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Items: 1 to 50 of 143

1.

The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii.

Crépin S, Ottosen EN, Chandler CE, Sintsova A, Ernst RK, Mobley HLT.

Mol Microbiol. 2019 Nov 3. doi: 10.1111/mmi.14407. [Epub ahead of print]

PMID:
31680352
2.

Lipopolysaccharides of different Burkholderia species with different lipid A structures induce TLR4 activation and react with melioidosis patient sera.

Sengyee S, Yoon SH, West TE, Ernst RK, Chantratita N.

Infect Immun. 2019 Sep 23. pii: IAI.00692-19. doi: 10.1128/IAI.00692-19. [Epub ahead of print]

3.

Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria.

Barker WT, Nemeth AM, Brackett SM, Basak AK, Chandler CE, Jania LA, Zuercher WJ, Melander RJ, Koller BH, Ernst RK, Melander C.

ACS Infect Dis. 2019 Oct 11;5(10):1764-1771. doi: 10.1021/acsinfecdis.9b00212. Epub 2019 Sep 4.

PMID:
31434474
4.

Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane.

Krishnamoorthy G, Weeks JW, Zhang Z, Chandler CE, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00956-19. doi: 10.1128/AAC.00956-19. Print 2019 Oct.

PMID:
31383661
5.

Model-Based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids.

Ryu SY, Wendt GA, Chandler CE, Ernst RK, Goodlett DR.

Anal Chem. 2019 Sep 3;91(17):11482-11487. doi: 10.1021/acs.analchem.9b03340. Epub 2019 Aug 15.

PMID:
31369253
6.

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii.

Martin SE, Melander RJ, Brackett CM, Scott AJ, Chandler CE, Nguyen CM, Minrovic BM, Harrill SE, Ernst RK, Manoil C, Melander C.

ACS Infect Dis. 2019 Jul 12;5(7):1223-1230. doi: 10.1021/acsinfecdis.9b00067. Epub 2019 Apr 26.

PMID:
31002491
7.

Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants.

Kutschera A, Dawid C, Gisch N, Schmid C, Raasch L, Gerster T, Schäffer M, Smakowska-Luzan E, Belkhadir Y, Vlot AC, Chandler CE, Schellenberger R, Schwudke D, Ernst RK, Dorey S, Hückelhoven R, Hofmann T, Ranf S.

Science. 2019 Apr 12;364(6436):178-181. doi: 10.1126/science.aau1279.

PMID:
30975887
8.

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria.

Barker WT, Chandler CE, Melander RJ, Ernst RK, Melander C.

Bioorg Med Chem. 2019 May 1;27(9):1776-1788. doi: 10.1016/j.bmc.2019.03.019. Epub 2019 Mar 8.

PMID:
30898435
9.

Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis.

Cooke AC, Nello AV, Ernst RK, Schertzer JW.

PLoS One. 2019 Feb 14;14(2):e0212275. doi: 10.1371/journal.pone.0212275. eCollection 2019.

10.

Temporal proteomic profiling reveals changes that support Burkholderia biofilms.

Khan MM, Chattagul S, Tran BQ, Freiberg JA, Nita-Lazar A, Shirtliff ME, Sermswan RW, Ernst RK, Goodlett DR.

Pathog Dis. 2019 Mar 1;77(2). pii: ftz005. doi: 10.1093/femspd/ftz005.

PMID:
30759239
11.

Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers.

Kumagai A, Dupuy FG, Arsov Z, Elhady Y, Moody D, Ernst RK, Deslouches B, Montelaro RC, Peter Di Y, Tristram-Nagle S.

Soft Matter. 2019 Feb 20;15(8):1860-1868. doi: 10.1039/c8sm02180e.

PMID:
30702120
12.

Rapid Microbial Identification and Antibiotic Resistance Detection by Mass Spectrometric Analysis of Membrane Lipids.

Liang T, Leung LM, Opene B, Fondrie WE, Lee YI, Chandler CE, Yoon SH, Doi Y, Ernst RK, Goodlett DR.

Anal Chem. 2019 Jan 15;91(2):1286-1294. doi: 10.1021/acs.analchem.8b02611. Epub 2019 Jan 4.

PMID:
30571097
13.

A Prospective Study of Acinetobacter baumannii Complex Isolates and Colistin Susceptibility Monitoring by Mass Spectrometry of Microbial Membrane Glycolipids.

Leung LM, McElheny CL, Gardner FM, Chandler CE, Bowler SL, Mettus RT, Spychala CN, Fowler EL, Opene BNA, Myers RA, Goodlett DR, Doi Y, Ernst RK.

J Clin Microbiol. 2019 Feb 27;57(3). pii: e01100-18. doi: 10.1128/JCM.01100-18. Print 2019 Mar.

14.

Genomic and Phenotypic Diversity among Ten Laboratory Isolates of Pseudomonas aeruginosa PAO1.

Chandler CE, Horspool AM, Hill PJ, Wozniak DJ, Schertzer JW, Rasko DA, Ernst RK.

J Bacteriol. 2019 Feb 11;201(5). pii: e00595-18. doi: 10.1128/JB.00595-18. Print 2019 Mar 1.

15.

Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.

Fondrie WE, Liang T, Oyler BL, Leung LM, Ernst RK, Strickland DK, Goodlett DR.

Sci Rep. 2018 Oct 26;8(1):15857. doi: 10.1038/s41598-018-33681-8.

16.

Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii.

Mustapha MM, Li B, Pacey MP, Mettus RT, McElheny CL, Marshall CW, Ernst RK, Cooper VS, Doi Y.

J Antimicrob Chemother. 2018 Nov 1;73(11):2952-2959. doi: 10.1093/jac/dky290.

17.

Rickettsia Lipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition.

Guillotte ML, Gillespie JJ, Chandler CE, Rahman MS, Ernst RK, Azad AF.

J Bacteriol. 2018 Sep 10;200(19). pii: e00334-18. doi: 10.1128/JB.00334-18. Print 2018 Oct 1.

18.

In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays.

Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell CM, Scott AJ, Ernst RK.

Infect Immun. 2018 Aug 22;86(9). pii: e00406-18. doi: 10.1128/IAI.00406-18. Print 2018 Sep.

19.

Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin.

Khan MM, Ernst O, Sun J, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A.

J Mol Biol. 2018 Aug 17;430(17):2641-2660. doi: 10.1016/j.jmb.2018.06.032. Epub 2018 Jun 24. Review.

PMID:
29949751
20.

A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model.

Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK.

Vaccine. 2018 Jun 27;36(28):4023-4031. doi: 10.1016/j.vaccine.2018.05.101. Epub 2018 May 31.

21.

Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1230. doi: 10.1007/s13361-018-1960-8.

PMID:
29687418
22.

Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation.

Sengyee S, Yoon SH, Paksanont S, Yimthin T, Wuthiekanun V, Limmathurotsakul D, West TE, Ernst RK, Chantratita N.

PLoS Negl Trop Dis. 2018 Feb 23;12(2):e0006287. doi: 10.1371/journal.pntd.0006287. eCollection 2018 Feb.

23.

Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1221-1229. doi: 10.1007/s13361-018-1897-y. Epub 2018 Feb 20. Erratum in: J Am Soc Mass Spectrom. 2018 Apr 23;:.

PMID:
29464544
24.

CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens.

Crawford MA, Fisher DJ, Leung LM, Lomonaco S, Lascols C, Cannatelli A, Giani T, Rossolini GM, Doi Y, Goodlett DR, Allard MW, Sharma SK, Khan E, Ernst RK, Hughes MA.

MBio. 2017 Nov 14;8(6). pii: e01549-17. doi: 10.1128/mBio.01549-17.

25.

Host-based lipid inflammation drives pathogenesis in Francisella infection.

Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12596-12601. doi: 10.1073/pnas.1712887114. Epub 2017 Nov 6.

26.

Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.

Hajjar AM, Ernst RK, Yi J, Yam CS, Miller SI.

PLoS One. 2017 Oct 11;12(10):e0186308. doi: 10.1371/journal.pone.0186308. eCollection 2017.

27.

Probing the sRNA regulatory landscape of P. aeruginosa: post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility.

Zhang YF, Han K, Chandler CE, Tjaden B, Ernst RK, Lory S.

Mol Microbiol. 2017 Dec;106(6):919-937. doi: 10.1111/mmi.13857. Epub 2017 Nov 2.

28.

Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae.

Leung LM, Cooper VS, Rasko DA, Guo Q, Pacey MP, McElheny CL, Mettus RT, Yoon SH, Goodlett DR, Ernst RK, Doi Y.

J Antimicrob Chemother. 2017 Nov 1;72(11):3035-3042. doi: 10.1093/jac/dkx234.

29.

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria.

Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C.

Bioorg Med Chem. 2017 Oct 15;25(20):5749-5753. doi: 10.1016/j.bmc.2017.08.055. Epub 2017 Sep 9.

30.

Structural basis of MsbA-mediated lipopolysaccharide transport.

Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M.

Nature. 2017 Sep 14;549(7671):233-237. doi: 10.1038/nature23649. Epub 2017 Sep 6.

31.

Bacterial lipids: powerful modifiers of the innate immune response.

Chandler CE, Ernst RK.

F1000Res. 2017 Aug 7;6. pii: F1000 Faculty Rev-1334. doi: 10.12688/f1000research.11388.1. eCollection 2017. Review.

32.

Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress.

Robert CB, Thomson M, Vercellone A, Gardner F, Ernst RK, Larrouy-Maumus G, Nigou J.

Biochimie. 2017 Oct;141:16-20. doi: 10.1016/j.biochi.2017.08.008. Epub 2017 Aug 12.

PMID:
28807561
33.

Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids.

Leung LM, Fondrie WE, Doi Y, Johnson JK, Strickland DK, Ernst RK, Goodlett DR.

Sci Rep. 2017 Jul 25;7(1):6403. doi: 10.1038/s41598-017-04793-4.

34.

Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery.

Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK.

MBio. 2017 May 9;8(3). pii: e00492-17. doi: 10.1128/mBio.00492-17.

35.

Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens.

Liu YY, Chandler CE, Leung LM, McElheny CL, Mettus RT, Shanks RMQ, Liu JH, Goodlett DR, Ernst RK, Doi Y.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00580-17. doi: 10.1128/AAC.00580-17. Print 2017 Jun.

36.

Infection-derived lipids elicit an immune deficiency circuit in arthropods.

Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH.

Nat Commun. 2017 Feb 14;8:14401. doi: 10.1038/ncomms14401.

37.

Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship.

Scott AJ, Oyler BL, Goodlett DR, Ernst RK.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Nov;1862(11):1439-1450. doi: 10.1016/j.bbalip.2017.01.004. Epub 2017 Jan 17. Review.

38.

Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity.

Richard K, Mann BJ, Qin A, Barry EM, Ernst RK, Vogel SN.

Clin Vaccine Immunol. 2017 Mar 6;24(3). pii: e00574-16. doi: 10.1128/CVI.00574-16. Print 2017 Mar.

39.

In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress.

Jones CL, Singh SS, Alamneh Y, Casella LG, Ernst RK, Lesho EP, Waterman PE, Zurawski DV.

Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e00598-16. doi: 10.1128/AAC.00598-16. Print 2017 Mar.

40.

Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms.

Freiberg JA, Le Breton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Mongodin EF, Goodlett DR, McIver KS, Shirtliff ME.

mSystems. 2016 Dec 6;1(6). pii: e00149-16. eCollection 2016 Nov-Dec.

41.

Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry.

Kilgour DPA, Hughes S, Kilgour SL, Mackay CL, Palmblad M, Tran BQ, Goo YA, Ernst RK, Clarke DJ, Goodlett DR.

J Am Soc Mass Spectrom. 2017 Feb;28(2):253-262. doi: 10.1007/s13361-016-1549-z. Epub 2016 Dec 6.

42.

1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.

Corey BW, Thompson MG, Hittle LE, Jacobs AC, Asafo-Adjei EA, Huggins WM, Melander RJ, Melander C, Ernst RK, Zurawski DV.

ACS Infect Dis. 2017 Jan 13;3(1):62-71. doi: 10.1021/acsinfecdis.6b00133. Epub 2016 Nov 3.

43.

A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils.

SenGupta S, Hittle LE, Ernst RK, Uriarte SM, Mitchell TC.

J Leukoc Biol. 2016 Nov;100(5):1047-1059. Epub 2016 Aug 18.

44.

Norharmane Matrix Enhances Detection of Endotoxin by MALDI-MS for Simultaneous Profiling of Pathogen, Host, and Vector Systems.

Scott AJ, Flinders B, Cappell J, Liang T, Pelc RS, Tran B, Kilgour DP, Heeren RM, Goodlett DR, Ernst RK.

Pathog Dis. 2016 Sep 19. pii: ftw097. [Epub ahead of print]

PMID:
27650574
45.

Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm.

Yoon SH, Liang T, Schneider T, Oyler BL, Chandler CE, Ernst RK, Yen GS, Huang Y, Nilsson E, Goodlett DR.

Rapid Commun Mass Spectrom. 2016 Dec 15;30(23):2555-2560. doi: 10.1002/rcm.7728.

PMID:
27582344
46.

Structural derivation of lipid A from Cronobacter sakazakii using tandem mass spectrometry.

Li Y, Yoon SH, Wang X, Ernst RK, Goodlett DR.

Rapid Commun Mass Spectrom. 2016 Oct 30;30(20):2265-70. doi: 10.1002/rcm.7712.

PMID:
27502448
47.

Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity.

Brackett CM, Furlani RE, Anderson RG, Krishnamurthy A, Melander RJ, Moskowitz SM, Ernst RK, Melander C.

Tetrahedron. 2016 Jun 23;72(25):3549-3553.

48.

Type IV pili promote early biofilm formation by Clostridium difficile.

Maldarelli GA, Piepenbrink KH, Scott AJ, Freiberg JA, Song Y, Achermann Y, Ernst RK, Shirtliff ME, Sundberg EJ, Donnenberg MS, von Rosenvinge EC.

Pathog Dis. 2016 Aug;74(6). pii: ftw061. doi: 10.1093/femspd/ftw061. Epub 2016 Jun 30.

49.

Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C.

Medchemcomm. 2016 Jan 1;7(1):128-131. Epub 2015 Sep 30.

50.

Modification of the 1-Phosphate Group during Biosynthesis of Capnocytophaga canimorsus Lipid A.

Renzi F, Zähringer U, Chandler CE, Ernst RK, Cornelis GR, Ittig SJ.

Infect Immun. 2015 Dec 7;84(2):550-61. doi: 10.1128/IAI.01006-15. Print 2016 Feb.

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