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Items: 1 to 50 of 545

1.

Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes.

Heinrich F, Salyapongse A, Kumagai A, Dupuy FG, Shukla K, Penk A, Huster D, Ernst RK, Pavlova A, Gumbart JC, Deslouches B, Di YP, Tristram-Nagle S.

Chemistry. 2020 Mar 13. doi: 10.1002/chem.202000212. [Epub ahead of print]

PMID:
32166806
2.

Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness.

Levental KR, Malmberg E, Symons JL, Fan YY, Chapkin RS, Ernst R, Levental I.

Nat Commun. 2020 Mar 12;11(1):1339. doi: 10.1038/s41467-020-15203-1.

3.

Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model.

Kampa JM, Sahin M, Slopianka M, Giampà M, Bednarz H, Ernst R, Riefke B, Niehaus K, Fatangare A.

Toxicol Lett. 2020 Jun 1;325:43-50. doi: 10.1016/j.toxlet.2020.02.007. Epub 2020 Feb 21.

PMID:
32092452
4.

Toll-like Receptor 4-Independent Effects of Lipopolysaccharide Identified Using Longitudinal Serum Proteomics.

Harberts E, Liang T, Yoon SH, Opene BN, McFarland MA, Goodlett DR, Ernst RK.

J Proteome Res. 2020 Mar 6;19(3):1258-1266. doi: 10.1021/acs.jproteome.9b00765. Epub 2020 Feb 24.

5.

Modifier genes in SCN1A-related epilepsy syndromes.

de Lange IM, Mulder F, van 't Slot R, Sonsma ACM, van Kempen MJA, Nijman IJ, Ernst RF, Knoers NVAM, Brilstra EH, Koeleman BPC.

Mol Genet Genomic Med. 2020 Feb 7:e1103. doi: 10.1002/mgg3.1103. [Epub ahead of print]

6.

Regulation of lipid saturation without sensing membrane fluidity.

Ballweg S, Sezgin E, Doktorova M, Covino R, Reinhard J, Wunnicke D, Hänelt I, Levental I, Hummer G, Ernst R.

Nat Commun. 2020 Feb 6;11(1):756. doi: 10.1038/s41467-020-14528-1.

7.

Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging.

Scott AJ, Chandler CE, Ellis SR, Heeren RMA, Ernst RK.

Sci Rep. 2019 Dec 27;9(1):20160. doi: 10.1038/s41598-019-56364-4.

8.

Proton Pump Inhibitors and Kidney Function Decline in Community-Dwelling Older Adults.

de Godoi Rezende Costa Molino C, Meyer U, Ernst R, Bischoff-Ferrari HA.

J Am Med Dir Assoc. 2020 Jan;21(1):129-130. doi: 10.1016/j.jamda.2019.10.014. Epub 2019 Nov 26. No abstract available.

PMID:
31784188
9.

Phase I/II Manufacture of Lentiviral Vectors Under GMP in an Academic Setting.

Dasgupta A, Tinch S, Szczur K, Ernst R, Shryock N, Kaylor C, Lewis K, Day E, Truong T, Swaney W.

Methods Mol Biol. 2020;2086:27-60. doi: 10.1007/978-1-0716-0146-4_3.

PMID:
31707666
10.

The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii.

Crépin S, Ottosen EN, Chandler CE, Sintsova A, Ernst RK, Mobley HLT.

Mol Microbiol. 2020 Jan;113(1):153-172. doi: 10.1111/mmi.14407. Epub 2019 Nov 19.

PMID:
31680352
11.

Nodal drainage pathways in primary rectal cancer: anatomy of regional and distant nodal spread.

Kaur H, Ernst RD, Rauch GM, Harisinghani M.

Abdom Radiol (NY). 2019 Nov;44(11):3527-3535. doi: 10.1007/s00261-019-02094-0. Review.

PMID:
31628513
12.

Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera.

Sengyee S, Yoon SH, West TE, Ernst RK, Chantratita N.

Infect Immun. 2019 Nov 18;87(12). pii: e00692-19. doi: 10.1128/IAI.00692-19. Print 2019 Dec.

13.

Fifteen shades of green: The evolution of Bufotes toads revisited.

Dufresnes C, Mazepa G, Jablonski D, Oliveira RC, Wenseleers T, Shabanov DA, Auer M, Ernst R, Koch C, Ramírez-Chaves HE, Mulder KP, Simonov E, Tiutenko A, Kryvokhyzha D, Wennekes PL, Zinenko OI, Korshunov OV, Al-Johany AM, Peregontsev EA, Masroor R, Betto-Colliard C, Denoël M, Borkin LJ, Skorinov DV, Pasynkova RA, Mazanaeva LF, Rosanov JM, Dubey S, Litvinchuk S.

Mol Phylogenet Evol. 2019 Dec;141:106615. doi: 10.1016/j.ympev.2019.106615. Epub 2019 Sep 11.

14.

Polypharmacy and Kidney Function in Community-Dwelling Adults Age 60 Years and Older: A Prospective Observational Study.

Ernst R, Fischer K, de Godoi Rezende Costa Molino C, Orav EJ, Theiler R, Meyer U, Fischler M, Gagesch M, Ambühl PM, Freystätter G, Egli A, Bischoff-Ferrari HA.

J Am Med Dir Assoc. 2020 Feb;21(2):254-259.e1. doi: 10.1016/j.jamda.2019.07.007. Epub 2019 Sep 6.

15.

Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-Negative Bacteria.

Barker WT, Nemeth AM, Brackett SM, Basak AK, Chandler CE, Jania LA, Zuercher WJ, Melander RJ, Koller BH, Ernst RK, Melander C.

ACS Infect Dis. 2019 Oct 11;5(10):1764-1771. doi: 10.1021/acsinfecdis.9b00212. Epub 2019 Sep 4.

PMID:
31434474
16.

Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane.

Krishnamoorthy G, Weeks JW, Zhang Z, Chandler CE, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00956-19. doi: 10.1128/AAC.00956-19. Print 2019 Oct.

17.

Model-Based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids.

Ryu SY, Wendt GA, Chandler CE, Ernst RK, Goodlett DR.

Anal Chem. 2019 Sep 3;91(17):11482-11487. doi: 10.1021/acs.analchem.9b03340. Epub 2019 Aug 15.

PMID:
31369253
18.

Sexual Dichromatism Drives Diversification within a Major Radiation of African Amphibians.

Portik DM, Bell RC, Blackburn DC, Bauer AM, Barratt CD, Branch WR, Burger M, Channing A, Colston TJ, Conradie W, Dehling JM, Drewes RC, Ernst R, Greenbaum E, Gvoždík V, Harvey J, Hillers A, Hirschfeld M, Jongsma GFM, Kielgast J, Kouete MT, Lawson LP, Leaché AD, Loader SP, Lötters S, Meijden AV, Menegon M, Müller S, Nagy ZT, Ofori-Boateng C, Ohler A, Papenfuss TJ, Rößler D, Sinsch U, Rödel MO, Veith M, Vindum J, Zassi-Boulou AG, McGuire JA.

Syst Biol. 2019 Nov 1;68(6):859-875. doi: 10.1093/sysbio/syz023.

PMID:
31140573
19.

MR staging of anal cancer: what the radiologist needs to know.

Golia Pernicka JS, Sheedy SP, Ernst RD, Minsky BD, Ganeshan D, Rauch GM.

Abdom Radiol (NY). 2019 Nov;44(11):3726-3739. doi: 10.1007/s00261-019-02020-4. Review.

PMID:
31041496
20.

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii.

Martin SE, Melander RJ, Brackett CM, Scott AJ, Chandler CE, Nguyen CM, Minrovic BM, Harrill SE, Ernst RK, Manoil C, Melander C.

ACS Infect Dis. 2019 Jul 12;5(7):1223-1230. doi: 10.1021/acsinfecdis.9b00067. Epub 2019 Apr 26.

PMID:
31002491
21.

Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants.

Kutschera A, Dawid C, Gisch N, Schmid C, Raasch L, Gerster T, Schäffer M, Smakowska-Luzan E, Belkhadir Y, Vlot AC, Chandler CE, Schellenberger R, Schwudke D, Ernst RK, Dorey S, Hückelhoven R, Hofmann T, Ranf S.

Science. 2019 Apr 12;364(6436):178-181. doi: 10.1126/science.aau1279.

PMID:
30975887
22.

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria.

Barker WT, Chandler CE, Melander RJ, Ernst RK, Melander C.

Bioorg Med Chem. 2019 May 1;27(9):1776-1788. doi: 10.1016/j.bmc.2019.03.019. Epub 2019 Mar 8.

PMID:
30898435
23.

Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis.

Cooke AC, Nello AV, Ernst RK, Schertzer JW.

PLoS One. 2019 Feb 14;14(2):e0212275. doi: 10.1371/journal.pone.0212275. eCollection 2019.

24.

Temporal proteomic profiling reveals changes that support Burkholderia biofilms.

Khan MM, Chattagul S, Tran BQ, Freiberg JA, Nita-Lazar A, Shirtliff ME, Sermswan RW, Ernst RK, Goodlett DR.

Pathog Dis. 2019 Mar 1;77(2). pii: ftz005. doi: 10.1093/femspd/ftz005.

25.

Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers.

Kumagai A, Dupuy FG, Arsov Z, Elhady Y, Moody D, Ernst RK, Deslouches B, Montelaro RC, Peter Di Y, Tristram-Nagle S.

Soft Matter. 2019 Feb 20;15(8):1860-1868. doi: 10.1039/c8sm02180e.

PMID:
30702120
26.

Rapid Microbial Identification and Antibiotic Resistance Detection by Mass Spectrometric Analysis of Membrane Lipids.

Liang T, Leung LM, Opene B, Fondrie WE, Lee YI, Chandler CE, Yoon SH, Doi Y, Ernst RK, Goodlett DR.

Anal Chem. 2019 Jan 15;91(2):1286-1294. doi: 10.1021/acs.analchem.8b02611. Epub 2019 Jan 4.

PMID:
30571097
27.

A Prospective Study of Acinetobacter baumannii Complex Isolates and Colistin Susceptibility Monitoring by Mass Spectrometry of Microbial Membrane Glycolipids.

Leung LM, McElheny CL, Gardner FM, Chandler CE, Bowler SL, Mettus RT, Spychala CN, Fowler EL, Opene BNA, Myers RA, Goodlett DR, Doi Y, Ernst RK.

J Clin Microbiol. 2019 Feb 27;57(3). pii: e01100-18. doi: 10.1128/JCM.01100-18. Print 2019 Mar.

28.

Genomic and Phenotypic Diversity among Ten Laboratory Isolates of Pseudomonas aeruginosa PAO1.

Chandler CE, Horspool AM, Hill PJ, Wozniak DJ, Schertzer JW, Rasko DA, Ernst RK.

J Bacteriol. 2019 Feb 11;201(5). pii: e00595-18. doi: 10.1128/JB.00595-18. Print 2019 Mar 1.

29.

Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.

Maywood ES, Elliott TS, Patton AP, Krogager TP, Chesham JE, Ernst RJ, Beránek V, Brancaccio M, Chin JW, Hastings MH.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12388-E12397. doi: 10.1073/pnas.1811438115. Epub 2018 Nov 28.

30.

Assessment of parental mosaicism in SCN1A-related epilepsy by single-molecule molecular inversion probes and next-generation sequencing.

de Lange IM, Koudijs MJ, van 't Slot R, Sonsma ACM, Mulder F, Carbo EC, van Kempen MJA, Nijman IJ, Ernst RF, Savelberg SMC, Knoers NVAM, Brilstra EH, Koeleman BPC.

J Med Genet. 2019 Feb;56(2):75-80. doi: 10.1136/jmedgenet-2018-105672. Epub 2018 Oct 27.

PMID:
30368457
31.

Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.

Fondrie WE, Liang T, Oyler BL, Leung LM, Ernst RK, Strickland DK, Goodlett DR.

Sci Rep. 2018 Oct 26;8(1):15857. doi: 10.1038/s41598-018-33681-8.

32.

Comparative performance of IDEXX SDMA Test and the DLD SDMA ELISA for the measurement of SDMA in canine and feline serum.

Ernst R, Ogeer J, McCrann D, Cross J, Strong-Townsend M, Friis H, Coyne M, Clements C, Drake C, Murphy R.

PLoS One. 2018 Oct 15;13(10):e0205030. doi: 10.1371/journal.pone.0205030. eCollection 2018.

33.

Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii.

Mustapha MM, Li B, Pacey MP, Mettus RT, McElheny CL, Marshall CW, Ernst RK, Cooper VS, Doi Y.

J Antimicrob Chemother. 2018 Nov 1;73(11):2952-2959. doi: 10.1093/jac/dky290.

34.

Lack of alkaloids and tetrodotoxin in the neotropical frogs Allobates spp. (Aromobatidae) and Silverstoneia flotator (Dendrobatidae).

Mebs D, Yotsu-Yamashita M, Pogoda W, Vargas Alvarez J, Ernst R, Köhler G, Toennes SW.

Toxicon. 2018 Sep 15;152:103-105. doi: 10.1016/j.toxicon.2018.07.027. Epub 2018 Aug 4.

PMID:
30081062
35.

Integrated Functions of Membrane Property Sensors and a Hidden Side of the Unfolded Protein Response.

Covino R, Hummer G, Ernst R.

Mol Cell. 2018 Aug 2;71(3):458-467. doi: 10.1016/j.molcel.2018.07.019. Review.

36.

Rickettsia Lipid A Biosynthesis Utilizes the Late Acyltransferase LpxJ for Secondary Fatty Acid Addition.

Guillotte ML, Gillespie JJ, Chandler CE, Rahman MS, Ernst RK, Azad AF.

J Bacteriol. 2018 Sep 10;200(19). pii: e00334-18. doi: 10.1128/JB.00334-18. Print 2018 Oct 1.

37.

In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays.

Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell CM, Scott AJ, Ernst RK.

Infect Immun. 2018 Aug 22;86(9). pii: e00406-18. doi: 10.1128/IAI.00406-18. Print 2018 Sep.

38.

Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin.

Khan MM, Ernst O, Sun J, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A.

J Mol Biol. 2018 Aug 17;430(17):2641-2660. doi: 10.1016/j.jmb.2018.06.032. Epub 2018 Jun 24. Review.

PMID:
29949751
39.

The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1.

Hofbauer HF, Gecht M, Fischer SC, Seybert A, Frangakis AS, Stelzer EHK, Covino R, Hummer G, Ernst R.

J Cell Biol. 2018 Sep 3;217(9):3109-3126. doi: 10.1083/jcb.201802027. Epub 2018 Jun 25.

40.

A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model.

Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK.

Vaccine. 2018 Jun 27;36(28):4023-4031. doi: 10.1016/j.vaccine.2018.05.101. Epub 2018 May 31.

41.

Cellular mechanisms of physicochemical membrane homeostasis.

Ernst R, Ballweg S, Levental I.

Curr Opin Cell Biol. 2018 Aug;53:44-51. doi: 10.1016/j.ceb.2018.04.013. Epub 2018 May 19. Review.

42.

Geographic range expansion of tetrodotoxin in amphibians - First record in Atelopus hoogmoedi from the Guiana Shield.

Mebs D, Lorentz M, Yotsu-Yamashita M, Rößler DC, Ernst R, Lötters S.

Toxicon. 2018 Aug;150:175-179. doi: 10.1016/j.toxicon.2018.05.011. Epub 2018 May 19.

PMID:
29782950
43.

Correction to: Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1230. doi: 10.1007/s13361-018-1960-8.

PMID:
29687418
44.

Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery.

Morrison K, Haag F, Ernst R, Iglarz M, Clozel M.

J Pharmacol Exp Ther. 2018 Jun;365(3):727-733. doi: 10.1124/jpet.117.246058. Epub 2018 Mar 27.

PMID:
29588339
45.

An Emerging Group of Membrane Property Sensors Controls the Physical State of Organellar Membranes to Maintain Their Identity.

Radanović T, Reinhard J, Ballweg S, Pesek K, Ernst R.

Bioessays. 2018 May;40(5):e1700250. doi: 10.1002/bies.201700250. Epub 2018 Mar 25. Review.

PMID:
29574931
46.

Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation.

Sengyee S, Yoon SH, Paksanont S, Yimthin T, Wuthiekanun V, Limmathurotsakul D, West TE, Ernst RK, Chantratita N.

PLoS Negl Trop Dis. 2018 Feb 23;12(2):e0006287. doi: 10.1371/journal.pntd.0006287. eCollection 2018 Feb.

47.

Top Down Tandem Mass Spectrometric Analysis of a Chemically Modified Rough-Type Lipopolysaccharide Vaccine Candidate.

Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour DPA, Ernst RK, Cross AS, Goodlett DR.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1221-1229. doi: 10.1007/s13361-018-1897-y. Epub 2018 Feb 20. Erratum in: J Am Soc Mass Spectrom. 2018 Apr 23;:.

PMID:
29464544
48.

Mosaicism of de novo pathogenic SCN1A variants in epilepsy is a frequent phenomenon that correlates with variable phenotypes.

de Lange IM, Koudijs MJ, van 't Slot R, Gunning B, Sonsma ACM, van Gemert LJJM, Mulder F, Carbo EC, van Kempen MJA, Verbeek NE, Nijman IJ, Ernst RF, Savelberg SMC, Knoers NVAM, Brilstra EH, Koeleman BPC.

Epilepsia. 2018 Mar;59(3):690-703. doi: 10.1111/epi.14021. Epub 2018 Feb 20.

49.

Labeling and identifying cell-specific proteomes in the mouse brain.

Krogager TP, Ernst RJ, Elliott TS, Calo L, Beránek V, Ciabatti E, Spillantini MG, Tripodi M, Hastings MH, Chin JW.

Nat Biotechnol. 2018 Feb;36(2):156-159. doi: 10.1038/nbt.4056. Epub 2017 Dec 18.

50.

Diversity and biogeography of frogs in the genus Amnirana (Anura: Ranidae) across sub-Saharan Africa.

Jongsma GFM, Barej MF, Barratt CD, Burger M, Conradie W, Ernst R, Greenbaum E, Hirschfeld M, Leaché AD, Penner J, Portik DM, Zassi-Boulou AG, Rödel MO, Blackburn DC.

Mol Phylogenet Evol. 2018 Mar;120:274-285. doi: 10.1016/j.ympev.2017.12.006. Epub 2017 Dec 12.

PMID:
29246817

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