jul 17.

PMID:
26158321
41.

MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: Critical issues to discern between modulatory effects and potential artefacts.

Nuñez-Sánchez MA, Dávalos A, González-Sarrías A, Casas-Agustench P, Visioli F, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, Martínez-Díaz F, Tomás-Barberán FA, García-Conesa MT, Espín JC.

Mol Nutr Food Res. 2015 Oct;59(10):1973-86. doi: 10.1002/mnfr.201500357. Epub 2015 Jul 20.

PMID:
26105520
42.

The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells.

González-Sarrías A, Tomé-Carneiro J, Bellesia A, Tomás-Barberán FA, Espín JC.

Food Funct. 2015 May;6(5):1460-9. doi: 10.1039/c5fo00120j.

PMID:
25857357
43.

The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16.

Ramírez de Molina A, Vargas T, Molina S, Sánchez J, Martínez-Romero J, González-Vallinas M, Martín-Hernández R, Sánchez-Martínez R, Gómez de Cedrón M, Dávalos A, Calani L, Del Rio D, González-Sarrías A, Espín JC, Tomás-Barberán FA, Reglero G.

J Pharmacol Exp Ther. 2015 May;353(2):433-44. doi: 10.1124/jpet.114.221796. Epub 2015 Mar 10.

PMID:
25758919
44.

Dietary phenolics against colorectal cancer--From promising preclinical results to poor translation into clinical trials: Pitfalls and future needs.

Núñez-Sánchez MA, González-Sarrías A, Romo-Vaquero M, García-Villalba R, Selma MV, Tomás-Barberán FA, García-Conesa MT, Espín JC.

Mol Nutr Food Res. 2015 Jul;59(7):1274-91. doi: 10.1002/mnfr.201400866. Epub 2015 Mar 31. Review.

PMID:
25693744
45.

Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status.

Tomás-Barberán FA, García-Villalba R, González-Sarrías A, Selma MV, Espín JC.

J Agric Food Chem. 2014 Jul 16;62(28):6535-8. doi: 10.1021/jf5024615. Epub 2014 Jul 1.

PMID:
24976365
46.

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species.

Selma MV, Beltrán D, García-Villalba R, Espín JC, Tomás-Barberán FA.

Food Funct. 2014 Aug;5(8):1779-84. doi: 10.1039/c4fo00092g.

PMID:
24909569
47.

Gordonibacter urolithinfaciens sp. nov., a urolithin-producing bacterium isolated from the human gut.

Selma MV, Tomás-Barberán FA, Beltrán D, García-Villalba R, Espín JC.

Int J Syst Evol Microbiol. 2014 Jul;64(Pt 7):2346-52. doi: 10.1099/ijs.0.055095-0. Epub 2014 Apr 17.

PMID:
24744017
48.

Role of ABCG2 in transport of the mammalian lignan enterolactone and its secretion into milk in Abcg2 knockout mice.

Miguel V, Otero JA, García-Villalba R, Tomás-Barberán F, Espín JC, Merino G, Álvarez AI.

Drug Metab Dispos. 2014 May;42(5):943-6. doi: 10.1124/dmd.113.055970. Epub 2014 Feb 25.

PMID:
24568887
49.

A rosemary extract enriched in carnosic acid improves circulating adipocytokines and modulates key metabolic sensors in lean Zucker rats: Critical and contrasting differences in the obese genotype.

Romo-Vaquero M, Larrosa M, Yáñez-Gascón MJ, Issaly N, Flanagan J, Roller M, Tomás-Barberán FA, Espín JC, García-Conesa MT.

Mol Nutr Food Res. 2014 May;58(5):942-53. doi: 10.1002/mnfr.201300524. Epub 2013 Dec 23.

PMID:
24550204
50.

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients.

Nuñez-Sánchez MA, García-Villalba R, Monedero-Saiz T, García-Talavera NV, Gómez-Sánchez MB, Sánchez-Álvarez C, García-Albert AM, Rodríguez-Gil FJ, Ruiz-Marín M, Pastor-Quirante FA, Martínez-Díaz F, Yáñez-Gascón MJ, González-Sarrías A, Tomás-Barberán FA, Espín JC.

Mol Nutr Food Res. 2014 Jun;58(6):1199-211. doi: 10.1002/mnfr.201300931. Epub 2014 Feb 16.

PMID:
24532260

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