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Items: 5

1.

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

Klotz L, Eschborn M, Lindner M, Liebmann M, Herold M, Janoschka C, Torres Garrido B, Schulte-Mecklenbeck A, Gross CC, Breuer J, Hundehege P, Posevitz V, Pignolet B, Nebel G, Glander S, Freise N, Austermann J, Wirth T, Campbell GR, Schneider-Hohendorf T, Eveslage M, Brassat D, Schwab N, Loser K, Roth J, Busch KB, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A, Wiendl H.

Sci Transl Med. 2019 May 1;11(490). pii: eaao5563. doi: 10.1126/scitranslmed.aao5563.

PMID:
31043571
2.

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity.

Liebmann M, Hucke S, Koch K, Eschborn M, Ghelman J, Chasan AI, Glander S, Schädlich M, Kuhlencord M, Daber NM, Eveslage M, Beyer M, Dietrich M, Albrecht P, Stoll M, Busch KB, Wiendl H, Roth J, Kuhlmann T, Klotz L.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8017-E8026. doi: 10.1073/pnas.1721049115. Epub 2018 Aug 2.

3.

Intracellular APOL1 Risk Variants Cause Cytotoxicity Accompanied by Energy Depletion.

Granado D, Müller D, Krausel V, Kruzel-Davila E, Schuberth C, Eschborn M, Wedlich-Söldner R, Skorecki K, Pavenstädt H, Michgehl U, Weide T.

J Am Soc Nephrol. 2017 Nov;28(11):3227-3238. doi: 10.1681/ASN.2016111220. Epub 2017 Jul 10.

4.

Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity.

Hucke S, Eschborn M, Liebmann M, Herold M, Freise N, Engbers A, Ehling P, Meuth SG, Roth J, Kuhlmann T, Wiendl H, Klotz L.

J Autoimmun. 2016 Feb;67:90-101. doi: 10.1016/j.jaut.2015.11.001. Epub 2015 Nov 14.

PMID:
26584738
5.

Activated glycoprotein A repetitions predominant (GARP)-expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice.

Eschborn M, Weigmann B, Reissig S, Waisman A, Saloga J, Bellinghausen I.

J Allergy Clin Immunol. 2015 Jul;136(1):159-68. doi: 10.1016/j.jaci.2015.04.020.

PMID:
26145987

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