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Avicenna J Med Biotechnol. 2015 Oct-Dec;7(4):168-72.

Association of Transforming Growth Factor Alpha Polymorphisms with Nonsyndromic Cleft Lip and Palate in Iranian Population.

Author information

1
Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Department of Orthodontic, Faculty of Dentistry, Shahid Behehsti University of Medical Sciences, Tehran, Iran.
2
Department of Orthodontic, Dentofacial Deformities Research Center, Faculty of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Genetic Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
4
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
5
Department of Public Health, Faculty of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
6
Medical Laboratory Sciences, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
7
Department of Orthodontic, Faculty of Dentistry, Semnan University of Medical Sciences, Semnan, Iran.

Abstract

BACKGROUND:

Cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies and the etiology of orofacial clefts is multifactorial. Transforming growth factor alpha (TGFA) is expressed at the medial edge epithelium of fusing palatal shelves during craniofacial development. In this study, the association of two important TGFA gene polymorphisms, BamHI (rs11466297) and RsaI (rs3732248), with CL/P was evaluated in an Iranian population.

METHODS:

The frequencies of BamHI and RsaI variations were determined in 105 unrelated Iranian subjects with nonsyndromic CL/P and 218 control subjects using PCR and RFLP methods, and the results were compared with healthy controls. A p-value of <0.05 was considered statistically significant.

RESULTS:

The BamHI AC genotype was significantly higher (p=0.016) in the patients (12.4%) than the control group (5.0%). The BamHI C allele was significantly higher (p=0.001; OR=3.4, 95% CI: 1.6-7.4) in the cases (8.0%) compared with the control group (2.5%).

CONCLUSION:

Our study showed that there was an association between the TGFA BamHI variation and nonsyndromic CL/P in Iranian population.

KEYWORDS:

Association Study; Cleft lip/palate; Polymorphism; Transforming Growth Factor Alpha

PMID:
26605011
PMCID:
PMC4629459

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