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Items: 1 to 50 of 60

1.

Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes.

Barrett S, De Franco M, Kellett A, Dempsey E, Marzano C, Erxleben A, Gandin V, Montagner D.

J Biol Inorg Chem. 2020 Feb;25(1):49-60. doi: 10.1007/s00775-019-01732-8. Epub 2019 Oct 26.

PMID:
31655896
2.

Editorial: Advances in the Development of Artificial Metalloenzymes.

Parac-Vogt TN, Erxleben A, Schenk G, Prabhakar R.

Front Chem. 2019 Aug 28;7:599. doi: 10.3389/fchem.2019.00599. eCollection 2019. No abstract available.

3.

Coordination polymers of CdII and PbII derived from bipyridine-glycoluril: influence of metal-ion size and counter-ions.

Tayade SB, Markad D, Kumbhar AS, Erxleben A, Chakravarty D.

Acta Crystallogr C Struct Chem. 2019 Aug 1;75(Pt 8):1084-1090. doi: 10.1107/S2053229619008325. Epub 2019 Jul 9.

PMID:
31380791
4.

Mechanistic Studies of Homo- and Heterodinuclear Zinc Phosphoesterase Mimics: What Has Been Learned?

Erxleben A.

Front Chem. 2019 Feb 21;7:82. doi: 10.3389/fchem.2019.00082. eCollection 2019. Review.

5.

Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide.

Aljohani M, MacFhionnghaile P, McArdle P, Erxleben A.

Int J Pharm. 2019 Apr 20;561:35-42. doi: 10.1016/j.ijpharm.2019.02.024. Epub 2019 Feb 23.

PMID:
30802549
6.

A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage.

Molphy Z, Montagner D, Bhat SS, Slator C, Long C, Erxleben A, Kellett A.

Nucleic Acids Res. 2018 Nov 2;46(19):9918-9931. doi: 10.1093/nar/gky806.

7.

Community-Driven Data Analysis Training for Biology.

Batut B, Hiltemann S, Bagnacani A, Baker D, Bhardwaj V, Blank C, Bretaudeau A, Brillet-Guéguen L, Čech M, Chilton J, Clements D, Doppelt-Azeroual O, Erxleben A, Freeberg MA, Gladman S, Hoogstrate Y, Hotz HR, Houwaart T, Jagtap P, Larivière D, Le Corguillé G, Manke T, Mareuil F, Ramírez F, Ryan D, Sigloch FC, Soranzo N, Wolff J, Videm P, Wolfien M, Wubuli A, Yusuf D; Galaxy Training Network, Taylor J, Backofen R, Nekrutenko A, Grüning B.

Cell Syst. 2018 Jun 27;6(6):752-758.e1. doi: 10.1016/j.cels.2018.05.012.

8.

Mitochondria-Targeting Anticancer Metal Complexes.

Erxleben A.

Curr Med Chem. 2019;26(4):694-728. doi: 10.2174/0929867325666180307112029. Review.

PMID:
29521200
9.

Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes.

Thriene K, Grüning BA, Bornert O, Erxleben A, Leppert J, Athanasiou I, Weber E, Kiritsi D, Nyström A, Reinheckel T, Backofen R, Has C, Bruckner-Tuderman L, Dengjel J.

Mol Cell Proteomics. 2018 Apr;17(4):565-579. doi: 10.1074/mcp.RA117.000437. Epub 2018 Jan 11.

10.

The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems.

Gniado K, MacFhionnghaile P, McArdle P, Erxleben A.

Int J Pharm. 2018 Jan 15;535(1-2):132-139. doi: 10.1016/j.ijpharm.2017.10.049. Epub 2017 Oct 28.

PMID:
29107615
11.

Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid.

Almotairy ARZ, Gandin V, Morrison L, Marzano C, Montagner D, Erxleben A.

J Inorg Biochem. 2017 Dec;177:1-7. doi: 10.1016/j.jinorgbio.2017.09.009. Epub 2017 Sep 10.

PMID:
28918353
12.

A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations.

Pallipurath AR, Civati F, Sibik J, Crowley C, Zeitler JA, McArdle P, Erxleben A.

Int J Pharm. 2017 Aug 7;528(1-2):312-321. doi: 10.1016/j.ijpharm.2017.06.020. Epub 2017 Jun 8.

PMID:
28603011
13.

The RNA workbench: best practices for RNA and high-throughput sequencing bioinformatics in Galaxy.

Grüning BA, Fallmann J, Yusuf D, Will S, Erxleben A, Eggenhofer F, Houwaart T, Batut B, Videm P, Bagnacani A, Wolfien M, Lott SC, Hoogstrate Y, Hess WR, Wolkenhauer O, Hoffmann S, Akalin A, Ohler U, Stadler PF, Backofen R.

Nucleic Acids Res. 2017 Jul 3;45(W1):W560-W566. doi: 10.1093/nar/gkx409.

14.

RNA-bioinformatics: Tools, services and databases for the analysis of RNA-based regulation.

Backofen R, Engelhardt J, Erxleben A, Fallmann J, Grüning B, Ohler U, Rajewsky N, Stadler PF.

J Biotechnol. 2017 Nov 10;261:76-84. doi: 10.1016/j.jbiotec.2017.05.019. Epub 2017 May 26. Review.

15.

Investigation of Non-covalent Interactions of Metal Complexes with DNA in Cell-free Systems.

Erxleben A.

Chimia (Aarau). 2017 Mar 29;71(3):102-111. doi: 10.2533/chimia.2017.102. Review.

PMID:
28351455
16.

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights.

Montagner D, Fresch B, Browne K, Gandin V, Erxleben A.

Chem Commun (Camb). 2016 Dec 20;53(1):134-137.

PMID:
27924322
17.
18.

Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance.

Shirazi RN, Aldabbagh F, Ronan W, Erxleben A, Rochev Y, McHugh P.

J Mater Sci Mater Med. 2016 Oct;27(10):154. doi: 10.1007/s10856-016-5760-z. Epub 2016 Sep 2.

PMID:
27590824
19.

Ruthenium(II) polypyridyl complexes with hydrophobic ancillary ligand as Aβ aggregation inhibitors.

Vyas NA, Ramteke SN, Kumbhar AS, Kulkarni PP, Jani V, Sonawane UB, Joshi RR, Joshi B, Erxleben A.

Eur J Med Chem. 2016 Oct 4;121:793-802. doi: 10.1016/j.ejmech.2016.06.038. Epub 2016 Jun 24.

PMID:
27406812
20.

Oxidative Stress Induced by Pt(IV) Pro-drugs Based on the Cisplatin Scaffold and Indole Carboxylic Acids in Axial Position.

Tolan D, Gandin V, Morrison L, El-Nahas A, Marzano C, Montagner D, Erxleben A.

Sci Rep. 2016 Jul 11;6:29367. doi: 10.1038/srep29367.

21.

The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems.

Gniado K, Löbmann K, Rades T, Erxleben A.

Int J Pharm. 2016 May 17;504(1-2):20-6. doi: 10.1016/j.ijpharm.2016.03.023. Epub 2016 Mar 16.

PMID:
26992818
22.

Copper(ii) mixed-ligand polypyridyl complexes with doxycycline - structures and biological evaluation.

Abosede OO, Vyas NA, Singh SB, Kumbhar AS, Kate A, Kumbhar AA, Khan A, Erxleben A, Smith P, de Kock C, Hoffmann F, Obaleye JA.

Dalton Trans. 2016 Feb 21;45(7):3003-12. doi: 10.1039/c5dt04405g. Epub 2016 Jan 13.

PMID:
26758215
23.

StreptomeDB 2.0--an extended resource of natural products produced by streptomycetes.

Klementz D, Döring K, Lucas X, Telukunta KK, Erxleben A, Deubel D, Erber A, Santillana I, Thomas OS, Bechthold A, Günther S.

Nucleic Acids Res. 2016 Jan 4;44(D1):D509-14. doi: 10.1093/nar/gkv1319. Epub 2015 Nov 28.

24.

Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives.

Tabrizi L, McArdle P, Erxleben A, Chiniforoshan H.

Eur J Med Chem. 2015 Oct 20;103:516-29. doi: 10.1016/j.ejmech.2015.09.018. Epub 2015 Sep 15.

PMID:
26402729
25.

Sulfamerazine: Understanding the Influence of Slip Planes in the Polymorphic Phase Transformation through X-Ray Crystallographic Studies and ab Initio Lattice Dynamics.

Pallipurath AR, Skelton JM, Warren MR, Kamali N, McArdle P, Erxleben A.

Mol Pharm. 2015 Oct 5;12(10):3735-48. doi: 10.1021/acs.molpharmaceut.5b00504. Epub 2015 Sep 8.

PMID:
26317333
26.

DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex.

Montagner D, Gandin V, Marzano C, Erxleben A.

J Inorg Biochem. 2015 Apr;145:101-7. doi: 10.1016/j.jinorgbio.2015.01.013. Epub 2015 Jan 26.

PMID:
25660211
27.

Nanomechanical properties of poly(lactic-co-glycolic) acid film during degradation.

Shirazi RN, Aldabbagh F, Erxleben A, Rochev Y, McHugh P.

Acta Biomater. 2014 Nov;10(11):4695-4703. doi: 10.1016/j.actbio.2014.08.004. Epub 2014 Aug 10.

PMID:
25117951
28.

Large-scale gene expression profiling data for the model moss Physcomitrella patens aid understanding of developmental progression, culture and stress conditions.

Hiss M, Laule O, Meskauskiene RM, Arif MA, Decker EL, Erxleben A, Frank W, Hanke ST, Lang D, Martin A, Neu C, Reski R, Richardt S, Schallenberg-Rüdinger M, Szövényi P, Tiko T, Wiedemann G, Wolf L, Zimmermann P, Rensing SA.

Plant J. 2014 Aug;79(3):530-9. doi: 10.1111/tpj.12572. Epub 2014 Jul 9.

29.

Metabolic pathway monitoring of phenalinolactone biosynthesis from Streptomyces sp. Tü6071 by liquid chromatography/mass spectrometry coupling.

Kiske C, Erxleben A, Lucas X, Willmann L, Klementz D, Günther S, Römer W, Kammerer B.

Rapid Commun Mass Spectrom. 2014 Jul 15;28(13):1459-67. doi: 10.1002/rcm.6920.

PMID:
24861595
30.

Effects of ball-milling and cryomilling on sulfamerazine polymorphs: a quantitative study.

Macfhionnghaile P, Hu Y, Gniado K, Curran S, Mcardle P, Erxleben A.

J Pharm Sci. 2014 Jun;103(6):1766-78. doi: 10.1002/jps.23978. Epub 2014 Apr 22.

PMID:
24756899
31.

Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.

Schwer CI, Lehane C, Guelzow T, Zenker S, Strosing KM, Spassov S, Erxleben A, Heimrich B, Buerkle H, Humar M.

PLoS One. 2013 Oct 22;8(10):e77258. doi: 10.1371/journal.pone.0077258. eCollection 2013.

32.

Carbimazole is an inhibitor of protein synthesis and protects from neuronal hypoxic damage in vitro.

Lehane C, Guelzow T, Zenker S, Erxleben A, Schwer CI, Heimrich B, Buerkle H, Humar M.

J Pharmacol Exp Ther. 2013 Dec;347(3):781-93. doi: 10.1124/jpet.113.205989. Epub 2013 Sep 18.

PMID:
24049063
33.

Draft Genome Sequence of Streptomyces viridochromogenes Strain Tu57, Producer of Avilamycin.

Grüning BA, Erxleben A, Hähnlein A, Günther S.

Genome Announc. 2013 Jun 20;1(3). pii: e00384-13. doi: 10.1128/genomeA.00384-13.

34.

17β-Hy-droxy-17α-methyl-androsta-1,4-dien-3-one.

Karpinska J, Erxleben A, McArdle P.

Acta Crystallogr Sect E Struct Rep Online. 2013 Jan 1;69(Pt 1):o60. doi: 10.1107/S1600536812049860. Epub 2012 Dec 8.

35.

Amorphous solid dispersions of sulfonamide/Soluplus® and sulfonamide/PVP prepared by ball milling.

Caron V, Hu Y, Tajber L, Erxleben A, Corrigan OI, McArdle P, Healy AM.

AAPS PharmSciTech. 2013 Mar;14(1):464-74. doi: 10.1208/s12249-013-9931-7. Epub 2013 Feb 7.

36.

StreptomeDB: a resource for natural compounds isolated from Streptomyces species.

Lucas X, Senger C, Erxleben A, Grüning BA, Döring K, Mosch J, Flemming S, Günther S.

Nucleic Acids Res. 2013 Jan;41(Database issue):D1130-6. doi: 10.1093/nar/gks1253. Epub 2012 Nov 28.

37.

Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling.

Curtin V, Amharar Y, Hu Y, Erxleben A, McArdle P, Caron V, Tajber L, Corrigan OI, Healy AM.

Mol Pharm. 2013 Jan 7;10(1):386-96. doi: 10.1021/mp300529a. Epub 2012 Dec 5.

PMID:
23186332
38.

Ethyl N-[2-(4-phen-oxy-phen-oxy)eth-yl]carbamate.

Karpinska J, Kuhs M, Rasmuson A, Erxleben A, McArdle P.

Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2834-5. doi: 10.1107/S1600536812037105. Epub 2012 Sep 5.

39.

Formation, physical stability, and quantification of process-induced disorder in cryomilled samples of a model polymorphic drug.

Hu Y, Macfhionnghaile P, Caron V, Tajber L, Healy AM, Erxleben A, McArdle P.

J Pharm Sci. 2013 Jan;102(1):93-103. doi: 10.1002/jps.23338. Epub 2012 Oct 9.

PMID:
23047833
40.

Genome sequence of the fungus Glarea lozoyensis: the first genome sequence of a species from the Helotiaceae family.

Youssar L, Grüning BA, Erxleben A, Günther S, Hüttel W.

Eukaryot Cell. 2012 Feb;11(2):250. doi: 10.1128/EC.05302-11. Erratum in: Eukaryot Cell. 2012 Jun;11(6):829.

41.

Mining and evaluation of molecular relationships in literature.

Senger C, Grüning BA, Erxleben A, Döring K, Patel H, Flemming S, Merfort I, Günther S.

Bioinformatics. 2012 Mar 1;28(5):709-14. doi: 10.1093/bioinformatics/bts026. Epub 2012 Jan 13.

PMID:
22247277
42.

Metabolite profiling of the moss Physcomitrella patens reveals evolutionary conservation of osmoprotective substances.

Erxleben A, Gessler A, Vervliet-Scheebaum M, Reski R.

Plant Cell Rep. 2012 Feb;31(2):427-36. doi: 10.1007/s00299-011-1177-9. Epub 2011 Oct 29.

PMID:
22038371
43.

Genome sequence of Streptomyces sp. strain Tü6071.

Erxleben A, Wunsch-Palasis J, Grüning BA, Luzhetska M, Bechthold A, Günther S.

J Bacteriol. 2011 Aug;193(16):4278-9. doi: 10.1128/JB.00377-11. Epub 2011 Jun 24.

44.

Compounds In Literature (CIL): screening for compounds and relatives in PubMed.

Grüning BA, Senger C, Erxleben A, Flemming S, Günther S.

Bioinformatics. 2011 May 1;27(9):1341-2. doi: 10.1093/bioinformatics/btr130. Epub 2011 Mar 16.

PMID:
21414988
45.

Mixed ligand cobalt(II) picolinate complexes: synthesis, characterization, DNA binding and photocleavage.

Kawade VA, Kumbhar AA, Kumbhar AS, Näther C, Erxleben A, Sonawane UB, Joshi RR.

Dalton Trans. 2011 Jan 21;40(3):639-50. doi: 10.1039/c0dt01078b. Epub 2010 Dec 3.

PMID:
21127806
46.

Synthesis, single-crystal and solution structure analysis and in vitro cytotoxic activity of two novel complexes of ruthenium(II) with in situ formed flavanone-based ligands.

Ochocki J, Kasprzak M, Chęcińska L, Erxleben A, Zyner E, Szmigiero L, Garza-Ortiz A, Reedijk J.

Dalton Trans. 2010 Oct 28;39(40):9711-8. doi: 10.1039/c0dt00535e. Epub 2010 Sep 7.

PMID:
20830400
47.

Quantitative analysis of sulfathiazole polymorphs in ternary mixtures by attenuated total reflectance infrared, near-infrared and Raman spectroscopy.

Hu Y, Erxleben A, Ryder AG, McArdle P.

J Pharm Biomed Anal. 2010 Nov 2;53(3):412-20. doi: 10.1016/j.jpba.2010.05.002. Epub 2010 May 10.

PMID:
20605386
48.
49.

Binding and hydrolysis studies of antitumoural titanocene dichloride and Titanocene Y with phosphate diesters.

Erxleben A, Claffey J, Tacke M.

J Inorg Biochem. 2010 Apr;104(4):390-6. doi: 10.1016/j.jinorgbio.2009.11.010. Epub 2009 Dec 3.

PMID:
20036426

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