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Items: 17

1.

Ssu72 phosphatase is a conserved telomere replication terminator.

Escandell JM, Carvalho ES, Gallo-Fernandez M, Reis CC, Matmati S, Luís IM, Abreu IA, Coulon S, Ferreira MG.

EMBO J. 2019 Apr 1;38(7). pii: e100476. doi: 10.15252/embj.2018100476. Epub 2019 Feb 21.

2.

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.

Macedo JC, Vaz S, Bakker B, Ribeiro R, Bakker PL, Escandell JM, Ferreira MG, Medema R, Foijer F, Logarinho E.

Nat Commun. 2018 Jul 19;9(1):2834. doi: 10.1038/s41467-018-05258-6.

3.

The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication.

Matmati S, Vaurs M, Escandell JM, Maestroni L, Nakamura TM, Ferreira MG, Géli V, Coulon S.

Sci Adv. 2018 May 16;4(5):eaar2740. doi: 10.1126/sciadv.aar2740. eCollection 2018 May.

4.

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.

Carlos AR, Escandell JM, Kotsantis P, Suwaki N, Bouwman P, Badie S, Folio C, Benitez J, Gomez-Lopez G, Pisano DG, Jonkers J, Tarsounas M.

Nat Commun. 2013;4:2697. doi: 10.1038/ncomms3697.

PMID:
24162189
5.

ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.

Thanasoula M, Escandell JM, Suwaki N, Tarsounas M.

EMBO J. 2012 Aug 15;31(16):3398-410. doi: 10.1038/emboj.2012.191. Epub 2012 Jul 27.

6.

Cucurbitacins as inducers of cell death and a rich source of potential anticancer compounds.

Ríos JL, Andújar I, Escandell JM, Giner RM, Recio MC.

Curr Pharm Des. 2012;18(12):1663-76. Review.

PMID:
22443631
7.

BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.

Badie S, Escandell JM, Bouwman P, Carlos AR, Thanasoula M, Gallardo MM, Suram A, Jaco I, Benitez J, Herbig U, Blasco MA, Jonkers J, Tarsounas M.

Nat Struct Mol Biol. 2010 Dec;17(12):1461-9. doi: 10.1038/nsmb.1943. Epub 2010 Nov 14.

8.

Bcl-2 is a negative regulator of interleukin-1beta secretion in murine macrophages in pharmacological-induced apoptosis.

Escandell JM, Recio MC, Giner RM, Máñez S, Ríos JL.

Br J Pharmacol. 2010 Aug;160(7):1844-56. doi: 10.1111/j.1476-5381.2010.00856.x.

9.

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers.

Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H, Hiddingh S, Thanasoula M, Kulkarni A, Yang Q, Haffty BG, Tommiska J, Blomqvist C, Drapkin R, Adams DJ, Nevanlinna H, Bartek J, Tarsounas M, Ganesan S, Jonkers J.

Nat Struct Mol Biol. 2010 Jun;17(6):688-95. doi: 10.1038/nsmb.1831. Epub 2010 May 9.

10.

p53 prevents entry into mitosis with uncapped telomeres.

Thanasoula M, Escandell JM, Martinez P, Badie S, Muñoz P, Blasco MA, Tarsounas M.

Curr Biol. 2010 Mar 23;20(6):521-6. doi: 10.1016/j.cub.2010.01.046. Epub 2010 Mar 11.

11.

Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus.

Escandell JM, Recio MC, Giner RM, Máñez S, Cerdá-Nicolás M, Merfort I, Ríos JL.

J Pharmacol Exp Ther. 2010 Feb;332(2):352-63. doi: 10.1124/jpet.109.159327. Epub 2009 Oct 21.

PMID:
19846588
12.

Inhibition of transcription factors by plant-derived compounds and their implications in inflammation and cancer.

Ríos JL, Recio MC, Escandell JM, Andújar I.

Curr Pharm Des. 2009;15(11):1212-37. Review.

PMID:
19355962
13.

Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.

Escandell JM, Kaler P, Recio MC, Sasazuki T, Shirasawa S, Augenlicht L, Ríos JL, Klampfer L.

Biochem Pharmacol. 2008 Jul 15;76(2):198-207. doi: 10.1016/j.bcp.2008.05.004. Epub 2008 May 8.

14.

Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation.

Escandell JM, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Gil-Benso R, Ríos JL.

J Pharmacol Exp Ther. 2007 Sep;322(3):1261-8. Epub 2007 Jun 11.

PMID:
17562851
15.

New insight into the inhibition of the inflammatory response to experimental delayed-type hypersensitivity reactions in mice by scropolioside A.

Bas E, Recio MC, Máñez S, Giner RM, Escandell JM, López-Ginés C, Ríos JL.

Eur J Pharmacol. 2007 Jan 26;555(2-3):199-210. Epub 2006 Oct 17.

PMID:
17113578
16.

Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages.

Escandell JM, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.

J Pharmacol Exp Ther. 2007 Feb;320(2):581-90. Epub 2006 Oct 25.

PMID:
17065367
17.

Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis.

Escandell JM, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.

Eur J Pharmacol. 2006 Feb 17;532(1-2):145-54. Epub 2006 Jan 27.

PMID:
16443215

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