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Items: 1 to 50 of 61

1.

High-Accuracy Mass Spectrometry Based Screening Method for the Discovery of Cysteine Containing Peptides in Animal Venoms and Toxins.

van Oosten LN, Pinkse MWH, Pieterse M, Escoubas P, Verhaert PDEM.

Methods Mol Biol. 2018;1719:335-348. doi: 10.1007/978-1-4939-7537-2_22.

PMID:
29476522
2.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

3.

Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

Er SY, Cristofori-Armstrong B, Escoubas P, Rash LD.

Neuropharmacology. 2017 Dec;127:185-195. doi: 10.1016/j.neuropharm.2017.03.020. Epub 2017 Mar 19.

PMID:
28327374
4.

Combined Peptidomic and Proteomic Analysis of Electrically Stimulated and Manually Dissected Venom from the South American Bullet Ant Paraponera clavata.

Aili SR, Touchard A, Petitclerc F, Dejean A, Orivel J, Padula MP, Escoubas P, Nicholson GM.

J Proteome Res. 2017 Mar 3;16(3):1339-1351. doi: 10.1021/acs.jproteome.6b00948. Epub 2017 Jan 31.

PMID:
28118015
5.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

6.

Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.

Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562. doi: 10.1016/j.bbagen.2016.07.027. Epub 2016 Jul 28.

PMID:
27474999
7.

Comparisons of Protein and Peptide Complexity in Poneroid and Formicoid Ant Venoms.

Aili SR, Touchard A, Koh JM, Dejean A, Orivel J, Padula MP, Escoubas P, Nicholson GM.

J Proteome Res. 2016 Sep 2;15(9):3039-54. doi: 10.1021/acs.jproteome.6b00182. Epub 2016 Aug 2.

PMID:
27436154
8.

The Biochemical Toxin Arsenal from Ant Venoms.

Touchard A, Aili SR, Fox EG, Escoubas P, Orivel J, Nicholson GM, Dejean A.

Toxins (Basel). 2016 Jan 20;8(1). pii: E30. doi: 10.3390/toxins8010030. Review.

9.

The complexity and structural diversity of ant venom peptidomes is revealed by mass spectrometry profiling.

Touchard A, Koh JM, Aili SR, Dejean A, Nicholson GM, Orivel J, Escoubas P.

Rapid Commun Mass Spectrom. 2015 Mar 15;29(5):385-96. doi: 10.1002/rcm.7116.

PMID:
26349460
10.

Diversity of peptide toxins from stinging ant venoms.

Aili SR, Touchard A, Escoubas P, Padula MP, Orivel J, Dejean A, Nicholson GM.

Toxicon. 2014 Dec 15;92:166-78. doi: 10.1016/j.toxicon.2014.10.021. Epub 2014 Oct 28. Review.

PMID:
25448389
11.

Venom toxicity and composition in three Pseudomyrmex ant species having different nesting modes.

Touchard A, Labrière N, Roux O, Petitclerc F, Orivel J, Escoubas P, Koh JM, Nicholson GM, Dejean A.

Toxicon. 2014 Sep;88:67-76. doi: 10.1016/j.toxicon.2014.05.022. Epub 2014 Jun 11.

PMID:
24929139
12.

Elucidation of the unexplored biodiversity of ant venom peptidomes via MALDI-TOF mass spectrometry and its application for chemotaxonomy.

Touchard A, Dauvois M, Arguel MJ, Petitclerc F, Leblanc M, Dejean A, Orivel J, Nicholson GM, Escoubas P.

J Proteomics. 2014 Jun 13;105:217-31. doi: 10.1016/j.jprot.2014.01.009. Epub 2014 Jan 20.

PMID:
24456813
13.

Characterization of monomeric and multimeric snake neurotoxins and other bioactive proteins from the venom of the lethal Australian common copperhead (Austrelaps superbus).

Marcon F, Purtell L, Santos J, Hains PG, Escoubas P, Graudins A, Nicholson GM.

Biochem Pharmacol. 2013 May 15;85(10):1555-73. doi: 10.1016/j.bcp.2013.02.034. Epub 2013 Mar 13.

PMID:
23500536
14.

Unravelling the complex venom landscapes of lethal Australian funnel-web spiders (Hexathelidae: Atracinae) using LC-MALDI-TOF mass spectrometry.

Palagi A, Koh JM, Leblanc M, Wilson D, Dutertre S, King GF, Nicholson GM, Escoubas P.

J Proteomics. 2013 Mar 27;80:292-310. doi: 10.1016/j.jprot.2013.01.002. Epub 2013 Jan 23.

PMID:
23352897
15.

Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors.

Marcon F, Leblanc M, Vetter I, Lewis RJ, Escoubas P, Nicholson GM.

Biochem Pharmacol. 2012 Sep 15;84(6):851-63. doi: 10.1016/j.bcp.2012.06.024. Epub 2012 Jul 4.

PMID:
22771828
16.

A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus.

Windley MJ, Escoubas P, Valenzuela SM, Nicholson GM.

Mol Pharmacol. 2011 Jul;80(1):1-13. doi: 10.1124/mol.110.070540. Epub 2011 Mar 29.

17.

α-Elapitoxin-Aa2a, a long-chain snake α-neurotoxin with potent actions on muscle (α1)(2)βγδ nicotinic receptors, lacks the classical high affinity for neuronal α7 nicotinic receptors.

Blacklow B, Kornhauser R, Hains PG, Loiacono R, Escoubas P, Graudins A, Nicholson GM.

Biochem Pharmacol. 2011 Jan 15;81(2):314-25. doi: 10.1016/j.bcp.2010.10.004. Epub 2010 Oct 13.

PMID:
20950587
18.

Characterisation of the heterotrimeric presynaptic phospholipase A(2) neurotoxin complex from the venom of the common death adder (Acanthophis antarcticus).

Blacklow B, Escoubas P, Nicholson GM.

Biochem Pharmacol. 2010 Jul 15;80(2):277-87. doi: 10.1016/j.bcp.2010.03.030. Epub 2010 Mar 31.

PMID:
20361942
19.

ArachnoServer: a database of protein toxins from spiders.

Wood DL, Miljenović T, Cai S, Raven RJ, Kaas Q, Escoubas P, Herzig V, Wilson D, King GF.

BMC Genomics. 2009 Aug 13;10:375. doi: 10.1186/1471-2164-10-375.

20.

Venomics as a drug discovery platform.

Escoubas P, King GF.

Expert Rev Proteomics. 2009 Jun;6(3):221-4. doi: 10.1586/epr.09.45. Review. No abstract available.

PMID:
19489692
21.

Peptide toxins that selectively target insect Na(V) and Ca(V) channels.

King GF, Escoubas P, Nicholson GM.

Channels (Austin). 2008 Mar-Apr;2(2):100-16. Epub 2008 Mar 9. Review.

PMID:
18849658
22.

A rational nomenclature for naming peptide toxins from spiders and other venomous animals.

King GF, Gentz MC, Escoubas P, Nicholson GM.

Toxicon. 2008 Aug 1;52(2):264-76. doi: 10.1016/j.toxicon.2008.05.020. Epub 2008 Jun 13.

PMID:
18619481
23.

Intersexual variations in Northern (Missulena pruinosa) and Eastern (M. bradleyi) mouse spider venom.

Herzig V, Khalife AA, Chong Y, Isbister GK, Currie BJ, Churchill TB, Horner S, Escoubas P, Nicholson GM, Hodgson WC.

Toxicon. 2008 Jun 1;51(7):1167-77. doi: 10.1016/j.toxicon.2008.02.001. Epub 2008 Feb 8.

PMID:
18346773
24.

Venomics: unravelling the complexity of animal venoms with mass spectrometry.

Escoubas P, Quinton L, Nicholson GM.

J Mass Spectrom. 2008 Mar;43(3):279-95. doi: 10.1002/jms.1389. Review.

PMID:
18302316
25.

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.

Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, Voilley N, Blondeau N, Escoubas P, Gélot A, Cupo A, Zimmer A, Zimmer AM, Eschalier A, Lazdunski M.

Nat Neurosci. 2007 Aug;10(8):943-5. Epub 2007 Jul 15.

PMID:
17632507
26.

Spider peptide toxins as leads for drug development.

Escoubas P, Bosmans F.

Expert Opin Drug Discov. 2007 Jun;2(6):823-35. doi: 10.1517/17460441.2.6.823.

PMID:
23489000
27.

Peptides inhibitors of acid-sensing ion channels.

Diochot S, Salinas M, Baron A, Escoubas P, Lazdunski M.

Toxicon. 2007 Feb;49(2):271-84. Epub 2006 Oct 4. Review.

PMID:
17113616
28.

AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels.

Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F.

EMBO J. 2006 Dec 13;25(24):5864-72. Epub 2006 Nov 16.

29.

Molecular diversification in spider venoms: a web of combinatorial peptide libraries.

Escoubas P.

Mol Divers. 2006 Nov;10(4):545-54. Epub 2006 Nov 10. Review.

PMID:
17096075
30.

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.

Rouault M, Rash LD, Escoubas P, Boilard E, Bollinger J, Lomonte B, Maurin T, Guillaume C, Canaan S, Deregnaucourt C, Schrével J, Doglio A, Gutiérrez JM, Lazdunski M, Gelb MH, Lambeau G.

Biochemistry. 2006 May 9;45(18):5800-16.

31.

Venom landscapes: mining the complexity of spider venoms via a combined cDNA and mass spectrometric approach.

Escoubas P, Sollod B, King GF.

Toxicon. 2006 May;47(6):650-63. Epub 2006 Mar 30.

PMID:
16574177
32.
33.

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a.

Salinas M, Rash LD, Baron A, Lambeau G, Escoubas P, Lazdunski M.

J Physiol. 2006 Jan 15;570(Pt 2):339-54. Epub 2005 Nov 10.

34.

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.

Bosmans F, Rash L, Zhu S, Diochot S, Lazdunski M, Escoubas P, Tytgat J.

Mol Pharmacol. 2006 Feb;69(2):419-29. Epub 2005 Nov 2.

35.

Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels.

Chagot B, Escoubas P, Diochot S, Bernard C, Lazdunski M, Darbon H.

Protein Sci. 2005 Aug;14(8):2003-10. Epub 2005 Jun 29.

36.

A spider toxin that induces a typical effect of scorpion alpha-toxins but competes with beta-toxins on binding to insect sodium channels.

Corzo G, Escoubas P, Villegas E, Karbat I, Gordon D, Gurevitz M, Nakajima T, Gilles N.

Biochemistry. 2005 Feb 8;44(5):1542-9.

PMID:
15683238
37.

Comparative analysis of two 14-3-3 homologues and their expression pattern in the root-knot nematode Meloidogyne incognita.

Jaubert S, Laffaire JB, Ledger TN, Escoubas P, Amri EZ, Abad P, Rosso MN.

Int J Parasitol. 2004 Jun;34(7):873-80.

PMID:
15157770
38.

Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus.

Chagot B, Escoubas P, Villegas E, Bernard C, Ferrat G, Corzo G, Lazdunski M, Darbon H.

Protein Sci. 2004 May;13(5):1197-208.

39.

Tarantulas: eight-legged pharmacists and combinatorial chemists.

Escoubas P, Rash L.

Toxicon. 2004 Apr;43(5):555-74. Review.

PMID:
15066413
40.

A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.

Diochot S, Baron A, Rash LD, Deval E, Escoubas P, Scarzello S, Salinas M, Lazdunski M.

EMBO J. 2004 Apr 7;23(7):1516-25. Epub 2004 Mar 25.

41.

Pharmacologically active spider peptide toxins.

Corzo G, Escoubas P.

Cell Mol Life Sci. 2003 Nov;60(11):2409-26. Review.

PMID:
14625686
42.

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels.

Escoubas P, Bernard C, Lambeau G, Lazdunski M, Darbon H.

Protein Sci. 2003 Jul;12(7):1332-43.

43.

Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies.

Escoubas P, Diochot S, Célérier ML, Nakajima T, Lazdunski M.

Mol Pharmacol. 2002 Jul;62(1):48-57.

44.
45.

Characterization of unique amphipathic antimicrobial peptides from venom of the scorpion Pandinus imperator.

Corzo G, Escoubas P, Villegas E, Barnham KJ, He W, Norton RS, Nakajima T.

Biochem J. 2001 Oct 1;359(Pt 1):35-45.

46.

Structure and pharmacology of spider venom neurotoxins.

Escoubas P, Diochot S, Corzo G.

Biochimie. 2000 Sep-Oct;82(9-10):893-907. Review.

PMID:
11086219
47.

Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensi.

Escoubas P, Stankiewicz M, Takaoka T, Pelhate M, Romi-Lebrun R, Wu FQ, Nakajima T.

FEBS Lett. 2000 Oct 20;483(2-3):175-80.

48.

Isolation, synthesis and pharmacological characterization of delta-palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae).

Corzo G, Escoubas P, Stankiewicz M, Pelhate M, Kristensen CP, Nakajima T.

Eur J Biochem. 2000 Sep;267(18):5783-95.

49.

Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.

Escoubas P, De Weille JR, Lecoq A, Diochot S, Waldmann R, Champigny G, Moinier D, Ménez A, Lazdunski M.

J Biol Chem. 2000 Aug 18;275(33):25116-21.

50.

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