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Items: 1 to 50 of 318

1.

Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.

Prondzynski M, Lemoine MD, Zech AT, Horváth A, Di Mauro V, Koivumäki JT, Kresin N, Busch J, Krause T, Krämer E, Schlossarek S, Spohn M, Friedrich FW, Münch J, Laufer SD, Redwood C, Volk AE, Hansen A, Mearini G, Catalucci D, Meyer C, Christ T, Patten M, Eschenhagen T, Carrier L.

EMBO Mol Med. 2019 Nov 3:e11115. doi: 10.15252/emmm.201911115. [Epub ahead of print]

2.

A magnetics-based approach for fine-tuning afterload in engineered heart tissues.

Rodriguez ML, Werner TR, Becker B, Eschenhagen T, Hirt MN.

ACS Biomater Sci Eng. 2019 Jul 8;5(7):3663-3675. doi: 10.1021/acsbiomaterials.8b01568. Epub 2019 Jun 11.

PMID:
31637285
3.

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis.

Kenneweg F, Bang C, Xiao K, Boulanger CM, Loyer X, Mazlan S, Schroen B, Hermans-Beijnsberger S, Foinquinos A, Hirt MN, Eschenhagen T, Funcke S, Stojanovic S, Genschel C, Schimmel K, Just A, Pfanne A, Scherf K, Dehmel S, Raemon-Buettner SM, Fiedler J, Thum T.

Mol Ther Nucleic Acids. 2019 Sep 13;18:363-374. doi: 10.1016/j.omtn.2019.09.003. [Epub ahead of print]

4.

Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue.

Lemme M, Braren I, Prondzynski M, Aksehirlioglu B, Ulmer BM, Schulze ML, Ismaili D, Meyer C, Hansen A, Christ T, Lemoine MD, Eschenhagen T.

Cardiovasc Res. 2019 Oct 9. pii: cvz245. doi: 10.1093/cvr/cvz245. [Epub ahead of print]

PMID:
31598634
5.

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL.

Nat Commun. 2019 Sep 20;10(1):4325. doi: 10.1038/s41467-019-12354-8.

6.

Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?

de Korte T, Katili PA, Mohd Yusof NAN, van Meer BJ, Saleem U, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C.

Annu Rev Pharmacol Toxicol. 2019 Sep 10. doi: 10.1146/annurev-pharmtox-010919-023309. [Epub ahead of print]

PMID:
31506008
7.

Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue.

Werner TR, Kunze AC, Stenzig J, Eschenhagen T, Hirt MN.

Sci Rep. 2019 Aug 7;9(1):11494. doi: 10.1038/s41598-019-46818-0.

8.

Author Correction: Differentiation of cardiomyocytes and generation of human engineered heart tissue.

Breckwoldt K, Brenière-Letuffe D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A.

Nat Protoc. 2019 Sep;14(9):2748. doi: 10.1038/s41596-019-0228-5.

PMID:
31384055
9.

Human iPS cell-derived engineered heart tissue does not affect ventricular arrhythmias in a guinea pig cryo-injury model.

Pecha S, Yorgan K, Röhl M, Geertz B, Hansen A, Weinberger F, Sehner S, Ehmke H, Reichenspurner H, Eschenhagen T, Schwoerer AP.

Sci Rep. 2019 Jul 8;9(1):9831. doi: 10.1038/s41598-019-46409-z.

10.

Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism.

Ulmer BM, Eschenhagen T.

Biochim Biophys Acta Mol Cell Res. 2019 Apr 4. pii: S0167-4889(18)30398-7. doi: 10.1016/j.bbamcr.2019.04.001. [Epub ahead of print] Review.

11.

Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation.

Schaefer A, Schneeberger Y, Schulz S, Krasemann S, Werner T, Piasecki A, Höppner G, Müller C, Morhenn K, Lorenz K, Wieczorek D, Schwoerer AP, Eschenhagen T, Ehmke H, Reichenspurner H, Stenzig J, Cuello F.

Sci Rep. 2019 Apr 5;9(1):5710. doi: 10.1038/s41598-019-42263-1.

12.

Dissecting hiPSC-CM pacemaker function in a cardiac organoid model.

Schulze ML, Lemoine MD, Fischer AW, Scherschel K, David R, Riecken K, Hansen A, Eschenhagen T, Ulmer BM.

Biomaterials. 2019 Jun;206:133-145. doi: 10.1016/j.biomaterials.2019.03.023. Epub 2019 Mar 21.

PMID:
30933775
13.

Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model.

Castro L, Geertz B, Reinsch M, Aksehirlioglu B, Hansen A, Eschenhagen T, Reichenspurner H, Weinberger F, Pecha S.

J Vis Exp. 2019 Mar 18;(145). doi: 10.3791/58810.

PMID:
30933073
14.

Heart Repair With Myocytes.

Eschenhagen T, Weinberger F.

Circ Res. 2019 Mar 15;124(6):843-845. doi: 10.1161/CIRCRESAHA.118.314336. No abstract available.

PMID:
30870126
15.

Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors.

Längle D, Werner TR, Wesseler F, Reckzeh E, Schaumann N, Drowley L, Polla M, Plowright AT, Hirt MN, Eschenhagen T, Schade D.

ChemMedChem. 2019 Apr 17;14(8):810-822. doi: 10.1002/cmdc.201900036. Epub 2019 Feb 28.

PMID:
30768867
16.

Preserved cardiovascular homeostasis despite blunted acetylcholine-induced dilation in mice with endothelial muscarinic M3 receptor deletion.

Rhoden A, Speiser J, Geertz B, Uebeler J, Schmidt K, de Wit C, Eschenhagen T.

Acta Physiol (Oxf). 2019 May;226(1):e13262. doi: 10.1111/apha.13262. Epub 2019 Feb 18.

PMID:
30716211
17.

ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure.

Madonna R, Van Laake LW, Botker HE, Davidson SM, De Caterina R, Engel FB, Eschenhagen T, Fernandez-Aviles F, Hausenloy DJ, Hulot JS, Lecour S, Leor J, Menasché P, Pesce M, Perrino C, Prunier F, Van Linthout S, Ytrehus K, Zimmermann WH, Ferdinandy P, Sluijter JPG.

Cardiovasc Res. 2019 Mar 1;115(3):488-500. doi: 10.1093/cvr/cvz010.

PMID:
30657875
18.

Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy.

Morhenn K, Quentin T, Wichmann H, Steinmetz M, Prondzynski M, Söhren KD, Christ T, Geertz B, Schröder S, Schöndube FA, Hasenfuss G, Schlossarek S, Zimmermann WH, Carrier L, Eschenhagen T, Cardinaux JR, Lutz S, Oetjen E.

J Mol Cell Cardiol. 2019 Feb;127:31-43. doi: 10.1016/j.yjmcc.2018.12.001. Epub 2018 Dec 4.

PMID:
30521840
19.

Correction: Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue.

Jacob F, Yonis AY, Cuello F, Luther P, Schulze T, Eder A, Streichert T, Mannhardt I, Hirt MN, Schaaf S, Stenzig J, Force T, Eschenhagen T, Hansen A.

PLoS One. 2018 Nov 27;13(11):e0208342. doi: 10.1371/journal.pone.0208342. eCollection 2018.

20.

Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium.

Lemme M, Ulmer BM, Lemoine MD, Zech ATL, Flenner F, Ravens U, Reichenspurner H, Rol-Garcia M, Smith G, Hansen A, Christ T, Eschenhagen T.

Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.

21.

Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.

Smith JGW, Owen T, Bhagwan JR, Mosqueira D, Scott E, Mannhardt I, Patel A, Barriales-Villa R, Monserrat L, Hansen A, Eschenhagen T, Harding SE, Marston S, Denning C.

Stem Cell Reports. 2018 Nov 13;11(5):1226-1243. doi: 10.1016/j.stemcr.2018.10.006. Epub 2018 Nov 1.

22.

Normalization of force to muscle cross-sectional area: A helpful attempt to reduce data scattering in contractility studies?

Pecha S, Koivumäki J, Geelhoed B, Kempe R, Berk E, Engel A, Reichenspurner H, Eschenhagen T, Ravens U, Kaumann A, Christ T.

Acta Physiol (Oxf). 2018 Dec;224(4):e13202. doi: 10.1111/apha.13202. No abstract available.

PMID:
30338659
23.

Piezo-bending actuators for isometric or auxotonic contraction analysis of engineered heart tissue.

Mannhardt I, Warncke C, Trieu HK, Müller J, Eschenhagen T.

J Tissue Eng Regen Med. 2019 Jan;13(1):3-11. doi: 10.1002/term.2755. Epub 2018 Nov 26.

PMID:
30334614
24.

Cardiomyopathy phenotypes in human-induced pluripotent stem cell-derived cardiomyocytes-a systematic review.

Eschenhagen T, Carrier L.

Pflugers Arch. 2019 May;471(5):755-768. doi: 10.1007/s00424-018-2214-0. Epub 2018 Oct 15. Review.

25.

Treatments targeting inotropy.

Maack C, Eschenhagen T, Hamdani N, Heinzel FR, Lyon AR, Manstein DJ, Metzger J, Papp Z, Tocchetti CG, Yilmaz MB, Anker SD, Balligand JL, Bauersachs J, Brutsaert D, Carrier L, Chlopicki S, Cleland JG, de Boer RA, Dietl A, Fischmeister R, Harjola VP, Heymans S, Hilfiker-Kleiner D, Holzmeister J, de Keulenaer G, Limongelli G, Linke WA, Lund LH, Masip J, Metra M, Mueller C, Pieske B, Ponikowski P, Ristic A, Ruschitzka F, Seferovic PM, Skouri H, Zimmermann WH, Mebazaa A.

Eur Heart J. 2018 Oct 8. doi: 10.1093/eurheartj/ehy600. [Epub ahead of print]

26.

Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture.

Prüller J, Mannhardt I, Eschenhagen T, Zammit PS, Figeac N.

PLoS One. 2018 Sep 17;13(9):e0202574. doi: 10.1371/journal.pone.0202574. eCollection 2018.

27.

Rat atrial engineered heart tissue: a new in vitro model to study atrial biology.

Krause J, Löser A, Lemoine MD, Christ T, Scherschel K, Meyer C, Blankenberg S, Zeller T, Eschenhagen T, Stenzig J.

Basic Res Cardiol. 2018 Sep 3;113(5):41. doi: 10.1007/s00395-018-0701-2.

PMID:
30178427
28.

From basic science to high performance medicine.

Eschenhagen T.

Eur Heart J. 2018 Aug 21;39(32):2919-2921. doi: 10.1093/eurheartj/ehy425. No abstract available.

PMID:
30165623
29.

Exaggerated Cardiotoxicity of Sunitinib in Stressed 3-Dimensional Heart Muscles.

Eschenhagen T.

JACC Basic Transl Sci. 2018 May 30;3(2):277-279. doi: 10.1016/j.jacbts.2018.01.011. eCollection 2018 Apr. No abstract available.

30.

Uvulopalatopharyngoplasty with or without tonsillectomy in the treatment of adult obstructive sleep apnea - A systematic review.

Stuck BA, Ravesloot MJL, Eschenhagen T, de Vet HCW, Sommer JU.

Sleep Med. 2018 Oct;50:152-165. doi: 10.1016/j.sleep.2018.05.004. Epub 2018 May 12.

PMID:
30056286
31.

Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers.

Lemoine MD, Krause T, Koivumäki JT, Prondzynski M, Schulze ML, Girdauskas E, Willems S, Hansen A, Eschenhagen T, Christ T.

Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e006035. doi: 10.1161/CIRCEP.117.006035.

PMID:
29925535
32.

Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks.

Brenière-Letuffe D, Domke-Shibamiya A, Hansen A, Eschenhagen T, Fehse B, Riecken K, Stenzig J.

Stem Cell Res Ther. 2018 Jun 18;9(1):165. doi: 10.1186/s13287-018-0893-2.

33.

No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart.

Weinberger F, Nicol P, Starbatty J, Stubbendorff M, Becher PM, Schrepfer S, Eschenhagen T.

Pharmacol Res Perspect. 2018 Jun;6(3):e00407. doi: 10.1002/prp2.407.

34.

Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.

Stenzig J, Schneeberger Y, Löser A, Peters BS, Schaefer A, Zhao RR, Ng SL, Höppner G, Geertz B, Hirt MN, Tan W, Wong E, Reichenspurner H, Foo RS, Eschenhagen T.

J Mol Cell Cardiol. 2018 Jul;120:53-63. doi: 10.1016/j.yjmcc.2018.05.012. Epub 2018 May 21.

PMID:
29792884
35.

CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy.

Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A, Denning C.

Eur Heart J. 2018 Nov 14;39(43):3879-3892. doi: 10.1093/eurheartj/ehy249.

36.

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering.

Maffioletti SM, Sarcar S, Henderson ABH, Mannhardt I, Pinton L, Moyle LA, Steele-Stallard H, Cappellari O, Wells KE, Ferrari G, Mitchell JS, Tyzack GE, Kotiadis VN, Khedr M, Ragazzi M, Wang W, Duchen MR, Patani R, Zammit PS, Wells DJ, Eschenhagen T, Tedesco FS.

Cell Rep. 2018 Apr 17;23(3):899-908. doi: 10.1016/j.celrep.2018.03.091.

37.

A new concept of fibroblast dynamics in post-myocardial infarction remodeling.

Eschenhagen T.

J Clin Invest. 2018 May 1;128(5):1731-1733. doi: 10.1172/JCI121079. Epub 2018 Apr 16.

38.

[Cardiology 2018 : From basic science to high efficiency medicine].

Eschenhagen T.

Herz. 2018 Mar;43(2):101-102. doi: 10.1007/s00059-018-4681-7. German. No abstract available.

PMID:
29516153
39.

Contractile Work Contributes to Maturation of Energy Metabolism in hiPSC-Derived Cardiomyocytes.

Ulmer BM, Stoehr A, Schulze ML, Patel S, Gucek M, Mannhardt I, Funcke S, Murphy E, Eschenhagen T, Hansen A.

Stem Cell Reports. 2018 Mar 13;10(3):834-847. doi: 10.1016/j.stemcr.2018.01.039. Epub 2018 Mar 1.

40.

Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes.

Horváth A, Lemoine MD, Löser A, Mannhardt I, Flenner F, Uzun AU, Neuber C, Breckwoldt K, Hansen A, Girdauskas E, Reichenspurner H, Willems S, Jost N, Wettwer E, Eschenhagen T, Christ T.

Stem Cell Reports. 2018 Mar 13;10(3):822-833. doi: 10.1016/j.stemcr.2018.01.012. Epub 2018 Feb 8.

41.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

42.

Cardiovascular Research in Germany.

Heusch G, Eschenhagen T, Dimmeler S.

Circ Res. 2017 Aug 18;121(5):492-495. doi: 10.1161/CIRCRESAHA.117.311132. No abstract available.

PMID:
28819038
43.

Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats.

Mulla W, Etzion S, Elyagon S, Gillis R, Murninkas M, Konstantino Y, Mannhardt I, Eschenhagen T, Liel-Cohen N, Etzion Y.

Sci Rep. 2017 Jul 19;7(1):5931. doi: 10.1038/s41598-017-06197-w.

44.

Human iPSC-derived cardiomyocytes cultured in 3D engineered heart tissue show physiological upstroke velocity and sodium current density.

Lemoine MD, Mannhardt I, Breckwoldt K, Prondzynski M, Flenner F, Ulmer B, Hirt MN, Neuber C, Horváth A, Kloth B, Reichenspurner H, Willems S, Hansen A, Eschenhagen T, Christ T.

Sci Rep. 2017 Jul 14;7(1):5464. doi: 10.1038/s41598-017-05600-w.

45.

Cardiomyocyte Regeneration: A Consensus Statement.

Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA.

Circulation. 2017 Aug 15;136(7):680-686. doi: 10.1161/CIRCULATIONAHA.117.029343. Epub 2017 Jul 6. Review. No abstract available.

46.

Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.

Prondzynski M, Krämer E, Laufer SD, Shibamiya A, Pless O, Flenner F, Müller OJ, Münch J, Redwood C, Hansen A, Patten M, Eschenhagen T, Mearini G, Carrier L.

Mol Ther Nucleic Acids. 2017 Jun 16;7:475-486. doi: 10.1016/j.omtn.2017.05.008. Epub 2017 May 17.

47.

AkrinorTM, a Cafedrine/ Theodrenaline Mixture (20:1), Increases Force of Contraction of Human Atrial Myocardium But Does Not Constrict Internal Mammary Artery In Vitro.

Kloth B, Pecha S, Moritz E, Schneeberger Y, Söhren KD, Schwedhelm E, Reichenspurner H, Eschenhagen T, Böger RH, Christ T, Stehr SN.

Front Pharmacol. 2017 May 23;8:272. doi: 10.3389/fphar.2017.00272. eCollection 2017.

48.

Differentiation of cardiomyocytes and generation of human engineered heart tissue.

Breckwoldt K, Letuffe-Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T, Hansen A.

Nat Protoc. 2017 Jun;12(6):1177-1197. doi: 10.1038/nprot.2017.033. Epub 2017 May 11. Erratum in: Nat Protoc. 2019 Sep;14(9):2748.

PMID:
28492526
49.

Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae.

Mannhardt I, Eder A, Dumotier B, Prondzynski M, Krämer E, Traebert M, Söhren KD, Flenner F, Stathopoulou K, Lemoine MD, Carrier L, Christ T, Eschenhagen T, Hansen A.

Toxicol Sci. 2017 Jul 1;158(1):164-175. doi: 10.1093/toxsci/kfx081.

50.

Engineering Cardiac Muscle Tissue: A Maturating Field of Research.

Weinberger F, Mannhardt I, Eschenhagen T.

Circ Res. 2017 Apr 28;120(9):1487-1500. doi: 10.1161/CIRCRESAHA.117.310738. Review.

PMID:
28450366

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