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Should We Divide Crohn's Disease Into Ileum-Dominant and Isolated Colonic Diseases?

Dulai PS, Singh S, Casteele NV, Boland BS, Rivera-Nieves J, Ernst PB, Eckmann L, Barrett KE, Chang JT, Sandborn WJ.

Clin Gastroenterol Hepatol. 2019 Apr 19. pii: S1542-3565(19)30430-6. doi: 10.1016/j.cgh.2019.04.040. [Epub ahead of print] Review.


Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death.

Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, Kelliher M, Boone D, Guma M, Karin M.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9192-E9200. doi: 10.1073/pnas.1810584115. Epub 2018 Sep 12.


Implementation of Mass Cytometry as a Tool for Mechanism of Action Studies in Inflammatory Bowel Disease.

Tyler CJ, Pérez-Jeldres T, Ehinger E, Capaldo B, Karuppuchamy T, Boyer JD, Patel D, Dulai P, Boland BS, Lannigan J, Eckmann L, Ernst PB, Sandborn WJ, Ho SB, Rivera-Nieves J.

Inflamm Bowel Dis. 2018 Oct 12;24(11):2366-2376. doi: 10.1093/ibd/izy214.


Of mice, men and immunity: a case for evolutionary systems biology.

Ernst PB, Carvunis AR.

Nat Immunol. 2018 May;19(5):421-425. doi: 10.1038/s41590-018-0084-4. No abstract available.


Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.

Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H.

Front Immunol. 2017 Dec 13;8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017. Review.


ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection.

Sarkar A, Tindle C, Pranadinata RF, Reed S, Eckmann L, Stappenbeck TS, Ernst PB, Das S.

J Infect Dis. 2017 Dec 19;216(12):1655-1666. doi: 10.1093/infdis/jix528.


Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis.

Butcher LD, den Hartog G, Ernst PB, Crowe SE.

Cell Mol Gastroenterol Hepatol. 2017 Feb 20;3(3):316-322. doi: 10.1016/j.jcmgh.2017.02.002. eCollection 2017 May. Review.


Our New President- Sheila E. Crowe, MD.

Ernst PB.

Gastroenterology. 2017 May;152(6):1599-1604. doi: 10.1053/j.gastro.2017.03.028. Epub 2017 Mar 29. No abstract available.


Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease.

Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK.

Science. 2016 May 27;352(6289):1116-20. doi: 10.1126/science.aad9948. Epub 2016 May 5.


ELMO1 has an essential role in the internalization of Salmonella Typhimurium into enteric macrophages that impacts disease outcome.

Das S, Sarkar A, Choudhury SS, Owen KA, Castillo V, Fox S, Eckmann L, Elliott MR, Casanova JE, Ernst PB.

Cell Mol Gastroenterol Hepatol. 2015 Apr 1;1(3):311-324.


Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia.

den Hartog G, Chattopadhyay R, Ablack A, Hall EH, Butcher LD, Bhattacharyya A, Eckmann L, Harris PR, Das S, Ernst PB, Crowe SE.

PLoS Pathog. 2016 Jan 13;12(1):e1005382. doi: 10.1371/journal.ppat.1005382. eCollection 2016 Jan.


The role of C1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during Helicobacter pylori infection.

Fox S, Ryan KA, Berger AH, Petro K, Das S, Crowe SE, Ernst PB.

J Inflamm (Lond). 2015 Sep 8;12:51. doi: 10.1186/s12950-015-0098-8. eCollection 2015.


Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT.

Inflamm Bowel Dis. 2015 Feb;21(2):323-30. doi: 10.1097/MIB.0000000000000264.


Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT.

Aliment Pharmacol Ther. 2014 Sep;40(5):477-85. doi: 10.1111/apt.12862. Epub 2014 Jul 13.


Studies in human intestinal tissues: is it time to reemphasize research in human immunology?

Chang JT, Sandborn WJ, Ernst PB.

Gastroenterology. 2014 Jul;147(1):26-30. doi: 10.1053/j.gastro.2014.05.025. Epub 2014 May 27. No abstract available.


Extracellular adenosine regulates colitis through effects on lymphoid and nonlymphoid cells.

Kurtz CC, Drygiannakis I, Naganuma M, Feldman S, Bekiaris V, Linden J, Ware CF, Ernst PB.

Am J Physiol Gastrointest Liver Physiol. 2014 Aug 1;307(3):G338-46. doi: 10.1152/ajpgi.00404.2013. Epub 2014 May 29.


Ecto-5'-nucleotidase (CD73) regulates host inflammatory responses and exacerbates murine salmonellosis.

Alam MS, Kuo JL, Ernst PB, Derr-Castillo V, Pereira M, Gaines D, Costales M, Bigley E, Williams K.

Sci Rep. 2014 Mar 27;4:4486. doi: 10.1038/srep04486.


Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells.

Das S, Sarkar A, Ryan KA, Fox S, Berger AH, Juncadella IJ, Bimczok D, Smythies LE, Harris PR, Ravichandran KS, Crowe SE, Smith PD, Ernst PB.

FASEB J. 2014 May;28(5):2214-24. doi: 10.1096/fj.13-243238. Epub 2014 Feb 7.


Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells.

Bimczok D, Smythies LE, Waites KB, Grams JM, Stahl RD, Mannon PJ, Peter S, Wilcox CM, Harris PR, Das S, Ernst PB, Smith PD.

J Immunol. 2013 Jun 15;190(12):6626-34. doi: 10.4049/jimmunol.1203330. Epub 2013 May 17.


A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31.

Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS.

Curr Biol. 2013 Jan 21;23(2):162-7. doi: 10.1016/j.cub.2012.11.049. Epub 2012 Dec 27.


Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease.

Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizarro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB.

J Control Release. 2013 Feb 10;165(3):216-25. doi: 10.1016/j.jconrel.2012.10.021. Epub 2012 Nov 8. Erratum in: J Control Release. 2014 Jan 10;173:10. Pizzaro, Theresa T [corrected to Pizarro, Theresa T].


Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1.

Luo Y, Kong Q, Yang J, Mitra A, Golden G, Wanda SY, Roland KL, Jensen RV, Ernst PB, Curtiss R 3rd.

PLoS One. 2012;7(7):e40645. doi: 10.1371/journal.pone.0040645. Epub 2012 Jul 6.


Effects of adenosine A₂A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice.

Warren CA, Calabrese GM, Li Y, Pawlowski SW, Figler RA, Rieger J, Ernst PB, Linden J, Guerrant RL.

BMC Infect Dis. 2012 Jan 20;12:13. doi: 10.1186/1471-2334-12-13.


Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.

Ernst PB, Erickson LD, Loo WM, Scott KG, Wiznerowicz EB, Brown CC, Torres-Velez FJ, Alam MS, Black SG, McDuffie M, Feldman SH, Wallace JL, McKnight GW, Padol IT, Hunt RH, Tung KS.

Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G105-15. doi: 10.1152/ajpgi.00194.2011. Epub 2011 Sep 15.


Pathogenesis of gastritis in ileitis-prone SAMP1/Yit mice.

Ernst PB, Wiznerowicz EB, Feldman SH, Tung KS.

Keio J Med. 2011;60(2):65-8. Review.


Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169).

Luo Y, Kong Q, Yang J, Golden G, Wanda SY, Jensen RV, Ernst PB, Curtiss R 3rd.

J Bacteriol. 2011 Aug;193(15):4035-6. doi: 10.1128/JB.05224-11. Epub 2011 May 27.


The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6.

Wilson JM, Kurtz CC, Black SG, Ross WG, Alam MS, Linden J, Ernst PB.

J Immunol. 2011 Jun 15;186(12):6746-52. doi: 10.4049/jimmunol.1100117. Epub 2011 May 18.


Vaccine-induced immunity against Helicobacter pylori in the absence of IL-17A.

DeLyria ES, Nedrud JG, Ernst PB, Alam MS, Redline RW, Ding H, Czinn SJ, Xu J, Blanchard TG.

Helicobacter. 2011 Jun;16(3):169-78. doi: 10.1111/j.1523-5378.2011.00839.x.


Immunological alterations mediated by adenosine during host-microbial interactions.

Drygiannakis I, Ernst PB, Lowe D, Glomski IJ.

Immunol Res. 2011 May;50(1):69-77. doi: 10.1007/s12026-011-8207-0. Review.


Host Inflammatory Response to Infection.

Wang J, Blanchard TG, Ernst PB.

In: Mobley HLT, Mendz GL, Hazell SL, editors. Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press; 2001. Chapter 39.


Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria.

Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2136-41. doi: 10.1073/pnas.1014775108. Epub 2011 Jan 18.


Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium.

Bhattacharyya A, Chattopadhyay R, Hall EH, Mebrahtu ST, Ernst PB, Crowe SE.

Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1177-86. doi: 10.1152/ajpgi.00372.2010. Epub 2010 Sep 9.


Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology.

Ernst PB, Garrison JC, Thompson LF.

J Immunol. 2010 Aug 15;185(4):1993-8. doi: 10.4049/jimmunol.1000108. Review.


Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.

Bhattacharyya A, Chattopadhyay R, Burnette BR, Cross JV, Mitra S, Ernst PB, Bhakat KK, Crowe SE.

Gastroenterology. 2009 Jun;136(7):2258-69. doi: 10.1053/j.gastro.2009.02.014.


Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1.

O'Hara AM, Bhattacharyya A, Bai J, Mifflin RC, Ernst PB, Mitra S, Crowe SE.

Cytokine. 2009 Jun;46(3):359-69. doi: 10.1016/j.cyto.2009.03.010. Epub 2009 Apr 18.


The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells.

Wilson JM, Ross WG, Agbai ON, Frazier R, Figler RA, Rieger J, Linden J, Ernst PB.

J Immunol. 2009 Apr 15;182(8):4616-23. doi: 10.4049/jimmunol.0801279.


CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.

Alam MS, Kurtz CC, Rowlett RM, Reuter BK, Wiznerowicz E, Das S, Linden J, Crowe SE, Ernst PB.

J Infect Dis. 2009 Feb 15;199(4):494-504. doi: 10.1086/596205.


A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.

Alam MS, Kurtz CC, Wilson JM, Burnette BR, Wiznerowicz EB, Ross WG, Rieger JM, Figler RA, Linden J, Crowe SE, Ernst PB.

Mucosal Immunol. 2009 May;2(3):232-42. doi: 10.1038/mi.2009.4. Epub 2009 Mar 4.


A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis.

Ho J, Kurtz CC, Naganuma M, Ernst PB, Cominelli F, Rivera-Nieves J.

J Immunol. 2008 Feb 15;180(4):2573-80.


MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.

Rowlett RM, Chrestensen CA, Nyce M, Harp MG, Pelo JW, Cominelli F, Ernst PB, Pizarro TT, Sturgill TW, Worthington MT.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G452-9. Epub 2007 Nov 21.


Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells.

Ding SZ, Minohara Y, Fan XJ, Wang J, Reyes VE, Patel J, Dirden-Kramer B, Boldogh I, Ernst PB, Crowe SE.

Infect Immun. 2007 Aug;75(8):4030-9. Epub 2007 Jun 11.


Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1.

O'Hara AM, Bhattacharyya A, Mifflin RC, Smith MF, Ryan KA, Scott KG, Naganuma M, Casola A, Izumi T, Mitra S, Ernst PB, Crowe SE.

J Immunol. 2006 Dec 1;177(11):7990-9.


Cutting edge: Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis.

Naganuma M, Wiznerowicz EB, Lappas CM, Linden J, Worthington MT, Ernst PB.

J Immunol. 2006 Sep 1;177(5):2765-9.


Microbial-induced regulation of syndecan expression: important host defense mechanism or an opportunity for pathogens?

Smith MF Jr, Gautam JK, Black SG, Ernst PB.

ScientificWorldJournal. 2006 Apr 4;6:442-5. Review. No abstract available.


The primary defect in experimental ileitis originates from a nonhematopoietic source.

Olson TS, Reuter BK, Scott KG, Morris MA, Wang XM, Hancock LN, Burcin TL, Cohn SM, Ernst PB, Cominelli F, Meddings JB, Ley K, Pizarro TT.

J Exp Med. 2006 Mar 20;203(3):541-52. Epub 2006 Feb 27.


The translation of Helicobacter pylori basic research to patient care.

Ernst PB, Peura DA, Crowe SE.

Gastroenterology. 2006 Jan;130(1):188-206; quiz 212-3. Review.


Understanding immunity to Helicobacter pylori: unraveling the riddle, wrapped in a mystery, inside an enigma.

Ernst PB.

Gastroenterology. 2005 Jul;129(1):380-3. Review. No abstract available.


Polarized expression of CD74 by gastric epithelial cells.

Barrera CA, Beswick EJ, Sierra JC, Bland D, Espejo R, Mifflin R, Adegboyega P, Crowe SE, Ernst PB, Reyes VE.

J Histochem Cytochem. 2005 Dec;53(12):1481-9. Epub 2005 May 27.

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